BacMap

Definition	Myxococcus xanthus DK 1622 chromosome, complete genome.
Accession	NC_008095
Length	9,139,763

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The map label for this gene is ppiB [H]

Identifier: 108761771

GI number: 108761771

Start: 5858976

End: 5859422

Strand: Reverse

Name: ppiB [H]

Synonym: MXAN_4676

Alternate gene names: 108761771

Gene position: 5859422-5858976 (Counterclockwise)

Preceding gene: 108757811

Following gene: 108760168

Centisome position: 64.11

GC content: 72.48

Gene sequence:

>447_bases
GTGGCCGCCCCGGCGCGCGCGGGGCTCGTGCTGCGCACCGACAAGGGGGACATCACCGTGCGGCTGGACGTGGACGAGGC
GCCCCTCACGTCGGGCAACCTCCACGCGCTGGCGCGCAAGGGCTATTTCAACGGCGTCACCTTCCACCGCGTGGTGCCGG
ACTTCGTCGCGCAGGGCGGAGACCCGCGCGGGGACGGTGAGGGCGGGCCGGGGTACTCCATTCGCTGCGAGATGACGCGT
CGGCCCTACGGCCGAGGCACCCTGGGCATGGCCCTGGCCGGGAAGGACACCGGTGGCAGCCAGTTCTTCTTCACCCACGC
CCCGCAGCCGCACCTGGACGGCCGCTACACGGCCTTTGGCGAGGTGGTGTCCGGCATGGACGTGGTTGACGCCCTCCTGG
AAGGGGACGTCATCCGCGAAGCGCGCGCGGTGGAGCTGGCGCCCTGA

Upstream 100 bases:

>100_bases
CGCCAACGTGCGGCGCGTGGCGGCGCAGGCCCTCACGCAGTTGACGGGGCAGCGGGTGCGCTCGGCGCGCGTGGAGCTGC
CCGCGAACACCTTCCGGCCC

Downstream 100 bases:

>100_bases
AGCGTCGATTCAGGCGCCGCTGGCACGGGCCAGGGGCGCGGGAGGACCGAGCGGGTCGCTGTTCCAGCGCTCGTTCTCCG
CCGCTTCCAAGGCCTCGACT

Product: cyclophilin-type peptidylprolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 148; Mature: 147

Protein sequence:

>148_residues
MAAPARAGLVLRTDKGDITVRLDVDEAPLTSGNLHALARKGYFNGVTFHRVVPDFVAQGGDPRGDGEGGPGYSIRCEMTR
RPYGRGTLGMALAGKDTGGSQFFFTHAPQPHLDGRYTAFGEVVSGMDVVDALLEGDVIREARAVELAP

Sequences:

>Translated_148_residues
MAAPARAGLVLRTDKGDITVRLDVDEAPLTSGNLHALARKGYFNGVTFHRVVPDFVAQGGDPRGDGEGGPGYSIRCEMTR
RPYGRGTLGMALAGKDTGGSQFFFTHAPQPHLDGRYTAFGEVVSGMDVVDALLEGDVIREARAVELAP
>Mature_147_residues
AAPARAGLVLRTDKGDITVRLDVDEAPLTSGNLHALARKGYFNGVTFHRVVPDFVAQGGDPRGDGEGGPGYSIRCEMTRR
PYGRGTLGMALAGKDTGGSQFFFTHAPQPHLDGRYTAFGEVVSGMDVVDALLEGDVIREARAVELAP

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI7706339, Length=127, Percent_Identity=46.4566929133858, Blast_Score=105, Evalue=2e-23,
Organism=Homo sapiens, GI19557636, Length=132, Percent_Identity=40.9090909090909, Blast_Score=102, Evalue=8e-23,
Organism=Homo sapiens, GI24308049, Length=128, Percent_Identity=44.53125, Blast_Score=100, Evalue=4e-22,
Organism=Homo sapiens, GI64276486, Length=124, Percent_Identity=40.3225806451613, Blast_Score=87, Evalue=5e-18,
Organism=Homo sapiens, GI4758950, Length=111, Percent_Identity=46.8468468468468, Blast_Score=83, Evalue=9e-17,
Organism=Homo sapiens, GI10863927, Length=125, Percent_Identity=40, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI256017253, Length=128, Percent_Identity=39.84375, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI221139811, Length=128, Percent_Identity=39.84375, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI256017251, Length=128, Percent_Identity=39.84375, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI4505991, Length=129, Percent_Identity=44.1860465116279, Blast_Score=81, Evalue=4e-16,
Organism=Homo sapiens, GI178057341, Length=129, Percent_Identity=38.7596899224806, Blast_Score=80, Evalue=5e-16,
Organism=Homo sapiens, GI4826932, Length=133, Percent_Identity=39.0977443609023, Blast_Score=80, Evalue=6e-16,
Organism=Homo sapiens, GI42560244, Length=130, Percent_Identity=39.2307692307692, Blast_Score=80, Evalue=7e-16,
Organism=Homo sapiens, GI209417936, Length=127, Percent_Identity=39.3700787401575, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI30102944, Length=127, Percent_Identity=39.3700787401575, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI219842199, Length=127, Percent_Identity=39.3700787401575, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI5031987, Length=125, Percent_Identity=40.8, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI310127646, Length=125, Percent_Identity=38.4, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI310114371, Length=125, Percent_Identity=38.4, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI310119221, Length=125, Percent_Identity=38.4, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI303305009, Length=141, Percent_Identity=36.8794326241135, Blast_Score=78, Evalue=3e-15,
Organism=Homo sapiens, GI45439316, Length=143, Percent_Identity=35.6643356643357, Blast_Score=78, Evalue=3e-15,
Organism=Homo sapiens, GI6631100, Length=137, Percent_Identity=38.6861313868613, Blast_Score=77, Evalue=4e-15,
Organism=Homo sapiens, GI5174637, Length=122, Percent_Identity=39.344262295082, Blast_Score=77, Evalue=6e-15,
Organism=Homo sapiens, GI150418007, Length=125, Percent_Identity=40.8, Blast_Score=76, Evalue=9e-15,
Organism=Homo sapiens, GI22547212, Length=129, Percent_Identity=41.0852713178295, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI7657473, Length=129, Percent_Identity=41.0852713178295, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI20911035, Length=140, Percent_Identity=34.2857142857143, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI22547215, Length=129, Percent_Identity=41.0852713178295, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI310129267, Length=126, Percent_Identity=36.5079365079365, Blast_Score=74, Evalue=3e-14,
Organism=Homo sapiens, GI310120620, Length=126, Percent_Identity=36.5079365079365, Blast_Score=74, Evalue=3e-14,
Organism=Homo sapiens, GI310110104, Length=126, Percent_Identity=36.5079365079365, Blast_Score=74, Evalue=6e-14,
Organism=Homo sapiens, GI169164185, Length=125, Percent_Identity=36.8, Blast_Score=70, Evalue=8e-13,
Organism=Homo sapiens, GI169163623, Length=125, Percent_Identity=36.8, Blast_Score=70, Evalue=8e-13,
Organism=Homo sapiens, GI169163387, Length=125, Percent_Identity=36.8, Blast_Score=70, Evalue=9e-13,
Organism=Homo sapiens, GI310127745, Length=143, Percent_Identity=32.1678321678322, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI310119290, Length=143, Percent_Identity=32.1678321678322, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI310114540, Length=139, Percent_Identity=34.5323741007194, Blast_Score=68, Evalue=2e-12,
Organism=Homo sapiens, GI169214050, Length=126, Percent_Identity=35.7142857142857, Blast_Score=68, Evalue=2e-12,
Organism=Homo sapiens, GI239751853, Length=126, Percent_Identity=35.7142857142857, Blast_Score=68, Evalue=3e-12,
Organism=Homo sapiens, GI113428306, Length=126, Percent_Identity=35.7142857142857, Blast_Score=68, Evalue=3e-12,
Organism=Escherichia coli, GI1789763, Length=142, Percent_Identity=37.3239436619718, Blast_Score=78, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17539496, Length=126, Percent_Identity=44.4444444444444, Blast_Score=110, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17506311, Length=126, Percent_Identity=44.4444444444444, Blast_Score=101, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71980594, Length=130, Percent_Identity=39.2307692307692, Blast_Score=100, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI71980590, Length=130, Percent_Identity=39.2307692307692, Blast_Score=100, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI71997782, Length=140, Percent_Identity=39.2857142857143, Blast_Score=92, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17506307, Length=128, Percent_Identity=46.09375, Blast_Score=87, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17552780, Length=123, Percent_Identity=45.5284552845528, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17559074, Length=134, Percent_Identity=40.2985074626866, Blast_Score=82, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17552784, Length=156, Percent_Identity=37.1794871794872, Blast_Score=82, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17532641, Length=133, Percent_Identity=33.8345864661654, Blast_Score=82, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17552782, Length=133, Percent_Identity=37.593984962406, Blast_Score=80, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17539498, Length=122, Percent_Identity=39.344262295082, Blast_Score=79, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17566266, Length=134, Percent_Identity=39.5522388059701, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17565860, Length=132, Percent_Identity=39.3939393939394, Blast_Score=76, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17551284, Length=100, Percent_Identity=44, Blast_Score=74, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17551282, Length=100, Percent_Identity=44, Blast_Score=73, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI32563659, Length=140, Percent_Identity=32.1428571428571, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17532643, Length=127, Percent_Identity=38.5826771653543, Blast_Score=70, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6323562, Length=128, Percent_Identity=42.96875, Blast_Score=86, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6320359, Length=125, Percent_Identity=44, Blast_Score=84, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6321848, Length=118, Percent_Identity=43.2203389830509, Blast_Score=80, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320510, Length=113, Percent_Identity=43.3628318584071, Blast_Score=79, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323246, Length=92, Percent_Identity=42.3913043478261, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17986117, Length=129, Percent_Identity=45.7364341085271, Blast_Score=110, Evalue=4e-25,
Organism=Drosophila melanogaster, GI19922376, Length=140, Percent_Identity=37.8571428571429, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI21357249, Length=128, Percent_Identity=41.40625, Blast_Score=100, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24652460, Length=130, Percent_Identity=36.1538461538462, Blast_Score=90, Evalue=5e-19,
Organism=Drosophila melanogaster, GI20130249, Length=123, Percent_Identity=46.3414634146341, Blast_Score=87, Evalue=4e-18,
Organism=Drosophila melanogaster, GI19922912, Length=129, Percent_Identity=46.5116279069767, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI45549139, Length=125, Percent_Identity=40, Blast_Score=81, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24650807, Length=148, Percent_Identity=39.8648648648649, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24664125, Length=129, Percent_Identity=39.5348837209302, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21357783, Length=129, Percent_Identity=39.5348837209302, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17647301, Length=128, Percent_Identity=37.5, Blast_Score=77, Evalue=6e-15,
Organism=Drosophila melanogaster, GI21355677, Length=137, Percent_Identity=35.7664233576642, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24586038, Length=134, Percent_Identity=33.5820895522388, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17136360, Length=132, Percent_Identity=37.1212121212121, Blast_Score=63, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 15701; Mature: 15570

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAPARAGLVLRTDKGDITVRLDVDEAPLTSGNLHALARKGYFNGVTFHRVVPDFVAQGG
CCCCCCCCEEEEECCCCEEEEEECCCCCCCCCCEEEEEECCCCCCEEHHHHHHHHHHCCC
DPRGDGEGGPGYSIRCEMTRRPYGRGTLGMALAGKDTGGSQFFFTHAPQPHLDGRYTAFG
CCCCCCCCCCCEEEEEEECCCCCCCCCEEEEEECCCCCCCEEEEECCCCCCCCCCEEHHH
EVVSGMDVVDALLEGDVIREARAVELAP
HHHCCHHHHHHHHCCCHHCCCCEEECCC
>Mature Secondary Structure 
AAPARAGLVLRTDKGDITVRLDVDEAPLTSGNLHALARKGYFNGVTFHRVVPDFVAQGG
CCCCCCCEEEEECCCCEEEEEECCCCCCCCCCEEEEEECCCCCCEEHHHHHHHHHHCCC
DPRGDGEGGPGYSIRCEMTRRPYGRGTLGMALAGKDTGGSQFFFTHAPQPHLDGRYTAFG
CCCCCCCCCCCEEEEEEECCCCCCCCCEEEEEECCCCCCCEEEEECCCCCCCCCCEEHHH
EVVSGMDVVDALLEGDVIREARAVELAP
HHHCCHHHHHHHHCCCHHCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9317025; 9665876 [H]