Click here to switch to the map view.

The map label for this gene is iorA [H]

Identifier: 108762686

GI number: 108762686

Start: 2075369

End: 2075848

Strand: Reverse

Name: iorA [H]

Synonym: MXAN_1751

Alternate gene names: 108762686

Gene position: 2075848-2075369 (Counterclockwise)

Preceding gene: 108758140

Following gene: 108760586

Centisome position: 22.71

GC content: 70.0

Gene sequence:

>480_bases
ATGGCGGCACATCAGTTCATCCTCAATGGCCAGACGGTGTTGGTGGAGGCGCCCGAGGACCTGTCGCTGCTGTGGGTGCT
GCGCGACGTGCTGGGCGTGACGGGCCCGAAGTACGGCTGCGGCGTGGGCGTGTGCGGCGCGTGCACCAGCCACCTGGACG
GCGAGGCCTTCCGCCCCTGCATCCACCCGGTGGGTGGGCTGTCTGGCCGCGAGGTGGTCACCATCGAGGGGCTGGGCGCC
CAGGGACTGCATCCCGTGCAACAGGCGTGGATGGAGGAAGATGTGGCCCAGTGCGGCTTCTGCCAGCCGGGGCAGATCAT
GGCCGCCGTGGCGCTGCTCAAGAAGAACGCCCAGCCCTCTGACGCGGACATCGACGCGGCGATGAGCGACAACGTCTGCC
GCTGTGGAACCTATGTCCGCATCCGCGCCGCCATCAAGCGCGCCGCCCTGCTGCTGCGAAGCGGCGCGGGCGGCGGGTGA

Upstream 100 bases:

>100_bases
TCGGCTATCCCAGCGCAGCGGCGGCCCTGACCAACGCCATCGCCCGGGCGCGAGGCTCGATGCCCACCCGCTTTCCCATC
CTCGACGAGGGAGTCTGAGC

Downstream 100 bases:

>100_bases
TACCGAGGAGGCCAGGGCGCCCGCTACGTCGAGACGCTCCATGAAAATCGGGTTCCATTGCGACACCACCCGGGATGCAC
TCAGGTGACGCCATCCTCGA

Product: isoquinoline 1-oxidoreductase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 159; Mature: 158

Protein sequence:

>159_residues
MAAHQFILNGQTVLVEAPEDLSLLWVLRDVLGVTGPKYGCGVGVCGACTSHLDGEAFRPCIHPVGGLSGREVVTIEGLGA
QGLHPVQQAWMEEDVAQCGFCQPGQIMAAVALLKKNAQPSDADIDAAMSDNVCRCGTYVRIRAAIKRAALLLRSGAGGG

Sequences:

>Translated_159_residues
MAAHQFILNGQTVLVEAPEDLSLLWVLRDVLGVTGPKYGCGVGVCGACTSHLDGEAFRPCIHPVGGLSGREVVTIEGLGA
QGLHPVQQAWMEEDVAQCGFCQPGQIMAAVALLKKNAQPSDADIDAAMSDNVCRCGTYVRIRAAIKRAALLLRSGAGGG
>Mature_158_residues
AAHQFILNGQTVLVEAPEDLSLLWVLRDVLGVTGPKYGCGVGVCGACTSHLDGEAFRPCIHPVGGLSGREVVTIEGLGAQ
GLHPVQQAWMEEDVAQCGFCQPGQIMAAVALLKKNAQPSDADIDAAMSDNVCRCGTYVRIRAAIKRAALLLRSGAGGG

Specific function: Specific towards N-containing N-heterocyclic substrates, including isoquinoline, isoquinolin-5-ol, phthalazine and quinazoline [H]

COG id: COG2080

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 2Fe-2S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=146, Percent_Identity=36.986301369863, Blast_Score=74, Evalue=8e-14,
Organism=Homo sapiens, GI71773480, Length=89, Percent_Identity=37.0786516853933, Blast_Score=68, Evalue=3e-12,
Organism=Escherichia coli, GI1786480, Length=163, Percent_Identity=39.2638036809816, Blast_Score=104, Evalue=2e-24,
Organism=Escherichia coli, GI1789232, Length=137, Percent_Identity=37.956204379562, Blast_Score=82, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17540638, Length=151, Percent_Identity=41.0596026490066, Blast_Score=108, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI17539860, Length=152, Percent_Identity=36.1842105263158, Blast_Score=99, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI32566215, Length=152, Percent_Identity=36.1842105263158, Blast_Score=96, Evalue=9e-21,
Organism=Drosophila melanogaster, GI17737937, Length=154, Percent_Identity=39.6103896103896, Blast_Score=100, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24647201, Length=155, Percent_Identity=31.6129032258064, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24647199, Length=156, Percent_Identity=32.6923076923077, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24647195, Length=162, Percent_Identity=33.3333333333333, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24647197, Length=162, Percent_Identity=33.3333333333333, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24647193, Length=146, Percent_Identity=34.2465753424658, Blast_Score=78, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002888
- InterPro:   IPR006058
- InterPro:   IPR012675
- InterPro:   IPR001041 [H]

Pfam domain/function: PF00111 Fer2; PF01799 Fer2_2 [H]

EC number: =1.3.99.16 [H]

Molecular weight: Translated: 16556; Mature: 16425

Theoretical pI: Translated: 6.08; Mature: 6.08

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
7.5 %Cys+Met (Translated Protein)
5.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAHQFILNGQTVLVEAPEDLSLLWVLRDVLGVTGPKYGCGVGVCGACTSHLDGEAFRPC
CCCCCEEECCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCHHHHHH
IHPVGGLSGREVVTIEGLGAQGLHPVQQAWMEEDVAQCGFCQPGQIMAAVALLKKNAQPS
HHHCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCC
DADIDAAMSDNVCRCGTYVRIRAAIKRAALLLRSGAGGG
CCCCCHHHCCCCHHCCCHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
AAHQFILNGQTVLVEAPEDLSLLWVLRDVLGVTGPKYGCGVGVCGACTSHLDGEAFRPC
CCCCEEECCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCHHHHHH
IHPVGGLSGREVVTIEGLGAQGLHPVQQAWMEEDVAQCGFCQPGQIMAAVALLKKNAQPS
HHHCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCC
DADIDAAMSDNVCRCGTYVRIRAAIKRAALLLRSGAGGG
CCCCCHHHCCCCHHCCCHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7782304; 8157655 [H]