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The map label for this gene is nprM [H]

Identifier: 108761953

GI number: 108761953

Start: 6771449

End: 6773152

Strand: Direct

Name: nprM [H]

Synonym: MXAN_5442

Alternate gene names: 108761953

Gene position: 6771449-6773152 (Clockwise)

Preceding gene: 108757897

Following gene: 108760944

Centisome position: 74.09

GC content: 67.84

Gene sequence:

>1704_bases
TTGTCCGCTCGCGCAGCAGCCGCCCGTTGTGTCCGGGCGGCATCCCCACTCAGGCCAGGTGGTGTCTTCCGTCTCGGACG
GCACGCCCTTCGTGTGTCCTGGCCTCGAGCCGTAGCAGAGCAGTCCCCACCTGAAGCAAGGGAGAACATCGTGACGACAA
ACTGGACTCGCAGTCTGGCGGGAGTGTGCCTCGTTGCCCTCGGTTCCGCGTGCGGTGAGTTGCCCGACGCGGGGAGCCCG
GGCTCCGCGGATGTGTCGGAAATGGGGCAGGCGAACATGGAGCTGGGCAATGGCTCCGCCATCATCCGGGGACGGCTCGG
GGCCATCTCCGCACCGCAGTCCCTCTCCGGGCTGCGCGGCCAGGACCTCACCCTCGCCGCGGACCAGGCGCTCAAGCCCG
TGCTCGGAGGCGTTGCCTCGCGGTTCGGACTGAGCCCCAAGGAGCTACGCGTCCGCTCCGCTCGCGTGGATGAGGTGGGG
CTGACTCACGTCAGGTATGACCAGGTGCGCGAGGGACTGCGCGTGGTGGGTGGAGAGCTCATCGTCCACGTCGACACGTC
CGGCCAGATCTTCGCGGTGAACGGCTCCGCCAGGGGCGCCCAGGCTCCGAGCTCGCTTTCGCGCGTCTCTCCCGACGCGG
CGATGGCGGCGGCCGTCAATGGATTGCCTGACATGAAGTCGATGGGAACCACCCAGTTGGTGTACTTCCTGGATGCCCAG
GGCTCACTCTTCCTGGCCTACGAGCTCGTCCGCGAGGGCGAGCGTGACGACGCCCCCGCGCGCGACACCGTCTATGTGGA
CGCCGCAACGGGGAGCGTCCTGGACGTTCATCCGCAGTACCACGCCGCGCAGAACCGGCGGATCCACTCGGCGGGCAACG
GCAGCAACCTCCCCGGTACGCTGCGACGCCAGGAGGGCGGCGCCGCCACCGGTGATGGCCACATCGACGACAACTACGAC
CACGTCGGCACCACGTACCGCTGCTACTCGACCATCTTCGGGCGGGATTCCTTCGATGACGCTGGCGCGACCATCACCAG
CACCGTCCACTACGGCAGCCGCTACGTCAACGCCTTCTGGGATGGCCGGCAGATCGTCTTCGGCGACGGGGACAACTTCA
ACTCGGGCGAGCTGGGGCGCGATCTGGACGTCGTCTCCCACGAGTTCACGCACGCGGTCACGCAGTACGACTCCGGGCTC
GTGTACCGCAATGAGTCCGGCGCCCTCAACGAGAGCCTGTCCGACATCGCCGCGGCCATCTGCGAGAGCTGGGCGCGCGG
CACCGTGGACGCGGACGTCTGGAAGATTGGCGAGGACATCTGGACCCCGGGCACGTCGGGCGACGCCCTCCGCTACATGG
ACAACCCCACCCGGGATGGCTCCTCCCGGGACTTCTACCCAGAGCGCTACGTCGGGACTGCCGACAACGGCGGCGTGCAC
TGGAACTCCGGCATCCCCAATCTCGCGTTCAAGCTGCTCGTGACGGGCGGCACGCACCCTCGGAGCAAGACGTCCATCAA
CGTGTCAGGCGTGGGGATGAACCGCGCAGCGCAGACCTTCTACTACGCGAACCAGTTCTACTTCACGGCCAACACCACCA
TGGCCCAGGCCCGAGCCCTGACCATCCAGGCCGCCGCGGACCGCTACCCCACTGACACGGTCAACGCCGTGCGCGATGCC
TGGAGCGCCGTGGGCGTGCAGTGA

Upstream 100 bases:

>100_bases
CTACGCGAAGCGCTGCTCGCGGGGCTTCATGAGTCGGGCGCTTCGTATGAAGAGGTCCAGCGACTGACGCGGCACCTCTG
AGCAGGACCGGTTACGAGCG

Downstream 100 bases:

>100_bases
GCGCCGCGCCCCATCATTCCCAGAGGCCGAACAAAGGACCGACCATGAAAAAGAACCTTCTGATTGCGATTGCAGTCACC
GCCGCAGCCTTGTCCAGCAC

Product: M4 family peptidase

Products: NA

Alternate protein names: Neutral protease [H]

Number of amino acids: Translated: 567; Mature: 566

Protein sequence:

>567_residues
MSARAAAARCVRAASPLRPGGVFRLGRHALRVSWPRAVAEQSPPEARENIVTTNWTRSLAGVCLVALGSACGELPDAGSP
GSADVSEMGQANMELGNGSAIIRGRLGAISAPQSLSGLRGQDLTLAADQALKPVLGGVASRFGLSPKELRVRSARVDEVG
LTHVRYDQVREGLRVVGGELIVHVDTSGQIFAVNGSARGAQAPSSLSRVSPDAAMAAAVNGLPDMKSMGTTQLVYFLDAQ
GSLFLAYELVREGERDDAPARDTVYVDAATGSVLDVHPQYHAAQNRRIHSAGNGSNLPGTLRRQEGGAATGDGHIDDNYD
HVGTTYRCYSTIFGRDSFDDAGATITSTVHYGSRYVNAFWDGRQIVFGDGDNFNSGELGRDLDVVSHEFTHAVTQYDSGL
VYRNESGALNESLSDIAAAICESWARGTVDADVWKIGEDIWTPGTSGDALRYMDNPTRDGSSRDFYPERYVGTADNGGVH
WNSGIPNLAFKLLVTGGTHPRSKTSINVSGVGMNRAAQTFYYANQFYFTANTTMAQARALTIQAAADRYPTDTVNAVRDA
WSAVGVQ

Sequences:

>Translated_567_residues
MSARAAAARCVRAASPLRPGGVFRLGRHALRVSWPRAVAEQSPPEARENIVTTNWTRSLAGVCLVALGSACGELPDAGSP
GSADVSEMGQANMELGNGSAIIRGRLGAISAPQSLSGLRGQDLTLAADQALKPVLGGVASRFGLSPKELRVRSARVDEVG
LTHVRYDQVREGLRVVGGELIVHVDTSGQIFAVNGSARGAQAPSSLSRVSPDAAMAAAVNGLPDMKSMGTTQLVYFLDAQ
GSLFLAYELVREGERDDAPARDTVYVDAATGSVLDVHPQYHAAQNRRIHSAGNGSNLPGTLRRQEGGAATGDGHIDDNYD
HVGTTYRCYSTIFGRDSFDDAGATITSTVHYGSRYVNAFWDGRQIVFGDGDNFNSGELGRDLDVVSHEFTHAVTQYDSGL
VYRNESGALNESLSDIAAAICESWARGTVDADVWKIGEDIWTPGTSGDALRYMDNPTRDGSSRDFYPERYVGTADNGGVH
WNSGIPNLAFKLLVTGGTHPRSKTSINVSGVGMNRAAQTFYYANQFYFTANTTMAQARALTIQAAADRYPTDTVNAVRDA
WSAVGVQ
>Mature_566_residues
SARAAAARCVRAASPLRPGGVFRLGRHALRVSWPRAVAEQSPPEARENIVTTNWTRSLAGVCLVALGSACGELPDAGSPG
SADVSEMGQANMELGNGSAIIRGRLGAISAPQSLSGLRGQDLTLAADQALKPVLGGVASRFGLSPKELRVRSARVDEVGL
THVRYDQVREGLRVVGGELIVHVDTSGQIFAVNGSARGAQAPSSLSRVSPDAAMAAAVNGLPDMKSMGTTQLVYFLDAQG
SLFLAYELVREGERDDAPARDTVYVDAATGSVLDVHPQYHAAQNRRIHSAGNGSNLPGTLRRQEGGAATGDGHIDDNYDH
VGTTYRCYSTIFGRDSFDDAGATITSTVHYGSRYVNAFWDGRQIVFGDGDNFNSGELGRDLDVVSHEFTHAVTQYDSGLV
YRNESGALNESLSDIAAAICESWARGTVDADVWKIGEDIWTPGTSGDALRYMDNPTRDGSSRDFYPERYVGTADNGGVHW
NSGIPNLAFKLLVTGGTHPRSKTSINVSGVGMNRAAQTFYYANQFYFTANTTMAQARALTIQAAADRYPTDTVNAVRDAW
SAVGVQ

Specific function: Extracellular zinc metalloprotease [H]

COG id: COG3227

COG function: function code E; Zinc metalloprotease (elastase)

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M4 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005075
- InterPro:   IPR013856
- InterPro:   IPR001570
- InterPro:   IPR011096 [H]

Pfam domain/function: PF07504 FTP; PF03413 PepSY; PF01447 Peptidase_M4; PF02868 Peptidase_M4_C [H]

EC number: =3.4.24.28 [H]

Molecular weight: Translated: 60343; Mature: 60212

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSARAAAARCVRAASPLRPGGVFRLGRHALRVSWPRAVAEQSPPEARENIVTTNWTRSLA
CCCHHHHHHHHHHCCCCCCCCHHHHCCHHHEEECHHHHHCCCCCHHHHCCEECCHHHHHH
GVCLVALGSACGELPDAGSPGSADVSEMGQANMELGNGSAIIRGRLGAISAPQSLSGLRG
HHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCEECCCCCEEEEECCCCCCCCHHHCCCCC
QDLTLAADQALKPVLGGVASRFGLSPKELRVRSARVDEVGLTHVRYDQVREGLRVVGGEL
CCEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCEEHHHHHHHHHEECCEE
IVHVDTSGQIFAVNGSARGAQAPSSLSRVSPDAAMAAAVNGLPDMKSMGTTQLVYFLDAQ
EEEECCCCEEEEECCCCCCCCCCHHHHHCCCHHHHHHHHCCCCCHHHCCCEEEEEEEECC
GSLFLAYELVREGERDDAPARDTVYVDAATGSVLDVHPQYHAAQNRRIHSAGNGSNLPGT
CCEEEEEHHHHCCCCCCCCCCCEEEEEECCCCEEECCCCHHHHHCCEEECCCCCCCCCCC
LRRQEGGAATGDGHIDDNYDHVGTTYRCYSTIFGRDSFDDAGATITSTVHYGSRYVNAFW
EEECCCCCCCCCCCCCCCCCCCCCHHEEHHHHHCCCCCCCCCCEEEEEEHHCCCEEEEEE
DGRQIVFGDGDNFNSGELGRDLDVVSHEFTHAVTQYDSGLVYRNESGALNESLSDIAAAI
CCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHH
CESWARGTVDADVWKIGEDIWTPGTSGDALRYMDNPTRDGSSRDFYPERYVGTADNGGVH
HHHHHCCCCCHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEE
WNSGIPNLAFKLLVTGGTHPRSKTSINVSGVGMNRAAQTFYYANQFYFTANTTMAQARAL
ECCCCCCEEEEEEEECCCCCCCCCEEEEECCCCCHHHHEEEEEEEEEEEECCHHHHHHEE
TIQAAADRYPTDTVNAVRDAWSAVGVQ
EEEECCCCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SARAAAARCVRAASPLRPGGVFRLGRHALRVSWPRAVAEQSPPEARENIVTTNWTRSLA
CCHHHHHHHHHHCCCCCCCCHHHHCCHHHEEECHHHHHCCCCCHHHHCCEECCHHHHHH
GVCLVALGSACGELPDAGSPGSADVSEMGQANMELGNGSAIIRGRLGAISAPQSLSGLRG
HHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCEECCCCCEEEEECCCCCCCCHHHCCCCC
QDLTLAADQALKPVLGGVASRFGLSPKELRVRSARVDEVGLTHVRYDQVREGLRVVGGEL
CCEEEEHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCEEHHHHHHHHHEECCEE
IVHVDTSGQIFAVNGSARGAQAPSSLSRVSPDAAMAAAVNGLPDMKSMGTTQLVYFLDAQ
EEEECCCCEEEEECCCCCCCCCCHHHHHCCCHHHHHHHHCCCCCHHHCCCEEEEEEEECC
GSLFLAYELVREGERDDAPARDTVYVDAATGSVLDVHPQYHAAQNRRIHSAGNGSNLPGT
CCEEEEEHHHHCCCCCCCCCCCEEEEEECCCCEEECCCCHHHHHCCEEECCCCCCCCCCC
LRRQEGGAATGDGHIDDNYDHVGTTYRCYSTIFGRDSFDDAGATITSTVHYGSRYVNAFW
EEECCCCCCCCCCCCCCCCCCCCCHHEEHHHHHCCCCCCCCCCEEEEEEHHCCCEEEEEE
DGRQIVFGDGDNFNSGELGRDLDVVSHEFTHAVTQYDSGLVYRNESGALNESLSDIAAAI
CCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHH
CESWARGTVDADVWKIGEDIWTPGTSGDALRYMDNPTRDGSSRDFYPERYVGTADNGGVH
HHHHHCCCCCHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEE
WNSGIPNLAFKLLVTGGTHPRSKTSINVSGVGMNRAAQTFYYANQFYFTANTTMAQARAL
ECCCCCCEEEEEEEECCCCCCCCCEEEEECCCCCHHHHEEEEEEEEEEEECCHHHHHHEE
TIQAAADRYPTDTVNAVRDAWSAVGVQ
EEEECCCCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7764969 [H]