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The map label for this gene is mfnA [H]

Identifier: 108762110

GI number: 108762110

Start: 6264351

End: 6266519

Strand: Direct

Name: mfnA [H]

Synonym: MXAN_5012

Alternate gene names: 108762110

Gene position: 6264351-6266519 (Clockwise)

Preceding gene: 108759471

Following gene: 108759731

Centisome position: 68.54

GC content: 64.68

Gene sequence:

>2169_bases
TTGCTGTGGGAATCAACCCACGGCAGGGAGGCACCGCTCGAGAACGAGCGGGACGTCGAGGCCTGGTTCCTGGGCCCCCG
CGCGGAGAACGCGGACATCTTCGAGCAACTGGTGCTGGAGGCCCTGAGAGACCACTCCTTCTGGCGCCGGAACTTCCACC
CGATGGACCCACCGGCCATCACCCAGAGCATCAAGAGAGACCCGGGCTACCTCCGGGCGCTCGACACACTGCACACCGAG
TTCGACAACCTCCTGGCCGAGCTGAAGAAGTCCGCGCCGTTCTTCAGCATGCGCTACCAGGGCCACATGACGTGGGAGCA
GACGCTCCCGGGCATGGCCGGCTACTTCGCGGCCATGCTCTACAATCAGAACAACGTCGCGCTGGAGGCCTCACCGCTGA
CGACGGTCCTGGAGGTCCGTGCTGGCGAGGACCTGTGCCGGATGGTGGGCTACACCCAGCAGAACGGCATCCGGCCCTGG
AGCCATCTGACCAGCGGTGGCACCACCGCCAACATCGAGGCGATGTGGGCCGCGCGAAACTTGAAGTTCTATCCCCTGTC
CCTGCGCGAGGCCCTTCAGCGGGAGTCCACGCTTTCCGCCGCGAAGGCCCTCAAGGTAACGCTGCCCTCGGGAACCCAGG
CACGTCTGGTTGACCTGGATGCGTGGCAAGCGTTGAACCTGGATGTGGACGAGGTGCTGGGCCTCCCCACCCGCATCCAT
GAGGAGTTCAAAATCCCGCCGGAGACCCTGACGGCGAACGTGAGCAACTACATGCTCCAGGATTTAGGGCTCGTGGAGTT
CACCCGCCGCTACCTGGGAGACCTCCCGGCGCCCGTGTTCATGGTCCCAGGCTCGAAGCACTACTCGCTGCCCAAGGCGG
CGGCGATTCTGGGCATCGGCGCGGACCACATGTTCAGCATTCCTCTGGATGAAGAGGGGCGCATGGACGTGTCGGCCCTG
GAGGCGCGGCTGGACCAATGCATGAAGGACAAGCAGCCCGTCATCGCGGTGACGGCCGTGATGGGGACGACGGAGGAAGG
GTTGGTGGACCCGCTCGCGTCCGTGCTGGCGCTTCGCCGGCAGAAGTACCATCCGCAGGGGATGTCGTTCTGCGTGCACG
CCGACGCGGCCTGGGGCGGGTACTTCGCCTCACTCCTCCGCGCGCCGCCGAGTTCAAACAAGCGCCTCGCGGGGCCTCCC
GCCCCCGTGCTGTCACTGAGCCGCTATGTCACGGAGCAGTTCGAGGCCCTCCCGGAGGCGGACACCATCACCGTGGATCC
GCACAAGACGGGCTATCTGCCCTACCCCGCCGGTGCGCTGTGCTACCGCAATCAGTCCATGCGCAGCTTGGTGGCCTTCG
AGGCGCCCTACATCAACACAGCGGGGAGCCAGGAGGACCTCACCGTGGGCAAGTACGGCATCGAGGGATCCAAGCCCGGT
GCCGCGGCGGCGGGCGTGTACCTCAGTCATGCCGTCGTGCCACCCGACCAACGTGGCTACGGGAAGATCCTCGGAAGGGC
GCTCTACAACTGCAAGCTCTTCCATGCCCGGCTACTGACGATGAACACCGTGGCGAGCGACTTCGTCGTGGTACCGGGTC
CGCGATTCAAGCTCTCCGATTCCCTCAAGCGCAAGTACGGCGGAGAGAAGCAGGCGCTGGAGTTCCTGCGTCAGCAAATC
CAGGGCATGCGTCAGGAGCAGCTCCTTAGCGCCTCGAGTGAGGAGGAACTGGAGCTGCTGCGCGAAACGGGCGCGGACCT
CAACATCCTCACCTACGCCTTCAACTTCAAGACCGAGCAGGGACTCAACACGAGCCTGGAGGAGGCAAACACCTTCAACC
GTATGATCTACGAGCGCCTGGGCGTCAAAGCCGATGGCCGTGACATCTACGGCTACCGGCTGCTGGTGAGCACCACGGAC
TTCATCGAGGAGGACTACGGCAAGAAGTTCTTCGACGACTACAAGACGCGCTTGTTGGGGAGTGGCACGGCGTCGGGACG
TGGCGAGGAGGGCCGCATCACCGTGCTGCGCTCCGTCATCATGGACCCCTGGATTACCGAAGACCTCCAGGGTCGGCCGT
TCCTCGACACCATCATCGAGGAGCTGCGAGCGGCCGTGATGGACGCGCTCAACGAGATGCGCGGCACCTCATCGAAGTGC
TCGCGCTGA

Upstream 100 bases:

>100_bases
GGCCCACAAGTCCCAGCCGGACTACTCCAGTCATGCCCTTGATGGATTGAAACAAGCTTTGCGCGAGCGCCTGAAGACCA
ACCAACTCGCGCACAGAGAG

Downstream 100 bases:

>100_bases
CGCGCTTCAGGGAGCTCTGTCAGCGACGAGGTTGTTGAGCCCGTGAGGCATTGGATTTCTCAAGGCCTGGCAACCTCGTC
GTCTTCGGAAAACCCCATCT

Product: group II decarboxylase family protein

Products: NA

Alternate protein names: TDC [H]

Number of amino acids: Translated: 722; Mature: 722

Protein sequence:

>722_residues
MLWESTHGREAPLENERDVEAWFLGPRAENADIFEQLVLEALRDHSFWRRNFHPMDPPAITQSIKRDPGYLRALDTLHTE
FDNLLAELKKSAPFFSMRYQGHMTWEQTLPGMAGYFAAMLYNQNNVALEASPLTTVLEVRAGEDLCRMVGYTQQNGIRPW
SHLTSGGTTANIEAMWAARNLKFYPLSLREALQRESTLSAAKALKVTLPSGTQARLVDLDAWQALNLDVDEVLGLPTRIH
EEFKIPPETLTANVSNYMLQDLGLVEFTRRYLGDLPAPVFMVPGSKHYSLPKAAAILGIGADHMFSIPLDEEGRMDVSAL
EARLDQCMKDKQPVIAVTAVMGTTEEGLVDPLASVLALRRQKYHPQGMSFCVHADAAWGGYFASLLRAPPSSNKRLAGPP
APVLSLSRYVTEQFEALPEADTITVDPHKTGYLPYPAGALCYRNQSMRSLVAFEAPYINTAGSQEDLTVGKYGIEGSKPG
AAAAGVYLSHAVVPPDQRGYGKILGRALYNCKLFHARLLTMNTVASDFVVVPGPRFKLSDSLKRKYGGEKQALEFLRQQI
QGMRQEQLLSASSEEELELLRETGADLNILTYAFNFKTEQGLNTSLEEANTFNRMIYERLGVKADGRDIYGYRLLVSTTD
FIEEDYGKKFFDDYKTRLLGSGTASGRGEEGRITVLRSVIMDPWITEDLQGRPFLDTIIEELRAAVMDALNEMRGTSSKC
SR

Sequences:

>Translated_722_residues
MLWESTHGREAPLENERDVEAWFLGPRAENADIFEQLVLEALRDHSFWRRNFHPMDPPAITQSIKRDPGYLRALDTLHTE
FDNLLAELKKSAPFFSMRYQGHMTWEQTLPGMAGYFAAMLYNQNNVALEASPLTTVLEVRAGEDLCRMVGYTQQNGIRPW
SHLTSGGTTANIEAMWAARNLKFYPLSLREALQRESTLSAAKALKVTLPSGTQARLVDLDAWQALNLDVDEVLGLPTRIH
EEFKIPPETLTANVSNYMLQDLGLVEFTRRYLGDLPAPVFMVPGSKHYSLPKAAAILGIGADHMFSIPLDEEGRMDVSAL
EARLDQCMKDKQPVIAVTAVMGTTEEGLVDPLASVLALRRQKYHPQGMSFCVHADAAWGGYFASLLRAPPSSNKRLAGPP
APVLSLSRYVTEQFEALPEADTITVDPHKTGYLPYPAGALCYRNQSMRSLVAFEAPYINTAGSQEDLTVGKYGIEGSKPG
AAAAGVYLSHAVVPPDQRGYGKILGRALYNCKLFHARLLTMNTVASDFVVVPGPRFKLSDSLKRKYGGEKQALEFLRQQI
QGMRQEQLLSASSEEELELLRETGADLNILTYAFNFKTEQGLNTSLEEANTFNRMIYERLGVKADGRDIYGYRLLVSTTD
FIEEDYGKKFFDDYKTRLLGSGTASGRGEEGRITVLRSVIMDPWITEDLQGRPFLDTIIEELRAAVMDALNEMRGTSSKC
SR
>Mature_722_residues
MLWESTHGREAPLENERDVEAWFLGPRAENADIFEQLVLEALRDHSFWRRNFHPMDPPAITQSIKRDPGYLRALDTLHTE
FDNLLAELKKSAPFFSMRYQGHMTWEQTLPGMAGYFAAMLYNQNNVALEASPLTTVLEVRAGEDLCRMVGYTQQNGIRPW
SHLTSGGTTANIEAMWAARNLKFYPLSLREALQRESTLSAAKALKVTLPSGTQARLVDLDAWQALNLDVDEVLGLPTRIH
EEFKIPPETLTANVSNYMLQDLGLVEFTRRYLGDLPAPVFMVPGSKHYSLPKAAAILGIGADHMFSIPLDEEGRMDVSAL
EARLDQCMKDKQPVIAVTAVMGTTEEGLVDPLASVLALRRQKYHPQGMSFCVHADAAWGGYFASLLRAPPSSNKRLAGPP
APVLSLSRYVTEQFEALPEADTITVDPHKTGYLPYPAGALCYRNQSMRSLVAFEAPYINTAGSQEDLTVGKYGIEGSKPG
AAAAGVYLSHAVVPPDQRGYGKILGRALYNCKLFHARLLTMNTVASDFVVVPGPRFKLSDSLKRKYGGEKQALEFLRQQI
QGMRQEQLLSASSEEELELLRETGADLNILTYAFNFKTEQGLNTSLEEANTFNRMIYERLGVKADGRDIYGYRLLVSTTD
FIEEDYGKKFFDDYKTRLLGSGTASGRGEEGRITVLRSVIMDPWITEDLQGRPFLDTIIEELRAAVMDALNEMRGTSSKC
SR

Specific function: Specifically catalyzes the decarboxylation of L-tyrosine to produce tyramine [H]

COG id: COG0076

COG function: function code E; Glutamate decarboxylase and related PLP-dependent proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the group II decarboxylase family. Archaeal L-tyrosine decarboxylase subfamily [H]

Homologues:

Organism=Homo sapiens, GI197276620, Length=204, Percent_Identity=28.921568627451, Blast_Score=74, Evalue=7e-13,
Organism=Homo sapiens, GI4503875, Length=204, Percent_Identity=28.921568627451, Blast_Score=74, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI71993062, Length=163, Percent_Identity=33.1288343558282, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71993058, Length=163, Percent_Identity=33.1288343558282, Blast_Score=78, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17555682, Length=163, Percent_Identity=33.1288343558282, Blast_Score=78, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002129
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR021115
- InterPro:   IPR020931 [H]

Pfam domain/function: PF00282 Pyridoxal_deC [H]

EC number: =4.1.1.25 [H]

Molecular weight: Translated: 80451; Mature: 80451

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLWESTHGREAPLENERDVEAWFLGPRAENADIFEQLVLEALRDHSFWRRNFHPMDPPAI
CCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
TQSIKRDPGYLRALDTLHTEFDNLLAELKKSAPFFSMRYQGHMTWEQTLPGMAGYFAAML
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHCCCHHHHHHHHH
YNQNNVALEASPLTTVLEVRAGEDLCRMVGYTQQNGIRPWSHLTSGGTTANIEAMWAARN
CCCCCEEEECCCCEEEHHHHCCHHHHHHHCCHHCCCCCCHHHHCCCCCEEEEEEEEEECC
LKFYPLSLREALQRESTLSAAKALKVTLPSGTQARLVDLDAWQALNLDVDEVLGLPTRIH
CEEEEHHHHHHHHHHHHHHHHHEEEEECCCCCCEEEEECCCCCCCCCCHHHHHCCCHHHH
EEFKIPPETLTANVSNYMLQDLGLVEFTRRYLGDLPAPVFMVPGSKHYSLPKAAAILGIG
HHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEECCCCCCCCCCHHHHEEECC
ADHMFSIPLDEEGRMDVSALEARLDQCMKDKQPVIAVTAVMGTTEEGLVDPLASVLALRR
CCCEEECCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHH
QKYHPQGMSFCVHADAAWGGYFASLLRAPPSSNKRLAGPPAPVLSLSRYVTEQFEALPEA
HHCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCC
DTITVDPHKTGYLPYPAGALCYRNQSMRSLVAFEAPYINTAGSQEDLTVGKYGIEGSKPG
CEEEECCCCCCCCCCCCCHHHHCCHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCC
AAAAGVYLSHAVVPPDQRGYGKILGRALYNCKLFHARLLTMNTVASDFVVVPGPRFKLSD
CHHHHHHHHCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCH
SLKRKYGGEKQALEFLRQQIQGMRQEQLLSASSEEELELLRETGADLNILTYAFNFKTEQ
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEEEEEECCCCC
GLNTSLEEANTFNRMIYERLGVKADGRDIYGYRLLVSTTDFIEEDYGKKFFDDYKTRLLG
CCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEECHHHHHHHHCHHHHHHHHHHHHC
SGTASGRGEEGRITVLRSVIMDPWITEDLQGRPFLDTIIEELRAAVMDALNEMRGTSSKC
CCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
SR
CC
>Mature Secondary Structure
MLWESTHGREAPLENERDVEAWFLGPRAENADIFEQLVLEALRDHSFWRRNFHPMDPPAI
CCCCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHH
TQSIKRDPGYLRALDTLHTEFDNLLAELKKSAPFFSMRYQGHMTWEQTLPGMAGYFAAML
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHCCCHHHHHHHHH
YNQNNVALEASPLTTVLEVRAGEDLCRMVGYTQQNGIRPWSHLTSGGTTANIEAMWAARN
CCCCCEEEECCCCEEEHHHHCCHHHHHHHCCHHCCCCCCHHHHCCCCCEEEEEEEEEECC
LKFYPLSLREALQRESTLSAAKALKVTLPSGTQARLVDLDAWQALNLDVDEVLGLPTRIH
CEEEEHHHHHHHHHHHHHHHHHEEEEECCCCCCEEEEECCCCCCCCCCHHHHHCCCHHHH
EEFKIPPETLTANVSNYMLQDLGLVEFTRRYLGDLPAPVFMVPGSKHYSLPKAAAILGIG
HHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEECCCCCCCCCCHHHHEEECC
ADHMFSIPLDEEGRMDVSALEARLDQCMKDKQPVIAVTAVMGTTEEGLVDPLASVLALRR
CCCEEECCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHHHHH
QKYHPQGMSFCVHADAAWGGYFASLLRAPPSSNKRLAGPPAPVLSLSRYVTEQFEALPEA
HHCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCC
DTITVDPHKTGYLPYPAGALCYRNQSMRSLVAFEAPYINTAGSQEDLTVGKYGIEGSKPG
CEEEECCCCCCCCCCCCCHHHHCCHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCCCC
AAAAGVYLSHAVVPPDQRGYGKILGRALYNCKLFHARLLTMNTVASDFVVVPGPRFKLSD
CHHHHHHHHCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCH
SLKRKYGGEKQALEFLRQQIQGMRQEQLLSASSEEELELLRETGADLNILTYAFNFKTEQ
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCEEEEEEEECCCCC
GLNTSLEEANTFNRMIYERLGVKADGRDIYGYRLLVSTTDFIEEDYGKKFFDDYKTRLLG
CCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEEECHHHHHHHHCHHHHHHHHHHHHC
SGTASGRGEEGRITVLRSVIMDPWITEDLQGRPFLDTIIEELRAAVMDALNEMRGTSSKC
CCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
SR
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA