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The map label for this gene is moeB [H]

Identifier: 108763332

GI number: 108763332

Start: 4986437

End: 4987204

Strand: Reverse

Name: moeB [H]

Synonym: MXAN_4069

Alternate gene names: 108763332

Gene position: 4987204-4986437 (Counterclockwise)

Preceding gene: 108760388

Following gene: 108758387

Centisome position: 54.57

GC content: 73.05

Gene sequence:

>768_bases
ATGCATGGCCACGGTACAGACCACCACCCCCGAATTCCCCATGCGTCCCGGCTGGAGCGCGCGCGCGTACTGCTGGTGGG
GGCTGGCGGGCTCGGATGCCCGGCGTCGTTGGCGTTGGCCCAGGCCGGTGTCGGGCACCTGACGCTGGCGGATCCGGACT
GCGTGGACGTGACGAACTTGCCGCGCCAGCTCTGGCACCGGGGCGAAGACGTGGGCCGGAACAAGGCGGAGTCCGCGACG
GCGGGCCTGGCGCGGGCCTTTCCCGGCCTGAGCACGGAGGCCATCCCCGAGCGCGTGGACGCGAGCAACGCGGAGGGGCT
CTTCCGCGCGCATGACGCCGTCATCGACGCCACGGATGGCGTGGCCACCAAGTTCTTCCTGTCGGACGTGGCGGTGCTGA
CGGGCGTGCCGCTCATCTATGGCGGTGTGCTGCGCATGCAGGGCCAGGCGATGCGCGTGGACCCGGGGGGGCCGTGTCTG
CGCTGCCTCTATGAAGCGCCGCCTCCGCCGGATGCCGTGCCCACGTGTGCCCAGGCGGGGGTGCTCGGCTCGCTGGCGGG
GCTGGTGGGCGCGGTGCAGGCCCTGCTGGCGCTGGAGCTGCTGTCGGGCGCCGCGCGAGGTGGGCAGGGCGAGGCTACGC
TGCACGTGCTGGATGCGGTGTCGATCCTGGGACGGCGGACACGCGTGGCGCGGGCACCGGACTGCGAGGGCTGTCGAGTC
ACGGCCATCCCCGCGTACCCGGAGTCTCCGGAGGCGTGCGCGACATGA

Upstream 100 bases:

>100_bases
CGCGGACGCGGGACGGTGGAGAGACACCTGCGCCCTTCTGCATCGTGGTACGCAGGCGGCCCCACCATATTCGTTTCCGA
CCGCGTGGAGCAGTCATCCG

Downstream 100 bases:

>100_bases
CGGCGAGGCTGGACATCACCCGCGAGGTCTGTCCGATGACCTACGTGCGGACGAAGCTGAAGTTGGAATCACTGGAGCCG
GGCACGTTGCTGGAGGTGCT

Product: ThiF/MoeZ/MoeB domain-containing protein

Products: NA

Alternate protein names: MoaD protein adenylase; Molybdopterin-converting factor subunit 1 adenylase [H]

Number of amino acids: Translated: 255; Mature: 255

Protein sequence:

>255_residues
MHGHGTDHHPRIPHASRLERARVLLVGAGGLGCPASLALAQAGVGHLTLADPDCVDVTNLPRQLWHRGEDVGRNKAESAT
AGLARAFPGLSTEAIPERVDASNAEGLFRAHDAVIDATDGVATKFFLSDVAVLTGVPLIYGGVLRMQGQAMRVDPGGPCL
RCLYEAPPPPDAVPTCAQAGVLGSLAGLVGAVQALLALELLSGAARGGQGEATLHVLDAVSILGRRTRVARAPDCEGCRV
TAIPAYPESPEACAT

Sequences:

>Translated_255_residues
MHGHGTDHHPRIPHASRLERARVLLVGAGGLGCPASLALAQAGVGHLTLADPDCVDVTNLPRQLWHRGEDVGRNKAESAT
AGLARAFPGLSTEAIPERVDASNAEGLFRAHDAVIDATDGVATKFFLSDVAVLTGVPLIYGGVLRMQGQAMRVDPGGPCL
RCLYEAPPPPDAVPTCAQAGVLGSLAGLVGAVQALLALELLSGAARGGQGEATLHVLDAVSILGRRTRVARAPDCEGCRV
TAIPAYPESPEACAT
>Mature_255_residues
MHGHGTDHHPRIPHASRLERARVLLVGAGGLGCPASLALAQAGVGHLTLADPDCVDVTNLPRQLWHRGEDVGRNKAESAT
AGLARAFPGLSTEAIPERVDASNAEGLFRAHDAVIDATDGVATKFFLSDVAVLTGVPLIYGGVLRMQGQAMRVDPGGPCL
RCLYEAPPPPDAVPTCAQAGVLGSLAGLVGAVQALLALELLSGAARGGQGEATLHVLDAVSILGRRTRVARAPDCEGCRV
TAIPAYPESPEACAT

Specific function: Catalyzes the adenylation by ATP of the carboxyl group of the C-terminal glycine of sulfur carrier protein moaD [H]

COG id: COG0476

COG function: function code H; Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hesA/moeB/thiF family [H]

Homologues:

Organism=Homo sapiens, GI7657339, Length=205, Percent_Identity=40.4878048780488, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI38045942, Length=177, Percent_Identity=29.3785310734463, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI38045944, Length=177, Percent_Identity=29.3785310734463, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI4885649, Length=151, Percent_Identity=33.7748344370861, Blast_Score=76, Evalue=3e-14,
Organism=Escherichia coli, GI1787048, Length=223, Percent_Identity=38.5650224215247, Blast_Score=144, Evalue=7e-36,
Organism=Escherichia coli, GI87082356, Length=225, Percent_Identity=35.5555555555556, Blast_Score=99, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17540406, Length=226, Percent_Identity=35.8407079646018, Blast_Score=151, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI71984476, Length=176, Percent_Identity=30.1136363636364, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI86565433, Length=175, Percent_Identity=28.5714285714286, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI86565431, Length=175, Percent_Identity=28.5714285714286, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6321903, Length=189, Percent_Identity=40.7407407407407, Blast_Score=152, Evalue=5e-38,
Organism=Saccharomyces cerevisiae, GI6322639, Length=174, Percent_Identity=27.5862068965517, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24582879, Length=224, Percent_Identity=39.7321428571429, Blast_Score=159, Evalue=1e-39,
Organism=Drosophila melanogaster, GI20129973, Length=175, Percent_Identity=26.8571428571429, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24660640, Length=147, Percent_Identity=29.2517006802721, Blast_Score=68, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007901
- InterPro:   IPR009036
- InterPro:   IPR012730
- InterPro:   IPR016040
- InterPro:   IPR000594 [H]

Pfam domain/function: PF05237 MoeZ_MoeB; PF00899 ThiF [H]

EC number: NA

Molecular weight: Translated: 26199; Mature: 26199

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHGHGTDHHPRIPHASRLERARVLLVGAGGLGCPASLALAQAGVGHLTLADPDCVDVTNL
CCCCCCCCCCCCCCHHHHHHCEEEEEECCCCCCHHHHHHHHCCCCEEEECCCCCCCHHHH
PRQLWHRGEDVGRNKAESATAGLARAFPGLSTEAIPERVDASNAEGLFRAHDAVIDATDG
HHHHHHCCHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCHHHHHHHEEECCCC
VATKFFLSDVAVLTGVPLIYGGVLRMQGQAMRVDPGGPCLRCLYEAPPPPDAVPTCAQAG
HHHHHHHHHHHHHHCCHHHHHHHHEECCCEEEECCCCHHHHHHHCCCCCCCCCCHHHHHH
VLGSLAGLVGAVQALLALELLSGAARGGQGEATLHVLDAVSILGRRTRVARAPDCEGCRV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEE
TAIPAYPESPEACAT
EEECCCCCCCHHCCC
>Mature Secondary Structure
MHGHGTDHHPRIPHASRLERARVLLVGAGGLGCPASLALAQAGVGHLTLADPDCVDVTNL
CCCCCCCCCCCCCCHHHHHHCEEEEEECCCCCCHHHHHHHHCCCCEEEECCCCCCCHHHH
PRQLWHRGEDVGRNKAESATAGLARAFPGLSTEAIPERVDASNAEGLFRAHDAVIDATDG
HHHHHHCCHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCHHHHHHHEEECCCC
VATKFFLSDVAVLTGVPLIYGGVLRMQGQAMRVDPGGPCLRCLYEAPPPPDAVPTCAQAG
HHHHHHHHHHHHHHCCHHHHHHHHEECCCEEEECCCCHHHHHHHCCCCCCCCCCHHHHHH
VLGSLAGLVGAVQALLALELLSGAARGGQGEATLHVLDAVSILGRRTRVARAPDCEGCRV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEE
TAIPAYPESPEACAT
EEECCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503 [H]