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The map label for this gene is pdp [H]

Identifier: 108762592

GI number: 108762592

Start: 7076593

End: 7077897

Strand: Reverse

Name: pdp [H]

Synonym: MXAN_5710

Alternate gene names: 108762592

Gene position: 7077897-7076593 (Counterclockwise)

Preceding gene: 108757559

Following gene: 108756776

Centisome position: 77.44

GC content: 68.97

Gene sequence:

>1305_bases
GTGCAACCCTACGAACTCATCAAGGCCAAGCGGGATGGCGGCCGGCTGGAACCGGCGGACATCCGTGCGTTCATCGAGGC
GTATACGGCGGGGACGGTGGCGGACTACCAGATGGCGGCCATGTGCATGGCCATCTTCTTCCGGGGCATGGACTCCCGGG
AGCTGGGCGCCTGGGCCCGCGCCATGCTGGAGTCCGGTGAGGTCCTGGACCTGTCCGACACGCCGGGTGTGAAGGTGGAC
AAGCATTCGACGGGCGGGGTGGGTGACAAGGTCTCCCTCAGCCTGGCGCCGCTGGCCGCCGCGTGCGGAGTTCCGGTGCC
CATGATTTCGGGCCGGGGCCTGGGGCACACGGGTGGGACCCTGGACAAGCTGGAGTCCATCCCCGGCTTCAACGTCAACC
TGCCGACGTCGGAGTACCGGCGGCTGGTGCGCGAGGTGAACTGCTGCCTGATTGGCCAGACGGCGCAGGTGGCCCCGGCG
GACAAGAAGCTCTATGCCCTGCGGGACGTGACGGCGACGGTGGACTGCATCCCGCTGATTGCGTCCTCCATCATGAGCAA
GAAGCTGGCGGAGGGCATCGACGCGCTGGTGCTGGACGTGAAGGTGGGCAGTGGCGCCTTCATGAAGCGCGACGAGGACG
CGCGCACGCTGGCGAAGACGATGATTGGCCTGGGCGCGGAGATGGGGAAGAAGGTCGTGGCCCTGCTCACCGACATGGAC
CAGCCGCTGGGCCGCAAGGTGGGCAACGCGCTGGAGGTCATCGAGGCGGTGGACATGCTCCGCGGCAACGCGCCGGAGGA
CTACACCGAGGTGACGTATGCCCTCACGGCGGAGATGCTGGTGCTGGGCAAGAAGGCCGCCACGGTGGAGGAGGCGCGCG
AGAAGCTGCGCAAGGTGGTGGAGGACGGCAGCGCGGTGCGCAAGCTGAAGGAGATCGTCCAGGTGCAGGGCGGAGACCCG
CGCTCCATCGACGACTACTCCCTGTTGCCCCAGGCGAAGGCCACCGTGGACGTGGTGGCGCCCCGGGACGGCTTCGTCAC
CGGCATCGACACGGAGGGCGTGGGCATGGCGGCGGTGGCGCTGGGCGCGGGCCGGCAGCGGACGGATAGCAAGATCGACC
CGGCCGTGGGCTTCACGCTGCTGAAGAAGTCGGGCGAGTCCGTGAAGCAGGGCGAGCCCGTGGTGCGCGTGCACTACAAC
GACGCGGCCCAGTTGGAGAACGTGAAGGCGCGCCTCTTGGCCGCGTACCGGTTCGGCGACGTGGCCCCCGTGGCCCGGCC
GCTCATCCGCGAGCGGGTGGAGTAG

Upstream 100 bases:

>100_bases
GCAAGGACGTGGAGGCGGAGCATCATGAGGCGCCTATCTACCAGATGCCCGCCCTTTCCCGGAGTGCATGAAGGGGGGGT
TCCTGCTATGGGCTCGCCTC

Downstream 100 bases:

>100_bases
GGCGCCGAGCCGTGTGGTGACCTGGGAGCCCCCCGTCGATGCCCTGCCAGGGCGCGGCGTGGGGCTCCTTTCACGTGGGG
CATCAGAGGGTGGCGCCGGT

Product: pyrimidine-nucleoside phosphorylase

Products: NA

Alternate protein names: PYNP [H]

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MQPYELIKAKRDGGRLEPADIRAFIEAYTAGTVADYQMAAMCMAIFFRGMDSRELGAWARAMLESGEVLDLSDTPGVKVD
KHSTGGVGDKVSLSLAPLAAACGVPVPMISGRGLGHTGGTLDKLESIPGFNVNLPTSEYRRLVREVNCCLIGQTAQVAPA
DKKLYALRDVTATVDCIPLIASSIMSKKLAEGIDALVLDVKVGSGAFMKRDEDARTLAKTMIGLGAEMGKKVVALLTDMD
QPLGRKVGNALEVIEAVDMLRGNAPEDYTEVTYALTAEMLVLGKKAATVEEAREKLRKVVEDGSAVRKLKEIVQVQGGDP
RSIDDYSLLPQAKATVDVVAPRDGFVTGIDTEGVGMAAVALGAGRQRTDSKIDPAVGFTLLKKSGESVKQGEPVVRVHYN
DAAQLENVKARLLAAYRFGDVAPVARPLIRERVE

Sequences:

>Translated_434_residues
MQPYELIKAKRDGGRLEPADIRAFIEAYTAGTVADYQMAAMCMAIFFRGMDSRELGAWARAMLESGEVLDLSDTPGVKVD
KHSTGGVGDKVSLSLAPLAAACGVPVPMISGRGLGHTGGTLDKLESIPGFNVNLPTSEYRRLVREVNCCLIGQTAQVAPA
DKKLYALRDVTATVDCIPLIASSIMSKKLAEGIDALVLDVKVGSGAFMKRDEDARTLAKTMIGLGAEMGKKVVALLTDMD
QPLGRKVGNALEVIEAVDMLRGNAPEDYTEVTYALTAEMLVLGKKAATVEEAREKLRKVVEDGSAVRKLKEIVQVQGGDP
RSIDDYSLLPQAKATVDVVAPRDGFVTGIDTEGVGMAAVALGAGRQRTDSKIDPAVGFTLLKKSGESVKQGEPVVRVHYN
DAAQLENVKARLLAAYRFGDVAPVARPLIRERVE
>Mature_434_residues
MQPYELIKAKRDGGRLEPADIRAFIEAYTAGTVADYQMAAMCMAIFFRGMDSRELGAWARAMLESGEVLDLSDTPGVKVD
KHSTGGVGDKVSLSLAPLAAACGVPVPMISGRGLGHTGGTLDKLESIPGFNVNLPTSEYRRLVREVNCCLIGQTAQVAPA
DKKLYALRDVTATVDCIPLIASSIMSKKLAEGIDALVLDVKVGSGAFMKRDEDARTLAKTMIGLGAEMGKKVVALLTDMD
QPLGRKVGNALEVIEAVDMLRGNAPEDYTEVTYALTAEMLVLGKKAATVEEAREKLRKVVEDGSAVRKLKEIVQVQGGDP
RSIDDYSLLPQAKATVDVVAPRDGFVTGIDTEGVGMAAVALGAGRQRTDSKIDPAVGFTLLKKSGESVKQGEPVVRVHYN
DAAQLENVKARLLAAYRFGDVAPVARPLIRERVE

Specific function: The Enzymes Which Catalyze The Reversible Phosphorolysis Of Pyrimidine Nucleosides Are Involved In The Degradation Of These Compounds And In Their Utilization As Carbon And Energy Sources, Or In The Rescue Of Pyrimidine Bases For Nucleotide Synthesis. [C

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI166158925, Length=434, Percent_Identity=46.5437788018433, Blast_Score=344, Evalue=1e-94,
Organism=Homo sapiens, GI4503445, Length=434, Percent_Identity=46.5437788018433, Blast_Score=344, Evalue=1e-94,
Organism=Homo sapiens, GI166158922, Length=434, Percent_Identity=46.5437788018433, Blast_Score=344, Evalue=1e-94,
Organism=Escherichia coli, GI1790842, Length=434, Percent_Identity=46.3133640552995, Blast_Score=352, Evalue=2e-98,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872 [H]

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C [H]

EC number: =2.4.2.2 [H]

Molecular weight: Translated: 46343; Mature: 46343

Theoretical pI: Translated: 5.95; Mature: 5.95

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQPYELIKAKRDGGRLEPADIRAFIEAYTAGTVADYQMAAMCMAIFFRGMDSRELGAWAR
CCCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHH
AMLESGEVLDLSDTPGVKVDKHSTGGVGDKVSLSLAPLAAACGVPVPMISGRGLGHTGGT
HHHCCCCEEECCCCCCCEEECCCCCCCCCEEEEEHHHHHHHCCCCCCCCCCCCCCCCCCC
LDKLESIPGFNVNLPTSEYRRLVREVNCCLIGQTAQVAPADKKLYALRDVTATVDCIPLI
HHHHHCCCCCCCCCCHHHHHHHHHHCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHH
ASSIMSKKLAEGIDALVLDVKVGSGAFMKRDEDARTLAKTMIGLGAEMGKKVVALLTDMD
HHHHHHHHHHCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHCC
QPLGRKVGNALEVIEAVDMLRGNAPEDYTEVTYALTAEMLVLGKKAATVEEAREKLRKVV
CHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
EDGSAVRKLKEIVQVQGGDPRSIDDYSLLPQAKATVDVVAPRDGFVTGIDTEGVGMAAVA
HCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEECCCCCCCHHHHH
LGAGRQRTDSKIDPAVGFTLLKKSGESVKQGEPVVRVHYNDAAQLENVKARLLAAYRFGD
HCCCCCCCCCCCCHHHHHHHHHHCCCHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHCCC
VAPVARPLIRERVE
CCHHHHHHHHHHCC
>Mature Secondary Structure
MQPYELIKAKRDGGRLEPADIRAFIEAYTAGTVADYQMAAMCMAIFFRGMDSRELGAWAR
CCCHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHH
AMLESGEVLDLSDTPGVKVDKHSTGGVGDKVSLSLAPLAAACGVPVPMISGRGLGHTGGT
HHHCCCCEEECCCCCCCEEECCCCCCCCCEEEEEHHHHHHHCCCCCCCCCCCCCCCCCCC
LDKLESIPGFNVNLPTSEYRRLVREVNCCLIGQTAQVAPADKKLYALRDVTATVDCIPLI
HHHHHCCCCCCCCCCHHHHHHHHHHCCCEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHH
ASSIMSKKLAEGIDALVLDVKVGSGAFMKRDEDARTLAKTMIGLGAEMGKKVVALLTDMD
HHHHHHHHHHCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHCC
QPLGRKVGNALEVIEAVDMLRGNAPEDYTEVTYALTAEMLVLGKKAATVEEAREKLRKVV
CHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
EDGSAVRKLKEIVQVQGGDPRSIDDYSLLPQAKATVDVVAPRDGFVTGIDTEGVGMAAVA
HCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEECCCCCCCHHHHH
LGAGRQRTDSKIDPAVGFTLLKKSGESVKQGEPVVRVHYNDAAQLENVKARLLAAYRFGD
HCCCCCCCCCCCCHHHHHHHHHHCCCHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHCCC
VAPVARPLIRERVE
CCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8987664; 9817849 [H]