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The map label for this gene is cls2 [H]

Identifier: 108762822

GI number: 108762822

Start: 616552

End: 618012

Strand: Reverse

Name: cls2 [H]

Synonym: MXAN_0537

Alternate gene names: 108762822

Gene position: 618012-616552 (Counterclockwise)

Preceding gene: 108759639

Following gene: 108761667

Centisome position: 6.76

GC content: 71.18

Gene sequence:

>1461_bases
ATGCACCTGTTCGACATCCCCGCGTGGTTGGAGGTGGCCTGGCCCCATGTGGTGGCGGCGCTGACCGTGCTCATCAGCGT
GGTGGCCAGCGCCCATGCGGTGCTGCACAAGCGGGACGTGCGGGCCGCGGTGGGCTGGGTGGGACTGGCGTGGCTGGTGC
CGGTGCTGGGCGGGGTGCTGTACGTCCTGCTGGGCATCAACCGCATCCGGCGCCGGGCGCGTTCATTGATGCTGAAACAA
GAGCACGGCCGCTTTCCGCCGCTGTTCCAGGTGGCCCCCATGAAGGCGGAGACGGTGAGTGGCCCCCACCCCGAGGCCGC
CCCCCTGGCACCCCTGGTGCGGCTGGGGGACGCGGTGGTGGGACGGCCGCTGCTGCCGGGCAACCGCTTCACCGTGCTGG
AGTCCCGCCGGGACGCCTACCCCGCAATGCTGGAGGCGATTGACGCGGCGCGCACGACGCTGTCGCTGTGCAGCTACATC
TTCGACAATGACATGGCGGGCCGGCGCTTCGTGGAGGCGCTGAGTGCAGCGGTGAAGCGGGGCGTGGAGGTGCGGGTGCT
GGTGGACGCGGTGGGCTCGCGCTACACGTGGCCGCCCATCCTGGGCCGGCTGCGGCGAGCCGGCGTCCGCGCCGCGCGCT
TCCTGCCGTCGCTGATGCCCTACCGGCTGCCCTTCGCCAACCTGCGCAACCACCGCAAGCTGATGGTGGTGGACGGGCGC
GTGGGCTTCACGGGAGGCATGAACATCCGCAAGGCCTTCTGGCCCGGCGAACATGCCGCCGTGGACCTGCACTTCCGCGT
CGAAGGACCGCTGGTGGGACAGCTCCAGGAGACCTTCGCGGAGGACTGGGCCTTCACCACGCGCGAGCGGCTGACAGGCG
AGGCCTGGTTCCCGCCGCTCACCGAAGTGGGCACCGTGCTCGCGCGAGGCATCGCGGACGGCCCGGACGAGGACTTCGAG
ACGCTGCGCACGGTGCTGCTGGGGGCCCTGGCCACGGCGCGAACGTCGGTGCGCATCGTCACGCCCTACTTCCTCCCGGA
CACGGCGCTCATCACCGCGCTGAGCGTGGCGGCGCTGCGCGGCGTCCAGGTGGACATCCTCCTTCCCGAGAAGGGCAATC
TTCCGCTGGTGCAGTGGGCCGCCTGGGCGCAGTTGTGGCAGGTGCTGCGGCCGGGCTGCCGCATCTTCCTCACCGCCCCG
CCCTTCGACCACACGAAGCTGATGGTGGTGGACGGCGTGTGGTCGCTCATCGGCTCGGCCAACTGGGACCCGCGCTCGCT
GCGGCTCAACTTCGAGTTCAACGTGGAGTGCTACGACACCGCGCTGGCCATGCAGTTGGAGGGCGTGGTGGCCGCGCGGC
TGCGCAACGCGCGGCCCCTCACGTTGGAGCAGGTGGACGCGCGCGCCCTGCCCATCCGCCTGCGGGATGGGCTGGCGCGG
CTGCTGTCGCCGTACCTCTAG

Upstream 100 bases:

>100_bases
ATGACGGCCGTGGGGGTTGATTCCCGACGCCCAGGGGCGCTGAGGACTGCGCGCTCCATGCGGGCGTGATAGGCGGAACA
GGAGGACCCCGCCGTTCGCT

Downstream 100 bases:

>100_bases
AGCAGAGCGCGCCGGACCCGCCAGAAGGTCTCCTTGGCGGCACGGTAGCCCCGCGAGTCCTGGGGCAGCAGCATGCGCAG
CAGCTCCGCGGACTGCGTCT

Product: putative cardiolipin synthase

Products: NA

Alternate protein names: CL synthase 2 [H]

Number of amino acids: Translated: 486; Mature: 486

Protein sequence:

>486_residues
MHLFDIPAWLEVAWPHVVAALTVLISVVASAHAVLHKRDVRAAVGWVGLAWLVPVLGGVLYVLLGINRIRRRARSLMLKQ
EHGRFPPLFQVAPMKAETVSGPHPEAAPLAPLVRLGDAVVGRPLLPGNRFTVLESRRDAYPAMLEAIDAARTTLSLCSYI
FDNDMAGRRFVEALSAAVKRGVEVRVLVDAVGSRYTWPPILGRLRRAGVRAARFLPSLMPYRLPFANLRNHRKLMVVDGR
VGFTGGMNIRKAFWPGEHAAVDLHFRVEGPLVGQLQETFAEDWAFTTRERLTGEAWFPPLTEVGTVLARGIADGPDEDFE
TLRTVLLGALATARTSVRIVTPYFLPDTALITALSVAALRGVQVDILLPEKGNLPLVQWAAWAQLWQVLRPGCRIFLTAP
PFDHTKLMVVDGVWSLIGSANWDPRSLRLNFEFNVECYDTALAMQLEGVVAARLRNARPLTLEQVDARALPIRLRDGLAR
LLSPYL

Sequences:

>Translated_486_residues
MHLFDIPAWLEVAWPHVVAALTVLISVVASAHAVLHKRDVRAAVGWVGLAWLVPVLGGVLYVLLGINRIRRRARSLMLKQ
EHGRFPPLFQVAPMKAETVSGPHPEAAPLAPLVRLGDAVVGRPLLPGNRFTVLESRRDAYPAMLEAIDAARTTLSLCSYI
FDNDMAGRRFVEALSAAVKRGVEVRVLVDAVGSRYTWPPILGRLRRAGVRAARFLPSLMPYRLPFANLRNHRKLMVVDGR
VGFTGGMNIRKAFWPGEHAAVDLHFRVEGPLVGQLQETFAEDWAFTTRERLTGEAWFPPLTEVGTVLARGIADGPDEDFE
TLRTVLLGALATARTSVRIVTPYFLPDTALITALSVAALRGVQVDILLPEKGNLPLVQWAAWAQLWQVLRPGCRIFLTAP
PFDHTKLMVVDGVWSLIGSANWDPRSLRLNFEFNVECYDTALAMQLEGVVAARLRNARPLTLEQVDARALPIRLRDGLAR
LLSPYL
>Mature_486_residues
MHLFDIPAWLEVAWPHVVAALTVLISVVASAHAVLHKRDVRAAVGWVGLAWLVPVLGGVLYVLLGINRIRRRARSLMLKQ
EHGRFPPLFQVAPMKAETVSGPHPEAAPLAPLVRLGDAVVGRPLLPGNRFTVLESRRDAYPAMLEAIDAARTTLSLCSYI
FDNDMAGRRFVEALSAAVKRGVEVRVLVDAVGSRYTWPPILGRLRRAGVRAARFLPSLMPYRLPFANLRNHRKLMVVDGR
VGFTGGMNIRKAFWPGEHAAVDLHFRVEGPLVGQLQETFAEDWAFTTRERLTGEAWFPPLTEVGTVLARGIADGPDEDFE
TLRTVLLGALATARTSVRIVTPYFLPDTALITALSVAALRGVQVDILLPEKGNLPLVQWAAWAQLWQVLRPGCRIFLTAP
PFDHTKLMVVDGVWSLIGSANWDPRSLRLNFEFNVECYDTALAMQLEGVVAARLRNARPLTLEQVDARALPIRLRDGLAR
LLSPYL

Specific function: Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol [H]

COG id: COG1502

COG function: function code I; Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PLD phosphodiesterase domains [H]

Homologues:

Organism=Escherichia coli, GI1787502, Length=467, Percent_Identity=28.9079229122056, Blast_Score=180, Evalue=2e-46,
Organism=Escherichia coli, GI1787007, Length=365, Percent_Identity=30.4109589041096, Blast_Score=125, Evalue=6e-30,
Organism=Escherichia coli, GI87081826, Length=397, Percent_Identity=26.448362720403, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022924
- InterPro:   IPR001736 [H]

Pfam domain/function: PF00614 PLDc [H]

EC number: 2.7.8.-

Molecular weight: Translated: 53816; Mature: 53816

Theoretical pI: Translated: 10.41; Mature: 10.41

Prosite motif: PS50035 PLD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHLFDIPAWLEVAWPHVVAALTVLISVVASAHAVLHKRDVRAAVGWVGLAWLVPVLGGVL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YVLLGINRIRRRARSLMLKQEHGRFPPLFQVAPMKAETVSGPHPEAAPLAPLVRLGDAVV
HHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCHHCCCCCCCCCCHHHHHHHHCHHHH
GRPLLPGNRFTVLESRRDAYPAMLEAIDAARTTLSLCSYIFDNDMAGRRFVEALSAAVKR
CCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHC
GVEVRVLVDAVGSRYTWPPILGRLRRAGVRAARFLPSLMPYRLPFANLRNHRKLMVVDGR
CCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCEEEEEECC
VGFTGGMNIRKAFWPGEHAAVDLHFRVEGPLVGQLQETFAEDWAFTTRERLTGEAWFPPL
CCCCCCCCCEEEECCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
TEVGTVLARGIADGPDEDFETLRTVLLGALATARTSVRIVTPYFLPDTALITALSVAALR
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEEEEECCHHHHHHHHHHHHHC
GVQVDILLPEKGNLPLVQWAAWAQLWQVLRPGCRIFLTAPPFDHTKLMVVDGVWSLIGSA
CCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEHHHHHHHCCC
NWDPRSLRLNFEFNVECYDTALAMQLEGVVAARLRNARPLTLEQVDARALPIRLRDGLAR
CCCCCEEEEEEEEEEEEHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCHHHHHHHHH
LLSPYL
HHCCCC
>Mature Secondary Structure
MHLFDIPAWLEVAWPHVVAALTVLISVVASAHAVLHKRDVRAAVGWVGLAWLVPVLGGVL
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YVLLGINRIRRRARSLMLKQEHGRFPPLFQVAPMKAETVSGPHPEAAPLAPLVRLGDAVV
HHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCHHCCCCCCCCCCHHHHHHHHCHHHH
GRPLLPGNRFTVLESRRDAYPAMLEAIDAARTTLSLCSYIFDNDMAGRRFVEALSAAVKR
CCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHC
GVEVRVLVDAVGSRYTWPPILGRLRRAGVRAARFLPSLMPYRLPFANLRNHRKLMVVDGR
CCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCEEEEEECC
VGFTGGMNIRKAFWPGEHAAVDLHFRVEGPLVGQLQETFAEDWAFTTRERLTGEAWFPPL
CCCCCCCCCEEEECCCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCH
TEVGTVLARGIADGPDEDFETLRTVLLGALATARTSVRIVTPYFLPDTALITALSVAALR
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCEEEEEEEEECCHHHHHHHHHHHHHC
GVQVDILLPEKGNLPLVQWAAWAQLWQVLRPGCRIFLTAPPFDHTKLMVVDGVWSLIGSA
CCEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEHHHHHHHCCC
NWDPRSLRLNFEFNVECYDTALAMQLEGVVAARLRNARPLTLEQVDARALPIRLRDGLAR
CCCCCEEEEEEEEEEEEHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCHHHHHHHHH
LLSPYL
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring phosphorus-containing groups [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA