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The map label for this gene is atoC [H]

Identifier: 108763676

GI number: 108763676

Start: 3971524

End: 3972924

Strand: Reverse

Name: atoC [H]

Synonym: MXAN_3418

Alternate gene names: 108763676

Gene position: 3972924-3971524 (Counterclockwise)

Preceding gene: 108763457

Following gene: 108761715

Centisome position: 43.47

GC content: 66.17

Gene sequence:

>1401_bases
GTGACGGACAGACCGAGTGTTCTCGTTGTCGACGACAAGGAGAACATGCGCCACCTCATCACCCGCATTCTCGGTGACGC
TTATCAGGTGAGGACGGCTGAAGACGGAGGCCGTGCGCTCTCCCTCATCCAGACGCAGCCGTTCGACGTGGTGGTGACGG
ACATCCGAATGCCAGGAGCGGACGGCTTCGAGGTGCTCAAGGCCGTCAAGCAGCACGCGCCCACCACCGAGGTCATCCTG
ATGACGGCGTACGCCTCCGTCCCCAAGGCGGTAGAGGCCATCAAGGAGGGGGCCTACGACTACCTGCCCAAGCCCTTCGA
CCCGGACGAGGCGTCCCTGGTGGTAGCCCGCGCCGTCGAGCGCAAGCGGCTCAAGGAGCAGGCCGCCTCACTGCGGCGCG
AGCTGGAGGGCATCTACAGCTTCCAGAACATCATTGGCAGGAGCGCGCCCATGCGTGCGCTCTACGGCCTGCTGGAGCGC
GCCTCCCAGTTGGACATCACGGTGCTCATCACCGGGGAGACGGGGACGGGCAAGGAGTTGGTGGCGCGGGCCATCCACCA
CGACGGCCCACGCAAGGACCGGCCCTTCATTGCGGTCAACTGCGGCGCGCTGCCCTCCGAACTCATCGAGAGCGAGCTGT
TCGGTCACGCCCGGGGCGCCTTCACTGGCGCGGTAGAGACCAAGGCCGGTCTCTTCGAGGCAGCCTCCGGGGGAACCATC
TTCCTGGACGAGATTGGAGAGTTGCCCCTGTCCGTTCAGGTGAAGCTCAACCGCACGCTCCAGGACAAGGAAGTGCGCCG
TGTCGGAGACGCGGTTGCGCGCTGCATCGACGCACGCGTCATCACCGCCACCCACCGCGACCTCAAGGCCGAAGTGACTG
CGGGCCGCTTCCGCGAAGACCTCTACTACCGGCTCAATGTCTTCCCGGTGCATCTGCCGTCCCTGCGGGAGCGGCGCGAG
GACATCCCCCTGCTGGCCATGCACTTCGTACAGAAGGCGGCGAAGACCTACCGGCAGCCGGTGGATGGCCTGGAGCCGGA
CGCGTTGCGTGCGCTCACCGGGTACACCTGGCCGGGCAACGTGCGCCAACTAGAGAATGCCATCGAACGCGCGGTGGCCA
TCACCACTGGCTCCCGAGTGGGCCCTGACGCACTCCCCCCTGAAGTCACGGGCGGACAACAGGGAGCACTGCCCGTAGAC
CATCTGGTGAAGATGCCCTTCCGGGAGGCGGTGGACCTGGCGCGGGACCGTGCATCGCGCGATTACCTCATCGCCCTGCT
GCGGGAATTCGGGGGCAATGTGACGCGGGCTGCTGAACGCGCGGGCATGGAGCGCGAGAGCCTCCACCGGCTCCTCAAGC
GCTTTGGCCTGCGTTCCGATGACTTCAAGGAGTCACCCTAA

Upstream 100 bases:

>100_bases
TGTCGCAGGCCATCGCCCAGGCCCATGGTGGGCGCATCCAGCCGCGCAACCTGCCTGGACGTGGTGCGGAATTCACCCTG
CATCTCCCCCGGAGTACGCC

Downstream 100 bases:

>100_bases
GCAACACATGCAATCAAGCTGCATTCACAACCGGACACTGCCTCTGTAGATGCCGTCGACATGATTCCGCCGAAAGGACC
GTCGAAATGGAACGCATGAA

Product: sigma-54 dependent DNA-binding response regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 466; Mature: 465

Protein sequence:

>466_residues
MTDRPSVLVVDDKENMRHLITRILGDAYQVRTAEDGGRALSLIQTQPFDVVVTDIRMPGADGFEVLKAVKQHAPTTEVIL
MTAYASVPKAVEAIKEGAYDYLPKPFDPDEASLVVARAVERKRLKEQAASLRRELEGIYSFQNIIGRSAPMRALYGLLER
ASQLDITVLITGETGTGKELVARAIHHDGPRKDRPFIAVNCGALPSELIESELFGHARGAFTGAVETKAGLFEAASGGTI
FLDEIGELPLSVQVKLNRTLQDKEVRRVGDAVARCIDARVITATHRDLKAEVTAGRFREDLYYRLNVFPVHLPSLRERRE
DIPLLAMHFVQKAAKTYRQPVDGLEPDALRALTGYTWPGNVRQLENAIERAVAITTGSRVGPDALPPEVTGGQQGALPVD
HLVKMPFREAVDLARDRASRDYLIALLREFGGNVTRAAERAGMERESLHRLLKRFGLRSDDFKESP

Sequences:

>Translated_466_residues
MTDRPSVLVVDDKENMRHLITRILGDAYQVRTAEDGGRALSLIQTQPFDVVVTDIRMPGADGFEVLKAVKQHAPTTEVIL
MTAYASVPKAVEAIKEGAYDYLPKPFDPDEASLVVARAVERKRLKEQAASLRRELEGIYSFQNIIGRSAPMRALYGLLER
ASQLDITVLITGETGTGKELVARAIHHDGPRKDRPFIAVNCGALPSELIESELFGHARGAFTGAVETKAGLFEAASGGTI
FLDEIGELPLSVQVKLNRTLQDKEVRRVGDAVARCIDARVITATHRDLKAEVTAGRFREDLYYRLNVFPVHLPSLRERRE
DIPLLAMHFVQKAAKTYRQPVDGLEPDALRALTGYTWPGNVRQLENAIERAVAITTGSRVGPDALPPEVTGGQQGALPVD
HLVKMPFREAVDLARDRASRDYLIALLREFGGNVTRAAERAGMERESLHRLLKRFGLRSDDFKESP
>Mature_465_residues
TDRPSVLVVDDKENMRHLITRILGDAYQVRTAEDGGRALSLIQTQPFDVVVTDIRMPGADGFEVLKAVKQHAPTTEVILM
TAYASVPKAVEAIKEGAYDYLPKPFDPDEASLVVARAVERKRLKEQAASLRRELEGIYSFQNIIGRSAPMRALYGLLERA
SQLDITVLITGETGTGKELVARAIHHDGPRKDRPFIAVNCGALPSELIESELFGHARGAFTGAVETKAGLFEAASGGTIF
LDEIGELPLSVQVKLNRTLQDKEVRRVGDAVARCIDARVITATHRDLKAEVTAGRFREDLYYRLNVFPVHLPSLRERRED
IPLLAMHFVQKAAKTYRQPVDGLEPDALRALTGYTWPGNVRQLENAIERAVAITTGSRVGPDALPPEVTGGQQGALPVDH
LVKMPFREAVDLARDRASRDYLIALLREFGGNVTRAAERAGMERESLHRLLKRFGLRSDDFKESP

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=467, Percent_Identity=42.3982869379015, Blast_Score=369, Evalue=1e-103,
Organism=Escherichia coli, GI1788905, Length=466, Percent_Identity=43.7768240343348, Blast_Score=359, Evalue=1e-100,
Organism=Escherichia coli, GI1790437, Length=455, Percent_Identity=43.0769230769231, Blast_Score=354, Evalue=8e-99,
Organism=Escherichia coli, GI1790299, Length=470, Percent_Identity=43.1914893617021, Blast_Score=349, Evalue=3e-97,
Organism=Escherichia coli, GI87082117, Length=346, Percent_Identity=44.2196531791908, Blast_Score=280, Evalue=2e-76,
Organism=Escherichia coli, GI1789087, Length=344, Percent_Identity=44.1860465116279, Blast_Score=264, Evalue=8e-72,
Organism=Escherichia coli, GI87082152, Length=327, Percent_Identity=44.6483180428135, Blast_Score=243, Evalue=2e-65,
Organism=Escherichia coli, GI1789233, Length=251, Percent_Identity=43.8247011952191, Blast_Score=227, Evalue=1e-60,
Organism=Escherichia coli, GI1786524, Length=340, Percent_Identity=40.2941176470588, Blast_Score=207, Evalue=1e-54,
Organism=Escherichia coli, GI1787583, Length=330, Percent_Identity=38.1818181818182, Blast_Score=202, Evalue=6e-53,
Organism=Escherichia coli, GI87081872, Length=323, Percent_Identity=37.1517027863777, Blast_Score=187, Evalue=2e-48,
Organism=Escherichia coli, GI1789828, Length=313, Percent_Identity=33.2268370607029, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI87081858, Length=304, Percent_Identity=28.9473684210526, Blast_Score=118, Evalue=1e-27,
Organism=Escherichia coli, GI1789809, Length=142, Percent_Identity=30.2816901408451, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI145693157, Length=123, Percent_Identity=32.520325203252, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI87082012, Length=105, Percent_Identity=33.3333333333333, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 51528; Mature: 51396

Theoretical pI: Translated: 7.37; Mature: 7.37

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDRPSVLVVDDKENMRHLITRILGDAYQVRTAEDGGRALSLIQTQPFDVVVTDIRMPGA
CCCCCCEEEEECHHHHHHHHHHHHCCHHEEEECCCCCCEEEEEECCCCEEEEEEEECCCC
DGFEVLKAVKQHAPTTEVILMTAYASVPKAVEAIKEGAYDYLPKPFDPDEASLVVARAVE
CHHHHHHHHHHCCCCHHEEEEHHHHHHHHHHHHHHHCHHHCCCCCCCCCHHHHHHHHHHH
RKRLKEQAASLRRELEGIYSFQNIIGRSAPMRALYGLLERASQLDITVLITGETGTGKEL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCHHH
VARAIHHDGPRKDRPFIAVNCGALPSELIESELFGHARGAFTGAVETKAGLFEAASGGTI
HHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCEE
FLDEIGELPLSVQVKLNRTLQDKEVRRVGDAVARCIDARVITATHRDLKAEVTAGRFRED
EEECCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHH
LYYRLNVFPVHLPSLRERREDIPLLAMHFVQKAAKTYRQPVDGLEPDALRALTGYTWPGN
HEEEEEEEEEECHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCC
VRQLENAIERAVAITTGSRVGPDALPPEVTGGQQGALPVDHLVKMPFREAVDLARDRASR
HHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHCCH
DYLIALLREFGGNVTRAAERAGMERESLHRLLKRFGLRSDDFKESP
HHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
TDRPSVLVVDDKENMRHLITRILGDAYQVRTAEDGGRALSLIQTQPFDVVVTDIRMPGA
CCCCCEEEEECHHHHHHHHHHHHCCHHEEEECCCCCCEEEEEECCCCEEEEEEEECCCC
DGFEVLKAVKQHAPTTEVILMTAYASVPKAVEAIKEGAYDYLPKPFDPDEASLVVARAVE
CHHHHHHHHHHCCCCHHEEEEHHHHHHHHHHHHHHHCHHHCCCCCCCCCHHHHHHHHHHH
RKRLKEQAASLRRELEGIYSFQNIIGRSAPMRALYGLLERASQLDITVLITGETGTGKEL
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCHHH
VARAIHHDGPRKDRPFIAVNCGALPSELIESELFGHARGAFTGAVETKAGLFEAASGGTI
HHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCEE
FLDEIGELPLSVQVKLNRTLQDKEVRRVGDAVARCIDARVITATHRDLKAEVTAGRFRED
EEECCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHH
LYYRLNVFPVHLPSLRERREDIPLLAMHFVQKAAKTYRQPVDGLEPDALRALTGYTWPGN
HEEEEEEEEEECHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCC
VRQLENAIERAVAITTGSRVGPDALPPEVTGGQQGALPVDHLVKMPFREAVDLARDRASR
HHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHCCH
DYLIALLREFGGNVTRAAERAGMERESLHRLLKRFGLRSDDFKESP
HHHHHHHHHHCCCHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]