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The map label for this gene is kbl [C]

Identifier: 108763369

GI number: 108763369

Start: 2992195

End: 2993550

Strand: Direct

Name: kbl [C]

Synonym: MXAN_2571

Alternate gene names: 108763369

Gene position: 2992195-2993550 (Clockwise)

Preceding gene: 108758992

Following gene: 108763056

Centisome position: 32.74

GC content: 70.43

Gene sequence:

>1356_bases
ATGGATTTCCGAGCTCAACTCGACTCGCCGCTCTTCACCCACTTCATCTCCCATTACGCGCAGCCGACGGGACCTGACCT
GCTGGGTCGGACGGAACCCTTCTTCGAGTGGCAGGAGTCGCGGCGGCAGGCGGGCCTGTGGCCGTACTCGCGAAGCCTGG
AGGCGGCACCGAAGGCGGAGTGTGGTGTCCGCAGTGAGACGGGGGCGGTGCGCCAGGGGCTGAACTTCGGTTCGCAGGAT
TACTTGTCGCTGTCCACGCACCCGGCGGTGGTGGAGGCGGCCCAGCGGGCCATCCAGGACTACGGGTTGCACAGCGCGGG
CTCGGCGATGCTGGGGGGCAATACGACGCCGTCGCTGATGCTGGAGAAGGCGCTCGCGGAGCACCTGCAGACGCCGCACG
TGGCGTTGTTCTCCACCGGCTGGGGCGCGGGCTTCGGCGTCATCGCTGGGCTGGTGCGTCCCGATGACCACGTGGTGCTC
GACGCGCTGTCGCACGCGTGCCTCCAGCAGGGCGCCGCCGCCGCGACGACGAACGTGAGCCGCGTGCCGCACCTCAACAA
CCGCGCCATGCGGCGCAAGCTTCAGGAGATTCGCGCCCGCGACACGCAGAACGCGGTGCTCGTCGTCACCGAGGGCCTGT
TCTCCATGGACTCGGACGTGCCGCGGATCGAAGAGCTCCAGTCCATCTGCCGTGAGTACGGCGCGACGCTGCTGGTGGAC
GTGGCCCATGACCTGGGCGCGATGGGGCCCCGGGGGACGGGCAGCCTGGGCGTGCAGGGCCTGCTGGGGAAGGTGGACCT
GGTGGTGGGCGCCTTCTCCAAGACGTTCGCGAGCAATGGCGGCTTCGTGGCCACGCGCTCGCCGGCGGTGCGCCAGTTCA
TCCGCATCATGGGCGGGCCCCACATCTTCTCCAACGCGCTGCTGCCCATGCAGGCGGCGGTGGTGCTGGAGTCGCTGCGC
ATCGTCCGCTCGGAAGAGGGCGACGCGCTGCGCGCGAAGGCGCGGGAGAACATCCTGGCGCTGCGCGGAGCCTTCGAGGC
GCGGGGCGTGACGTGCCTGGGCGAGCCGTCCAACGTCGTCCCCGTGCAGGTGGGCGACGCGAAGGTGGCGCGGCTGGCCT
CGAAGAAGGTGTTCGACCGCGACATCTTCGCCAACCTGGTGGAGTACCCGGCCGTTCGCTTGCGCGAGACGCGCTTCCGC
ATGCAGGTGATGGCGTCCCACACGCTGGAGCAGGTCCAGCGGGCCGCCGACGGGGTGTGCGACGCCATCGAGGAGGCCCG
CGCCGAGCTGGAGGTTCGTCCGGCCGCGACGCGCGCGTCCCGCCGCGACGAGCAGCGTCCGCAGGTGGAGCTGTAG

Upstream 100 bases:

>100_bases
ACTGGAAAGATGCAGAGGCATTAAATGTGCCGCTCGCCCCCCCCTCCCCGAGCGCCGCGCCTCTCGTTGACAGCGCGACC
TTTCCCCCTGGACGTGCTTC

Downstream 100 bases:

>100_bases
TCTCCACGAGCGTCCGCGCGGGCGCTCAGGTGTCGTCGAGGCTGGAGGCACGCAGATGGGTGACGTCACCCCACGTCACC
AGCCGCCACGCACCTTCGTG

Product: class II aminotransferase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MDFRAQLDSPLFTHFISHYAQPTGPDLLGRTEPFFEWQESRRQAGLWPYSRSLEAAPKAECGVRSETGAVRQGLNFGSQD
YLSLSTHPAVVEAAQRAIQDYGLHSAGSAMLGGNTTPSLMLEKALAEHLQTPHVALFSTGWGAGFGVIAGLVRPDDHVVL
DALSHACLQQGAAAATTNVSRVPHLNNRAMRRKLQEIRARDTQNAVLVVTEGLFSMDSDVPRIEELQSICREYGATLLVD
VAHDLGAMGPRGTGSLGVQGLLGKVDLVVGAFSKTFASNGGFVATRSPAVRQFIRIMGGPHIFSNALLPMQAAVVLESLR
IVRSEEGDALRAKARENILALRGAFEARGVTCLGEPSNVVPVQVGDAKVARLASKKVFDRDIFANLVEYPAVRLRETRFR
MQVMASHTLEQVQRAADGVCDAIEEARAELEVRPAATRASRRDEQRPQVEL

Sequences:

>Translated_451_residues
MDFRAQLDSPLFTHFISHYAQPTGPDLLGRTEPFFEWQESRRQAGLWPYSRSLEAAPKAECGVRSETGAVRQGLNFGSQD
YLSLSTHPAVVEAAQRAIQDYGLHSAGSAMLGGNTTPSLMLEKALAEHLQTPHVALFSTGWGAGFGVIAGLVRPDDHVVL
DALSHACLQQGAAAATTNVSRVPHLNNRAMRRKLQEIRARDTQNAVLVVTEGLFSMDSDVPRIEELQSICREYGATLLVD
VAHDLGAMGPRGTGSLGVQGLLGKVDLVVGAFSKTFASNGGFVATRSPAVRQFIRIMGGPHIFSNALLPMQAAVVLESLR
IVRSEEGDALRAKARENILALRGAFEARGVTCLGEPSNVVPVQVGDAKVARLASKKVFDRDIFANLVEYPAVRLRETRFR
MQVMASHTLEQVQRAADGVCDAIEEARAELEVRPAATRASRRDEQRPQVEL
>Mature_451_residues
MDFRAQLDSPLFTHFISHYAQPTGPDLLGRTEPFFEWQESRRQAGLWPYSRSLEAAPKAECGVRSETGAVRQGLNFGSQD
YLSLSTHPAVVEAAQRAIQDYGLHSAGSAMLGGNTTPSLMLEKALAEHLQTPHVALFSTGWGAGFGVIAGLVRPDDHVVL
DALSHACLQQGAAAATTNVSRVPHLNNRAMRRKLQEIRARDTQNAVLVVTEGLFSMDSDVPRIEELQSICREYGATLLVD
VAHDLGAMGPRGTGSLGVQGLLGKVDLVVGAFSKTFASNGGFVATRSPAVRQFIRIMGGPHIFSNALLPMQAAVVLESLR
IVRSEEGDALRAKARENILALRGAFEARGVTCLGEPSNVVPVQVGDAKVARLASKKVFDRDIFANLVEYPAVRLRETRFR
MQVMASHTLEQVQRAADGVCDAIEEARAELEVRPAATRASRRDEQRPQVEL

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=382, Percent_Identity=28.0104712041885, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI284448556, Length=347, Percent_Identity=28.5302593659942, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI83977442, Length=380, Percent_Identity=27.3684210526316, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI83977444, Length=380, Percent_Identity=27.3684210526316, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI83977440, Length=380, Percent_Identity=27.3684210526316, Blast_Score=149, Evalue=5e-36,
Organism=Homo sapiens, GI4502025, Length=369, Percent_Identity=28.1842818428184, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI40316939, Length=369, Percent_Identity=28.1842818428184, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI4758668, Length=364, Percent_Identity=26.0989010989011, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI119220554, Length=392, Percent_Identity=26.0204081632653, Blast_Score=125, Evalue=1e-28,
Organism=Homo sapiens, GI5454084, Length=294, Percent_Identity=25.5102040816327, Blast_Score=86, Evalue=6e-17,
Organism=Escherichia coli, GI1790046, Length=380, Percent_Identity=28.9473684210526, Blast_Score=166, Evalue=3e-42,
Organism=Escherichia coli, GI1786993, Length=361, Percent_Identity=32.1329639889197, Blast_Score=155, Evalue=7e-39,
Organism=Caenorhabditis elegans, GI71994529, Length=352, Percent_Identity=27.8409090909091, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI32566772, Length=376, Percent_Identity=27.3936170212766, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17560914, Length=359, Percent_Identity=25.0696378830084, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17560912, Length=359, Percent_Identity=24.7910863509749, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI71982625, Length=260, Percent_Identity=25, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71982617, Length=260, Percent_Identity=25, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320438, Length=380, Percent_Identity=26.0526315789474, Blast_Score=132, Evalue=9e-32,
Organism=Saccharomyces cerevisiae, GI6320267, Length=400, Percent_Identity=24.5, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6323954, Length=268, Percent_Identity=24.6268656716418, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24662918, Length=377, Percent_Identity=26.790450928382, Blast_Score=153, Evalue=2e-37,
Organism=Drosophila melanogaster, GI17137420, Length=344, Percent_Identity=27.6162790697674, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI17136286, Length=429, Percent_Identity=26.8065268065268, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24653280, Length=253, Percent_Identity=24.901185770751, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24653276, Length=253, Percent_Identity=24.901185770751, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24653278, Length=253, Percent_Identity=24.901185770751, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR010962
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 48935; Mature: 48935

Theoretical pI: Translated: 7.38; Mature: 7.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFRAQLDSPLFTHFISHYAQPTGPDLLGRTEPFFEWQESRRQAGLWPYSRSLEAAPKAE
CCCHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCC
CGVRSETGAVRQGLNFGSQDYLSLSTHPAVVEAAQRAIQDYGLHSAGSAMLGGNTTPSLM
CCCCCHHHHHHHCCCCCCCCCEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHH
LEKALAEHLQTPHVALFSTGWGAGFGVIAGLVRPDDHVVLDALSHACLQQGAAAATTNVS
HHHHHHHHHCCCCEEEEECCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHCCHH
RVPHLNNRAMRRKLQEIRARDTQNAVLVVTEGLFSMDSDVPRIEELQSICREYGATLLVD
HCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCHHHCCCCCCHHHHHHHHHHHHCCEEEEH
VAHDLGAMGPRGTGSLGVQGLLGKVDLVVGAFSKTFASNGGFVATRSPAVRQFIRIMGGP
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHCCC
HIFSNALLPMQAAVVLESLRIVRSEEGDALRAKARENILALRGAFEARGVTCLGEPSNVV
HHHHCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHCCEEEECCCCCEE
PVQVGDAKVARLASKKVFDRDIFANLVEYPAVRLRETRFRMQVMASHTLEQVQRAADGVC
EEEECCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DAIEEARAELEVRPAATRASRRDEQRPQVEL
HHHHHHHHHEECCCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MDFRAQLDSPLFTHFISHYAQPTGPDLLGRTEPFFEWQESRRQAGLWPYSRSLEAAPKAE
CCCHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCC
CGVRSETGAVRQGLNFGSQDYLSLSTHPAVVEAAQRAIQDYGLHSAGSAMLGGNTTPSLM
CCCCCHHHHHHHCCCCCCCCCEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHH
LEKALAEHLQTPHVALFSTGWGAGFGVIAGLVRPDDHVVLDALSHACLQQGAAAATTNVS
HHHHHHHHHCCCCEEEEECCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHCCHH
RVPHLNNRAMRRKLQEIRARDTQNAVLVVTEGLFSMDSDVPRIEELQSICREYGATLLVD
HCCCCCCHHHHHHHHHHHHCCCCCEEEEEECCHHHCCCCCCHHHHHHHHHHHHCCEEEEH
VAHDLGAMGPRGTGSLGVQGLLGKVDLVVGAFSKTFASNGGFVATRSPAVRQFIRIMGGP
HHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHCCC
HIFSNALLPMQAAVVLESLRIVRSEEGDALRAKARENILALRGAFEARGVTCLGEPSNVV
HHHHCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHHCCEEEECCCCCEE
PVQVGDAKVARLASKKVFDRDIFANLVEYPAVRLRETRFRMQVMASHTLEQVQRAADGVC
EEEECCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DAIEEARAELEVRPAATRASRRDEQRPQVEL
HHHHHHHHHEECCCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA