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The map label for this gene is cysK [H]

Identifier: 108762761

GI number: 108762761

Start: 1845524

End: 1846444

Strand: Reverse

Name: cysK [H]

Synonym: MXAN_1571

Alternate gene names: 108762761

Gene position: 1846444-1845524 (Counterclockwise)

Preceding gene: 108757081

Following gene: 108761768

Centisome position: 20.2

GC content: 66.67

Gene sequence:

>921_bases
ATGAAGGTGAACAACATCCTGGAGACCATCGGAAACACGCCGCACGTGCGCATCAACCGGCTGTTTCCGTCCCGCGTGAC
GGTCCATATGAAGCTCGAGCGCGCCAACCCGGGCGGCAGCATCAAGGACCGCATCGCGTTGTCCATGATTGAGGACGCGG
AGCAGCGCGGCCTGCTCAAGAAGGACAGCGTCATCATCGAGCCGACCAGCGGCAACACCGGCATCGGCCTGGCCATGGTG
GCGGCGGTGAAGGGCTACAAGCTGGTGCTCGTCATGCCGGAGTCCATGAGCGTCGAGCGCCGCCGGCTGATGGCCGCCTA
CGGCGCCACCTTCGAGCTGACCCCGCGCGCGCAGGGCATGAAGGGCGCCATCGCTCGCGCCAATGAACTGCTGTCGCAGG
TGCCCAACTCGTGGATGCCGCAGCAGTTCGAGAACGAGGCCAACATCGAGGTCCACCGCCGCACGACGGTGCAGGAAATC
CTCAAGGACTTCCCGGAAGGGCTGGACTACCTCATCACCGGCGTGGGCACCGGCGGGCACATCACCGCGTGCGCCGAGGA
GCTGAAGAAGGTCTGGCCGAAGCTGAAGGTCTTCGCCGTGGAGCCCACCAAGTCGCCCGTCATCAGCGGCGGCCAGCCGG
GCCCGCACCCCATCCAGGGCATTGGCGCCGGCTTCATCCCGAAGAACCTGCACAAGGACGCGCTGGACGGCGCCATTCAG
GTGACCGAGGAGGACGCCTTCGAGTTCACCCGCCGCGCCGCGCGTGAGGAGGGCATCTTCGTGGGCATCTCCACCGGCGC
CGCGCTGTCCGCCGTGAATCAGAAGCTGGGCGAGATGACCGACGGCAGCCGCGTGCTCGCCTTCAACTACGACACGGGCG
AGCGCTACCTCTCCATCGAGCCGCTCTTCCCGGCCCAGTAG

Upstream 100 bases:

>100_bases
ATCCGTGGTTACCCGCCGCAGCGAGGTGCGTCAGCGCGGCGAGAATGGCTCGCTGGACGCACTCGAATTCCACATCTGAC
CCACCGACGAGGCCCCCGAC

Downstream 100 bases:

>100_bases
TCCCGGGGCCCTCAGCCGCGGTGCGTCCGCACCAGCTCCACCAACCGGTCCATCTCCTCGGGCAGGTTGTAGAAGTGGGG
TGAGAGGCGGACGCGCCCGC

Product: cysteine synthase A

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MKVNNILETIGNTPHVRINRLFPSRVTVHMKLERANPGGSIKDRIALSMIEDAEQRGLLKKDSVIIEPTSGNTGIGLAMV
AAVKGYKLVLVMPESMSVERRRLMAAYGATFELTPRAQGMKGAIARANELLSQVPNSWMPQQFENEANIEVHRRTTVQEI
LKDFPEGLDYLITGVGTGGHITACAEELKKVWPKLKVFAVEPTKSPVISGGQPGPHPIQGIGAGFIPKNLHKDALDGAIQ
VTEEDAFEFTRRAAREEGIFVGISTGAALSAVNQKLGEMTDGSRVLAFNYDTGERYLSIEPLFPAQ

Sequences:

>Translated_306_residues
MKVNNILETIGNTPHVRINRLFPSRVTVHMKLERANPGGSIKDRIALSMIEDAEQRGLLKKDSVIIEPTSGNTGIGLAMV
AAVKGYKLVLVMPESMSVERRRLMAAYGATFELTPRAQGMKGAIARANELLSQVPNSWMPQQFENEANIEVHRRTTVQEI
LKDFPEGLDYLITGVGTGGHITACAEELKKVWPKLKVFAVEPTKSPVISGGQPGPHPIQGIGAGFIPKNLHKDALDGAIQ
VTEEDAFEFTRRAAREEGIFVGISTGAALSAVNQKLGEMTDGSRVLAFNYDTGERYLSIEPLFPAQ
>Mature_306_residues
MKVNNILETIGNTPHVRINRLFPSRVTVHMKLERANPGGSIKDRIALSMIEDAEQRGLLKKDSVIIEPTSGNTGIGLAMV
AAVKGYKLVLVMPESMSVERRRLMAAYGATFELTPRAQGMKGAIARANELLSQVPNSWMPQQFENEANIEVHRRTTVQEI
LKDFPEGLDYLITGVGTGGHITACAEELKKVWPKLKVFAVEPTKSPVISGGQPGPHPIQGIGAGFIPKNLHKDALDGAIQ
VTEEDAFEFTRRAAREEGIFVGISTGAALSAVNQKLGEMTDGSRVLAFNYDTGERYLSIEPLFPAQ

Specific function: Cysteine biosynthesis. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=305, Percent_Identity=38.3606557377049, Blast_Score=203, Evalue=1e-52,
Organism=Homo sapiens, GI295821200, Length=305, Percent_Identity=38.3606557377049, Blast_Score=203, Evalue=1e-52,
Organism=Homo sapiens, GI4557415, Length=305, Percent_Identity=38.3606557377049, Blast_Score=203, Evalue=1e-52,
Organism=Escherichia coli, GI1788754, Length=300, Percent_Identity=48, Blast_Score=231, Evalue=5e-62,
Organism=Escherichia coli, GI2367138, Length=297, Percent_Identity=36.7003367003367, Blast_Score=177, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17535051, Length=294, Percent_Identity=42.5170068027211, Blast_Score=221, Evalue=5e-58,
Organism=Caenorhabditis elegans, GI115535073, Length=305, Percent_Identity=44.5901639344262, Blast_Score=208, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI17562970, Length=298, Percent_Identity=38.9261744966443, Blast_Score=207, Evalue=7e-54,
Organism=Caenorhabditis elegans, GI32566674, Length=295, Percent_Identity=39.3220338983051, Blast_Score=206, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI17561720, Length=305, Percent_Identity=39.0163934426229, Blast_Score=184, Evalue=6e-47,
Organism=Caenorhabditis elegans, GI17534315, Length=282, Percent_Identity=36.1702127659575, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI32566672, Length=210, Percent_Identity=36.1904761904762, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI25147552, Length=280, Percent_Identity=34.2857142857143, Blast_Score=138, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17561716, Length=105, Percent_Identity=40, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6321594, Length=315, Percent_Identity=33.3333333333333, Blast_Score=167, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6321449, Length=322, Percent_Identity=33.2298136645963, Blast_Score=115, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24643623, Length=305, Percent_Identity=35.7377049180328, Blast_Score=171, Evalue=8e-43,
Organism=Drosophila melanogaster, GI20129101, Length=305, Percent_Identity=35.7377049180328, Blast_Score=171, Evalue=8e-43,

Paralogues:

None

Copy number: 2820 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 33344; Mature: 33344

Theoretical pI: Translated: 7.76; Mature: 7.76

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVNNILETIGNTPHVRINRLFPSRVTVHMKLERANPGGSIKDRIALSMIEDAEQRGLLK
CCHHHHHHHHCCCCCEEEEEECCCEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCC
KDSVIIEPTSGNTGIGLAMVAAVKGYKLVLVMPESMSVERRRLMAAYGATFELTPRAQGM
CCCEEEEECCCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHCCEEEECCCCCCC
KGAIARANELLSQVPNSWMPQQFENEANIEVHRRTTVQEILKDFPEGLDYLITGVGTGGH
HHHHHHHHHHHHHCCCCCCCHHHCCCCCEEEEHHHHHHHHHHHHHCCCEEEEEECCCCCH
ITACAEELKKVWPKLKVFAVEPTKSPVISGGQPGPHPIQGIGAGFIPKNLHKDALDGAIQ
HHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCEEE
VTEEDAFEFTRRAAREEGIFVGISTGAALSAVNQKLGEMTDGSRVLAFNYDTGERYLSIE
ECHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEC
PLFPAQ
CCCCCC
>Mature Secondary Structure
MKVNNILETIGNTPHVRINRLFPSRVTVHMKLERANPGGSIKDRIALSMIEDAEQRGLLK
CCHHHHHHHHCCCCCEEEEEECCCEEEEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCC
KDSVIIEPTSGNTGIGLAMVAAVKGYKLVLVMPESMSVERRRLMAAYGATFELTPRAQGM
CCCEEEEECCCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHCCEEEECCCCCCC
KGAIARANELLSQVPNSWMPQQFENEANIEVHRRTTVQEILKDFPEGLDYLITGVGTGGH
HHHHHHHHHHHHHCCCCCCCHHHCCCCCEEEEHHHHHHHHHHHHHCCCEEEEEECCCCCH
ITACAEELKKVWPKLKVFAVEPTKSPVISGGQPGPHPIQGIGAGFIPKNLHKDALDGAIQ
HHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCEEE
VTEEDAFEFTRRAAREEGIFVGISTGAALSAVNQKLGEMTDGSRVLAFNYDTGERYLSIE
ECHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEC
PLFPAQ
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8867384 [H]