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The map label for this gene is cobB2 [H]

Identifier: 108762625

GI number: 108762625

Start: 2709304

End: 2710167

Strand: Direct

Name: cobB2 [H]

Synonym: MXAN_2331

Alternate gene names: 108762625

Gene position: 2709304-2710167 (Clockwise)

Preceding gene: 108759775

Following gene: 108763816

Centisome position: 29.64

GC content: 72.11

Gene sequence:

>864_bases
ATGACTGCCCCGCACGATGCCCTGCCTGTCCCCAGCCTCGCTCCGAGCATGGAGGCGCTGGTCTCATTGCTCACGCGCCG
CAGCACGGTGGTGCTCACCGGGGCGGGGTGCAGCACCGAGTCAGGCATCCCCGACTATCGGGGGCCCGGGACGCGGGCGC
GGGCGCGCAACCCCATTCAGCATCGCGAGTTCCTCACGCGCCCCGAGGTCCGGGCGCGCTACTGGGCGCGGAGCCTGATG
GGCTGGCCGCGCTTCTCCTCGGCCCGGCCCAACGCTGCGCACGCGGCGCTGGCGGAGCTGGAGCAGGCGGGCCACGTCCG
AGGCCTCATCACCCAGAACGTGGACGGGCTGCACCATGCCGCTGGCAGCTCGCGGGTGATTGAGCTGCATGGCGCGCTGG
CCCAGGTCCGGTGCCTGGCGTGCGGCGCGCAGGAGGCGCGCGAGGCGTTGCAGGCGCGGCTGCTGTCACTCAACCCTGGC
TTCTCCCTCGAGGTGCTGGAGCTGCGTCCGGACGGTGACGCGGACCTGACCTCCGAGCAGCTGTCGTCCTTCCAGGTCCC
TGCGTGCCTGGTGTGTGGTGGAACGCTCAAGCCGGACGTCGTCTTCTTCGGCGACAACGTGCCGGTTCCCACCGTGGCGT
CGGCGTTCGCCCTGTTGGAGGAGGGCGACGCGCTGCTGGTGGTGGGCTCTTCGCTGGCCATCTTCTCCGGCTACCGCTTC
CTGGTGCGCGCGTCCGAGCGCCGGATGCCCATCGCCATTCTCAACCTGGGGGAGTGCCGGGGCGTGGAGCTCGCGGACGT
GCACCTGGAGGCGCGGGCAGGGGATGCGCTCCCCCGGCTCGCGGCGGCACTGGCCCGGAGCTGA

Upstream 100 bases:

>100_bases
GCCTGCCTGAGTGGGCGGGGGCAGATGTGCGTCCGGGAGGTCCCAGGGGACGGCGGACGTCCGGCGCGGCCAGGGACGCG
CGGTTAATATGTAGGCCGCG

Downstream 100 bases:

>100_bases
AGGGCCGTACGGCAATCACCTCACGTCGTACACCTTGCGGACCGGGCTCCCTCCTCGCTCGATGTCGAGCTCGAGGTGCG
AAGCGCCCCGTAGCAGCATG

Product: Sir2 family protein

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog 2 [H]

Number of amino acids: Translated: 287; Mature: 286

Protein sequence:

>287_residues
MTAPHDALPVPSLAPSMEALVSLLTRRSTVVLTGAGCSTESGIPDYRGPGTRARARNPIQHREFLTRPEVRARYWARSLM
GWPRFSSARPNAAHAALAELEQAGHVRGLITQNVDGLHHAAGSSRVIELHGALAQVRCLACGAQEAREALQARLLSLNPG
FSLEVLELRPDGDADLTSEQLSSFQVPACLVCGGTLKPDVVFFGDNVPVPTVASAFALLEEGDALLVVGSSLAIFSGYRF
LVRASERRMPIAILNLGECRGVELADVHLEARAGDALPRLAAALARS

Sequences:

>Translated_287_residues
MTAPHDALPVPSLAPSMEALVSLLTRRSTVVLTGAGCSTESGIPDYRGPGTRARARNPIQHREFLTRPEVRARYWARSLM
GWPRFSSARPNAAHAALAELEQAGHVRGLITQNVDGLHHAAGSSRVIELHGALAQVRCLACGAQEAREALQARLLSLNPG
FSLEVLELRPDGDADLTSEQLSSFQVPACLVCGGTLKPDVVFFGDNVPVPTVASAFALLEEGDALLVVGSSLAIFSGYRF
LVRASERRMPIAILNLGECRGVELADVHLEARAGDALPRLAAALARS
>Mature_286_residues
TAPHDALPVPSLAPSMEALVSLLTRRSTVVLTGAGCSTESGIPDYRGPGTRARARNPIQHREFLTRPEVRARYWARSLMG
WPRFSSARPNAAHAALAELEQAGHVRGLITQNVDGLHHAAGSSRVIELHGALAQVRCLACGAQEAREALQARLLSLNPGF
SLEVLELRPDGDADLTSEQLSSFQVPACLVCGGTLKPDVVFFGDNVPVPTVASAFALLEEGDALLVVGSSLAIFSGYRFL
VRASERRMPIAILNLGECRGVELADVHLEARAGDALPRLAAALARS

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI6912662, Length=271, Percent_Identity=51.2915129151292, Blast_Score=272, Evalue=3e-73,
Organism=Homo sapiens, GI6912664, Length=271, Percent_Identity=30.2583025830258, Blast_Score=108, Evalue=7e-24,
Organism=Homo sapiens, GI13787215, Length=248, Percent_Identity=31.4516129032258, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI300795542, Length=269, Percent_Identity=28.996282527881, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI300797577, Length=280, Percent_Identity=27.1428571428571, Blast_Score=82, Evalue=6e-16,
Organism=Escherichia coli, GI308199517, Length=240, Percent_Identity=32.0833333333333, Blast_Score=75, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI71990482, Length=272, Percent_Identity=43.0147058823529, Blast_Score=228, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI71990487, Length=274, Percent_Identity=42.7007299270073, Blast_Score=223, Evalue=8e-59,
Organism=Caenorhabditis elegans, GI17567771, Length=274, Percent_Identity=40.1459854014599, Blast_Score=211, Evalue=5e-55,
Organism=Caenorhabditis elegans, GI17541892, Length=234, Percent_Identity=29.0598290598291, Blast_Score=94, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6324504, Length=228, Percent_Identity=27.6315789473684, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI28571445, Length=279, Percent_Identity=45.8781362007168, Blast_Score=253, Evalue=1e-67,
Organism=Drosophila melanogaster, GI28571443, Length=218, Percent_Identity=45.8715596330275, Blast_Score=210, Evalue=1e-54,
Organism=Drosophila melanogaster, GI28571441, Length=218, Percent_Identity=45.8715596330275, Blast_Score=210, Evalue=1e-54,
Organism=Drosophila melanogaster, GI24648389, Length=217, Percent_Identity=26.7281105990783, Blast_Score=88, Evalue=8e-18,
Organism=Drosophila melanogaster, GI17137536, Length=234, Percent_Identity=29.9145299145299, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24645650, Length=135, Percent_Identity=34.0740740740741, Blast_Score=71, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 30550; Mature: 30419

Theoretical pI: Translated: 7.21; Mature: 7.21

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPHDALPVPSLAPSMEALVSLLTRRSTVVLTGAGCSTESGIPDYRGPGTRARARNPIQ
CCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCHHCCCCHH
HREFLTRPEVRARYWARSLMGWPRFSSARPNAAHAALAELEQAGHVRGLITQNVDGLHHA
HHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCEEEHHHCCCCHHHHC
AGSSRVIELHGALAQVRCLACGAQEAREALQARLLSLNPGFSLEVLELRPDGDADLTSEQ
CCCCEEEEEHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCHHH
LSSFQVPACLVCGGTLKPDVVFFGDNVPVPTVASAFALLEEGDALLVVGSSLAIFSGYRF
HHHCCCCEEEEECCCCCCCEEEECCCCCCHHHHHHHHHHHCCCEEEEECCCCHHHHCCEE
LVRASERRMPIAILNLGECRGVELADVHLEARAGDALPRLAAALARS
EEECCCCCCCEEEEECCCCCCCEEEEEEEECCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
TAPHDALPVPSLAPSMEALVSLLTRRSTVVLTGAGCSTESGIPDYRGPGTRARARNPIQ
CCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCHHCCCCHH
HREFLTRPEVRARYWARSLMGWPRFSSARPNAAHAALAELEQAGHVRGLITQNVDGLHHA
HHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCEEEHHHCCCCHHHHC
AGSSRVIELHGALAQVRCLACGAQEAREALQARLLSLNPGFSLEVLELRPDGDADLTSEQ
CCCCEEEEEHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCHHH
LSSFQVPACLVCGGTLKPDVVFFGDNVPVPTVASAFALLEEGDALLVVGSSLAIFSGYRF
HHHCCCCEEEEECCCCCCCEEEECCCCCCHHHHHHHHHHHCCCEEEEECCCCHHHHCCEE
LVRASERRMPIAILNLGECRGVELADVHLEARAGDALPRLAAALARS
EEECCCCCCCEEEEECCCCCCCEEEEEEEECCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]