BacMap

Definition	Mycobacterium sp. MCS chromosome, complete genome.
Accession	NC_008146
Length	5,705,448

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The map label for this gene is ppiA [H]

Identifier: 108796991

GI number: 108796991

Start: 13835

End: 14362

Strand: Direct

Name: ppiA [H]

Synonym: Mmcs_0010

Alternate gene names: 108796991

Gene position: 13835-14362 (Clockwise)

Preceding gene: 108796989

Following gene: 108796994

Centisome position: 0.24

GC content: 66.1

Gene sequence:

>528_bases
GTGACGAGCCCTATTCAGACCGCGACGGCGACCCTGCACACCAATCGTGGCGACATCAAGATCGCCCTGTTCGGAAACCA
CGCCCCCAAGACGGTGTCGAACTTCGTCGGCCTGGCGCAGGGCACGAAGGACTACAAGGGTGAGAACGCCTCCGGCAGCA
CGTCGGGTCCGTTCTACGACGGTGCGGTGTTCCACCGGGTCATCGACGGCTTCATGATCCAGGGCGGCGATCCGACCGGC
ACCGGGCGTGGCGGGCCGGGTTACCAGTTCGCCGACGAGTTCCACCCCGAGCTGCAGTTCGACAAGCCCTACCTGCTGGC
GATGGCCAACGCCGGGCCGGGCACGAATGGTTCGCAGTTCTTCATCACCGTGGGCAAGACCCCCCACCTCAACCGCCGCC
ACACCATCTTCGGCGAGGTCGTCGACCCCGAGTCGCAGAAGGTCGTCGACGCGATCGCCACGACCGCGACCGACCGCAAC
GACCGGCCGACCGATCCCGTGGTCATCGAGTCGGTCACCATCAGCTGA

Upstream 100 bases:

>100_bases
CATGCGTCACCTCTTCTGCAACGGTCCGGTGGGTCACCACAGCCTGCCATCACCGGGTGCGGCGTCGGCGCCCAATCGGC
GGATGGCACACTGACTTCCC

Downstream 100 bases:

>100_bases
CCGACGACTGCGTTCACTGCGTGCCGGTGTAGCCGGCCGCAGTGAGCGCATCGAGCACGTCAACGGGGTCAGTCCCCAGA
TCCCACCGCGTGAACACGTG

Product: peptidylprolyl isomerase

Products: NA

Alternate protein names: PPIase A; Rotamase A [H]

Number of amino acids: Translated: 175; Mature: 174

Protein sequence:

>175_residues
MTSPIQTATATLHTNRGDIKIALFGNHAPKTVSNFVGLAQGTKDYKGENASGSTSGPFYDGAVFHRVIDGFMIQGGDPTG
TGRGGPGYQFADEFHPELQFDKPYLLAMANAGPGTNGSQFFITVGKTPHLNRRHTIFGEVVDPESQKVVDAIATTATDRN
DRPTDPVVIESVTIS

Sequences:

>Translated_175_residues
MTSPIQTATATLHTNRGDIKIALFGNHAPKTVSNFVGLAQGTKDYKGENASGSTSGPFYDGAVFHRVIDGFMIQGGDPTG
TGRGGPGYQFADEFHPELQFDKPYLLAMANAGPGTNGSQFFITVGKTPHLNRRHTIFGEVVDPESQKVVDAIATTATDRN
DRPTDPVVIESVTIS
>Mature_174_residues
TSPIQTATATLHTNRGDIKIALFGNHAPKTVSNFVGLAQGTKDYKGENASGSTSGPFYDGAVFHRVIDGFMIQGGDPTGT
GRGGPGYQFADEFHPELQFDKPYLLAMANAGPGTNGSQFFITVGKTPHLNRRHTIFGEVVDPESQKVVDAIATTATDRND
RPTDPVVIESVTIS

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI7706339, Length=167, Percent_Identity=46.7065868263473, Blast_Score=137, Evalue=4e-33,
Organism=Homo sapiens, GI24308049, Length=170, Percent_Identity=45.8823529411765, Blast_Score=137, Evalue=4e-33,
Organism=Homo sapiens, GI19557636, Length=170, Percent_Identity=42.3529411764706, Blast_Score=135, Evalue=2e-32,
Organism=Homo sapiens, GI64276486, Length=177, Percent_Identity=39.5480225988701, Blast_Score=130, Evalue=8e-31,
Organism=Homo sapiens, GI4505991, Length=160, Percent_Identity=46.25, Blast_Score=111, Evalue=4e-25,
Organism=Homo sapiens, GI4758950, Length=157, Percent_Identity=44.5859872611465, Blast_Score=108, Evalue=2e-24,
Organism=Homo sapiens, GI22547212, Length=167, Percent_Identity=41.3173652694611, Blast_Score=103, Evalue=7e-23,
Organism=Homo sapiens, GI7657473, Length=167, Percent_Identity=41.3173652694611, Blast_Score=103, Evalue=7e-23,
Organism=Homo sapiens, GI22547215, Length=167, Percent_Identity=41.3173652694611, Blast_Score=102, Evalue=1e-22,
Organism=Homo sapiens, GI42560244, Length=160, Percent_Identity=42.5, Blast_Score=101, Evalue=3e-22,
Organism=Homo sapiens, GI6631100, Length=153, Percent_Identity=43.1372549019608, Blast_Score=99, Evalue=1e-21,
Organism=Homo sapiens, GI5454154, Length=163, Percent_Identity=41.1042944785276, Blast_Score=99, Evalue=2e-21,
Organism=Homo sapiens, GI4826932, Length=132, Percent_Identity=46.2121212121212, Blast_Score=97, Evalue=7e-21,
Organism=Homo sapiens, GI10863927, Length=157, Percent_Identity=39.4904458598726, Blast_Score=97, Evalue=8e-21,
Organism=Homo sapiens, GI256017253, Length=157, Percent_Identity=39.4904458598726, Blast_Score=93, Evalue=1e-19,
Organism=Homo sapiens, GI221139811, Length=157, Percent_Identity=39.4904458598726, Blast_Score=93, Evalue=1e-19,
Organism=Homo sapiens, GI256017251, Length=157, Percent_Identity=39.4904458598726, Blast_Score=93, Evalue=1e-19,
Organism=Homo sapiens, GI178057341, Length=157, Percent_Identity=38.8535031847134, Blast_Score=91, Evalue=4e-19,
Organism=Homo sapiens, GI209417936, Length=156, Percent_Identity=37.1794871794872, Blast_Score=91, Evalue=8e-19,
Organism=Homo sapiens, GI30102944, Length=156, Percent_Identity=37.1794871794872, Blast_Score=91, Evalue=8e-19,
Organism=Homo sapiens, GI219842199, Length=156, Percent_Identity=37.1794871794872, Blast_Score=91, Evalue=8e-19,
Organism=Homo sapiens, GI310129267, Length=154, Percent_Identity=35.7142857142857, Blast_Score=90, Evalue=1e-18,
Organism=Homo sapiens, GI310120620, Length=154, Percent_Identity=35.7142857142857, Blast_Score=90, Evalue=1e-18,
Organism=Homo sapiens, GI310110104, Length=139, Percent_Identity=38.8489208633094, Blast_Score=87, Evalue=9e-18,
Organism=Homo sapiens, GI169163387, Length=157, Percent_Identity=38.2165605095541, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI310127646, Length=156, Percent_Identity=35.2564102564103, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI310114371, Length=156, Percent_Identity=35.2564102564103, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI310119221, Length=156, Percent_Identity=35.2564102564103, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI169164185, Length=157, Percent_Identity=37.5796178343949, Blast_Score=85, Evalue=3e-17,
Organism=Homo sapiens, GI169163623, Length=157, Percent_Identity=37.5796178343949, Blast_Score=85, Evalue=3e-17,
Organism=Homo sapiens, GI5031987, Length=157, Percent_Identity=38.8535031847134, Blast_Score=84, Evalue=5e-17,
Organism=Homo sapiens, GI5174637, Length=157, Percent_Identity=37.5796178343949, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI169214050, Length=156, Percent_Identity=34.6153846153846, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI150418007, Length=129, Percent_Identity=38.7596899224806, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI14277126, Length=171, Percent_Identity=35.0877192982456, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI45439316, Length=130, Percent_Identity=40.7692307692308, Blast_Score=81, Evalue=4e-16,
Organism=Homo sapiens, GI239751853, Length=156, Percent_Identity=34.6153846153846, Blast_Score=81, Evalue=4e-16,
Organism=Homo sapiens, GI113428306, Length=156, Percent_Identity=34.6153846153846, Blast_Score=81, Evalue=4e-16,
Organism=Homo sapiens, GI303305009, Length=130, Percent_Identity=40.7692307692308, Blast_Score=81, Evalue=4e-16,
Organism=Homo sapiens, GI310132444, Length=156, Percent_Identity=33.3333333333333, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI310113152, Length=156, Percent_Identity=33.3333333333333, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI20911035, Length=174, Percent_Identity=32.183908045977, Blast_Score=77, Evalue=6e-15,
Organism=Homo sapiens, GI310127745, Length=132, Percent_Identity=37.1212121212121, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI310114540, Length=132, Percent_Identity=37.1212121212121, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI310119290, Length=132, Percent_Identity=37.1212121212121, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI27735045, Length=155, Percent_Identity=32.9032258064516, Blast_Score=72, Evalue=3e-13,
Organism=Escherichia coli, GI1786736, Length=180, Percent_Identity=36.6666666666667, Blast_Score=83, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17539496, Length=174, Percent_Identity=44.2528735632184, Blast_Score=132, Evalue=7e-32,
Organism=Caenorhabditis elegans, GI17506311, Length=170, Percent_Identity=45.8823529411765, Blast_Score=130, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI71980594, Length=169, Percent_Identity=39.6449704142012, Blast_Score=121, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI71997782, Length=148, Percent_Identity=43.2432432432432, Blast_Score=120, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17551282, Length=159, Percent_Identity=45.9119496855346, Blast_Score=118, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17551284, Length=159, Percent_Identity=45.9119496855346, Blast_Score=118, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI71980590, Length=158, Percent_Identity=39.873417721519, Blast_Score=117, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17552784, Length=160, Percent_Identity=44.375, Blast_Score=115, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17552780, Length=157, Percent_Identity=47.7707006369427, Blast_Score=111, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17506307, Length=159, Percent_Identity=47.1698113207547, Blast_Score=105, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17532641, Length=139, Percent_Identity=41.0071942446043, Blast_Score=102, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17559074, Length=158, Percent_Identity=41.1392405063291, Blast_Score=96, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17532643, Length=157, Percent_Identity=42.0382165605096, Blast_Score=96, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17566266, Length=131, Percent_Identity=44.2748091603053, Blast_Score=91, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17565860, Length=157, Percent_Identity=40.7643312101911, Blast_Score=90, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17552782, Length=157, Percent_Identity=40.1273885350318, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17539498, Length=130, Percent_Identity=41.5384615384615, Blast_Score=84, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI32563659, Length=169, Percent_Identity=29.585798816568, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323246, Length=166, Percent_Identity=39.7590361445783, Blast_Score=108, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6323562, Length=162, Percent_Identity=42.5925925925926, Blast_Score=99, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6321848, Length=158, Percent_Identity=42.4050632911392, Blast_Score=97, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6320359, Length=130, Percent_Identity=46.1538461538462, Blast_Score=95, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6320510, Length=157, Percent_Identity=41.4012738853503, Blast_Score=94, Evalue=8e-21,
Organism=Saccharomyces cerevisiae, GI6322492, Length=180, Percent_Identity=37.2222222222222, Blast_Score=81, Evalue=9e-17,
Organism=Drosophila melanogaster, GI17986117, Length=163, Percent_Identity=47.239263803681, Blast_Score=139, Evalue=8e-34,
Organism=Drosophila melanogaster, GI19922912, Length=169, Percent_Identity=44.3786982248521, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI19922376, Length=166, Percent_Identity=38.5542168674699, Blast_Score=118, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24652460, Length=137, Percent_Identity=40.1459854014599, Blast_Score=107, Evalue=4e-24,
Organism=Drosophila melanogaster, GI20130249, Length=157, Percent_Identity=45.2229299363057, Blast_Score=106, Evalue=8e-24,
Organism=Drosophila melanogaster, GI21357249, Length=143, Percent_Identity=38.4615384615385, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24650807, Length=159, Percent_Identity=42.1383647798742, Blast_Score=103, Evalue=5e-23,
Organism=Drosophila melanogaster, GI17136360, Length=161, Percent_Identity=37.888198757764, Blast_Score=95, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24664125, Length=160, Percent_Identity=40, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI21357783, Length=160, Percent_Identity=40, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI45549139, Length=130, Percent_Identity=43.8461538461538, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24586038, Length=163, Percent_Identity=39.8773006134969, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17647301, Length=160, Percent_Identity=36.25, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI21355677, Length=177, Percent_Identity=28.8135593220339, Blast_Score=69, Evalue=2e-12,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 18639; Mature: 18508

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSPIQTATATLHTNRGDIKIALFGNHAPKTVSNFVGLAQGTKDYKGENASGSTSGPFYD
CCCCCCCEEEEEECCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
GAVFHRVIDGFMIQGGDPTGTGRGGPGYQFADEFHPELQFDKPYLLAMANAGPGTNGSQF
HHHHHHHHHCEEEECCCCCCCCCCCCCCCCCHHCCCCCCCCCCEEEEEECCCCCCCCCEE
FITVGKTPHLNRRHTIFGEVVDPESQKVVDAIATTATDRNDRPTDPVVIESVTIS
EEEECCCCCCCCCEEEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCEEEEEEECC
>Mature Secondary Structure 
TSPIQTATATLHTNRGDIKIALFGNHAPKTVSNFVGLAQGTKDYKGENASGSTSGPFYD
CCCCCCEEEEEECCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
GAVFHRVIDGFMIQGGDPTGTGRGGPGYQFADEFHPELQFDKPYLLAMANAGPGTNGSQF
HHHHHHHHHCEEEECCCCCCCCCCCCCCCCCHHCCCCCCCCCCEEEEEECCCCCCCCCEE
FITVGKTPHLNRRHTIFGEVVDPESQKVVDAIATTATDRNDRPTDPVVIESVTIS
EEEECCCCCCCCCEEEEEEEECCCHHHHHHHHHHHCCCCCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]