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The map label for this gene is lieA [H]

Identifier: 108797533

GI number: 108797533

Start: 612219

End: 613724

Strand: Direct

Name: lieA [H]

Synonym: Mmcs_0553

Alternate gene names: 108797533

Gene position: 612219-613724 (Clockwise)

Preceding gene: 108797532

Following gene: 108797534

Centisome position: 10.73

GC content: 67.13

Gene sequence:

>1506_bases
ATGGTGCGCGAGATGCTGGCGGTGCTGTCGATAGTGGCCGTCACGGCAGGCTTGACCGGTTGCGGCGACGATGAAAAGGG
AAACCCGGTGCCGGCGCCGTCCACCCAGGAGACCGCACCCGAAGCCAAGGAGTTCGGCGCTGCACTGAAGGACAAGGTGA
CCGTGGACGCGATGATGGGCCACCTCGACGAACTCCAGAAGATCGCGGACGCCCACGGCGGCAACCGGGCGCTCAGCACA
CCGGGATACGACGCGAGCGTCGACTATGTGGCCAACACCCTGCGCGACAAGGGTTTCGACGTGCAGACCCCCGACTTCGA
AGTACGCCTGCCGTTCGCCGAGAAGCCGCAGCTGACCGTCGGCGGGCGGGCCGTCGAGGCCAAAGCGCTGGAGTACACCA
TCGGCACCGCGCCGCAGGGCGTCGAAGGTCCGCTCGTGCCCGCCCGCGTCGAAGACTCACCGGGCTGCACCGCGTCGGAC
TACGACGGACTGCCGGTGCAGGGTGCGGTGGTGCTGGTCGACCGCGGGGAATGCCCGTTCGGGGTCAAACAGGCCGTCGC
CGCCCAACGCGGCGCGGTGGCGCTGGTGGTGGTCAACAACGTCGACGGGGAGGTGGTGAGCGGGACCCTCGGCGACGACA
CCGACGTCAAGATCCCCGCCGTCAGCGTCACCAAGGCGGTCGGCGGCGAGTTACGCGACGCTCCGGGGCAGACCACTCTG
CGGCTGGAGGCCGGTGTGCGCACAGATCGCACCCGGAATGTCATCGCCCAGACCAAGACCGGATCAACCTCCGATGTGGT
GATGGTGGGGGCGCACCTCGACAGCGTTCCGGAGGGTCCTGGCATCAACGACAACGGATCCGGTGTGGCCGCCATCCTCG
AGACGGCCTTGCAGCTGGGTGTCGACCCCGACGTGCGCAACACGGTGCGCTTCGGATTCTGGGGCGCCGAGGAACAGGGT
CTGCTCGGATCCATGGATTACGTCCAGTCGCTGAACGAGGAACAGCTCAAGGACATCTCGCTCTACCTCAACTTCGACAT
GTTGGGCTCACCGAACCCCGGCTATTTCACCTACGACGGCGATCAGTCCGCACCGCCGAACCCCGAGGCGGGTTCGCCTC
GGGTGCCGGAGGGGTCGGCGGGCATCGAACGCACCCTCATGCAGTACCTCGACGATGCGGGCAAACCGGGCGAGGACACC
AGCTTCGACGGCCGCTCCGACTACGACGGCTTCACCCTCGCAGGCATCCCGGCCGGTGGTTTGTTCTCCGGCGCCGAAGA
GGAGAAGACCCCGGAGCAGGCCGAGCGCTGGGGTGGTGAAGCCGACCGACCCTTCGATCCGAACTATCACAAGAAGGAAG
ACGATCTCACCCACATCGACCGCACCGCGATGGAGATCAACGGCGGCGGCGTGGCGTACGCGGTCGGGCTGTACGCCCAG
GATCAGCGCGGCCGCAACGGGATTCCGATCCGTGACGACCGCACGCGCCATCCCGTCGAATCCTGA

Upstream 100 bases:

>100_bases
CGGGCGCCACTCGAGGCAACGGTCAGCGGACATGACCCGCGACCTCGCGCGAAGCGGCGGTTGAGCCTGGCCCACAGTTG
CAGCCGCTAACGTGGATGCA

Downstream 100 bases:

>100_bases
TGCACATCAGCCGGGCGGTCACAGCGCTGGTGGCGGCGCTGGTCGCGGCGTGCTCGTCACCCGCCCCGCCGCCGGATGTC
ACGGGCGGTGATCTGGCAGG

Product: aminopeptidase Y

Products: NA

Alternate protein names: LIE1 [H]

Number of amino acids: Translated: 501; Mature: 501

Protein sequence:

>501_residues
MVREMLAVLSIVAVTAGLTGCGDDEKGNPVPAPSTQETAPEAKEFGAALKDKVTVDAMMGHLDELQKIADAHGGNRALST
PGYDASVDYVANTLRDKGFDVQTPDFEVRLPFAEKPQLTVGGRAVEAKALEYTIGTAPQGVEGPLVPARVEDSPGCTASD
YDGLPVQGAVVLVDRGECPFGVKQAVAAQRGAVALVVVNNVDGEVVSGTLGDDTDVKIPAVSVTKAVGGELRDAPGQTTL
RLEAGVRTDRTRNVIAQTKTGSTSDVVMVGAHLDSVPEGPGINDNGSGVAAILETALQLGVDPDVRNTVRFGFWGAEEQG
LLGSMDYVQSLNEEQLKDISLYLNFDMLGSPNPGYFTYDGDQSAPPNPEAGSPRVPEGSAGIERTLMQYLDDAGKPGEDT
SFDGRSDYDGFTLAGIPAGGLFSGAEEEKTPEQAERWGGEADRPFDPNYHKKEDDLTHIDRTAMEINGGGVAYAVGLYAQ
DQRGRNGIPIRDDRTRHPVES

Sequences:

>Translated_501_residues
MVREMLAVLSIVAVTAGLTGCGDDEKGNPVPAPSTQETAPEAKEFGAALKDKVTVDAMMGHLDELQKIADAHGGNRALST
PGYDASVDYVANTLRDKGFDVQTPDFEVRLPFAEKPQLTVGGRAVEAKALEYTIGTAPQGVEGPLVPARVEDSPGCTASD
YDGLPVQGAVVLVDRGECPFGVKQAVAAQRGAVALVVVNNVDGEVVSGTLGDDTDVKIPAVSVTKAVGGELRDAPGQTTL
RLEAGVRTDRTRNVIAQTKTGSTSDVVMVGAHLDSVPEGPGINDNGSGVAAILETALQLGVDPDVRNTVRFGFWGAEEQG
LLGSMDYVQSLNEEQLKDISLYLNFDMLGSPNPGYFTYDGDQSAPPNPEAGSPRVPEGSAGIERTLMQYLDDAGKPGEDT
SFDGRSDYDGFTLAGIPAGGLFSGAEEEKTPEQAERWGGEADRPFDPNYHKKEDDLTHIDRTAMEINGGGVAYAVGLYAQ
DQRGRNGIPIRDDRTRHPVES
>Mature_501_residues
MVREMLAVLSIVAVTAGLTGCGDDEKGNPVPAPSTQETAPEAKEFGAALKDKVTVDAMMGHLDELQKIADAHGGNRALST
PGYDASVDYVANTLRDKGFDVQTPDFEVRLPFAEKPQLTVGGRAVEAKALEYTIGTAPQGVEGPLVPARVEDSPGCTASD
YDGLPVQGAVVLVDRGECPFGVKQAVAAQRGAVALVVVNNVDGEVVSGTLGDDTDVKIPAVSVTKAVGGELRDAPGQTTL
RLEAGVRTDRTRNVIAQTKTGSTSDVVMVGAHLDSVPEGPGINDNGSGVAAILETALQLGVDPDVRNTVRFGFWGAEEQG
LLGSMDYVQSLNEEQLKDISLYLNFDMLGSPNPGYFTYDGDQSAPPNPEAGSPRVPEGSAGIERTLMQYLDDAGKPGEDT
SFDGRSDYDGFTLAGIPAGGLFSGAEEEKTPEQAERWGGEADRPFDPNYHKKEDDLTHIDRTAMEINGGGVAYAVGLYAQ
DQRGRNGIPIRDDRTRHPVES

Specific function: A leucine-specific metalloprotease that plays a role in controlling the amount of leupeptin during colony development. Degrades leupeptin into three components, acetyl-leucine, leucine and argininal [H]

COG id: COG2234

COG function: function code R; Predicted aminopeptidases

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M28 family. M28A subfamily [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6319763, Length=474, Percent_Identity=31.0126582278481, Blast_Score=195, Evalue=2e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008979
- InterPro:   IPR007484
- InterPro:   IPR002884 [H]

Pfam domain/function: PF01483 P_proprotein; PF04389 Peptidase_M28 [H]

EC number: NA

Molecular weight: Translated: 52830; Mature: 52830

Theoretical pI: Translated: 4.19; Mature: 4.19

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVREMLAVLSIVAVTAGLTGCGDDEKGNPVPAPSTQETAPEAKEFGAALKDKVTVDAMMG
CHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
HLDELQKIADAHGGNRALSTPGYDASVDYVANTLRDKGFDVQTPDFEVRLPFAEKPQLTV
HHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCEEE
GGRAVEAKALEYTIGTAPQGVEGPLVPARVEDSPGCTASDYDGLPVQGAVVLVDRGECPF
CCCEEEEEEEEEEECCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCH
GVKQAVAAQRGAVALVVVNNVDGEVVSGTLGDDTDVKIPAVSVTKAVGGELRDAPGQTTL
HHHHHHHHCCCCEEEEEEECCCCCEEECCCCCCCCEEECHHHHHHHHCCCCCCCCCCEEE
RLEAGVRTDRTRNVIAQTKTGSTSDVVMVGAHLDSVPEGPGINDNGSGVAAILETALQLG
EEECCCCCCCCCCEEEECCCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHC
VDPDVRNTVRFGFWGAEEQGLLGSMDYVQSLNEEQLKDISLYLNFDMLGSPNPGYFTYDG
CCCCCCCEEEEEECCCCCCCCCCCHHHHHHCCHHHHCEEEEEEEEEECCCCCCCEEEECC
DQSAPPNPEAGSPRVPEGSAGIERTLMQYLDDAGKPGEDTSFDGRSDYDGFTLAGIPAGG
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCC
LFSGAEEEKTPEQAERWGGEADRPFDPNYHKKEDDLTHIDRTAMEINGGGVAYAVGLYAQ
CCCCCCHHCCHHHHHHCCCCCCCCCCCCCCCCCCCHHHHCCEEEEECCCCEEEEEEEEEE
DQRGRNGIPIRDDRTRHPVES
CCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MVREMLAVLSIVAVTAGLTGCGDDEKGNPVPAPSTQETAPEAKEFGAALKDKVTVDAMMG
CHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
HLDELQKIADAHGGNRALSTPGYDASVDYVANTLRDKGFDVQTPDFEVRLPFAEKPQLTV
HHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCCEEE
GGRAVEAKALEYTIGTAPQGVEGPLVPARVEDSPGCTASDYDGLPVQGAVVLVDRGECPF
CCCEEEEEEEEEEECCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCH
GVKQAVAAQRGAVALVVVNNVDGEVVSGTLGDDTDVKIPAVSVTKAVGGELRDAPGQTTL
HHHHHHHHCCCCEEEEEEECCCCCEEECCCCCCCCEEECHHHHHHHHCCCCCCCCCCEEE
RLEAGVRTDRTRNVIAQTKTGSTSDVVMVGAHLDSVPEGPGINDNGSGVAAILETALQLG
EEECCCCCCCCCCEEEECCCCCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHC
VDPDVRNTVRFGFWGAEEQGLLGSMDYVQSLNEEQLKDISLYLNFDMLGSPNPGYFTYDG
CCCCCCCEEEEEECCCCCCCCCCCHHHHHHCCHHHHCEEEEEEEEEECCCCCCCEEEECC
DQSAPPNPEAGSPRVPEGSAGIERTLMQYLDDAGKPGEDTSFDGRSDYDGFTLAGIPAGG
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCC
LFSGAEEEKTPEQAERWGGEADRPFDPNYHKKEDDLTHIDRTAMEINGGGVAYAVGLYAQ
CCCCCCHHCCHHHHHHCCCCCCCCCCCCCCCCCCCHHHHCCEEEEECCCCEEEEEEEEEE
DQRGRNGIPIRDDRTRHPVES
CCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA