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The map label for this gene is apt

Identifier: 108762776

GI number: 108762776

Start: 6666289

End: 6666843

Strand: Direct

Name: apt

Synonym: MXAN_5352

Alternate gene names: 108762776

Gene position: 6666289-6666843 (Clockwise)

Preceding gene: 108758686

Following gene: 108762228

Centisome position: 72.94

GC content: 70.81

Gene sequence:

>555_bases
ATGCACCCGCCCGTCCCGAGCCTGACCGACACCACCCTCGTCGCCGACCTGAATGCCCGGCTCCGGGACGTACCGGACTT
CCCCAAGCCCGGCATCGTCTTCAAGGACATCACCCCCGTGCTGGCGGACCCGCGCCTGTTCGGCCGCGTCATCGACGCCA
TGTCGGCGCCCTTCCGGGGCCAGCACGTCACGAAGGTGGTGGGCGTGGAGGCCCGAGGCTTCCTGCTGGGCGCCCCCATC
GCGCTGGCGCTCAACGCGGGCTTCGTGCCGGCGCGCAAGCCTGGGAAGCTGCCTCACCGCTCGGTGGTGGAGCGCTACTC
GCTGGAGTACGGCTCTGACGGCGTGGAGATGCACGAGGACGCCATCCTCCAGGGGGAGCGGGTGCTCGTCGTGGATGACG
TGCTGGCCACGGGAGGCACGGCGGAGGCCACCGCGAGGCTCGTGTCCCGGCTCGGCGGCGAGTTGGTGGGCTTCTGCTTC
CTCCTCAGCCTGGACTTCCTCGAAGGCCCCAACCGCCTCGGGCGCGAGCGCGTGACGACGCTGCTGACCTTCTGA

Upstream 100 bases:

>100_bases
TCGCCATGGCGACAGGGCGGGCGGCCGTCCGAGCCTTCCGTCCCCCGGTCCTCCCCTTCCCCGCCCCACCGTTTTTCATC
CTCCCGCTGGAGCGCACGCC

Downstream 100 bases:

>100_bases
TTGGCGCGTGCCGACCGCGAAGCGCTCCGGCCTCTCCCACCGGAGCGCGATGCCACGCCCGGACGACGGCACGCCCACGG
GGATGAGCGGCGAGCAACCT

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 184; Mature: 184

Protein sequence:

>184_residues
MHPPVPSLTDTTLVADLNARLRDVPDFPKPGIVFKDITPVLADPRLFGRVIDAMSAPFRGQHVTKVVGVEARGFLLGAPI
ALALNAGFVPARKPGKLPHRSVVERYSLEYGSDGVEMHEDAILQGERVLVVDDVLATGGTAEATARLVSRLGGELVGFCF
LLSLDFLEGPNRLGRERVTTLLTF

Sequences:

>Translated_184_residues
MHPPVPSLTDTTLVADLNARLRDVPDFPKPGIVFKDITPVLADPRLFGRVIDAMSAPFRGQHVTKVVGVEARGFLLGAPI
ALALNAGFVPARKPGKLPHRSVVERYSLEYGSDGVEMHEDAILQGERVLVVDDVLATGGTAEATARLVSRLGGELVGFCF
LLSLDFLEGPNRLGRERVTTLLTF
>Mature_184_residues
MHPPVPSLTDTTLVADLNARLRDVPDFPKPGIVFKDITPVLADPRLFGRVIDAMSAPFRGQHVTKVVGVEARGFLLGAPI
ALALNAGFVPARKPGKLPHRSVVERYSLEYGSDGVEMHEDAILQGERVLVVDDVLATGGTAEATARLVSRLGGELVGFCF
LLSLDFLEGPNRLGRERVTTLLTF

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=171, Percent_Identity=40.9356725146199, Blast_Score=126, Evalue=1e-29,
Organism=Homo sapiens, GI71773201, Length=125, Percent_Identity=44.8, Blast_Score=107, Evalue=4e-24,
Organism=Escherichia coli, GI1786675, Length=164, Percent_Identity=51.219512195122, Blast_Score=178, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17509087, Length=170, Percent_Identity=41.1764705882353, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6323619, Length=178, Percent_Identity=40.4494382022472, Blast_Score=125, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6320649, Length=166, Percent_Identity=35.5421686746988, Blast_Score=92, Evalue=7e-20,
Organism=Drosophila melanogaster, GI17136334, Length=181, Percent_Identity=36.4640883977901, Blast_Score=108, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_MYXXD (Q1D1H1)

Other databases:

- EMBL:   CP000113
- RefSeq:   YP_633502.1
- ProteinModelPortal:   Q1D1H1
- SMR:   Q1D1H1
- STRING:   Q1D1H1
- GeneID:   4106529
- GenomeReviews:   CP000113_GR
- KEGG:   mxa:MXAN_5352
- TIGR:   MXAN_5352
- eggNOG:   COG0503
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- PhylomeDB:   Q1D1H1
- ProtClustDB:   PRK02304
- BioCyc:   MXAN246197:MXAN_5352-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 19838; Mature: 19838

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHPPVPSLTDTTLVADLNARLRDVPDFPKPGIVFKDITPVLADPRLFGRVIDAMSAPFRG
CCCCCCCCCCCCCEECCCHHHHCCCCCCCCCEECCCCCHHHCCHHHHHHHHHHHCCCCCC
QHVTKVVGVEARGFLLGAPIALALNAGFVPARKPGKLPHRSVVERYSLEYGSDGVEMHED
CCHHHHCCCCCCCEEECCCHHEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHH
AILQGERVLVVDDVLATGGTAEATARLVSRLGGELVGFCFLLSLDFLEGPNRLGRERVTT
HHHCCCEEEEEECHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
LLTF
HHCC
>Mature Secondary Structure
MHPPVPSLTDTTLVADLNARLRDVPDFPKPGIVFKDITPVLADPRLFGRVIDAMSAPFRG
CCCCCCCCCCCCCEECCCHHHHCCCCCCCCCEECCCCCHHHCCHHHHHHHHHHHCCCCCC
QHVTKVVGVEARGFLLGAPIALALNAGFVPARKPGKLPHRSVVERYSLEYGSDGVEMHED
CCHHHHCCCCCCCEEECCCHHEEECCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHH
AILQGERVLVVDDVLATGGTAEATARLVSRLGGELVGFCFLLSLDFLEGPNRLGRERVTT
HHHCCCEEEEEECHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
LLTF
HHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA