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The map label for this gene is gltT [H]

Identifier: 108763823

GI number: 108763823

Start: 2795114

End: 2796391

Strand: Direct

Name: gltT [H]

Synonym: MXAN_2403

Alternate gene names: 108763823

Gene position: 2795114-2796391 (Clockwise)

Preceding gene: 108758950

Following gene: 108763800

Centisome position: 30.58

GC content: 68.7

Gene sequence:

>1278_bases
ATGAAAGCGCACCAGAAGATGCTCGTTGGCATTGCCTCCGGCGCGGTGGCGGGCCTCGTCGCCAACGTCGTCGCGGGCGG
CGCGCCCTGGCTGGCCTTCGTCGTGGACAACGTGGCCTCGCCGGTGGGGCAGATCTTCATCCGCCTGCTGCTGATGCTCG
TGGTGCCGCTGCTGTTCTCCGCCATCGTCGTGGCCGTGGCGGAGCTGGACCTCAAGCAGGTGGGGCGGCTGGGGGCTCGC
ACGCTGGGCTACACCGTCGTCCTGTCCTCCATCTCCGTCCTCATCGGGCTGGTGCTGGTCAACACGCTGGAGCCCGGCGC
GGGCCTGAGCGACGAGGCCCGGGCGTTGGCCCAGGGCGGGATGACCATCCAGGCGGCCGCCGCGCCAGGGGCGTCCTCGT
TCGGCGCGGTGCTCGTCTCCATGGTGCCCACCAACCCCATCAAGGCCGCGGCGGATGGAGACTTCATTGGCCTCATCGTC
TTCTCGCTCATCTTCGGCATGGGCGTGGCGCTCACGCCGAGCGAGCCTGTCCAGCGCCTGCGCGAGTCCATCCAGGGCCT
CTATGACGTGATGATGAAGCTCATCGACGGTGTGCTGAGCCTGGCGCCCTTCGGTGTGGCCGCGCTGCTGTTCGCCATGA
CGGCGCGGCTGGGCTTCGGCATCTTCGTGCAGCTCGCCTCCTACATGGGCACGGTGTTGCTGGCGCTGGGCCTGCACATG
TTCGTCGTCTACTCGCTGTCGGTGCGCTTCCTGGGCGGGCGCAGCCCCATCGAGTTCTTCCGCAGCAGCCGGCTGGCCAT
CGTCACCGCCTTCTCCACGTCGTCGTCCAGCGCTACGCTGCCCACCGCGCTCAAGGTGGCGGAGGAGCACCTCAAGCTGC
CGCGCAGCGTGTCGCGCTTCGTGCTCACCGCCGGCTCGGCCATGAACCAGAACGGCACCGCGCTCTTCGAAGGCGTCACG
GTGCTCTTCCTCGCCCAGGTCTACGGCGTGCCGCTCAGCCTGTCCGACCAGGCGCTCATCATGTTCATCTGCATCCTGGC
GGGCATCGGCACCGCGGGCGTGCCGGCGGGCTCCATTCCCGTCATCGCGATGATTCTGGGCATGTTCAAGATTCCGGTGG
AGGGCCTGGGGCTCATCCTGGGCGTGGATCGCTTCCTGGACATGTGCCGCACCACGCTCAACGTCACCGGCGACCTGGCC
GCCGCCGTCTACGTGGCGCGCGGAGAGTCGGCCGACAGCCCGGCCGAAGAGGGGGCCGTGGACCCCTCTGCTTCCTGA

Upstream 100 bases:

>100_bases
AGTCGAACGAGGGTTTCCACGAGGAGGACAGCATGCCATCTTCGCCTACCGCCCGGTGGCGCGGACCATTCTCCTCCGGC
GAGGAGGGCTCGGAGATTCG

Downstream 100 bases:

>100_bases
CGCCGGGCATTTCCCGCCGCACCTTCCTCACAGCAAACGCAGTCCCACCGCAGTCATCGGCAAGGAGCCCCGCATGAGGG
TCGCCAAGGATTCCGTCGTC

Product: sodium:dicarboxylate symporter family protein

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MKAHQKMLVGIASGAVAGLVANVVAGGAPWLAFVVDNVASPVGQIFIRLLLMLVVPLLFSAIVVAVAELDLKQVGRLGAR
TLGYTVVLSSISVLIGLVLVNTLEPGAGLSDEARALAQGGMTIQAAAAPGASSFGAVLVSMVPTNPIKAAADGDFIGLIV
FSLIFGMGVALTPSEPVQRLRESIQGLYDVMMKLIDGVLSLAPFGVAALLFAMTARLGFGIFVQLASYMGTVLLALGLHM
FVVYSLSVRFLGGRSPIEFFRSSRLAIVTAFSTSSSSATLPTALKVAEEHLKLPRSVSRFVLTAGSAMNQNGTALFEGVT
VLFLAQVYGVPLSLSDQALIMFICILAGIGTAGVPAGSIPVIAMILGMFKIPVEGLGLILGVDRFLDMCRTTLNVTGDLA
AAVYVARGESADSPAEEGAVDPSAS

Sequences:

>Translated_425_residues
MKAHQKMLVGIASGAVAGLVANVVAGGAPWLAFVVDNVASPVGQIFIRLLLMLVVPLLFSAIVVAVAELDLKQVGRLGAR
TLGYTVVLSSISVLIGLVLVNTLEPGAGLSDEARALAQGGMTIQAAAAPGASSFGAVLVSMVPTNPIKAAADGDFIGLIV
FSLIFGMGVALTPSEPVQRLRESIQGLYDVMMKLIDGVLSLAPFGVAALLFAMTARLGFGIFVQLASYMGTVLLALGLHM
FVVYSLSVRFLGGRSPIEFFRSSRLAIVTAFSTSSSSATLPTALKVAEEHLKLPRSVSRFVLTAGSAMNQNGTALFEGVT
VLFLAQVYGVPLSLSDQALIMFICILAGIGTAGVPAGSIPVIAMILGMFKIPVEGLGLILGVDRFLDMCRTTLNVTGDLA
AAVYVARGESADSPAEEGAVDPSAS
>Mature_425_residues
MKAHQKMLVGIASGAVAGLVANVVAGGAPWLAFVVDNVASPVGQIFIRLLLMLVVPLLFSAIVVAVAELDLKQVGRLGAR
TLGYTVVLSSISVLIGLVLVNTLEPGAGLSDEARALAQGGMTIQAAAAPGASSFGAVLVSMVPTNPIKAAADGDFIGLIV
FSLIFGMGVALTPSEPVQRLRESIQGLYDVMMKLIDGVLSLAPFGVAALLFAMTARLGFGIFVQLASYMGTVLLALGLHM
FVVYSLSVRFLGGRSPIEFFRSSRLAIVTAFSTSSSSATLPTALKVAEEHLKLPRSVSRFVLTAGSAMNQNGTALFEGVT
VLFLAQVYGVPLSLSDQALIMFICILAGIGTAGVPAGSIPVIAMILGMFKIPVEGLGLILGVDRFLDMCRTTLNVTGDLA
AAVYVARGESADSPAEEGAVDPSAS

Specific function: This carrier protein is part of the Na(+)-dependent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI4827012, Length=429, Percent_Identity=29.8368298368298, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI66773030, Length=435, Percent_Identity=29.6551724137931, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI169790839, Length=433, Percent_Identity=29.5612009237875, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI40254478, Length=445, Percent_Identity=28.7640449438202, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI5032093, Length=395, Percent_Identity=29.1139240506329, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI21314632, Length=414, Percent_Identity=26.5700483091787, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI223468566, Length=280, Percent_Identity=32.5, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI223468564, Length=271, Percent_Identity=32.8413284132841, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI194239697, Length=246, Percent_Identity=32.9268292682927, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI262359914, Length=346, Percent_Identity=28.6127167630058, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI301601644, Length=186, Percent_Identity=35.4838709677419, Blast_Score=99, Evalue=6e-21,
Organism=Escherichia coli, GI1790514, Length=381, Percent_Identity=34.3832020997375, Blast_Score=209, Evalue=3e-55,
Organism=Escherichia coli, GI1789947, Length=371, Percent_Identity=29.3800539083558, Blast_Score=149, Evalue=5e-37,
Organism=Escherichia coli, GI1788024, Length=405, Percent_Identity=27.6543209876543, Blast_Score=115, Evalue=8e-27,
Organism=Escherichia coli, GI1789473, Length=290, Percent_Identity=30.6896551724138, Blast_Score=82, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI71996953, Length=411, Percent_Identity=31.6301703163017, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI71983106, Length=421, Percent_Identity=29.2161520190024, Blast_Score=161, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI71983099, Length=421, Percent_Identity=29.2161520190024, Blast_Score=161, Evalue=6e-40,
Organism=Caenorhabditis elegans, GI193206505, Length=408, Percent_Identity=29.9019607843137, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17537407, Length=424, Percent_Identity=29.4811320754717, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17541374, Length=396, Percent_Identity=29.2929292929293, Blast_Score=150, Evalue=9e-37,
Organism=Caenorhabditis elegans, GI193206654, Length=414, Percent_Identity=27.2946859903382, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24583025, Length=437, Percent_Identity=29.5194508009153, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI17137668, Length=437, Percent_Identity=29.5194508009153, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI24583023, Length=437, Percent_Identity=29.5194508009153, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI281360483, Length=418, Percent_Identity=26.0765550239234, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI17137666, Length=418, Percent_Identity=26.0765550239234, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI281360481, Length=418, Percent_Identity=26.0765550239234, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 43812; Mature: 43812

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCC
>Mature Secondary Structure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CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]