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The map label for this gene is taF [H]

Identifier: 108763558

GI number: 108763558

Start: 4804604

End: 4805854

Strand: Reverse

Name: taF [H]

Synonym: MXAN_3945

Alternate gene names: 108763558

Gene position: 4805854-4804604 (Counterclockwise)

Preceding gene: 108759877

Following gene: 108760550

Centisome position: 52.58

GC content: 66.59

Gene sequence:

>1251_bases
GTGGCTGAGCGGGTTCCCGGCGGAGTCGGCATCGAGGCCATCAACGCCTACGGCGGCGCCGCCTCCATTCCGGTGTTGGA
CTTGTTCCGGGGCCGGCGGCTGGACCCCGAGCGATTCTCCAACCTGATGATGCAGGAGCGCGGCGTCGCGCTGCCGTTCG
AGGACCCCGTCACCAACGCGGTCAATGCGGCGCGGCCCATCCTGGACGCGATGTCGCCCGAGGCCCGGGAGCGCATCGAG
CTCCTGGTCACCTCGAGCGAGTCCGGCGTGGACTTCAGCAAGTCCATCTCCTCGTATGCGCACGAGCACCTGGGGCTGAG
CCGCCACTGCCGGTTCCTGGAGGTGAAGCAGGCGTGTTACGCCGCCACCGGAGCGCTCCAGCTAGCGCTGGGCTACATCG
CGTCGGGCGTGTCACCGGGGGCCAAGGCCCTGGTGATTGCCACGGACGTGACGCTGGTGGACGAGAGCGGTCTGTACTCC
GAGCCGGCGATGGGCACCGGCGGCGTCGCCGTGCTGCTGGGCGACGAGCCGCGCGTGATGAAGATGGACCTGGGAGCGTT
CGGCAACTACAGCTACGACGTCTTCGACACCGCGCGGCCCTCGCCGGAGATTGATATCGGCGACGTGGACCGGTCGCTCT
TCACGTACCTGGACTGCCTCAAGCACAGCTTCGCCGCGTATGGCCGCCGGGTGGACGGTGTCGACTTCGTGTCGACGTTC
GACTACCTGGCGATGCACACGCCGTTCGCCGGACTGGTGAAGGCCGGGCACCGCAAGATGATGCGCGAGCTCACCCCGTG
CGACGTGGACGAAATCGAAGCGGACTTCGGCCGGCGCGTGAAGCCGTCACTGCAGTACCCGAGTCTGGTCGGGAACCTGT
GCTCCGGCTCCGTGTACCTGAGCCTGTGCAGCATCATCGACACCATCAAGCCCGAGCGGTCCGCTCGGGTGGGAATGTTC
TCCTATGGGTCGGGTTGCTCGTCGGAGTTCTTCAGCGGCGTCATCGGCCCGGAGTCCGTGTCCGCGCTAGCTGGGTTGGA
CATCGGTGGCCACCTCCGGGGGCGCCGCCAGCTCACGTTCGACCAATATGTCGAATTGCTGAAAGAGAACCTTCGCTGTC
TGGTTCCAACGAAGAACCGGGACGTGGACGTGGAGCGCTACCTCCCGCTGGTGACGCGGACGGCGAGCCGCCCGCGCATG
CTCGCCTTGCGAAGGGTCGTGGACTATCATCGTCAGTACGAGTGGGTGTAG

Upstream 100 bases:

>100_bases
ATCCTGGACAGCCTGCGGCTGCAGAAGACGCCACTGGCGAAGTTCGCCGACATCCGCAACATCGACGCGCTGGTGGCGTT
CCTGGCCGGTGAGGTCGCGG

Downstream 100 bases:

>100_bases
CTCATACGCCACCTCCAATTCCGACGAATGAACACTCCTTCCTTGACGAACTGGCCTGCCCGCCTGGGCTATCTCCTTGC
CGTTGGCGGCGCATGGTTCG

Product: polyketide TA biosynthesis protein TaF

Products: NA

Alternate protein names: HMG synthase [H]

Number of amino acids: Translated: 416; Mature: 415

Protein sequence:

>416_residues
MAERVPGGVGIEAINAYGGAASIPVLDLFRGRRLDPERFSNLMMQERGVALPFEDPVTNAVNAARPILDAMSPEARERIE
LLVTSSESGVDFSKSISSYAHEHLGLSRHCRFLEVKQACYAATGALQLALGYIASGVSPGAKALVIATDVTLVDESGLYS
EPAMGTGGVAVLLGDEPRVMKMDLGAFGNYSYDVFDTARPSPEIDIGDVDRSLFTYLDCLKHSFAAYGRRVDGVDFVSTF
DYLAMHTPFAGLVKAGHRKMMRELTPCDVDEIEADFGRRVKPSLQYPSLVGNLCSGSVYLSLCSIIDTIKPERSARVGMF
SYGSGCSSEFFSGVIGPESVSALAGLDIGGHLRGRRQLTFDQYVELLKENLRCLVPTKNRDVDVERYLPLVTRTASRPRM
LALRRVVDYHRQYEWV

Sequences:

>Translated_416_residues
MAERVPGGVGIEAINAYGGAASIPVLDLFRGRRLDPERFSNLMMQERGVALPFEDPVTNAVNAARPILDAMSPEARERIE
LLVTSSESGVDFSKSISSYAHEHLGLSRHCRFLEVKQACYAATGALQLALGYIASGVSPGAKALVIATDVTLVDESGLYS
EPAMGTGGVAVLLGDEPRVMKMDLGAFGNYSYDVFDTARPSPEIDIGDVDRSLFTYLDCLKHSFAAYGRRVDGVDFVSTF
DYLAMHTPFAGLVKAGHRKMMRELTPCDVDEIEADFGRRVKPSLQYPSLVGNLCSGSVYLSLCSIIDTIKPERSARVGMF
SYGSGCSSEFFSGVIGPESVSALAGLDIGGHLRGRRQLTFDQYVELLKENLRCLVPTKNRDVDVERYLPLVTRTASRPRM
LALRRVVDYHRQYEWV
>Mature_415_residues
AERVPGGVGIEAINAYGGAASIPVLDLFRGRRLDPERFSNLMMQERGVALPFEDPVTNAVNAARPILDAMSPEARERIEL
LVTSSESGVDFSKSISSYAHEHLGLSRHCRFLEVKQACYAATGALQLALGYIASGVSPGAKALVIATDVTLVDESGLYSE
PAMGTGGVAVLLGDEPRVMKMDLGAFGNYSYDVFDTARPSPEIDIGDVDRSLFTYLDCLKHSFAAYGRRVDGVDFVSTFD
YLAMHTPFAGLVKAGHRKMMRELTPCDVDEIEADFGRRVKPSLQYPSLVGNLCSGSVYLSLCSIIDTIKPERSARVGMFS
YGSGCSSEFFSGVIGPESVSALAGLDIGGHLRGRRQLTFDQYVELLKENLRCLVPTKNRDVDVERYLPLVTRTASRPRML
ALRRVVDYHRQYEWV

Specific function: Involved in some intermediate steps for the synthesis of the antibiotic polyketide bacillaene which is involved in secondary metabolism. It catalyzes the aldol condensation between the acetyl group attached to the acyl-carrier-protein AcpK (Ac- AcpK) and

COG id: COG3425

COG function: function code I; 3-hydroxy-3-methylglutaryl CoA synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA synthase family [H]

Homologues:

Organism=Caenorhabditis elegans, GI17560126, Length=409, Percent_Identity=22.4938875305623, Blast_Score=78, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6323509, Length=350, Percent_Identity=26.5714285714286, Blast_Score=99, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013746
- InterPro:   IPR013528
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF08540 HMG_CoA_synt_C; PF01154 HMG_CoA_synt_N [H]

EC number: NA

Molecular weight: Translated: 45562; Mature: 45430

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAERVPGGVGIEAINAYGGAASIPVLDLFRGRRLDPERFSNLMMQERGVALPFEDPVTNA
CCCCCCCCCCHHHHHCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHH
VNAARPILDAMSPEARERIELLVTSSESGVDFSKSISSYAHEHLGLSRHCRFLEVKQACY
HHHHHHHHHHCCHHHHHHEEEEEECCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
AATGALQLALGYIASGVSPGAKALVIATDVTLVDESGLYSEPAMGTGGVAVLLGDEPRVM
HHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCEEEEECCCCCEE
KMDLGAFGNYSYDVFDTARPSPEIDIGDVDRSLFTYLDCLKHSFAAYGRRVDGVDFVSTF
EEECCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
DYLAMHTPFAGLVKAGHRKMMRELTPCDVDEIEADFGRRVKPSLQYPSLVGNLCSGSVYL
HHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHCCHHHH
SLCSIIDTIKPERSARVGMFSYGSGCSSEFFSGVIGPESVSALAGLDIGGHLRGRRQLTF
HHHHHHHHCCCCCCCCCCEEECCCCCCHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCH
DQYVELLKENLRCLVPTKNRDVDVERYLPLVTRTASRPRMLALRRVVDYHRQYEWV
HHHHHHHHHCCEEEECCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
AERVPGGVGIEAINAYGGAASIPVLDLFRGRRLDPERFSNLMMQERGVALPFEDPVTNA
CCCCCCCCCHHHHHCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHH
VNAARPILDAMSPEARERIELLVTSSESGVDFSKSISSYAHEHLGLSRHCRFLEVKQACY
HHHHHHHHHHCCHHHHHHEEEEEECCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
AATGALQLALGYIASGVSPGAKALVIATDVTLVDESGLYSEPAMGTGGVAVLLGDEPRVM
HHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEEEECCCCCCCCCCCCCCEEEEECCCCCEE
KMDLGAFGNYSYDVFDTARPSPEIDIGDVDRSLFTYLDCLKHSFAAYGRRVDGVDFVSTF
EEECCCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
DYLAMHTPFAGLVKAGHRKMMRELTPCDVDEIEADFGRRVKPSLQYPSLVGNLCSGSVYL
HHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCHHHHHHHHCCHHHH
SLCSIIDTIKPERSARVGMFSYGSGCSSEFFSGVIGPESVSALAGLDIGGHLRGRRQLTF
HHHHHHHHCCCCCCCCCCEEECCCCCCHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCH
DQYVELLKENLRCLVPTKNRDVDVERYLPLVTRTASRPRMLALRRVVDYHRQYEWV
HHHHHHHHHCCEEEECCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7704258; 9384377 [H]