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The map label for this gene is czcD [H]

Identifier: 108763219

GI number: 108763219

Start: 6559009

End: 6559956

Strand: Direct

Name: czcD [H]

Synonym: MXAN_5264

Alternate gene names: 108763219

Gene position: 6559009-6559956 (Clockwise)

Preceding gene: 108760680

Following gene: 108759891

Centisome position: 71.76

GC content: 69.62

Gene sequence:

>948_bases
ATGGCGGGACACTCGCACTCCCACTCGCACTCCCACTCGCACTCTCACGGACACGGGCACGCGCACGCCGCGCCCGATTC
GCACAGCCGGGCCTTCATGCTCGGCATCGGTCTCAACCTGGCCTTCGTCGGCGTCGAAGCCACGTATGGCATCCTGTCCG
GCTCGCTCGCCCTGCTGGCGGATGCGGGGCACAACCTGAGTGACGTGCTGGGGCTCGTCCTCGCCTGGGGGGCCAGCGTC
CTGGGCCGGCGCAAGGCGACGGAGCGCCATACCTACGGCTTCCGGAGCGCCACCATCCTGGCCGCGCTGCTCAACGCCCT
GTTGCTGCTGGTCGCGGTGGGGGGCATGGGCTGGGAGGCGGTGCGGCGGCTGGGGCAGCCCGCCACCGTGTCCAGCTTCA
CCATCATGTCGGTGGCGGGCATGGGCATCGTTGTCAACGCGGCCACGGCGCTGCTCTTCTGGAAGGGCCGCGAGCGCGAC
CTCAACATCCGAGGCGCCTTCCTCCACCTGGCCGCTGACGCGGCCGTGTCGCTGGGCGTCGTCCTGGCGGGTCTCCTCAT
CTACTACACGGGTTGGGCGTGGCTGGACCCGGTGGTGACGCTGGTCATCGCGGGCCTCATCTTCGTGGGGACGTGGGGGC
TGCTCAAGGACTCCGTCAACCTCGCGCTCCAGGCGGTGCCGGGACACATCGACGTGCGTCAGGTGCGCGAGCGGCTCGTT
CAGACTCCAGGGGTGTCCGAGGTCCATGACCTGCACGTCTGGGCCATGAGCACCACCGAGGCCGCGCTCACCGCGCACCT
CGTCATGCGGGAGCCGCGGCTGGACGACGCCTTCCTCGACGACGTGAAGCGGCGGCTCCATGACGAGTTCGGCATCGAGC
ACATCACGCTCCAGGTGGAGGAGGGAGCGCTCACGGGTTGCTGCCAGCTCGCGTTCGAGCCTGCCTGA

Upstream 100 bases:

>100_bases
AAGGGCTGCGTGGACTGCCCCTGCGAGGAGGCGGGCGGACTGTAACCGGGGCCCAGGCGCGTCGTCAGGAGGGAGAACTG
GAACGAAGGAGCCGTTCTCC

Downstream 100 bases:

>100_bases
CGCGGCGGCCCGGAGCCGGCCGTGGTGCCCACGGGCGTGAAGCCCCGGCCTCTGCTTGGAGCGGAGGCCGGGGGGACAGG
ACGCGCCCGGCCCCGGCTCC

Product: cation efflux family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 315; Mature: 314

Protein sequence:

>315_residues
MAGHSHSHSHSHSHSHGHGHAHAAPDSHSRAFMLGIGLNLAFVGVEATYGILSGSLALLADAGHNLSDVLGLVLAWGASV
LGRRKATERHTYGFRSATILAALLNALLLLVAVGGMGWEAVRRLGQPATVSSFTIMSVAGMGIVVNAATALLFWKGRERD
LNIRGAFLHLAADAAVSLGVVLAGLLIYYTGWAWLDPVVTLVIAGLIFVGTWGLLKDSVNLALQAVPGHIDVRQVRERLV
QTPGVSEVHDLHVWAMSTTEAALTAHLVMREPRLDDAFLDDVKRRLHDEFGIEHITLQVEEGALTGCCQLAFEPA

Sequences:

>Translated_315_residues
MAGHSHSHSHSHSHSHGHGHAHAAPDSHSRAFMLGIGLNLAFVGVEATYGILSGSLALLADAGHNLSDVLGLVLAWGASV
LGRRKATERHTYGFRSATILAALLNALLLLVAVGGMGWEAVRRLGQPATVSSFTIMSVAGMGIVVNAATALLFWKGRERD
LNIRGAFLHLAADAAVSLGVVLAGLLIYYTGWAWLDPVVTLVIAGLIFVGTWGLLKDSVNLALQAVPGHIDVRQVRERLV
QTPGVSEVHDLHVWAMSTTEAALTAHLVMREPRLDDAFLDDVKRRLHDEFGIEHITLQVEEGALTGCCQLAFEPA
>Mature_314_residues
AGHSHSHSHSHSHSHGHGHAHAAPDSHSRAFMLGIGLNLAFVGVEATYGILSGSLALLADAGHNLSDVLGLVLAWGASVL
GRRKATERHTYGFRSATILAALLNALLLLVAVGGMGWEAVRRLGQPATVSSFTIMSVAGMGIVVNAATALLFWKGRERDL
NIRGAFLHLAADAAVSLGVVLAGLLIYYTGWAWLDPVVTLVIAGLIFVGTWGLLKDSVNLALQAVPGHIDVRQVRERLVQ
TPGVSEVHDLHVWAMSTTEAALTAHLVMREPRLDDAFLDDVKRRLHDEFGIEHITLQVEEGALTGCCQLAFEPA

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI52352805, Length=310, Percent_Identity=27.0967741935484, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI20070323, Length=319, Percent_Identity=28.5266457680251, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI289803013, Length=274, Percent_Identity=27.007299270073, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI289803009, Length=274, Percent_Identity=27.007299270073, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI289803007, Length=274, Percent_Identity=27.007299270073, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI289803003, Length=274, Percent_Identity=27.007299270073, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI64762489, Length=309, Percent_Identity=26.8608414239482, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI21359890, Length=257, Percent_Identity=27.2373540856031, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI21361112, Length=298, Percent_Identity=26.8456375838926, Blast_Score=104, Evalue=9e-23,
Organism=Homo sapiens, GI14210520, Length=216, Percent_Identity=26.3888888888889, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI52352803, Length=213, Percent_Identity=27.6995305164319, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI52351208, Length=168, Percent_Identity=26.1904761904762, Blast_Score=78, Evalue=9e-15,
Organism=Homo sapiens, GI222080086, Length=128, Percent_Identity=31.25, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI40255009, Length=128, Percent_Identity=31.25, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1786966, Length=288, Percent_Identity=37.8472222222222, Blast_Score=164, Evalue=7e-42,
Organism=Caenorhabditis elegans, GI193210990, Length=323, Percent_Identity=28.4829721362229, Blast_Score=147, Evalue=7e-36,
Organism=Caenorhabditis elegans, GI17555794, Length=330, Percent_Identity=26.3636363636364, Blast_Score=135, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17555796, Length=296, Percent_Identity=27.3648648648649, Blast_Score=130, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI32564488, Length=304, Percent_Identity=27.9605263157895, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17550442, Length=302, Percent_Identity=23.841059602649, Blast_Score=71, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17550440, Length=302, Percent_Identity=23.841059602649, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324892, Length=152, Percent_Identity=34.8684210526316, Blast_Score=90, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6323899, Length=151, Percent_Identity=34.4370860927152, Blast_Score=83, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6320411, Length=183, Percent_Identity=32.7868852459016, Blast_Score=80, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24583858, Length=352, Percent_Identity=25.5681818181818, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI24656728, Length=326, Percent_Identity=27.3006134969325, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24656724, Length=326, Percent_Identity=27.3006134969325, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24656720, Length=326, Percent_Identity=27.3006134969325, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24656715, Length=326, Percent_Identity=27.3006134969325, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI21357035, Length=326, Percent_Identity=27.3006134969325, Blast_Score=108, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24584409, Length=158, Percent_Identity=28.4810126582279, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI28574430, Length=158, Percent_Identity=28.4810126582279, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24585900, Length=147, Percent_Identity=29.9319727891156, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24585898, Length=147, Percent_Identity=29.9319727891156, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24585896, Length=147, Percent_Identity=29.9319727891156, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI19921672, Length=147, Percent_Identity=29.9319727891156, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24645863, Length=121, Percent_Identity=37.1900826446281, Blast_Score=72, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 33612; Mature: 33481

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGHSHSHSHSHSHSHGHGHAHAAPDSHSRAFMLGIGLNLAFVGVEATYGILSGSLALLA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCEEEEEEHHHHHHHHHCCHHEEE
DAGHNLSDVLGLVLAWGASVLGRRKATERHTYGFRSATILAALLNALLLLVAVGGMGWEA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHH
VRRLGQPATVSSFTIMSVAGMGIVVNAATALLFWKGRERDLNIRGAFLHLAADAAVSLGV
HHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHEEECCCCCCCCEEHHHEEHHHHHHHHHHH
VLAGLLIYYTGWAWLDPVVTLVIAGLIFVGTWGLLKDSVNLALQAVPGHIDVRQVRERLV
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHH
QTPGVSEVHDLHVWAMSTTEAALTAHLVMREPRLDDAFLDDVKRRLHDEFGIEHITLQVE
CCCCCCCHHHEEEEEECCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCEEEEEEEE
EGALTGCCQLAFEPA
CCCCCHHHHEEECCC
>Mature Secondary Structure 
AGHSHSHSHSHSHSHGHGHAHAAPDSHSRAFMLGIGLNLAFVGVEATYGILSGSLALLA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCEEEEEEHHHHHHHHHCCHHEEE
DAGHNLSDVLGLVLAWGASVLGRRKATERHTYGFRSATILAALLNALLLLVAVGGMGWEA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHH
VRRLGQPATVSSFTIMSVAGMGIVVNAATALLFWKGRERDLNIRGAFLHLAADAAVSLGV
HHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHEEECCCCCCCCEEHHHEEHHHHHHHHHHH
VLAGLLIYYTGWAWLDPVVTLVIAGLIFVGTWGLLKDSVNLALQAVPGHIDVRQVRERLV
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHH
QTPGVSEVHDLHVWAMSTTEAALTAHLVMREPRLDDAFLDDVKRRLHDEFGIEHITLQVE
CCCCCCCHHHEEEEEECCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCEEEEEEEE
EGALTGCCQLAFEPA
CCCCCHHHHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA