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The map label for this gene is pamO [H]

Identifier: 108797491

GI number: 108797491

Start: 566059

End: 567705

Strand: Direct

Name: pamO [H]

Synonym: Mmcs_0511

Alternate gene names: 108797491

Gene position: 566059-567705 (Clockwise)

Preceding gene: 108797490

Following gene: 108797492

Centisome position: 9.92

GC content: 68.0

Gene sequence:

>1647_bases
ATGTCCGCCCAGCAGGATTCGCCCGACCGGTTCGACGTCGTGATCGTCGGTGCCGGCTTCGCCGGCCTGTACATGCTGCA
CCGCGTCCGCGCGCTGGGGCTCACCGCGCGGATCGTCGAACGGGGTGAGGACGTGGGCGGCACCTGGTACTGGAACCGCT
ATCCCGGCGCACGCTGCGACATCGAGAGCATCGACTACGCGTACTCCTTCGACGAGACCCTGACCCGTGAGTGGCGGTGG
ACCGAGCGGTACGCCGCGCAACCCGAGATCCTGTCCTACATCGGCCATGTCGCCGACCGCTTCGACCTGCGCGACGACAT
CACGTTCGGCACCACGGTGCGGCGCGCCGACTGGGACGACGACACGGCACAGTGGACGCTGGTCTGCGATACCGGCCAGG
TACTGCGGGCGACGTTCTGCGTGATGGCGACAGGCTGCCTGTCCGTGGCCAAACAGCCGGAATTCCCGGGCCTTTCACAG
TTTCGCGGACGGTGGTACCACACCGGGCGGTGGCCCCACGACCCCGTGGACTTCACCGGCAGGCGGGTCGCGGTGATCGG
CACCGGATCGTCGGGTATCCAGGCCATTCCGCGCATCGCCGAGGCGGCCGAACAGCTCTTCGTGCTGCAGCGCACCCCGA
ACTACAGCATGCCGGCACAGAACCGGCCGCTCGCGGCCGATGAATTCGATTCGGCCATCGCCGATTTCGCCACCCGCCGC
CGCATCTGTCAGCGCAGCGACGCCGGGGTCCCGCATCCGCCGCCGACCCAGGGCACCTTCGACGTCACCGCAGAGGAGCG
CGAACGGCGCTACGAGGAGGGCTGGCAACGCGGCGGGATCAACGCGCTGTCGGCCGCGTTCACCGATTTCTTCACCGACG
AAGACGCGAACCGGATGGCTCAGGAGTTCGCGCGCAACAAGATCCGCAGCATCGTCGAGGACGCCCAGACCGCCGAACTC
CTCTGCCCCCAACACCACATCGGCACCAAACGCACGTGTGTGGACACCGGCTACTTCCAGACCTACAACCGCGACAACGT
CGAGCTGGTCAACAGCCGCGCAGAACCGATCGACCAGATCACCGCCACCGGGATCCGGCTCGTCGGCGGACGCCACCTCG
ACGTCGACACGCTCGTGTTCGCGATCGGCTTCGATGCGATCACCGGGGCGCTGACCGACATCGACATCCGCGGCACCGGC
GGCGCGGCACTGCGCGACGAATGGGACGACGGCCCACGGACCCTGCTCGGCCTGCAGACGGCCGGATTCCCGAACCTGTT
CATGGTCACCGGGCCCGGAAGCCCGTCGGTGCTGAGCAACATGCTGGTGTCGATCGAACAGCACGTCGACTGGATCGCCG
ACTGCCTGCTGCACCTGCGCAAACTCGGCCACGACCGCATCGAGGCCACCCGCGACGCGCAGGACCGGTGGATGGAGCAC
ATCGGCGAGCTGGCCGCCGAAACCCTCTACCCACAGGCGAACTCGTGGTACCTGGGCGCCAACATTCCCGGGAAGGCGCG
CACCTTCATGCCCTACGTCGCCGGATGCGGTGAGTACCGGCGCGAGTGCGACGAGGTCGTCGCGTCGGGCTACTCGGGTT
TCCTGCTCGGGCGACCCAGTCCGGTCCGCGAGGGGACGAGCGCATGA

Upstream 100 bases:

>100_bases
GCCCCGCAACCGTGGGACCGCGCCGAGGTGCACCAGGCGTTCGCCCGCGCGCTGGCCACCCGTGACCGCGGCCTCGTCAC
GGCCGCAGGTTAGGAAAACC

Downstream 100 bases:

>100_bases
TCGACGCACGCACCGCCCCCACCGCCTCGGAGGTCCTCGCCCGACTGCACGCTGAGGACATCGCGACGGTGATCCTCGGC
GGCACCGACACCCACGGGGT

Product: cyclohexanone monooxygenase

Products: NA

Alternate protein names: PAMO; Baeyer-Villiger monooxygenase; BVMO [H]

Number of amino acids: Translated: 548; Mature: 547

Protein sequence:

>548_residues
MSAQQDSPDRFDVVIVGAGFAGLYMLHRVRALGLTARIVERGEDVGGTWYWNRYPGARCDIESIDYAYSFDETLTREWRW
TERYAAQPEILSYIGHVADRFDLRDDITFGTTVRRADWDDDTAQWTLVCDTGQVLRATFCVMATGCLSVAKQPEFPGLSQ
FRGRWYHTGRWPHDPVDFTGRRVAVIGTGSSGIQAIPRIAEAAEQLFVLQRTPNYSMPAQNRPLAADEFDSAIADFATRR
RICQRSDAGVPHPPPTQGTFDVTAEERERRYEEGWQRGGINALSAAFTDFFTDEDANRMAQEFARNKIRSIVEDAQTAEL
LCPQHHIGTKRTCVDTGYFQTYNRDNVELVNSRAEPIDQITATGIRLVGGRHLDVDTLVFAIGFDAITGALTDIDIRGTG
GAALRDEWDDGPRTLLGLQTAGFPNLFMVTGPGSPSVLSNMLVSIEQHVDWIADCLLHLRKLGHDRIEATRDAQDRWMEH
IGELAAETLYPQANSWYLGANIPGKARTFMPYVAGCGEYRRECDEVVASGYSGFLLGRPSPVREGTSA

Sequences:

>Translated_548_residues
MSAQQDSPDRFDVVIVGAGFAGLYMLHRVRALGLTARIVERGEDVGGTWYWNRYPGARCDIESIDYAYSFDETLTREWRW
TERYAAQPEILSYIGHVADRFDLRDDITFGTTVRRADWDDDTAQWTLVCDTGQVLRATFCVMATGCLSVAKQPEFPGLSQ
FRGRWYHTGRWPHDPVDFTGRRVAVIGTGSSGIQAIPRIAEAAEQLFVLQRTPNYSMPAQNRPLAADEFDSAIADFATRR
RICQRSDAGVPHPPPTQGTFDVTAEERERRYEEGWQRGGINALSAAFTDFFTDEDANRMAQEFARNKIRSIVEDAQTAEL
LCPQHHIGTKRTCVDTGYFQTYNRDNVELVNSRAEPIDQITATGIRLVGGRHLDVDTLVFAIGFDAITGALTDIDIRGTG
GAALRDEWDDGPRTLLGLQTAGFPNLFMVTGPGSPSVLSNMLVSIEQHVDWIADCLLHLRKLGHDRIEATRDAQDRWMEH
IGELAAETLYPQANSWYLGANIPGKARTFMPYVAGCGEYRRECDEVVASGYSGFLLGRPSPVREGTSA
>Mature_547_residues
SAQQDSPDRFDVVIVGAGFAGLYMLHRVRALGLTARIVERGEDVGGTWYWNRYPGARCDIESIDYAYSFDETLTREWRWT
ERYAAQPEILSYIGHVADRFDLRDDITFGTTVRRADWDDDTAQWTLVCDTGQVLRATFCVMATGCLSVAKQPEFPGLSQF
RGRWYHTGRWPHDPVDFTGRRVAVIGTGSSGIQAIPRIAEAAEQLFVLQRTPNYSMPAQNRPLAADEFDSAIADFATRRR
ICQRSDAGVPHPPPTQGTFDVTAEERERRYEEGWQRGGINALSAAFTDFFTDEDANRMAQEFARNKIRSIVEDAQTAELL
CPQHHIGTKRTCVDTGYFQTYNRDNVELVNSRAEPIDQITATGIRLVGGRHLDVDTLVFAIGFDAITGALTDIDIRGTGG
AALRDEWDDGPRTLLGLQTAGFPNLFMVTGPGSPSVLSNMLVSIEQHVDWIADCLLHLRKLGHDRIEATRDAQDRWMEHI
GELAAETLYPQANSWYLGANIPGKARTFMPYVAGCGEYRRECDEVVASGYSGFLLGRPSPVREGTSA

Specific function: Catalyzes a Baeyer-Villiger oxidation reaction, i.e., the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters. Is most efficient with phenylacetone as substrate, leading to the formation of benzyl

COG id: COG2072

COG function: function code P; Predicted flavoprotein involved in K+ transport

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-binding monooxygenase family [H]

Homologues:

Organism=Homo sapiens, GI4503757, Length=218, Percent_Identity=28.8990825688073, Blast_Score=83, Evalue=7e-16,
Organism=Homo sapiens, GI4503755, Length=209, Percent_Identity=28.2296650717703, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI221316674, Length=228, Percent_Identity=28.5087719298246, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI221316672, Length=228, Percent_Identity=28.5087719298246, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI221316678, Length=228, Percent_Identity=28.5087719298246, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI4503759, Length=219, Percent_Identity=27.8538812785388, Blast_Score=70, Evalue=6e-12,
Organism=Drosophila melanogaster, GI19921694, Length=235, Percent_Identity=28.0851063829787, Blast_Score=75, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020946 [H]

Pfam domain/function: PF00743 FMO-like [H]

EC number: =1.14.13.92 [H]

Molecular weight: Translated: 61154; Mature: 61023

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00213 LIPOCALIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAQQDSPDRFDVVIVGAGFAGLYMLHRVRALGLTARIVERGEDVGGTWYWNRYPGARCD
CCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCC
IESIDYAYSFDETLTREWRWTERYAAQPEILSYIGHVADRFDLRDDITFGTTVRRADWDD
HHHCCCEECCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCC
DTAQWTLVCDTGQVLRATFCVMATGCLSVAKQPEFPGLSQFRGRWYHTGRWPHDPVDFTG
CCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCEECCCCCCCCCCCCC
RRVAVIGTGSSGIQAIPRIAEAAEQLFVLQRTPNYSMPAQNRPLAADEFDSAIADFATRR
CEEEEEECCCHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
RICQRSDAGVPHPPPTQGTFDVTAEERERRYEEGWQRGGINALSAAFTDFFTDEDANRMA
HHHHHCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHH
QEFARNKIRSIVEDAQTAELLCPQHHIGTKRTCVDTGYFQTYNRDNVELVNSRAEPIDQI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCCCHHHHCCCCCHHHHH
TATGIRLVGGRHLDVDTLVFAIGFDAITGALTDIDIRGTGGAALRDEWDDGPRTLLGLQT
HHCCEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCEEEEEEC
AGFPNLFMVTGPGSPSVLSNMLVSIEQHVDWIADCLLHLRKLGHDRIEATRDAQDRWMEH
CCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHH
IGELAAETLYPQANSWYLGANIPGKARTFMPYVAGCGEYRRECDEVVASGYSGFLLGRPS
HHHHHHHHCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCC
PVREGTSA
CCCCCCCC
>Mature Secondary Structure 
SAQQDSPDRFDVVIVGAGFAGLYMLHRVRALGLTARIVERGEDVGGTWYWNRYPGARCD
CCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCC
IESIDYAYSFDETLTREWRWTERYAAQPEILSYIGHVADRFDLRDDITFGTTVRRADWDD
HHHCCCEECCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCC
DTAQWTLVCDTGQVLRATFCVMATGCLSVAKQPEFPGLSQFRGRWYHTGRWPHDPVDFTG
CCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCEECCCCCCCCCCCCC
RRVAVIGTGSSGIQAIPRIAEAAEQLFVLQRTPNYSMPAQNRPLAADEFDSAIADFATRR
CEEEEEECCCHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
RICQRSDAGVPHPPPTQGTFDVTAEERERRYEEGWQRGGINALSAAFTDFFTDEDANRMA
HHHHHCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHH
QEFARNKIRSIVEDAQTAELLCPQHHIGTKRTCVDTGYFQTYNRDNVELVNSRAEPIDQI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCCCHHHHCCCCCHHHHH
TATGIRLVGGRHLDVDTLVFAIGFDAITGALTDIDIRGTGGAALRDEWDDGPRTLLGLQT
HHCCEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCEEEEEEC
AGFPNLFMVTGPGSPSVLSNMLVSIEQHVDWIADCLLHLRKLGHDRIEATRDAQDRWMEH
CCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHH
IGELAAETLYPQANSWYLGANIPGKARTFMPYVAGCGEYRRECDEVVASGYSGFLLGRPS
HHHHHHHHCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCC
PVREGTSA
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA