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The map label for this gene is fdh [H]

Identifier: 108763328

GI number: 108763328

Start: 320920

End: 322092

Strand: Reverse

Name: fdh [H]

Synonym: MXAN_0269

Alternate gene names: 108763328

Gene position: 322092-320920 (Counterclockwise)

Preceding gene: 108759496

Following gene: 108759765

Centisome position: 3.52

GC content: 67.26

Gene sequence:

>1173_bases
ATGCGCGCACTCTGCTGGAACGGCATCAACGACCTGGGCGTGGAGACGGTGGGGGACCCTCGCATCGTCAACCCTCACGA
CGTCATCCTCCAGGTGAGGATGTCCACCACCTGCGGCTCCGACCTCCACTTCATCGACGGCTACATCCCGACGATGCGCA
AGGGAGACGTCATCGGCCACGAGTTCATGGGCACCGTCGTGGAGAAGGGCCCCGCGGTGAAGAAGGTCCAGGTGGGTGAC
CGCGTCGTCGTCCCGTCCTTCATCGGCTGTGGCAGTTGCTGGTACTGCCAGCACGACCTCTGGTCCCTCTGCGACAACAC
CAATCCCAAGGGTGAATTGCAGGAGCCCCTGTTCGGCTACCAGACCGCGGGCATCTACGGATACACCCACACCTTCGGCG
GCTACGCGGGCGCGCATGCGCAGTTCGTCCGCGTCCCCCACGCGGACAACGACTGCTTCCGGGTGCCCGAAGGCGTGACG
GATGAACAGGCGCTGTTCCTCTCCGACGCCGTGCCCACCGGCTACATGGGCGCGGACTTCTGCGACATCCAACCCGGCCA
GACGGTGGCCGTGTGGGGCTGCGGCGGCGTGGGGCTGATGGCGCAGAAGGCCGCGTTCCTCCTCGGCGCCGAGCGGGTGA
TTGGCATCGACCGCTTCCCCGAAAGACTGAAGCTGGCGCGGGAGAAGGTGGGCGCGGAGACCATCAGCTACGAAGAGGTG
GACAGTGTCCTCGACGTGCTGAAGGAACTCACCGGCGGCCGAGGCCCCGACGCCTGCATCGACGCGGTGGGCATGGAGGC
CCACGGCACGGGCGTGGGCGCCGCGTATGACCGCGCGAAACAGGCGATGCGGCTCCAAACGGACCGGGGGCAGGCGCTGC
GGCAGGCCATCCTCGCGTGCCGCAAGGGCGGCATCCTGTCCGTGGTGGGCGTCTACGGATTCATGGACGCGTTCCCCCTG
GGCGCCATCATGAACAAGGGCCTCACGGTCCGCTCCGCCCAGCAGCACGGACAGAAGTACCTGCCGCGCCTGCTGGAGCA
CGTGGTGAAGGGCGAGCTGGACCCGTCCTTCCTCGCCACCCACCGGTTCTCCCTGGAGGACGCGCCGAAGGGGTACGAGC
TCTTCAAGAAGAAGCAGGACGGCTGCGTCCGGGCGGTGTTCCTGCCCAACTGA

Upstream 100 bases:

>100_bases
TCAAGCGATTCAAGAGCCTCGTCGAGACGGGCGAGATTCCCACCACCCGGCCCAACCCCGCCGCTCGCGAGGGCGGCTAC
TCCTCCTGAGGAACCTGCCC

Downstream 100 bases:

>100_bases
TGCGCCAGTCCTCGCGAGGCCGTCCGGTGGCCGCGACACACCGGGCGGCTTCGTTTATCCGCGGCCCGCTCAGGCCTCGG
ACAACATGCCGTTGCCGGTG

Product: zinc-binding dehydrogenase family oxidoreductase

Products: NA

Alternate protein names: Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH [H]

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MRALCWNGINDLGVETVGDPRIVNPHDVILQVRMSTTCGSDLHFIDGYIPTMRKGDVIGHEFMGTVVEKGPAVKKVQVGD
RVVVPSFIGCGSCWYCQHDLWSLCDNTNPKGELQEPLFGYQTAGIYGYTHTFGGYAGAHAQFVRVPHADNDCFRVPEGVT
DEQALFLSDAVPTGYMGADFCDIQPGQTVAVWGCGGVGLMAQKAAFLLGAERVIGIDRFPERLKLAREKVGAETISYEEV
DSVLDVLKELTGGRGPDACIDAVGMEAHGTGVGAAYDRAKQAMRLQTDRGQALRQAILACRKGGILSVVGVYGFMDAFPL
GAIMNKGLTVRSAQQHGQKYLPRLLEHVVKGELDPSFLATHRFSLEDAPKGYELFKKKQDGCVRAVFLPN

Sequences:

>Translated_390_residues
MRALCWNGINDLGVETVGDPRIVNPHDVILQVRMSTTCGSDLHFIDGYIPTMRKGDVIGHEFMGTVVEKGPAVKKVQVGD
RVVVPSFIGCGSCWYCQHDLWSLCDNTNPKGELQEPLFGYQTAGIYGYTHTFGGYAGAHAQFVRVPHADNDCFRVPEGVT
DEQALFLSDAVPTGYMGADFCDIQPGQTVAVWGCGGVGLMAQKAAFLLGAERVIGIDRFPERLKLAREKVGAETISYEEV
DSVLDVLKELTGGRGPDACIDAVGMEAHGTGVGAAYDRAKQAMRLQTDRGQALRQAILACRKGGILSVVGVYGFMDAFPL
GAIMNKGLTVRSAQQHGQKYLPRLLEHVVKGELDPSFLATHRFSLEDAPKGYELFKKKQDGCVRAVFLPN
>Mature_390_residues
MRALCWNGINDLGVETVGDPRIVNPHDVILQVRMSTTCGSDLHFIDGYIPTMRKGDVIGHEFMGTVVEKGPAVKKVQVGD
RVVVPSFIGCGSCWYCQHDLWSLCDNTNPKGELQEPLFGYQTAGIYGYTHTFGGYAGAHAQFVRVPHADNDCFRVPEGVT
DEQALFLSDAVPTGYMGADFCDIQPGQTVAVWGCGGVGLMAQKAAFLLGAERVIGIDRFPERLKLAREKVGAETISYEEV
DSVLDVLKELTGGRGPDACIDAVGMEAHGTGVGAAYDRAKQAMRLQTDRGQALRQAILACRKGGILSVVGVYGFMDAFPL
GAIMNKGLTVRSAQQHGQKYLPRLLEHVVKGELDPSFLATHRFSLEDAPKGYELFKKKQDGCVRAVFLPN

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=382, Percent_Identity=24.3455497382199, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI4501929, Length=373, Percent_Identity=24.9329758713137, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI34577061, Length=385, Percent_Identity=25.1948051948052, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI71565152, Length=272, Percent_Identity=28.6764705882353, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI4501933, Length=245, Percent_Identity=29.7959183673469, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI156523966, Length=376, Percent_Identity=24.2021276595745, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI71565154, Length=391, Percent_Identity=24.2966751918159, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI4501939, Length=364, Percent_Identity=24.1758241758242, Blast_Score=76, Evalue=5e-14,
Organism=Escherichia coli, GI1786825, Length=392, Percent_Identity=41.3265306122449, Blast_Score=308, Evalue=4e-85,
Organism=Escherichia coli, GI1788073, Length=354, Percent_Identity=25.1412429378531, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1790045, Length=364, Percent_Identity=26.6483516483516, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1787863, Length=369, Percent_Identity=24.6612466124661, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI87082125, Length=389, Percent_Identity=24.9357326478149, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI87081918, Length=234, Percent_Identity=29.4871794871795, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1786552, Length=361, Percent_Identity=26.3157894736842, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1788075, Length=300, Percent_Identity=25.6666666666667, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17562876, Length=387, Percent_Identity=24.2894056847545, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17562878, Length=388, Percent_Identity=25.5154639175258, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI25146526, Length=394, Percent_Identity=24.8730964467005, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71997431, Length=393, Percent_Identity=24.9363867684478, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17565904, Length=372, Percent_Identity=24.7311827956989, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6323099, Length=370, Percent_Identity=23.5135135135135, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6319621, Length=344, Percent_Identity=28.4883720930233, Blast_Score=77, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6320033, Length=404, Percent_Identity=24.2574257425743, Blast_Score=74, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6323729, Length=253, Percent_Identity=28.4584980237154, Blast_Score=67, Evalue=4e-12,
Organism=Drosophila melanogaster, GI17137530, Length=387, Percent_Identity=25.3229974160207, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI17737897, Length=387, Percent_Identity=24.031007751938, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI17737895, Length=406, Percent_Identity=23.8916256157635, Blast_Score=79, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284 [H]

Molecular weight: Translated: 42330; Mature: 42330

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRALCWNGINDLGVETVGDPRIVNPHDVILQVRMSTTCGSDLHFIDGYIPTMRKGDVIGH
CCCCCCCCCCCCCCEECCCCEEECHHHEEEEEEECCCCCCCCHHHCCCCCCCCCCCCCHH
EFMGTVVEKGPAVKKVQVGDRVVVPSFIGCGSCWYCQHDLWSLCDNTNPKGELQEPLFGY
HHHHHHHHCCCCEEEEECCCEEECCHHHCCCCEEEEHHHHHHHHCCCCCCCCCCCCHHCC
QTAGIYGYTHTFGGYAGAHAQFVRVPHADNDCFRVPEGVTDEQALFLSDAVPTGYMGADF
CCCCEEEEHHCCCCCCCCCEEEEECCCCCCCCEECCCCCCCCHHEEEECCCCCCCCCCCC
CDIQPGQTVAVWGCGGVGLMAQKAAFLLGAERVIGIDRFPERLKLAREKVGAETISYEEV
CCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHCCHHHH
DSVLDVLKELTGGRGPDACIDAVGMEAHGTGVGAAYDRAKQAMRLQTDRGQALRQAILAC
HHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHH
RKGGILSVVGVYGFMDAFPLGAIMNKGLTVRSAQQHGQKYLPRLLEHVVKGELDPSFLAT
HCCCCEEHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
HRFSLEDAPKGYELFKKKQDGCVRAVFLPN
EECCCCCCCCCHHHHHHCCCCCEEEEECCC
>Mature Secondary Structure
MRALCWNGINDLGVETVGDPRIVNPHDVILQVRMSTTCGSDLHFIDGYIPTMRKGDVIGH
CCCCCCCCCCCCCCEECCCCEEECHHHEEEEEEECCCCCCCCHHHCCCCCCCCCCCCCHH
EFMGTVVEKGPAVKKVQVGDRVVVPSFIGCGSCWYCQHDLWSLCDNTNPKGELQEPLFGY
HHHHHHHHCCCCEEEEECCCEEECCHHHCCCCEEEEHHHHHHHHCCCCCCCCCCCCHHCC
QTAGIYGYTHTFGGYAGAHAQFVRVPHADNDCFRVPEGVTDEQALFLSDAVPTGYMGADF
CCCCEEEEHHCCCCCCCCCEEEEECCCCCCCCEECCCCCCCCHHEEEECCCCCCCCCCCC
CDIQPGQTVAVWGCGGVGLMAQKAAFLLGAERVIGIDRFPERLKLAREKVGAETISYEEV
CCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHCCHHHH
DSVLDVLKELTGGRGPDACIDAVGMEAHGTGVGAAYDRAKQAMRLQTDRGQALRQAILAC
HHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHH
RKGGILSVVGVYGFMDAFPLGAIMNKGLTVRSAQQHGQKYLPRLLEHVVKGELDPSFLAT
HCCCCEEHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
HRFSLEDAPKGYELFKKKQDGCVRAVFLPN
EECCCCCCCCCHHHHHHCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7926692 [H]