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The map label for this gene is ilvD [H]

Identifier: 108797126

GI number: 108797126

Start: 161931

End: 163673

Strand: Reverse

Name: ilvD [H]

Synonym: Mmcs_0146

Alternate gene names: 108797126

Gene position: 163673-161931 (Counterclockwise)

Preceding gene: 108797137

Following gene: 108797119

Centisome position: 2.87

GC content: 68.73

Gene sequence:

>1743_bases
ATGCCCTCAGGAAGTTCAGGAACTCCCGCTGATGCTCTTCGCGCGAGCGACTCATCGCCGGACATCAAGCCCCGCAGCCG
CGACGTCACCGACGGCCTCGAGAAGACCGCCGCCCGCGGGATGCTGCGGGCGGTCGGCATGGGCGACGACGACTGGGTCA
AACCGCAGATCGGCGTGGGTTCGTCGTGGAACGAGATCACCCCGTGCAACATGTCGCTGCAACGGCTGGCGCAGTCGGTG
AAGGGCGGCGTGCACTCCGCCGGCGGATTTCCGCTGGAGTTCGGCACGATCTCGGTGTCCGACGGCATCTCGATGGGCCA
CGAGGGCATGCACTTCTCGCTGGTCTCGCGTGAGGTGATCGCCGACAGCGTCGAGACCGTCGTGCAGGCCGAGCGTCTCG
ACGGCACGGTGCTGCTGGCCGGCTGCGACAAGTCGATTCCCGGCATGCTGATGGCCGCCGCCCGGCTCGACCTGGCCTCG
GTCTTCCTGTACAACGGTTCGATCATGCCGGGCGTCGCGAAGCTCACCGACGGCTCCGAGCGGGAAGTCACGATCATCGA
CGCCTTCGAGGCGGTCGGGGCGTGCGCCCGCGGGCTGATGTCCCGCGAGGACGTCGACATCATCGAACGGGCGATCTGTC
CGGGTGAGGGCGCCTGCGGCGGTATGTACACCGCCAACACCATGGCGTCGGCGGCGGAAGCGCTCGGCATGTCGTTGCCG
GGCAGCGCATCTCCTGTGGCCATCGACAAGCGGCGCGACGAGTACGCGCGGAAGTCGGGTGAGGCGGTCGTCGAGATGCT
GCGCCGCGGTATCACCGCCCGCGACATCCTCACCAAGGAGGCCTTCGAGAACGCGATCGCCGTCGTCATGGCGTTCGGCG
GCTCCACCAACGCCGTGCTGCACCTGCTGGCCATCGCGTGGGAGGCCAACGTGAAGCTCACCCTCGAGGACTTCACCCGC
GTCGGGCAGAAGGTGCCGCACCTCGCCGACGTCAAACCGTTCGGCCGTCACGTCATGAAGCACGTCGACGAGATCGGCGG
TGTGCCCGTGGTGATGAAGGCGCTGCTGGACGCCGGACTGCTGCACGGGGACTGCCTCACCATCACCGGCGAGACCATGG
CCGAGAACCTGGCCCACATCGAACCGCCGGACCCGGACGGCAAGGTGCTGCGGGCGATGAACAACCCGATCCACCCGACC
GGCGGCATCACGATCCTGCACGGATCGTTGGCGCCCGAGGGCGCGGTCGTGAAGTCGGCGGGCTTCGACTCCGACGTGTT
CGAGGGCACCGCAAGGGTTTTCGAGCGGGAGCGGGCAGCCCTGGACGCACTCGAGGACGGCACGATCACCCACGGCGACG
TCGTCGTCATCCGCTACGAGGGACCCAAGGGCGGGCCCGGGATGCGCGAGATGCTCGCCATCACCGGTGCGATCAAGGGT
GCCGGCCTGGGCAAGGACGTGCTGCTGATGACCGACGGCCGGTTCTCCGGCGGCACCACCGGCCTGTGCGTCGGGCATAT
CGCCCCCGAGGCGGTCGACGGCGGGCCCATCGCGTTCGTGCGCGACGGCGACCGGATCCGGCTCGACGTCGCCAAGGGCA
CGCTGGACCTCCTGGTCGACGAGGCCGAATTCGAGTCCCGCAAAGCGGGATTCGAGCCGTTGCCCCCGGTGTACACCACC
GGCGTGCTGGCCAAGTACACGAAGTTGGTCGGGTCGGCGGCGGTCGGCGCGGTCTGCGGCTAG

Upstream 100 bases:

>100_bases
TCGGAGGGCGCGTGACGTCATGAGACCAGCGTACTGGATACCCCAAGGGGGTATGCCGAATTGGTTTGGCCGGGTGAAAC
GCCAGAGGCATAATCGATAG

Downstream 100 bases:

>100_bases
GTCGCCGCGACCGCGCCTGCGCTGCGCCGACAGTACGTTTGTTGACGCGGTTACCCGCGTAAGCAGTGCAAGAACCGTAC
CGTCGGCGTTGCGCTACCCG

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 580; Mature: 579

Protein sequence:

>580_residues
MPSGSSGTPADALRASDSSPDIKPRSRDVTDGLEKTAARGMLRAVGMGDDDWVKPQIGVGSSWNEITPCNMSLQRLAQSV
KGGVHSAGGFPLEFGTISVSDGISMGHEGMHFSLVSREVIADSVETVVQAERLDGTVLLAGCDKSIPGMLMAAARLDLAS
VFLYNGSIMPGVAKLTDGSEREVTIIDAFEAVGACARGLMSREDVDIIERAICPGEGACGGMYTANTMASAAEALGMSLP
GSASPVAIDKRRDEYARKSGEAVVEMLRRGITARDILTKEAFENAIAVVMAFGGSTNAVLHLLAIAWEANVKLTLEDFTR
VGQKVPHLADVKPFGRHVMKHVDEIGGVPVVMKALLDAGLLHGDCLTITGETMAENLAHIEPPDPDGKVLRAMNNPIHPT
GGITILHGSLAPEGAVVKSAGFDSDVFEGTARVFERERAALDALEDGTITHGDVVVIRYEGPKGGPGMREMLAITGAIKG
AGLGKDVLLMTDGRFSGGTTGLCVGHIAPEAVDGGPIAFVRDGDRIRLDVAKGTLDLLVDEAEFESRKAGFEPLPPVYTT
GVLAKYTKLVGSAAVGAVCG

Sequences:

>Translated_580_residues
MPSGSSGTPADALRASDSSPDIKPRSRDVTDGLEKTAARGMLRAVGMGDDDWVKPQIGVGSSWNEITPCNMSLQRLAQSV
KGGVHSAGGFPLEFGTISVSDGISMGHEGMHFSLVSREVIADSVETVVQAERLDGTVLLAGCDKSIPGMLMAAARLDLAS
VFLYNGSIMPGVAKLTDGSEREVTIIDAFEAVGACARGLMSREDVDIIERAICPGEGACGGMYTANTMASAAEALGMSLP
GSASPVAIDKRRDEYARKSGEAVVEMLRRGITARDILTKEAFENAIAVVMAFGGSTNAVLHLLAIAWEANVKLTLEDFTR
VGQKVPHLADVKPFGRHVMKHVDEIGGVPVVMKALLDAGLLHGDCLTITGETMAENLAHIEPPDPDGKVLRAMNNPIHPT
GGITILHGSLAPEGAVVKSAGFDSDVFEGTARVFERERAALDALEDGTITHGDVVVIRYEGPKGGPGMREMLAITGAIKG
AGLGKDVLLMTDGRFSGGTTGLCVGHIAPEAVDGGPIAFVRDGDRIRLDVAKGTLDLLVDEAEFESRKAGFEPLPPVYTT
GVLAKYTKLVGSAAVGAVCG
>Mature_579_residues
PSGSSGTPADALRASDSSPDIKPRSRDVTDGLEKTAARGMLRAVGMGDDDWVKPQIGVGSSWNEITPCNMSLQRLAQSVK
GGVHSAGGFPLEFGTISVSDGISMGHEGMHFSLVSREVIADSVETVVQAERLDGTVLLAGCDKSIPGMLMAAARLDLASV
FLYNGSIMPGVAKLTDGSEREVTIIDAFEAVGACARGLMSREDVDIIERAICPGEGACGGMYTANTMASAAEALGMSLPG
SASPVAIDKRRDEYARKSGEAVVEMLRRGITARDILTKEAFENAIAVVMAFGGSTNAVLHLLAIAWEANVKLTLEDFTRV
GQKVPHLADVKPFGRHVMKHVDEIGGVPVVMKALLDAGLLHGDCLTITGETMAENLAHIEPPDPDGKVLRAMNNPIHPTG
GITILHGSLAPEGAVVKSAGFDSDVFEGTARVFERERAALDALEDGTITHGDVVVIRYEGPKGGPGMREMLAITGAIKGA
GLGKDVLLMTDGRFSGGTTGLCVGHIAPEAVDGGPIAFVRDGDRIRLDVAKGTLDLLVDEAEFESRKAGFEPLPPVYTTG
VLAKYTKLVGSAAVGAVCG

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=571, Percent_Identity=39.0542907180385, Blast_Score=380, Evalue=1e-106,
Organism=Escherichia coli, GI1786464, Length=497, Percent_Identity=34.8088531187123, Blast_Score=225, Evalue=7e-60,
Organism=Escherichia coli, GI2367371, Length=468, Percent_Identity=35.6837606837607, Blast_Score=220, Evalue=2e-58,
Organism=Escherichia coli, GI1788157, Length=520, Percent_Identity=30.9615384615385, Blast_Score=213, Evalue=2e-56,
Organism=Saccharomyces cerevisiae, GI6322476, Length=564, Percent_Identity=47.1631205673759, Blast_Score=499, Evalue=1e-142,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 60523; Mature: 60392

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: PS00886 ILVD_EDD_1 ; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSGSSGTPADALRASDSSPDIKPRSRDVTDGLEKTAARGMLRAVGMGDDDWVKPQIGVG
CCCCCCCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
SSWNEITPCNMSLQRLAQSVKGGVHSAGGFPLEFGTISVSDGISMGHEGMHFSLVSREVI
CCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEECEEEECCCCCCCCCCCEEHHHHHHHH
ADSVETVVQAERLDGTVLLAGCDKSIPGMLMAAARLDLASVFLYNGSIMPGVAKLTDGSE
HHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHEEEECCCCCCCHHCCCCCCC
REVTIIDAFEAVGACARGLMSREDVDIIERAICPGEGACGGMYTANTMASAAEALGMSLP
CEEEEEHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCC
GSASPVAIDKRRDEYARKSGEAVVEMLRRGITARDILTKEAFENAIAVVMAFGGSTNAVL
CCCCCEEECCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHEEEEEEECCCHHHHH
HLLAIAWEANVKLTLEDFTRVGQKVPHLADVKPFGRHVMKHVDEIGGVPVVMKALLDAGL
HHHHHHCCCCEEEEHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCC
LHGDCLTITGETMAENLAHIEPPDPDGKVLRAMNNPIHPTGGITILHGSLAPEGAVVKSA
CCCCEEEEECHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCCEEEEECCCCCCCCEEECC
GFDSDVFEGTARVFERERAALDALEDGTITHGDVVVIRYEGPKGGPGMREMLAITGAIKG
CCCHHHHHHHHHHHHHHHHHHHHHCCCCEECCCEEEEEECCCCCCCCHHHHHHHHHHHCC
AGLGKDVLLMTDGRFSGGTTGLCVGHIAPEAVDGGPIAFVRDGDRIRLDVAKGTLDLLVD
CCCCCCEEEEECCCCCCCCCCEEEECCCCCCCCCCCEEEEECCCEEEEEEECCCEEHEEE
EAEFESRKAGFEPLPPVYTTGVLAKYTKLVGSAAVGAVCG
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PSGSSGTPADALRASDSSPDIKPRSRDVTDGLEKTAARGMLRAVGMGDDDWVKPQIGVG
CCCCCCCCHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
SSWNEITPCNMSLQRLAQSVKGGVHSAGGFPLEFGTISVSDGISMGHEGMHFSLVSREVI
CCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEECEEEECCCCCCCCCCCEEHHHHHHHH
ADSVETVVQAERLDGTVLLAGCDKSIPGMLMAAARLDLASVFLYNGSIMPGVAKLTDGSE
HHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHEEEECCCCCCCHHCCCCCCC
REVTIIDAFEAVGACARGLMSREDVDIIERAICPGEGACGGMYTANTMASAAEALGMSLP
CEEEEEHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCC
GSASPVAIDKRRDEYARKSGEAVVEMLRRGITARDILTKEAFENAIAVVMAFGGSTNAVL
CCCCCEEECCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHEEEEEEECCCHHHHH
HLLAIAWEANVKLTLEDFTRVGQKVPHLADVKPFGRHVMKHVDEIGGVPVVMKALLDAGL
HHHHHHCCCCEEEEHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHCCC
LHGDCLTITGETMAENLAHIEPPDPDGKVLRAMNNPIHPTGGITILHGSLAPEGAVVKSA
CCCCEEEEECHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCCEEEEECCCCCCCCEEECC
GFDSDVFEGTARVFERERAALDALEDGTITHGDVVVIRYEGPKGGPGMREMLAITGAIKG
CCCHHHHHHHHHHHHHHHHHHHHHCCCCEECCCEEEEEECCCCCCCCHHHHHHHHHHHCC
AGLGKDVLLMTDGRFSGGTTGLCVGHIAPEAVDGGPIAFVRDGDRIRLDVAKGTLDLLVD
CCCCCCEEEEECCCCCCCCCCEEEECCCCCCCCCCCEEEEECCCEEEEEEECCCEEHEEE
EAEFESRKAGFEPLPPVYTTGVLAKYTKLVGSAAVGAVCG
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA