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The map label for this gene is kdsB

Identifier: 108763311

GI number: 108763311

Start: 1281228

End: 1281968

Strand: Reverse

Name: kdsB

Synonym: MXAN_1100

Alternate gene names: 108763311

Gene position: 1281968-1281228 (Counterclockwise)

Preceding gene: 108757527

Following gene: 108760735

Centisome position: 14.03

GC content: 70.99

Gene sequence:

>741_bases
ATGCAATCTTGCCGGACCGTTGCAGTCATTCCCGCCCGACATGCCAGCACCCGCTTCCCGGGCAAGCCGCTGGCAATCAT
CGCCGGCCGAACAATGATTGAGCACGTCTGGCGCCGCTGTCAGGAGGCCCAGGCCTTCGACGAGGTGTGGGTTGCCACCG
ATGACGACCGCATTCGCGCCGCAGTGGAGGGCTTTGGCGGCAAGGCGGTGATGACCAGCCCCGCCTGCGCCACGGGGACG
GACCGGGTCGCCGAGGTGGCGCTCGGCCGTCCAGACATCGACATCTGGGTGAACGTCCAGGGAGACGAGCCCCTGGTGGA
CCCCGCCACGCTCCAGCGGCTGGCGGGCCTCTTCCAGGACGCGTCCGTGCGGATGGGCACCCTGGTCCGCCCGCTCGAAG
CGGACGAAGCCGCCAGCCCGCACGTGGTGAAGGCGGTGCTCGCGCTCAACGGCGACGCGCTCTACTTCAGCCGCAGCCTG
GTACCCCACGTCCGCGAGCCGGGCACGCCCGTCCAGCGCTGGGGCCACATCGGCCTCTACGGCTACCGGCGCGAGGTGCT
GCTGTCGCTGGCGAAGCTGGCGCCCACGCCGCTGGAGGACGCGGAGAAGCTGGAGCAGCTCCGCGCGCTGGAGCACGGCA
TCCCCATCCGCTGCGCGAAGGTCACCTCGCACACGGTGGCCGTCGACCTCCCCGGTGACGTGGAGAAGGTGGAGGCCCTC
ATGCGCGCGCGGGGGGGCTGA

Upstream 100 bases:

>100_bases
CCAAAGCTAGGCACTGGAGCCGCGCTGGCCAGTGTCCGATGATGCAAATGTCCAATCCCGGGGGCCGGCAATCGTCGCGA
ACCTGATAGACGGAGGGGTC

Downstream 100 bases:

>100_bases
CCATGGGCTTCCTCAAGAACGTGTTTGGCGGTGGCGCGGCGAAGGCGGACGCGGAGTCCCCGGCGCCTGACGCGGCGCCC
GCTGCCGCGCCAGCCACATC

Product: 3-deoxy-D-manno-octulosonate cytidylyltransferase

Products: NA

Alternate protein names: CMP-2-keto-3-deoxyoctulosonic acid synthase; CKS; CMP-KDO synthase

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MQSCRTVAVIPARHASTRFPGKPLAIIAGRTMIEHVWRRCQEAQAFDEVWVATDDDRIRAAVEGFGGKAVMTSPACATGT
DRVAEVALGRPDIDIWVNVQGDEPLVDPATLQRLAGLFQDASVRMGTLVRPLEADEAASPHVVKAVLALNGDALYFSRSL
VPHVREPGTPVQRWGHIGLYGYRREVLLSLAKLAPTPLEDAEKLEQLRALEHGIPIRCAKVTSHTVAVDLPGDVEKVEAL
MRARGG

Sequences:

>Translated_246_residues
MQSCRTVAVIPARHASTRFPGKPLAIIAGRTMIEHVWRRCQEAQAFDEVWVATDDDRIRAAVEGFGGKAVMTSPACATGT
DRVAEVALGRPDIDIWVNVQGDEPLVDPATLQRLAGLFQDASVRMGTLVRPLEADEAASPHVVKAVLALNGDALYFSRSL
VPHVREPGTPVQRWGHIGLYGYRREVLLSLAKLAPTPLEDAEKLEQLRALEHGIPIRCAKVTSHTVAVDLPGDVEKVEAL
MRARGG
>Mature_246_residues
MQSCRTVAVIPARHASTRFPGKPLAIIAGRTMIEHVWRRCQEAQAFDEVWVATDDDRIRAAVEGFGGKAVMTSPACATGT
DRVAEVALGRPDIDIWVNVQGDEPLVDPATLQRLAGLFQDASVRMGTLVRPLEADEAASPHVVKAVLALNGDALYFSRSL
VPHVREPGTPVQRWGHIGLYGYRREVLLSLAKLAPTPLEDAEKLEQLRALEHGIPIRCAKVTSHTVAVDLPGDVEKVEAL
MRARGG

Specific function: Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria

COG id: COG1212

COG function: function code M; CMP-2-keto-3-deoxyoctulosonic acid synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kdsB family

Homologues:

Organism=Escherichia coli, GI1787147, Length=248, Percent_Identity=41.5322580645161, Blast_Score=154, Evalue=6e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KDSB_MYXXD (Q1DDB3)

Other databases:

- EMBL:   CP000113
- RefSeq:   YP_629360.1
- ProteinModelPortal:   Q1DDB3
- SMR:   Q1DDB3
- STRING:   Q1DDB3
- GeneID:   4107066
- GenomeReviews:   CP000113_GR
- KEGG:   mxa:MXAN_1100
- TIGR:   MXAN_1100
- eggNOG:   COG1212
- HOGENOM:   HBG637773
- OMA:   IIPARLK
- PhylomeDB:   Q1DDB3
- BioCyc:   MXAN246197:MXAN_1100-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00057
- InterPro:   IPR003329
- InterPro:   IPR004528
- TIGRFAMs:   TIGR00466

Pfam domain/function: PF02348 CTP_transf_3

EC number: =2.7.7.38

Molecular weight: Translated: 26718; Mature: 26718

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSCRTVAVIPARHASTRFPGKPLAIIAGRTMIEHVWRRCQEAQAFDEVWVATDDDRIRA
CCCCCEEEEEECCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHEEEECCCHHHHH
AVEGFGGKAVMTSPACATGTDRVAEVALGRPDIDIWVNVQGDEPLVDPATLQRLAGLFQD
HHHCCCCCEEEECCCCCCCCHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHC
ASVRMGTLVRPLEADEAASPHVVKAVLALNGDALYFSRSLVPHVREPGTPVQRWGHIGLY
CCHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHCCCCCHH
GYRREVLLSLAKLAPTPLEDAEKLEQLRALEHGIPIRCAKVTSHTVAVDLPGDVEKVEAL
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCEEEEECCCCHHHHHHH
MRARGG
HHHCCC
>Mature Secondary Structure
MQSCRTVAVIPARHASTRFPGKPLAIIAGRTMIEHVWRRCQEAQAFDEVWVATDDDRIRA
CCCCCEEEEEECCCCCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHEEEECCCHHHHH
AVEGFGGKAVMTSPACATGTDRVAEVALGRPDIDIWVNVQGDEPLVDPATLQRLAGLFQD
HHHCCCCCEEEECCCCCCCCHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHC
ASVRMGTLVRPLEADEAASPHVVKAVLALNGDALYFSRSLVPHVREPGTPVQRWGHIGLY
CCHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCCCCCCCHHHHCCCCCHH
GYRREVLLSLAKLAPTPLEDAEKLEQLRALEHGIPIRCAKVTSHTVAVDLPGDVEKVEAL
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCEEEEECCCCHHHHHHH
MRARGG
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA