Click here to switch to the map view.

The map label for this gene is thiD [H]

Identifier: 108763847

GI number: 108763847

Start: 2656880

End: 2657698

Strand: Reverse

Name: thiD [H]

Synonym: MXAN_2287

Alternate gene names: 108763847

Gene position: 2657698-2656880 (Counterclockwise)

Preceding gene: 108763074

Following gene: 108762991

Centisome position: 29.08

GC content: 72.77

Gene sequence:

>819_bases
ATGGCGGCCATGGAGACTTCGAAGTCCGTAGCCACCGCGCTCACCATCGCCGGCTCCGACAGCGGCGGCGGCGCCGGCAT
CCAGGCCGACCTGAGCACCTTCGCCTTCCACCGCGTTCACGGCACCAGCGCCCTGACGGCCATCACCGCACAGAACACAC
AGGGTGTCACTCGCGTGGACGTGATGGCCCCCGAAGCTGTCGCCGCGCAAATCGACGCCGTGGCCTCCGACATCGGCGCG
GGCGCGGTGAAGACGGGCATGCTCGTCAACCCGGCCATCATCACCACGGTGGCCCAACGCTTGCGCGCGCTGGGCCTGGG
TCCGCTGGTGGTGGACCCCGTCATGGTGTCCCGCGCCGGCGCGCGCCTCATCGACGACGCGGCGGTCGGCGCGCTCAAGG
AGCTGCTGCTGCCCCTGGCCACGGTGGCCACGCCCAACCGGCACGAGGCGGAGCTGCTCGCCGGCATGAAGTTGGAGACG
CTGGAGGACATGCGGGAGGCCGCGCGCCGCATCCACCGGCTCGGCCCCAAGGCGGTGCTGGTGAAGGGCGGCGGCATGAC
GGGTGCGCTGCGCGGCACCGACGTCTGGTTCGACGGCGAGCGCCTGGAGACGCTGCACCTGCGCGCGGTGGACACGCGCA
ACACCCACGGCACGGGTTGCACGCTGTCGGCGGCCATCGCCGCGCACCTGGCGCTGGGACAGCCGCCGCTGGAGGCCACG
CGGCGCGCGAAGGACTACGTCACCGCCGCGCTGGAGCACCCCCTGCCCCTGGGCAAGGGCCCGGGCCCCTTCAGCCACTT
CTTCCCGCTGGAGGGGTAG

Upstream 100 bases:

>100_bases
ACGAACGGCCACAGGGACCCGCTGCTGGACGCGGTGAAACACGCCTTCCTGGACCCGTGAGCGCGGGAAGCACTGGCGGC
GGAGCGCCCGCTCCCGCACC

Downstream 100 bases:

>100_bases
CCCGGGCCCGCCACCGGGCGACTACTTCGCGGCCTTCTTCGGCGCGGCCTGCGCGGCAGGCACGGGGAAGCCGCGCTTGC
GCATCAGGGCCTGGATGCCC

Product: phosphomethylpyrimidine kinase

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 272; Mature: 271

Protein sequence:

>272_residues
MAAMETSKSVATALTIAGSDSGGGAGIQADLSTFAFHRVHGTSALTAITAQNTQGVTRVDVMAPEAVAAQIDAVASDIGA
GAVKTGMLVNPAIITTVAQRLRALGLGPLVVDPVMVSRAGARLIDDAAVGALKELLLPLATVATPNRHEAELLAGMKLET
LEDMREAARRIHRLGPKAVLVKGGGMTGALRGTDVWFDGERLETLHLRAVDTRNTHGTGCTLSAAIAAHLALGQPPLEAT
RRAKDYVTAALEHPLPLGKGPGPFSHFFPLEG

Sequences:

>Translated_272_residues
MAAMETSKSVATALTIAGSDSGGGAGIQADLSTFAFHRVHGTSALTAITAQNTQGVTRVDVMAPEAVAAQIDAVASDIGA
GAVKTGMLVNPAIITTVAQRLRALGLGPLVVDPVMVSRAGARLIDDAAVGALKELLLPLATVATPNRHEAELLAGMKLET
LEDMREAARRIHRLGPKAVLVKGGGMTGALRGTDVWFDGERLETLHLRAVDTRNTHGTGCTLSAAIAAHLALGQPPLEAT
RRAKDYVTAALEHPLPLGKGPGPFSHFFPLEG
>Mature_271_residues
AAMETSKSVATALTIAGSDSGGGAGIQADLSTFAFHRVHGTSALTAITAQNTQGVTRVDVMAPEAVAAQIDAVASDIGAG
AVKTGMLVNPAIITTVAQRLRALGLGPLVVDPVMVSRAGARLIDDAAVGALKELLLPLATVATPNRHEAELLAGMKLETL
EDMREAARRIHRLGPKAVLVKGGGMTGALRGTDVWFDGERLETLHLRAVDTRNTHGTGCTLSAAIAAHLALGQPPLEATR
RAKDYVTAALEHPLPLGKGPGPFSHFFPLEG

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=259, Percent_Identity=40.9266409266409, Blast_Score=165, Evalue=4e-42,
Organism=Saccharomyces cerevisiae, GI6325378, Length=280, Percent_Identity=31.7857142857143, Blast_Score=121, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6324997, Length=284, Percent_Identity=32.7464788732394, Blast_Score=107, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6324517, Length=281, Percent_Identity=32.3843416370107, Blast_Score=103, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 28063; Mature: 27931

Theoretical pI: Translated: 7.35; Mature: 7.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAMETSKSVATALTIAGSDSGGGAGIQADLSTFAFHRVHGTSALTAITAQNTQGVTRVD
CCCCCCCHHHEEEEEEECCCCCCCCCEEHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEE
VMAPEAVAAQIDAVASDIGAGAVKTGMLVNPAIITTVAQRLRALGLGPLVVDPVMVSRAG
EECCHHHHHHHHHHHHHHCCCHHHCCCEECHHHHHHHHHHHHHHCCCCHHHHHHHHHHCC
ARLIDDAAVGALKELLLPLATVATPNRHEAELLAGMKLETLEDMREAARRIHRLGPKAVL
CHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEE
VKGGGMTGALRGTDVWFDGERLETLHLRAVDTRNTHGTGCTLSAAIAAHLALGQPPLEAT
EECCCCEEECCCCCEEECCCCEEEEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCHHHH
RRAKDYVTAALEHPLPLGKGPGPFSHFFPLEG
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AAMETSKSVATALTIAGSDSGGGAGIQADLSTFAFHRVHGTSALTAITAQNTQGVTRVD
CCCCCCHHHEEEEEEECCCCCCCCCEEHHHHHHHHHHHCCCCCEEEEEECCCCCCEEEE
VMAPEAVAAQIDAVASDIGAGAVKTGMLVNPAIITTVAQRLRALGLGPLVVDPVMVSRAG
EECCHHHHHHHHHHHHHHCCCHHHCCCEECHHHHHHHHHHHHHHCCCCHHHHHHHHHHCC
ARLIDDAAVGALKELLLPLATVATPNRHEAELLAGMKLETLEDMREAARRIHRLGPKAVL
CHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEE
VKGGGMTGALRGTDVWFDGERLETLHLRAVDTRNTHGTGCTLSAAIAAHLALGQPPLEAT
EECCCCEEECCCCCEEECCCCEEEEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCHHHH
RRAKDYVTAALEHPLPLGKGPGPFSHFFPLEG
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA