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The map label for this gene is psaA [H]

Identifier: 108762801

GI number: 108762801

Start: 3459613

End: 3460542

Strand: Reverse

Name: psaA [H]

Synonym: MXAN_2951

Alternate gene names: 108762801

Gene position: 3460542-3459613 (Counterclockwise)

Preceding gene: 108760901

Following gene: 108758944

Centisome position: 37.86

GC content: 68.92

Gene sequence:

>930_bases
ATGACCATGCGTCTCTCCCGTCTGTTCGCGGCCGTGTGCGCCGCCTTCACCCTCTTCGTCGCGTCCCCCGCTCGCGCGGA
CCTCAACGTCGTCACCACCCTGCCGGACCTGGCCGCCTTGACGAAGGCCGTGGGCGGCGACCACGTCAAAGTGCAGGCCC
TGGCGCTGTCCAGCCAGGACCCGCACTTCGTGGATGCCAAGCCGAACCTCGCCCTGGCGCTCAACCGCGCGGACCTGCTC
ATCGCGGTGGGCCTGGACCTGGAGATCGGCTGGCTGCCCACGCTTCAGGTGGGCGCGCGCAACCCGAAAATCCTCGTGGG
CAACCCGGGCTACCTGGTGGCCTCGCAGTTCGTGAAGCTGCTGGAGGTCCCCACCGCGCAGGTGGACCGGGGCCAGGGCG
ACGTCCACCCGGGCGGCAACCCGCACTTCCTCTATGACCCGCGCCAGGCGCTGTCCGTCGCGCGAGCCATCACCGACCGG
CTGGCGCAGTTGGATCCGAAGAACGCGCAGTCCTACCGCGACAACCTCGCCACCTTCACCACCGAGTTGGAGAAGTCGCG
CGCGGACTGGGAGAAGCGGCTGGCGCCGCTGCGTGGCCAGCCCGTCATCGCCTACCACCGGACCATGGCGTACCTGGCGG
ACTGGCTGGGCTTCGACACCATCACCTACCTGGAGCCCAAGCCCGGCATCCCGCCCAACCCGTCGCACGTCGCGAGCGTC
CTGGCCCAGGGCCGTCAGCGAAAGGCGCGCATGGTGCTGATGGAGAGCTACTACCCGGACACCACCGCGCGGTTGGTGGC
CTCGAAGATTCCCGCGCCGCTCGTCACCCTGCACGGCGGCACGGACTTCAAGGCGAAGGAGACGTACCTCCAGCACATCA
ACGAAATGGTCGAGCGCCTGGAGAAGGGGCTCGCCGGAAAGGGGACCTGA

Upstream 100 bases:

>100_bases
CGGGTGGCGGGATGAGCCCGGCTACTCCCTGATGCTCGCGCTCGAGCTGGTGACCGGCGCCCACGGCGCCCACGCTTTCT
AAACCCCTTTCGAAGGAGCC

Downstream 100 bases:

>100_bases
GCCATGCGGACCCGTCTCCTCCTTCCCCTTCTCTTCATATCCGGCTGCGCGCTGGAGCCCGGTGAGAGCTTCGCGGTGCT
GGAGCCCGCCGTCCGCGCGG

Product: ABC transporter periplasmic substrate binding protein

Products: Zn (II) [Cytoplasm]; ADP; phosphate [C]

Alternate protein names: Pneumococcal surface adhesin A [H]

Number of amino acids: Translated: 309; Mature: 308

Protein sequence:

>309_residues
MTMRLSRLFAAVCAAFTLFVASPARADLNVVTTLPDLAALTKAVGGDHVKVQALALSSQDPHFVDAKPNLALALNRADLL
IAVGLDLEIGWLPTLQVGARNPKILVGNPGYLVASQFVKLLEVPTAQVDRGQGDVHPGGNPHFLYDPRQALSVARAITDR
LAQLDPKNAQSYRDNLATFTTELEKSRADWEKRLAPLRGQPVIAYHRTMAYLADWLGFDTITYLEPKPGIPPNPSHVASV
LAQGRQRKARMVLMESYYPDTTARLVASKIPAPLVTLHGGTDFKAKETYLQHINEMVERLEKGLAGKGT

Sequences:

>Translated_309_residues
MTMRLSRLFAAVCAAFTLFVASPARADLNVVTTLPDLAALTKAVGGDHVKVQALALSSQDPHFVDAKPNLALALNRADLL
IAVGLDLEIGWLPTLQVGARNPKILVGNPGYLVASQFVKLLEVPTAQVDRGQGDVHPGGNPHFLYDPRQALSVARAITDR
LAQLDPKNAQSYRDNLATFTTELEKSRADWEKRLAPLRGQPVIAYHRTMAYLADWLGFDTITYLEPKPGIPPNPSHVASV
LAQGRQRKARMVLMESYYPDTTARLVASKIPAPLVTLHGGTDFKAKETYLQHINEMVERLEKGLAGKGT
>Mature_308_residues
TMRLSRLFAAVCAAFTLFVASPARADLNVVTTLPDLAALTKAVGGDHVKVQALALSSQDPHFVDAKPNLALALNRADLLI
AVGLDLEIGWLPTLQVGARNPKILVGNPGYLVASQFVKLLEVPTAQVDRGQGDVHPGGNPHFLYDPRQALSVARAITDRL
AQLDPKNAQSYRDNLATFTTELEKSRADWEKRLAPLRGQPVIAYHRTMAYLADWLGFDTITYLEPKPGIPPNPSHVASVL
AQGRQRKARMVLMESYYPDTTARLVASKIPAPLVTLHGGTDFKAKETYLQHINEMVERLEKGLAGKGT

Specific function: Part of an ATP-driven transport system for manganese. Also act as an adhesin which is involved on adherence to extracellular matrix. It is an important factor in pathogenesis and infection [H]

COG id: COG0803

COG function: function code P; ABC-type metal ion transport system, periplasmic component/surface adhesin

Gene ontology:

Cell location: Cell membrane; Lipid-anchor [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial solute-binding protein 9 family. Lipoprotein receptor antigen (Lrai) subfamily [H]

Homologues:

Organism=Escherichia coli, GI87081990, Length=290, Percent_Identity=22.4137931034483, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006127
- InterPro:   IPR006129
- InterPro:   IPR006128 [H]

Pfam domain/function: PF01297 SBP_bac_9 [H]

EC number: NA

Molecular weight: Translated: 33700; Mature: 33569

Theoretical pI: Translated: 9.62; Mature: 9.62

Prosite motif: PS00172 XYLOSE_ISOMERASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMRLSRLFAAVCAAFTLFVASPARADLNVVTTLPDLAALTKAVGGDHVKVQALALSSQD
CCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHCCCCEEEEEEEECCCC
PHFVDAKPNLALALNRADLLIAVGLDLEIGWLPTLQVGARNPKILVGNPGYLVASQFVKL
CCEEECCCCEEEEECCCCEEEEECCCEEECCCCCEEECCCCCEEEECCCCHHHHHHHHHH
LEVPTAQVDRGQGDVHPGGNPHFLYDPRQALSVARAITDRLAQLDPKNAQSYRDNLATFT
HHCCCHHHCCCCCCCCCCCCCCEEECHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
TELEKSRADWEKRLAPLRGQPVIAYHRTMAYLADWLGFDTITYLEPKPGIPPNPSHVASV
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHH
LAQGRQRKARMVLMESYYPDTTARLVASKIPAPLVTLHGGTDFKAKETYLQHINEMVERL
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHH
EKGLAGKGT
HHCCCCCCC
>Mature Secondary Structure 
TMRLSRLFAAVCAAFTLFVASPARADLNVVTTLPDLAALTKAVGGDHVKVQALALSSQD
CCHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHCCCCEEEEEEEECCCC
PHFVDAKPNLALALNRADLLIAVGLDLEIGWLPTLQVGARNPKILVGNPGYLVASQFVKL
CCEEECCCCEEEEECCCCEEEEECCCEEECCCCCEEECCCCCEEEECCCCHHHHHHHHHH
LEVPTAQVDRGQGDVHPGGNPHFLYDPRQALSVARAITDRLAQLDPKNAQSYRDNLATFT
HHCCCHHHCCCCCCCCCCCCCCEEECHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
TELEKSRADWEKRLAPLRGQPVIAYHRTMAYLADWLGFDTITYLEPKPGIPPNPSHVASV
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHH
LAQGRQRKARMVLMESYYPDTTARLVASKIPAPLVTLHGGTDFKAKETYLQHINEMVERL
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHH
EKGLAGKGT
HHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Zn (II) [Periplasm]; H2O; ATP [C]

Specific reaction: Zn (II) [Periplasm] + H2O + ATP = Zn (II) [Cytoplasm] + ADP + phosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7505262 [H]