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The map label for this gene is proC [H]

Identifier: 108797648

GI number: 108797648

Start: 728070

End: 728954

Strand: Direct

Name: proC [H]

Synonym: Mmcs_0668

Alternate gene names: 108797648

Gene position: 728070-728954 (Clockwise)

Preceding gene: 108797647

Following gene: 108797649

Centisome position: 12.76

GC content: 69.04

Gene sequence:

>885_bases
ATGCTTTGGCGCATGGCCAGAATCGCGATCATCGGTGGCGGAAGTATGGGTGAGGCGCTGCTGTCCGGGCTGCTCCGGGC
CGGCAGGCAGGTCAAGGATCTGGTGGTCGCCGAGAAGCATCCGGACCGCGCGAAGTTCCTCGCCGAGAAGCACTCGGTGC
TGGTGACCTCCGTCGTCGAGGCCATCGACAACGCCCACTACGTCATCGTCGCGGTGAAGCCGGCCGACGTCGAGCACGTC
ATCGACGACATCGCCGAGGCCGCCGCCAACGCCGACACCGACACCGCCGAGCAGGTCTTCGTCACGGTCGCGGCCGGGGT
GTCGACCGCGTACTACGAGAACAAGCTGCCGGCGGGCGCACCGGTGATCCGCGCGATGCCCAATGCGCCGGTCGTGGTCG
GCGGGGGAGTCAGCGCGCTGGCGCCGGGCCGCTTCGCGACCCCCGAGCACCTCAAGGAGGTCTCGGCGATCTTCGACTCG
GTCGGCGGCGTGCTGACCGTGCCGGAGTCGCAGCTGGACGCGGTGACCGCGGTGTCGGGCTCCGGGCCCGCCTACTTCTT
CCTGATGGTCGAGGCGTTGGTCGACGCCGCGGTGGCCAGTGGGCTGTCGCGCACGGTGGCCACCGACCTGGTGGTGCAGA
CGATGGCGGGTTCGGCCGCGATGTTGCTGGAGCGCCTCGACGAGGCCCAGCCGGTGGGCGATGCGGCAATGGGAACGGCG
ATGGACACCACGGCGGCGCAACTCCGCGCTACGGTTACCTCACCGGCCGGTACCACCGCCGCTGGGCTGCGAGAACTCGA
ACGCGGTGGTTTGCGGTCGGCGGTGGCGAATGCGGTGGAAGCCGCGAAAACCCGCTCTGAGCAGCTAGGAATTACATCAG
AGTAG

Upstream 100 bases:

>100_bases
CGACTGCGAGGGTCGCATCGTCGTGCAGAGTCGGCAGTTGGCGATGGTGCCCGCCGCGCAGTGACGCGCGCCGGATGACG
GTGCGCGAGGCGGACATGCC

Downstream 100 bases:

>100_bases
TTCGTGGATTTCGGACTGATTAGCCCACACCCGTCGCAGTAACCCCATCCGCCACGCTATTCTCCTCGTGTATGCACGGG
TCGGTGCCAGCGGTGGGGAA

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MLWRMARIAIIGGGSMGEALLSGLLRAGRQVKDLVVAEKHPDRAKFLAEKHSVLVTSVVEAIDNAHYVIVAVKPADVEHV
IDDIAEAAANADTDTAEQVFVTVAAGVSTAYYENKLPAGAPVIRAMPNAPVVVGGGVSALAPGRFATPEHLKEVSAIFDS
VGGVLTVPESQLDAVTAVSGSGPAYFFLMVEALVDAAVASGLSRTVATDLVVQTMAGSAAMLLERLDEAQPVGDAAMGTA
MDTTAAQLRATVTSPAGTTAAGLRELERGGLRSAVANAVEAAKTRSEQLGITSE

Sequences:

>Translated_294_residues
MLWRMARIAIIGGGSMGEALLSGLLRAGRQVKDLVVAEKHPDRAKFLAEKHSVLVTSVVEAIDNAHYVIVAVKPADVEHV
IDDIAEAAANADTDTAEQVFVTVAAGVSTAYYENKLPAGAPVIRAMPNAPVVVGGGVSALAPGRFATPEHLKEVSAIFDS
VGGVLTVPESQLDAVTAVSGSGPAYFFLMVEALVDAAVASGLSRTVATDLVVQTMAGSAAMLLERLDEAQPVGDAAMGTA
MDTTAAQLRATVTSPAGTTAAGLRELERGGLRSAVANAVEAAKTRSEQLGITSE
>Mature_294_residues
MLWRMARIAIIGGGSMGEALLSGLLRAGRQVKDLVVAEKHPDRAKFLAEKHSVLVTSVVEAIDNAHYVIVAVKPADVEHV
IDDIAEAAANADTDTAEQVFVTVAAGVSTAYYENKLPAGAPVIRAMPNAPVVVGGGVSALAPGRFATPEHLKEVSAIFDS
VGGVLTVPESQLDAVTAVSGSGPAYFFLMVEALVDAAVASGLSRTVATDLVVQTMAGSAAMLLERLDEAQPVGDAAMGTA
MDTTAAQLRATVTSPAGTTAAGLRELERGGLRSAVANAVEAAKTRSEQLGITSE

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=284, Percent_Identity=34.8591549295775, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI21361454, Length=288, Percent_Identity=35.4166666666667, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI24797097, Length=289, Percent_Identity=34.9480968858132, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI24797095, Length=289, Percent_Identity=34.9480968858132, Blast_Score=126, Evalue=2e-29,
Organism=Escherichia coli, GI1786585, Length=285, Percent_Identity=32.6315789473684, Blast_Score=132, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17569021, Length=288, Percent_Identity=34.7222222222222, Blast_Score=151, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI17540664, Length=293, Percent_Identity=30.3754266211604, Blast_Score=115, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6320861, Length=310, Percent_Identity=25.8064516129032, Blast_Score=90, Evalue=4e-19,
Organism=Drosophila melanogaster, GI21358587, Length=288, Percent_Identity=38.1944444444444, Blast_Score=162, Evalue=3e-40,
Organism=Drosophila melanogaster, GI24648116, Length=292, Percent_Identity=31.1643835616438, Blast_Score=125, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24647700, Length=184, Percent_Identity=44.0217391304348, Blast_Score=125, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 30114; Mature: 30114

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLWRMARIAIIGGGSMGEALLSGLLRAGRQVKDLVVAEKHPDRAKFLAEKHSVLVTSVVE
CCCEEEEEEEEECCCHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
AIDNAHYVIVAVKPADVEHVIDDIAEAAANADTDTAEQVFVTVAAGVSTAYYENKLPAGA
HHCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
PVIRAMPNAPVVVGGGVSALAPGRFATPEHLKEVSAIFDSVGGVLTVPESQLDAVTAVSG
CHHHCCCCCCEEECCCHHHCCCCCCCCHHHHHHHHHHHHHCCCEEECCHHHHHHHEEECC
SGPAYFFLMVEALVDAAVASGLSRTVATDLVVQTMAGSAAMLLERLDEAQPVGDAAMGTA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHCCH
MDTTAAQLRATVTSPAGTTAAGLRELERGGLRSAVANAVEAAKTRSEQLGITSE
HHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MLWRMARIAIIGGGSMGEALLSGLLRAGRQVKDLVVAEKHPDRAKFLAEKHSVLVTSVVE
CCCEEEEEEEEECCCHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
AIDNAHYVIVAVKPADVEHVIDDIAEAAANADTDTAEQVFVTVAAGVSTAYYENKLPAGA
HHCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
PVIRAMPNAPVVVGGGVSALAPGRFATPEHLKEVSAIFDSVGGVLTVPESQLDAVTAVSG
CHHHCCCCCCEEECCCHHHCCCCCCCCHHHHHHHHHHHHHCCCEEECCHHHHHHHEEECC
SGPAYFFLMVEALVDAAVASGLSRTVATDLVVQTMAGSAAMLLERLDEAQPVGDAAMGTA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHCCH
MDTTAAQLRATVTSPAGTTAAGLRELERGGLRSAVANAVEAAKTRSEQLGITSE
HHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]