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The map label for this gene is pepA [H]

Identifier: 108762265

GI number: 108762265

Start: 6207583

End: 6209178

Strand: Direct

Name: pepA [H]

Synonym: MXAN_4963

Alternate gene names: 108762265

Gene position: 6207583-6209178 (Clockwise)

Preceding gene: 108763285

Following gene: 108763315

Centisome position: 67.92

GC content: 71.05

Gene sequence:

>1596_bases
ATGAACTTCAGCTTCGTCTCCGGCGATGCCACACGGACGAGCGGCGACCTGCTCGTCATTCCCCTCTTCGAGGGCGAGCT
GGGAGACAGCGCCCCGTCCTCCCTCTCCTCGGCGGATGGCGCCCTGGAAGGACGCCTGCGCGGCGCCGCCACCCAGGAGG
GCTTCAAGGGACGCGCGGACCAGAGCCTGGTGATGCACACCCTGGGGCGCACGTCGTCCGAGCGCGTGCTGCTGCTGGGC
CTGGGAAACCGCGCCCGCTTCCACCCGGAAGTGCTGCGGCTGGCCGCCGGCCGCGCCGCGAAGACGGCGCAGCGGCTCAA
GGTCACCTCGGTGGCGTTCGCCCTGCCGGCCACCGAGTCCACGCAGGACGCGGTGCGCGCCGTGGTGGAAGGCGTGGCGC
TGGGCGTCTACCGCTTCGACAAGTACAAGTCCTCCGCGCGCGAGGAGAAGAAGGGCGCCGCGAAGCTGGGCAAGGTGTCC
CTGCTGCTCCCCGAGGGCACGGAGCGCACGCGCGAGCTCGATGCCGCGCTGACGCTGGCGCAGCGCGTCGCGGAGGCGAC
CAACTGGGCCCGTGACCTCGTCAACGAGCCGCCCAACGCGGTGACGCCCACGGTGCTGGCCGAGGCCGCGCGTCAGGCCG
CGAAGGAAGGCGGGCTGAAGGCCACCATCGGCGGCCGCCGCGACATCGAGAAGCTCGACATGGGCATGTTCCTCGGCGTC
ACCGCGGGGAGCACCGAGGAGCCTCGCCTCATCCACCTGACGTACATGCCCAAGAACGCGCGCGACGCCAAACAGCCGCC
GCTGGCGCTGGTGGGCAAGGCCGTCACCTTCGACTCGGGCGGCCTGTCGCTCAAGCCGACGGACGGCATGGTGGACATGA
AGACGGACATGGCGGGCTCGGCCGCGGTGCTGGGCGCCATGAAGGTCATCGCCGCGCTCAAGCCGCCCTTCCCCGTGCAC
GCCTTCATCGGCGCGTGCGAGAACATGCCGGCCGGCAACGCCTACAAGCCGGGTGACATCCTCACCTCGCGCCTGGGCAA
GACGGTGGAGATCACCAACACGGACGCGGAAGGCCGCCTGGTGCTGGGCGACATCCTGACGTGGGCCACCGAGCACAAGC
CGGCCGCCATCATCGACCTGGCCACGCTCACGGGCGCCTGCATCGTCGCGCTGGGCAACTACATCGTCGGCGCCTTCGGC
GACCACGAGGAGACGGTGACGCAGGTGCTCCAGGCCGCGCGCACCGCGGGCGAGGAGATGTGGCGCATGCCCATCAGCGA
CATGCAGAAGGACGCCCTGCGCTCCGAGGTCGCCGACATGAAGAACTCCGGCGAGCGCTGGGGTGGCTCCATCAACGCCG
CCATCTTCCTCCGCGAGTTCGTGGGCGAGACGCCGTGGGTGCACCTGGACATCGCGGGTCCGGCGAGCAGCCCCAAGGAG
CGTGGCTACCTGAGCAAGGGCGGCACCGGCGTGGGCGTGCGCACCCTGGTGGAGTACGTCCGCCTGCGCGCGCAGACGCA
GGACACCGCGCCCGCAGAAGCAGCGCCCGAGGCCAAGGCCAGCAAGGCCAAGCCGGCCCGGAAGCGCGCGAAGTAG

Upstream 100 bases:

>100_bases
CGAATGAAATCCAACGCTTTGCGTGTAACAGGGCGGGCGTTACAGTCCGCGCCCTTTCCACCAGCCCAAGCCTTTTCACT
GTTCAGGAGTTCCACGGCCC

Downstream 100 bases:

>100_bases
CTCGGCTTCCAGCCAGAGGGCGTCCCTGATGAAGGGGCGCCCTCAGCGCTGGGGCACCTTCCACGCCGTCGCCGGCCCCG
CAAGCGGGCGGACGCCCTGG

Product: cytosol aminopeptidase family protein

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 531; Mature: 531

Protein sequence:

>531_residues
MNFSFVSGDATRTSGDLLVIPLFEGELGDSAPSSLSSADGALEGRLRGAATQEGFKGRADQSLVMHTLGRTSSERVLLLG
LGNRARFHPEVLRLAAGRAAKTAQRLKVTSVAFALPATESTQDAVRAVVEGVALGVYRFDKYKSSAREEKKGAAKLGKVS
LLLPEGTERTRELDAALTLAQRVAEATNWARDLVNEPPNAVTPTVLAEAARQAAKEGGLKATIGGRRDIEKLDMGMFLGV
TAGSTEEPRLIHLTYMPKNARDAKQPPLALVGKAVTFDSGGLSLKPTDGMVDMKTDMAGSAAVLGAMKVIAALKPPFPVH
AFIGACENMPAGNAYKPGDILTSRLGKTVEITNTDAEGRLVLGDILTWATEHKPAAIIDLATLTGACIVALGNYIVGAFG
DHEETVTQVLQAARTAGEEMWRMPISDMQKDALRSEVADMKNSGERWGGSINAAIFLREFVGETPWVHLDIAGPASSPKE
RGYLSKGGTGVGVRTLVEYVRLRAQTQDTAPAEAAPEAKASKAKPARKRAK

Sequences:

>Translated_531_residues
MNFSFVSGDATRTSGDLLVIPLFEGELGDSAPSSLSSADGALEGRLRGAATQEGFKGRADQSLVMHTLGRTSSERVLLLG
LGNRARFHPEVLRLAAGRAAKTAQRLKVTSVAFALPATESTQDAVRAVVEGVALGVYRFDKYKSSAREEKKGAAKLGKVS
LLLPEGTERTRELDAALTLAQRVAEATNWARDLVNEPPNAVTPTVLAEAARQAAKEGGLKATIGGRRDIEKLDMGMFLGV
TAGSTEEPRLIHLTYMPKNARDAKQPPLALVGKAVTFDSGGLSLKPTDGMVDMKTDMAGSAAVLGAMKVIAALKPPFPVH
AFIGACENMPAGNAYKPGDILTSRLGKTVEITNTDAEGRLVLGDILTWATEHKPAAIIDLATLTGACIVALGNYIVGAFG
DHEETVTQVLQAARTAGEEMWRMPISDMQKDALRSEVADMKNSGERWGGSINAAIFLREFVGETPWVHLDIAGPASSPKE
RGYLSKGGTGVGVRTLVEYVRLRAQTQDTAPAEAAPEAKASKAKPARKRAK
>Mature_531_residues
MNFSFVSGDATRTSGDLLVIPLFEGELGDSAPSSLSSADGALEGRLRGAATQEGFKGRADQSLVMHTLGRTSSERVLLLG
LGNRARFHPEVLRLAAGRAAKTAQRLKVTSVAFALPATESTQDAVRAVVEGVALGVYRFDKYKSSAREEKKGAAKLGKVS
LLLPEGTERTRELDAALTLAQRVAEATNWARDLVNEPPNAVTPTVLAEAARQAAKEGGLKATIGGRRDIEKLDMGMFLGV
TAGSTEEPRLIHLTYMPKNARDAKQPPLALVGKAVTFDSGGLSLKPTDGMVDMKTDMAGSAAVLGAMKVIAALKPPFPVH
AFIGACENMPAGNAYKPGDILTSRLGKTVEITNTDAEGRLVLGDILTWATEHKPAAIIDLATLTGACIVALGNYIVGAFG
DHEETVTQVLQAARTAGEEMWRMPISDMQKDALRSEVADMKNSGERWGGSINAAIFLREFVGETPWVHLDIAGPASSPKE
RGYLSKGGTGVGVRTLVEYVRLRAQTQDTAPAEAAPEAKASKAKPARKRAK

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=509, Percent_Identity=35.1669941060904, Blast_Score=252, Evalue=5e-67,
Organism=Homo sapiens, GI47155554, Length=329, Percent_Identity=36.4741641337386, Blast_Score=142, Evalue=6e-34,
Organism=Escherichia coli, GI1790710, Length=511, Percent_Identity=36.0078277886497, Blast_Score=290, Evalue=1e-79,
Organism=Escherichia coli, GI87082123, Length=341, Percent_Identity=37.5366568914956, Blast_Score=180, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17556903, Length=292, Percent_Identity=34.5890410958904, Blast_Score=129, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17565172, Length=351, Percent_Identity=30.1994301994302, Blast_Score=99, Evalue=8e-21,
Organism=Drosophila melanogaster, GI20129969, Length=522, Percent_Identity=31.4176245210728, Blast_Score=190, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24661038, Length=385, Percent_Identity=31.6883116883117, Blast_Score=187, Evalue=2e-47,
Organism=Drosophila melanogaster, GI21355725, Length=333, Percent_Identity=34.2342342342342, Blast_Score=187, Evalue=2e-47,
Organism=Drosophila melanogaster, GI21355645, Length=517, Percent_Identity=28.4332688588008, Blast_Score=179, Evalue=4e-45,
Organism=Drosophila melanogaster, GI24662223, Length=517, Percent_Identity=28.4332688588008, Blast_Score=179, Evalue=4e-45,
Organism=Drosophila melanogaster, GI24662227, Length=417, Percent_Identity=30.9352517985612, Blast_Score=178, Evalue=7e-45,
Organism=Drosophila melanogaster, GI161077148, Length=482, Percent_Identity=29.8755186721992, Blast_Score=165, Evalue=6e-41,
Organism=Drosophila melanogaster, GI20130057, Length=482, Percent_Identity=29.8755186721992, Blast_Score=165, Evalue=6e-41,
Organism=Drosophila melanogaster, GI20129963, Length=414, Percent_Identity=32.1256038647343, Blast_Score=155, Evalue=5e-38,
Organism=Drosophila melanogaster, GI19922386, Length=376, Percent_Identity=29.5212765957447, Blast_Score=145, Evalue=5e-35,
Organism=Drosophila melanogaster, GI21357381, Length=335, Percent_Identity=33.7313432835821, Blast_Score=136, Evalue=3e-32,
Organism=Drosophila melanogaster, GI221379063, Length=335, Percent_Identity=33.7313432835821, Blast_Score=136, Evalue=4e-32,
Organism=Drosophila melanogaster, GI221379062, Length=335, Percent_Identity=33.7313432835821, Blast_Score=136, Evalue=4e-32,
Organism=Drosophila melanogaster, GI24646701, Length=257, Percent_Identity=31.5175097276265, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24646703, Length=257, Percent_Identity=31.5175097276265, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21358201, Length=257, Percent_Identity=31.5175097276265, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 56220; Mature: 56220

Theoretical pI: Translated: 9.40; Mature: 9.40

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFSFVSGDATRTSGDLLVIPLFEGELGDSAPSSLSSADGALEGRLRGAATQEGFKGRAD
CCCEEECCCCCCCCCCEEEEEEECCCCCCCCCCHHHHCCCHHHHHHCCCCCCCCCCCCCC
QSLVMHTLGRTSSERVLLLGLGNRARFHPEVLRLAAGRAAKTAQRLKVTSVAFALPATES
HHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHEEECCCCCC
TQDAVRAVVEGVALGVYRFDKYKSSAREEKKGAAKLGKVSLLLPEGTERTRELDAALTLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHH
QRVAEATNWARDLVNEPPNAVTPTVLAEAARQAAKEGGLKATIGGRRDIEKLDMGMFLGV
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEECCCCCCHHHHCCCEEEEE
TAGSTEEPRLIHLTYMPKNARDAKQPPLALVGKAVTFDSGGLSLKPTDGMVDMKTDMAGS
ECCCCCCCEEEEEEECCCCCCCCCCCCHHHHEEEEEECCCCCEECCCCCCEEECCCCCCH
AAVLGAMKVIAALKPPFPVHAFIGACENMPAGNAYKPGDILTSRLGKTVEITNTDAEGRL
HHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHCCCEEEEECCCCCCCE
VLGDILTWATEHKPAAIIDLATLTGACIVALGNYIVGAFGDHEETVTQVLQAARTAGEEM
EEHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHH
WRMPISDMQKDALRSEVADMKNSGERWGGSINAAIFLREFVGETPWVHLDIAGPASSPKE
HCCCHHHHHHHHHHHHHHHHHCCCHHCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHH
RGYLSKGGTGVGVRTLVEYVRLRAQTQDTAPAEAAPEAKASKAKPARKRAK
CCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCHHHCCC
>Mature Secondary Structure
MNFSFVSGDATRTSGDLLVIPLFEGELGDSAPSSLSSADGALEGRLRGAATQEGFKGRAD
CCCEEECCCCCCCCCCEEEEEEECCCCCCCCCCHHHHCCCHHHHHHCCCCCCCCCCCCCC
QSLVMHTLGRTSSERVLLLGLGNRARFHPEVLRLAAGRAAKTAQRLKVTSVAFALPATES
HHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHEEECCCCCC
TQDAVRAVVEGVALGVYRFDKYKSSAREEKKGAAKLGKVSLLLPEGTERTRELDAALTLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHH
QRVAEATNWARDLVNEPPNAVTPTVLAEAARQAAKEGGLKATIGGRRDIEKLDMGMFLGV
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCEEECCCCCCHHHHCCCEEEEE
TAGSTEEPRLIHLTYMPKNARDAKQPPLALVGKAVTFDSGGLSLKPTDGMVDMKTDMAGS
ECCCCCCCEEEEEEECCCCCCCCCCCCHHHHEEEEEECCCCCEECCCCCCEEECCCCCCH
AAVLGAMKVIAALKPPFPVHAFIGACENMPAGNAYKPGDILTSRLGKTVEITNTDAEGRL
HHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHCCCEEEEECCCCCCCE
VLGDILTWATEHKPAAIIDLATLTGACIVALGNYIVGAFGDHEETVTQVLQAARTAGEEM
EEHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHH
WRMPISDMQKDALRSEVADMKNSGERWGGSINAAIFLREFVGETPWVHLDIAGPASSPKE
HCCCHHHHHHHHHHHHHHHHHCCCHHCCCCCHHHHHHHHHHCCCCEEEEEECCCCCCHHH
RGYLSKGGTGVGVRTLVEYVRLRAQTQDTAPAEAAPEAKASKAKPARKRAK
CCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA