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The map label for this gene is macA [H]

Identifier: 108763234

GI number: 108763234

Start: 5126420

End: 5127679

Strand: Reverse

Name: macA [H]

Synonym: MXAN_4175

Alternate gene names: 108763234

Gene position: 5127679-5126420 (Counterclockwise)

Preceding gene: 108759473

Following gene: 108756984

Centisome position: 56.1

GC content: 68.02

Gene sequence:

>1260_bases
ATGAAGTGGTGGAAGGGTGCCATTGCTGGCGCGTTGTTCCTGGGTGCTGCGGCCATCACCGCGGGCGGGTTGAAGGACCG
TCCTCCGCCGTCGCTCGAAGTCCAGCTGTCGAAGGCCCGGAAGGGCTCCATCACCCGCACTATCACCGGCGCGGGCAAGG
TGCAGGCGGCCACGACGGTGAAGATCTCGTCCAGCCTCTCCGGTGACCTGGTGGAGCTGGCGGTGAAGGACGGCGAGGCG
GTGACGAAGGGCCAGGTGCTGGGCCGCATCGATCCGCGCCTCTACCAGGCCGCGCACAAGCAGGCCTTGGCGTCGCTGAA
CGCCTCGCGCGCCGACGTGCAGGTGGCGGAGGTGGAGGTGGGCCGCGCGCAGTTGGAGCTCGCGCGTGCGGAGGACCTGG
CGAAGAAGGGCCTTTCGTCCGCCGCCGAGGTGGACACGGCGCGGGCCACGAAGAACACGGGGGATGCGCGGCTGGCATCG
GCCAAGCAGATGCTGGCCCGCAACATGGCCATCGTGGACCAGGCGCAGACGGACCTCACGCGCACGACGCTGGTGTCGCC
CATCGACGGCAACGTCATCGAGCTGTCGCGTGAAGTGGGTGAGCGTGTTCGTGGCTCGGACCTGTCCGAGGACGTGGTGA
TGACCATCGCCGCGCTCAGCGCCATGGAGGTGAAGTTCGAGGTGGGCGAGCACGAGGTGGTGCACCTCAAGCCGGGCCAG
CCCGCGGAGATCACGCTCGACGCACTGGAGGGCCAGACGTACTCGGGCTCCGTGGTGGAGATTGCCCAGAAGGCGCTCAT
CAAGAACGAGGGCACCGAGGCCGAGGTGACGAGCTTCCCCATCACCGTCGCGCTGGACACCCGTCCGCCCAACGTGCTGC
CCGGCATGAGCTCCGAGGTGCGCATCTCCGCGGAGACGCACAATGACGTGGTGCTGGTGCCCATCCAGGCGGTGACGGTG
CGCTCGGAGCGCTCGCTGCCGGACTACAAGGCGCCCATCGAAGGGGGCGGGCTGACGGCGAAGCGGACGGAGTCGCTGGC
CAAGGTCGTGTTCGTGGTGGACAGCAGCAACAAGGCGCAGGTGCGCCGCGTGCAGACGGGCATCGCCTCTGACACGGAGC
TGGAGATCGTCTCCGGACTCAATGATGGCGACCGGGTGATTGAAGGTCCGTACCGGACGCTGTCGAAGGAGCTGAACGAC
GGCGACATCGTGCGTGAGCCGGAGCAGGGCGCGGGAATGAAGGGCGGTCGGAAGTCGTGA

Upstream 100 bases:

>100_bases
CGCGCGCTGAGCTCGCCTTGTTGGAAAACAGGATCGATGTCGAAATCGCCCGCTATTCATTGCAGCGGGCCATGGGCGCC
CTGAGCCCGGGAGAGTCGAA

Downstream 100 bases:

>100_bases
GTCAGGCCAGCGGCGCGGGACCGCTCATCCAGGTGGAGAACATCACCCGCGTCTTCCACGTGGGTGGAGAAGAGGTGCGC
GCGCTGCGCGGCGTCTCCTT

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MKWWKGAIAGALFLGAAAITAGGLKDRPPPSLEVQLSKARKGSITRTITGAGKVQAATTVKISSSLSGDLVELAVKDGEA
VTKGQVLGRIDPRLYQAAHKQALASLNASRADVQVAEVEVGRAQLELARAEDLAKKGLSSAAEVDTARATKNTGDARLAS
AKQMLARNMAIVDQAQTDLTRTTLVSPIDGNVIELSREVGERVRGSDLSEDVVMTIAALSAMEVKFEVGEHEVVHLKPGQ
PAEITLDALEGQTYSGSVVEIAQKALIKNEGTEAEVTSFPITVALDTRPPNVLPGMSSEVRISAETHNDVVLVPIQAVTV
RSERSLPDYKAPIEGGGLTAKRTESLAKVVFVVDSSNKAQVRRVQTGIASDTELEIVSGLNDGDRVIEGPYRTLSKELND
GDIVREPEQGAGMKGGRKS

Sequences:

>Translated_419_residues
MKWWKGAIAGALFLGAAAITAGGLKDRPPPSLEVQLSKARKGSITRTITGAGKVQAATTVKISSSLSGDLVELAVKDGEA
VTKGQVLGRIDPRLYQAAHKQALASLNASRADVQVAEVEVGRAQLELARAEDLAKKGLSSAAEVDTARATKNTGDARLAS
AKQMLARNMAIVDQAQTDLTRTTLVSPIDGNVIELSREVGERVRGSDLSEDVVMTIAALSAMEVKFEVGEHEVVHLKPGQ
PAEITLDALEGQTYSGSVVEIAQKALIKNEGTEAEVTSFPITVALDTRPPNVLPGMSSEVRISAETHNDVVLVPIQAVTV
RSERSLPDYKAPIEGGGLTAKRTESLAKVVFVVDSSNKAQVRRVQTGIASDTELEIVSGLNDGDRVIEGPYRTLSKELND
GDIVREPEQGAGMKGGRKS
>Mature_419_residues
MKWWKGAIAGALFLGAAAITAGGLKDRPPPSLEVQLSKARKGSITRTITGAGKVQAATTVKISSSLSGDLVELAVKDGEA
VTKGQVLGRIDPRLYQAAHKQALASLNASRADVQVAEVEVGRAQLELARAEDLAKKGLSSAAEVDTARATKNTGDARLAS
AKQMLARNMAIVDQAQTDLTRTTLVSPIDGNVIELSREVGERVRGSDLSEDVVMTIAALSAMEVKFEVGEHEVVHLKPGQ
PAEITLDALEGQTYSGSVVEIAQKALIKNEGTEAEVTSFPITVALDTRPPNVLPGMSSEVRISAETHNDVVLVPIQAVTV
RSERSLPDYKAPIEGGGLTAKRTESLAKVVFVVDSSNKAQVRRVQTGIASDTELEIVSGLNDGDRVIEGPYRTLSKELND
GDIVREPEQGAGMKGGRKS

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=389, Percent_Identity=28.0205655526992, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI87082036, Length=372, Percent_Identity=24.4623655913978, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1790519, Length=254, Percent_Identity=31.496062992126, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI87081951, Length=244, Percent_Identity=27.0491803278689, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1789929, Length=341, Percent_Identity=24.3401759530792, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 44268; Mature: 44268

Theoretical pI: Translated: 5.60; Mature: 5.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKWWKGAIAGALFLGAAAITAGGLKDRPPPSLEVQLSKARKGSITRTITGAGKVQAATTV
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCEEEEEECCCCEEEEEEE
KISSSLSGDLVELAVKDGEAVTKGQVLGRIDPRLYQAAHKQALASLNASRADVQVAEVEV
EECCCCCCCEEEEEECCCCCEECCCEEECCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEC
GRAQLELARAEDLAKKGLSSAAEVDTARATKNTGDARLASAKQMLARNMAIVDQAQTDLT
CHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RTTLVSPIDGNVIELSREVGERVRGSDLSEDVVMTIAALSAMEVKFEVGEHEVVHLKPGQ
HHHEECCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHEEEEEECCCEEEEEECCCC
PAEITLDALEGQTYSGSVVEIAQKALIKNEGTEAEVTSFPITVALDTRPPNVLPGMSSEV
CCEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCEEEECEEEEEECCCCCCCCCCCCCCE
RISAETHNDVVLVPIQAVTVRSERSLPDYKAPIEGGGLTAKRTESLAKVVFVVDSSNKAQ
EEEEECCCCEEEEEEEEEEEECCCCCCCCCCCCCCCCCCHHHHHCEEEEEEEEECCCCHH
VRRVQTGIASDTELEIVSGLNDGDRVIEGPYRTLSKELNDGDIVREPEQGAGMKGGRKS
HHHHHHCCCCCCCEEEEECCCCCCCEECCHHHHHHHCCCCCCCEECCCCCCCCCCCCCC
>Mature Secondary Structure
MKWWKGAIAGALFLGAAAITAGGLKDRPPPSLEVQLSKARKGSITRTITGAGKVQAATTV
CCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCEEEEEECCCCEEEEEEE
KISSSLSGDLVELAVKDGEAVTKGQVLGRIDPRLYQAAHKQALASLNASRADVQVAEVEV
EECCCCCCCEEEEEECCCCCEECCCEEECCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEC
GRAQLELARAEDLAKKGLSSAAEVDTARATKNTGDARLASAKQMLARNMAIVDQAQTDLT
CHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RTTLVSPIDGNVIELSREVGERVRGSDLSEDVVMTIAALSAMEVKFEVGEHEVVHLKPGQ
HHHEECCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHEEEEEECCCEEEEEECCCC
PAEITLDALEGQTYSGSVVEIAQKALIKNEGTEAEVTSFPITVALDTRPPNVLPGMSSEV
CCEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCEEEECEEEEEECCCCCCCCCCCCCCE
RISAETHNDVVLVPIQAVTVRSERSLPDYKAPIEGGGLTAKRTESLAKVVFVVDSSNKAQ
EEEEECCCCEEEEEEEEEEEECCCCCCCCCCCCCCCCCCHHHHHCEEEEEEEEECCCCHH
VRRVQTGIASDTELEIVSGLNDGDRVIEGPYRTLSKELNDGDIVREPEQGAGMKGGRKS
HHHHHHCCCCCCCEEEEECCCCCCCEECCHHHHHHHCCCCCCCEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]