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The map label for this gene is yhcR [H]

Identifier: 108763907

GI number: 108763907

Start: 6630258

End: 6632045

Strand: Reverse

Name: yhcR [H]

Synonym: MXAN_5325

Alternate gene names: 108763907

Gene position: 6632045-6630258 (Counterclockwise)

Preceding gene: 108762709

Following gene: 108758813

Centisome position: 72.56

GC content: 71.03

Gene sequence:

>1788_bases
ATGCGTTTCTTTCGACTCATCGCCCTCGCGTTGGCGTGCGGGGCCACCTCCGCGTGCTCCGGCTTCTGGACCCGCGGCGC
GCCGCCGGAGCCCATCCACATCACCCTGGTGGGCATCAACGACTTCCACGGACAGGTGGAGCCTCATCGCACGCCACTGA
AGGACGGCCAGGTGGTGGAGGAGGGCGGCGCCGCCACGCTCGCGGCCTACGTGGCGCGGCTGCGCGCGGCCAACCCGGGG
GGCGTGGTTCTGCTGGACGCGGGCGACATGTTCCAGGGCACGTTGCCTTCCAACCTCACGGAAGGGGCCGTCGTCATCGA
CGTGTACAACCACCTGGGAGTGGACGCGGCCGCCATTGGCAACCACGAGTTCGACTATGGCCCTGTGGGGCCGGGTTCCA
TGGCGCAGCGGCCCGGGGATGATGCGCTGGGTGCGCTCAAGGCGCGCATCGGCCAGGCGCGATTCCCCATGTTGTCGGCG
AACCTCCGCGACGCTTCCACCGGCGCGCGCCCCGCCTGGACGGGCAATGACGGCACGTACCTGATGAAGGTCAAGGGCGT
GAAGGTGGGCATCATCGGGCTCTCCACGGAGGACACCCCCAAGGTCACCAATCCCGCCAACGTGTCGTCCCTGCGCTTCC
TGCCCCTGGCGCCCGCCGCGCTGGAAGCGTCCCGTTCCCTGCGCGCGCGCGGCGCGGAGGTGGTGGTGGTGGTGGCGCAT
GCGGGAGGCAAGTGCGCGGACTTGAGCAACCCCCGCGACACGTCGAGCTGCGACGAGGGCGACGCGGAGATTCTGTCGAT
GCTGAAGCGCCTGCCGCCAGGCACGGTCGACGCCATCGTGGCGGGACACACCCACCAGACGATGGGCCACTTCTTCGCCC
AGGTGCCCATCATCGAGACGACGGGGCTGGCGCGCTCCCTGGGCGTGGTGGAGCTGTTCGTGGACCCGGACAGTCGCCGC
ATCCTGCCCGAACGCTCCCGCATCCAGGCCGCCATTCCCCTCTGTGCGAAGGTGGACGCCACCCAGGGAACGTGTGACGG
CCGCCGCCTGCGGAACGAGCCCCAGGTGCGCCTGGAGCCCGCGTCGTTCATGGCGGAGCCGGTGGTGCCCGACGCGCAGG
TGGCGCCGCTGCTGGCGCCAGCGCTGGAGCTGGCACGGGAGGCGCAGAATCGCCAGTTGGGGCTCGTGGCGGCCACGCCC
CTGGCCCGCGGCTACACGGAGGAGGGCGTGCTGGGCAATCTGGTGGCGGACGTGCTGCGTGCGTCGGCCAATGCGGACGT
GGGGCTGATGAACCCGGGCGGCGTCCGGGCCGACCTGGCCGCGGGGCCGCTCACCTTCGGTCAGGTGTTCGAGGTGCTGC
CCTTCGACAACACGGTGGCCGTGGCCACCCTGACGGGCCCCGAGCTGTCGCGGTTGCTGCACCTGGCCTATGGCAACGAC
ATGGGCTCCGTCTTCGCCGTCTCCGGCCTCGAGGTGACGCTGGAGCGCTGCCCGGGGCCTGGGCGGCTCTCGGGAGTGGC
CCTCGCCGGCGGTCAGCCGCTCGTGGTGGACTCCCGCAAGATGTACCGGGTGGCCCTCCCGGACTTTCTGGCGCGAGGCG
GTGACGGGCTTGAGCCCCTCTTGAGCACCGTGCCACCGGAGCGCATCGAGATGACCCCCGTCGACGGGCTCGACCTGCGC
GAAGCGCTCGTCGCCTACGGGAAAGCCCGGGGCGGCACGCTGGAGGCCCCCGACTTGGGACGTGTCCGCTACACGGGTGT
AGCAGGGTGTCAGCAAGAGGCGCGCTGA

Upstream 100 bases:

>100_bases
CGCTGCGTTCGCGTTGCTCGCTTTGGTGCGGGTGGGGCGTCGCCGTCGCGACTGAAGCGCGTTGCCAGCGGGCGCGCGCC
GCGCTGAAGTGCGCGCCCTC

Downstream 100 bases:

>100_bases
GAGCGTCCCGGCTGAAAATTCGGACGACGGTTGATCCGCTGGGGGTGAACGAAAGGACTCACCCCAGGGGAAGGACACAG
AAATCGCGCCGGGGGCCGAT

Product: 5`-nucleotidase family protein

Products: Phosphate; Uridine [C]

Alternate protein names: NA

Number of amino acids: Translated: 595; Mature: 595

Protein sequence:

>595_residues
MRFFRLIALALACGATSACSGFWTRGAPPEPIHITLVGINDFHGQVEPHRTPLKDGQVVEEGGAATLAAYVARLRAANPG
GVVLLDAGDMFQGTLPSNLTEGAVVIDVYNHLGVDAAAIGNHEFDYGPVGPGSMAQRPGDDALGALKARIGQARFPMLSA
NLRDASTGARPAWTGNDGTYLMKVKGVKVGIIGLSTEDTPKVTNPANVSSLRFLPLAPAALEASRSLRARGAEVVVVVAH
AGGKCADLSNPRDTSSCDEGDAEILSMLKRLPPGTVDAIVAGHTHQTMGHFFAQVPIIETTGLARSLGVVELFVDPDSRR
ILPERSRIQAAIPLCAKVDATQGTCDGRRLRNEPQVRLEPASFMAEPVVPDAQVAPLLAPALELAREAQNRQLGLVAATP
LARGYTEEGVLGNLVADVLRASANADVGLMNPGGVRADLAAGPLTFGQVFEVLPFDNTVAVATLTGPELSRLLHLAYGND
MGSVFAVSGLEVTLERCPGPGRLSGVALAGGQPLVVDSRKMYRVALPDFLARGGDGLEPLLSTVPPERIEMTPVDGLDLR
EALVAYGKARGGTLEAPDLGRVRYTGVAGCQQEAR

Sequences:

>Translated_595_residues
MRFFRLIALALACGATSACSGFWTRGAPPEPIHITLVGINDFHGQVEPHRTPLKDGQVVEEGGAATLAAYVARLRAANPG
GVVLLDAGDMFQGTLPSNLTEGAVVIDVYNHLGVDAAAIGNHEFDYGPVGPGSMAQRPGDDALGALKARIGQARFPMLSA
NLRDASTGARPAWTGNDGTYLMKVKGVKVGIIGLSTEDTPKVTNPANVSSLRFLPLAPAALEASRSLRARGAEVVVVVAH
AGGKCADLSNPRDTSSCDEGDAEILSMLKRLPPGTVDAIVAGHTHQTMGHFFAQVPIIETTGLARSLGVVELFVDPDSRR
ILPERSRIQAAIPLCAKVDATQGTCDGRRLRNEPQVRLEPASFMAEPVVPDAQVAPLLAPALELAREAQNRQLGLVAATP
LARGYTEEGVLGNLVADVLRASANADVGLMNPGGVRADLAAGPLTFGQVFEVLPFDNTVAVATLTGPELSRLLHLAYGND
MGSVFAVSGLEVTLERCPGPGRLSGVALAGGQPLVVDSRKMYRVALPDFLARGGDGLEPLLSTVPPERIEMTPVDGLDLR
EALVAYGKARGGTLEAPDLGRVRYTGVAGCQQEAR
>Mature_595_residues
MRFFRLIALALACGATSACSGFWTRGAPPEPIHITLVGINDFHGQVEPHRTPLKDGQVVEEGGAATLAAYVARLRAANPG
GVVLLDAGDMFQGTLPSNLTEGAVVIDVYNHLGVDAAAIGNHEFDYGPVGPGSMAQRPGDDALGALKARIGQARFPMLSA
NLRDASTGARPAWTGNDGTYLMKVKGVKVGIIGLSTEDTPKVTNPANVSSLRFLPLAPAALEASRSLRARGAEVVVVVAH
AGGKCADLSNPRDTSSCDEGDAEILSMLKRLPPGTVDAIVAGHTHQTMGHFFAQVPIIETTGLARSLGVVELFVDPDSRR
ILPERSRIQAAIPLCAKVDATQGTCDGRRLRNEPQVRLEPASFMAEPVVPDAQVAPLLAPALELAREAQNRQLGLVAATP
LARGYTEEGVLGNLVADVLRASANADVGLMNPGGVRADLAAGPLTFGQVFEVLPFDNTVAVATLTGPELSRLLHLAYGND
MGSVFAVSGLEVTLERCPGPGRLSGVALAGGQPLVVDSRKMYRVALPDFLARGGDGLEPLLSTVPPERIEMTPVDGLDLR
EALVAYGKARGGTLEAPDLGRVRYTGVAGCQQEAR

Specific function: Sugar-nonspecific endonuclease that yields nucleotide 3'-monophosphate products. No 5'-nucleotidase activity was detected, using 5'-AMP as the substrate, in the presence of diverse divalent metals and with various pH values [H]

COG id: COG0737

COG function: function code F; 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 TNase-like domain [H]

Homologues:

Organism=Homo sapiens, GI4505467, Length=546, Percent_Identity=23.992673992674, Blast_Score=113, Evalue=4e-25,
Organism=Escherichia coli, GI1786687, Length=547, Percent_Identity=25.7769652650823, Blast_Score=116, Evalue=3e-27,
Organism=Drosophila melanogaster, GI28573524, Length=597, Percent_Identity=26.465661641541, Blast_Score=108, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24641187, Length=559, Percent_Identity=24.865831842576, Blast_Score=99, Evalue=1e-20,
Organism=Drosophila melanogaster, GI19921980, Length=480, Percent_Identity=22.2916666666667, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI161076508, Length=480, Percent_Identity=22.2916666666667, Blast_Score=97, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24652512, Length=480, Percent_Identity=22.2916666666667, Blast_Score=97, Evalue=4e-20,
Organism=Drosophila melanogaster, GI19922446, Length=608, Percent_Identity=23.1907894736842, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24654424, Length=608, Percent_Identity=23.1907894736842, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI221329836, Length=591, Percent_Identity=23.5194585448393, Blast_Score=83, Evalue=4e-16,

Paralogues:

None

Copy number: 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 20 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008334
- InterPro:   IPR006146
- InterPro:   IPR006179
- InterPro:   IPR019948
- InterPro:   IPR019931
- InterPro:   IPR004843
- InterPro:   IPR016027
- InterPro:   IPR004365
- InterPro:   IPR016071
- InterPro:   IPR006021 [H]

Pfam domain/function: PF02872 5_nucleotid_C; PF00746 Gram_pos_anchor; PF00149 Metallophos; PF00565 SNase; PF01336 tRNA_anti [H]

EC number: 3.6.1.45; 3.1.3.5 [C]

Molecular weight: Translated: 62233; Mature: 62233

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFFRLIALALACGATSACSGFWTRGAPPEPIHITLVGINDFHGQVEPHRTPLKDGQVVE
CHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCEEE
EGGAATLAAYVARLRAANPGGVVLLDAGDMFQGTLPSNLTEGAVVIDVYNHLGVDAAAIG
CCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCEEEEEEHHHCCCCEEECC
NHEFDYGPVGPGSMAQRPGDDALGALKARIGQARFPMLSANLRDASTGARPAWTGNDGTY
CCCCCCCCCCCCHHHCCCCHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCEECCCCEE
LMKVKGVKVGIIGLSTEDTPKVTNPANVSSLRFLPLAPAALEASRSLRARGAEVVVVVAH
EEEEECEEEEEEEECCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHCCCCEEEEEEEE
AGGKCADLSNPRDTSSCDEGDAEILSMLKRLPPGTVDAIVAGHTHQTMGHFFAQVPIIET
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHCCEEEC
TGLARSLGVVELFVDPDSRRILPERSRIQAAIPLCAKVDATQGTCDGRRLRNEPQVRLEP
CCCHHHCCEEEEEECCCCCCCCCCHHHHHHHCCHHEECCCCCCCCCCHHCCCCCCEEECH
ASFMAEPVVPDAQVAPLLAPALELAREAQNRQLGLVAATPLARGYTEEGVLGNLVADVLR
HHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCHHCCCCCCCHHHHHHHHHHH
ASANADVGLMNPGGVRADLAAGPLTFGQVFEVLPFDNTVAVATLTGPELSRLLHLAYGND
HCCCCCEEEECCCCCEEECCCCCCCHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHCCC
MGSVFAVSGLEVTLERCPGPGRLSGVALAGGQPLVVDSRKMYRVALPDFLARGGDGLEPL
CCCEEEECCEEEEEECCCCCCCCCEEEEECCCEEEECCCCEEEECCHHHHHCCCCCHHHH
LSTVPPERIEMTPVDGLDLREALVAYGKARGGTLEAPDLGRVRYTGVAGCQQEAR
HHCCCCCCEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCCHHHCC
>Mature Secondary Structure
MRFFRLIALALACGATSACSGFWTRGAPPEPIHITLVGINDFHGQVEPHRTPLKDGQVVE
CHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCCCCCCEEE
EGGAATLAAYVARLRAANPGGVVLLDAGDMFQGTLPSNLTEGAVVIDVYNHLGVDAAAIG
CCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCEEEEEEHHHCCCCEEECC
NHEFDYGPVGPGSMAQRPGDDALGALKARIGQARFPMLSANLRDASTGARPAWTGNDGTY
CCCCCCCCCCCCHHHCCCCHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCEECCCCEE
LMKVKGVKVGIIGLSTEDTPKVTNPANVSSLRFLPLAPAALEASRSLRARGAEVVVVVAH
EEEEECEEEEEEEECCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHCCCCEEEEEEEE
AGGKCADLSNPRDTSSCDEGDAEILSMLKRLPPGTVDAIVAGHTHQTMGHFFAQVPIIET
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHCCEEEC
TGLARSLGVVELFVDPDSRRILPERSRIQAAIPLCAKVDATQGTCDGRRLRNEPQVRLEP
CCCHHHCCEEEEEECCCCCCCCCCHHHHHHHCCHHEECCCCCCCCCCHHCCCCCCEEECH
ASFMAEPVVPDAQVAPLLAPALELAREAQNRQLGLVAATPLARGYTEEGVLGNLVADVLR
HHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCHHCCCCCCCHHHHHHHHHHH
ASANADVGLMNPGGVRADLAAGPLTFGQVFEVLPFDNTVAVATLTGPELSRLLHLAYGND
HCCCCCEEEECCCCCEEECCCCCCCHHHHHHHCCCCCEEEEEEECCHHHHHHHHHHHCCC
MGSVFAVSGLEVTLERCPGPGRLSGVALAGGQPLVVDSRKMYRVALPDFLARGGDGLEPL
CCCEEEECCEEEEEECCCCCCCCCEEEEECCCEEEECCCCEEEECCHHHHHCCCCCHHHH
LSTVPPERIEMTPVDGLDLREALVAYGKARGGTLEAPDLGRVRYTGVAGCQQEAR
HHCCCCCCEEECCCCCCHHHHHHHHHCCCCCCCCCCCCCCCEEECCCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O; UMP [C]

Specific reaction: H2O + UMP --> Phosphate + Uridine [C]

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Inhibitor from Salmonella typhimurium cytoplasm [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969498; 9384377 [H]