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The map label for this gene is capI [H]

Identifier: 108762835

GI number: 108762835

Start: 4855909

End: 4856883

Strand: Reverse

Name: capI [H]

Synonym: MXAN_3987

Alternate gene names: 108762835

Gene position: 4856883-4855909 (Counterclockwise)

Preceding gene: 108759832

Following gene: 108761967

Centisome position: 53.14

GC content: 71.9

Gene sequence:

>975_bases
ATGCGGGTACTCGTCACGGGAGCTGCGGGCTTCATTGCCCACCACGTCAGTGCGCGGCTGTTGGCGCGCGGCGATGCCGT
CATCGGCGTGGACAACCTGGACCCGTCCGGGGACGTGGCGTTGAAGCAGGCCCGGCTGACGCGGCTCGGCACGCTGCCGG
GGGCGACGGGCTTCACCTTCCGTCCCGTGGACGTTACCGACAGCCCCTCGCTGCGAGCGCTCTTCGAGGAGATGCGCCCC
GAGGCCGTGGTGCACCTGGCCGCGCGTGTGGGCGTGCGGGCGCCGGCGGGCACCGCGCAGGCATACGTGGACGCCAACGT
GTCGGGGTTCCTCCAGGTGCTGGAGCAGGCCAGCGCGGCCCGGGTGCGGCACCTGGTCTACGCGTCCTCCAGCTCCGTGT
ACGGCGCGGGCTCGGTGCCGCCGTTCCAGGAAGGCGCCGCGGCGGACCACCCGCTCAGCGTCTACGCGGCCACGAAGCGC
GCCGATGAACTGCTGGCGCACGCGTACAGCCATCTGCACGGGCTCCCCACCAGTGGCCTGCGCTTCTTCACGGTGTACGG
CCCCTGGGGACGACCAGACATGGCCCCCCTGCGCTTTCTCCAGGCCATCCGTGACGGCACCGAGCTGTCACTGCACGGCG
AAGGCCGGATGCAGCGCGACTTCACCTACGTGGAGGACGTGGCGGAGGCCGTGGTGCGCGTGCTGGACCGGCCGCTCCCA
GGGGCACCTCGCCATCGCGTCCTCAACGTGGGCCGGGGCGAGCCTGTTTCGGTGCGGGCCTTCCTCTCTGTCCTGGAGCG
GATCCTGGGCGCCCGGGCGCGGGTGAAGTCCACGCCCGCGCAGCCTGGGGAGATGGACGCGACCTGGGCGGACCCTTCCG
CGCTGGAGCGAGAGACGGGATTCCGGCCGCGCGTCTCCGTGGAGGAGGGGCTGACACGACTGGTGGCGTGGTTCCACGAA
CAGTCGGGCACCTGA

Upstream 100 bases:

>100_bases
GAGGGCCTCCACCCTACGTGCAAGTGGCTGGGACGGGAAGCGCCGCGTCCACGTCTTCCGCCGTGGCGTGTTGGGGGCTG
GCGTGGGAGCGTGGAGGTGG

Downstream 100 bases:

>100_bases
GGCAGAACGACGAGACGTGGCTGGGCGTCTTCAACGTGCCTCGAGGTGGGGCCTCCGTGCCGGCTACCCGGACGTCACCG
TCACCTGGCCATGCTCCACG

Product: NAD-dependent epimerase/dehydratase family protein

Products: dTDP-4-dehydro-6-deoxy-D-glucose; H2O [C]

Alternate protein names: NA

Number of amino acids: Translated: 324; Mature: 324

Protein sequence:

>324_residues
MRVLVTGAAGFIAHHVSARLLARGDAVIGVDNLDPSGDVALKQARLTRLGTLPGATGFTFRPVDVTDSPSLRALFEEMRP
EAVVHLAARVGVRAPAGTAQAYVDANVSGFLQVLEQASAARVRHLVYASSSSVYGAGSVPPFQEGAAADHPLSVYAATKR
ADELLAHAYSHLHGLPTSGLRFFTVYGPWGRPDMAPLRFLQAIRDGTELSLHGEGRMQRDFTYVEDVAEAVVRVLDRPLP
GAPRHRVLNVGRGEPVSVRAFLSVLERILGARARVKSTPAQPGEMDATWADPSALERETGFRPRVSVEEGLTRLVAWFHE
QSGT

Sequences:

>Translated_324_residues
MRVLVTGAAGFIAHHVSARLLARGDAVIGVDNLDPSGDVALKQARLTRLGTLPGATGFTFRPVDVTDSPSLRALFEEMRP
EAVVHLAARVGVRAPAGTAQAYVDANVSGFLQVLEQASAARVRHLVYASSSSVYGAGSVPPFQEGAAADHPLSVYAATKR
ADELLAHAYSHLHGLPTSGLRFFTVYGPWGRPDMAPLRFLQAIRDGTELSLHGEGRMQRDFTYVEDVAEAVVRVLDRPLP
GAPRHRVLNVGRGEPVSVRAFLSVLERILGARARVKSTPAQPGEMDATWADPSALERETGFRPRVSVEEGLTRLVAWFHE
QSGT
>Mature_324_residues
MRVLVTGAAGFIAHHVSARLLARGDAVIGVDNLDPSGDVALKQARLTRLGTLPGATGFTFRPVDVTDSPSLRALFEEMRP
EAVVHLAARVGVRAPAGTAQAYVDANVSGFLQVLEQASAARVRHLVYASSSSVYGAGSVPPFQEGAAADHPLSVYAATKR
ADELLAHAYSHLHGLPTSGLRFFTVYGPWGRPDMAPLRFLQAIRDGTELSLHGEGRMQRDFTYVEDVAEAVVRVLDRPLP
GAPRHRVLNVGRGEPVSVRAFLSVLERILGARARVKSTPAQPGEMDATWADPSALERETGFRPRVSVEEGLTRLVAWFHE
QSGT

Specific function: Required for the biosynthesis of type 1 capsular polysaccharide [H]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI7657641, Length=336, Percent_Identity=29.1666666666667, Blast_Score=136, Evalue=2e-32,
Organism=Homo sapiens, GI56237023, Length=339, Percent_Identity=27.1386430678466, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI56118217, Length=339, Percent_Identity=27.1386430678466, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI189083684, Length=339, Percent_Identity=27.1386430678466, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI42516563, Length=329, Percent_Identity=24.9240121580547, Blast_Score=84, Evalue=1e-16,
Organism=Escherichia coli, GI1788353, Length=350, Percent_Identity=27.4285714285714, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI48994969, Length=344, Percent_Identity=28.7790697674419, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1786974, Length=335, Percent_Identity=26.5671641791045, Blast_Score=103, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71982035, Length=338, Percent_Identity=28.1065088757396, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI71982038, Length=339, Percent_Identity=27.7286135693215, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17568069, Length=330, Percent_Identity=23.3333333333333, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI115532424, Length=327, Percent_Identity=22.0183486238532, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17507723, Length=343, Percent_Identity=22.7405247813411, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6319493, Length=347, Percent_Identity=25.6484149855908, Blast_Score=79, Evalue=7e-16,
Organism=Drosophila melanogaster, GI19923002, Length=336, Percent_Identity=27.0833333333333, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI21356223, Length=330, Percent_Identity=25.1515151515152, Blast_Score=91, Evalue=9e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040
- InterPro:   IPR008089 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: 4.2.1.46 [C]

Molecular weight: Translated: 34866; Mature: 34866

Theoretical pI: Translated: 8.85; Mature: 8.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVLVTGAAGFIAHHVSARLLARGDAVIGVDNLDPSGDVALKQARLTRLGTLPGATGFTF
CEEEEECCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCEE
RPVDVTDSPSLRALFEEMRPEAVVHLAARVGVRAPAGTAQAYVDANVSGFLQVLEQASAA
EECCCCCCCHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCEEECCCHHHHHHHHHHHHHH
RVRHLVYASSSSVYGAGSVPPFQEGAAADHPLSVYAATKRADELLAHAYSHLHGLPTSGL
HHHHHHEECCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCE
RFFTVYGPWGRPDMAPLRFLQAIRDGTELSLHGEGRMQRDFTYVEDVAEAVVRVLDRPLP
EEEEEECCCCCCCHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCC
GAPRHRVLNVGRGEPVSVRAFLSVLERILGARARVKSTPAQPGEMDATWADPSALERETG
CCCCHHEEECCCCCCCHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCCCCHHHHHHHCC
FRPRVSVEEGLTRLVAWFHEQSGT
CCCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRVLVTGAAGFIAHHVSARLLARGDAVIGVDNLDPSGDVALKQARLTRLGTLPGATGFTF
CEEEEECCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCEE
RPVDVTDSPSLRALFEEMRPEAVVHLAARVGVRAPAGTAQAYVDANVSGFLQVLEQASAA
EECCCCCCCHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCCEEECCCHHHHHHHHHHHHHH
RVRHLVYASSSSVYGAGSVPPFQEGAAADHPLSVYAATKRADELLAHAYSHLHGLPTSGL
HHHHHHEECCCCCCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHCCCCCCCE
RFFTVYGPWGRPDMAPLRFLQAIRDGTELSLHGEGRMQRDFTYVEDVAEAVVRVLDRPLP
EEEEEECCCCCCCHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCC
GAPRHRVLNVGRGEPVSVRAFLSVLERILGARARVKSTPAQPGEMDATWADPSALERETG
CCCCHHEEECCCCCCCHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCCCCHHHHHHHCC
FRPRVSVEEGLTRLVAWFHEQSGT
CCCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NAD+ [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.019 {NAD+}} 0.034 {dTDPglucose}} [C]

Substrates: dTDPglucose [C]

Specific reaction: dTDPglucose --> dTDP-4-dehydro-6-deoxy-D-glucose + H2O [C]

General reaction: Elimination (of H2O C-O bond cleavage [C]

Inhibitor: TDP; TTP [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7961465 [H]