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The map label for this gene is nla6 [H]

Identifier: 108761709

GI number: 108761709

Start: 4951501

End: 4952955

Strand: Reverse

Name: nla6 [H]

Synonym: MXAN_4042

Alternate gene names: 108761709

Gene position: 4952955-4951501 (Counterclockwise)

Preceding gene: 108760882

Following gene: 108758691

Centisome position: 54.19

GC content: 67.77

Gene sequence:

>1455_bases
TTGGGCAGCGCACGAATCCTGGCCGTGGATGACGAACGCGACACGTGTGAGGCGCTGGCGGACATGCTCAGTGCCTGGGG
GCACAAGGTCGAGATCGCATTCGACGGGCATGACGCCCTTCGCAAGGCGAACGAGTTCCGGCCGGACGTGGTCTTGTCGG
ATCTGGCCATGCCGGAGACGGATGGGCTCTGGTTGCTGCGCAACCTGAAGGAGGAGCTGCCGGACTGCCCGGTGGTCTTC
CTGACGGGGCGAGGCACCATTGACGCCGCGGTGGAGTCCATCCGCGAGGGCGCCTACGACTTCATCGTCAAGCCGCTGGA
TACCGCGCGGCTCAAGGTCTGTATCGACCGGGCGCTGGAGAAGAAAGAGACGATGCGCGAGGTGCAGACGCTGCGGCGGC
GTCTGAAGCAGCTCGGCTCGTCGGACCTGATTGCCCAGTCCGTGGGCATGCGCAAGGTCATCGAGCTGGTGGAGAAGGTG
GCGCCCTCCAAGGCCAGCGTGTCCATCAGCGGCGAGTCCGGCACGGGCAAGGAAGTGGTGTCCCGCGCGGTGCACAATCT
GTCCTTGCGCCGCGACAAGCCCTTCATCGCCATCAACTGCGCGTCCATCCCGGCCACGCTCATCGAGTCCGAGCTGTTCG
GCCACGAGCGCGGCGCCTTCACCGGCGCTGATCAGCGGCGGCCCGGCGTGTTCGAGATGGCCCACGGCGGCACGCTCTTC
CTGGACGAATTGGGTGAGATCCCCATCGAGTTGCAGGCCAAGCTCCTGCGCGTGCTGGAAGAGGGCAAGCTGCGCCGGCT
GGGCGGCAAGGTGGAGATCGAGGTGGACGTGCGCGTGCTCTGCGCCACCAACCGTGACCTCAAGCAGGAGATCAAGAACG
GGCGCTTCCGCGAGGATCTCTACTTCCGCCTCAACGTCTTCCAGATCCACCTGCCGCCCCTGCGCGAGCGCCGCGATGAC
GTCCCCATCCTGGTGCAGCACTTCGTGGACAAGTTCCGCGGCGACTCCGGCAAGCGCGTCAGCGGCGTGCACCCGGAGGC
CATGGAGGTCCTGAAGAACTACGACTGGCCGGGCAACATCCGCGAGCTGCGCAACGCGGTGGAGCGCGCCGTCATCCTGT
GCGACGGGGAGCTGATCACCCGCGAGCACCTGCCGCCCGACATGGCCGGCAAGAGCCCGGAGCGCCACACCTTCCGGCTG
CCCTTCGGGCTGAGCCTGGACGCGGTGGAGCGCGAGTACATCCTGGGCAGCCTCCAGCGGAACGGGAACAACAAGGCCCG
CACCGCCGAGGTGCTGGGGGTGAGCGAGAAGACCCTCTACAACAAGCTCAACCGCTACGCGGCCGAGGCCCGCGCGCAAC
AGGCGCCCGGCGGCGGTGGCGGCGGCCCCCTGGGCGGGCAGGGGAGTGACGGCGCGATGGGGGCCATGGGCACCAACTCG
TTCGTCATCCGCTGA

Upstream 100 bases:

>100_bases
CTGAGTTTCTCCCGCGCCTGAGCGTCTCATCCAGGCGGGCCGGCTTCTGATTTCGAGTCACGACAACTTCGCGTCACGAC
GCAGTACGGGAGGTCTTCAC

Downstream 100 bases:

>100_bases
CCTCACAGGTAGGAAATCCCCTTCGGGTTCCGGGCTCTTGGCCTGGCTCGGAGGGGACGCCCGTCCAGGCGGCGACCCCG
CCGCGAAACCCCCGTCAATT

Product: sigma-54 dependent DNA-binding reponse regulator Nla6

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 484; Mature: 483

Protein sequence:

>484_residues
MGSARILAVDDERDTCEALADMLSAWGHKVEIAFDGHDALRKANEFRPDVVLSDLAMPETDGLWLLRNLKEELPDCPVVF
LTGRGTIDAAVESIREGAYDFIVKPLDTARLKVCIDRALEKKETMREVQTLRRRLKQLGSSDLIAQSVGMRKVIELVEKV
APSKASVSISGESGTGKEVVSRAVHNLSLRRDKPFIAINCASIPATLIESELFGHERGAFTGADQRRPGVFEMAHGGTLF
LDELGEIPIELQAKLLRVLEEGKLRRLGGKVEIEVDVRVLCATNRDLKQEIKNGRFREDLYFRLNVFQIHLPPLRERRDD
VPILVQHFVDKFRGDSGKRVSGVHPEAMEVLKNYDWPGNIRELRNAVERAVILCDGELITREHLPPDMAGKSPERHTFRL
PFGLSLDAVEREYILGSLQRNGNNKARTAEVLGVSEKTLYNKLNRYAAEARAQQAPGGGGGGPLGGQGSDGAMGAMGTNS
FVIR

Sequences:

>Translated_484_residues
MGSARILAVDDERDTCEALADMLSAWGHKVEIAFDGHDALRKANEFRPDVVLSDLAMPETDGLWLLRNLKEELPDCPVVF
LTGRGTIDAAVESIREGAYDFIVKPLDTARLKVCIDRALEKKETMREVQTLRRRLKQLGSSDLIAQSVGMRKVIELVEKV
APSKASVSISGESGTGKEVVSRAVHNLSLRRDKPFIAINCASIPATLIESELFGHERGAFTGADQRRPGVFEMAHGGTLF
LDELGEIPIELQAKLLRVLEEGKLRRLGGKVEIEVDVRVLCATNRDLKQEIKNGRFREDLYFRLNVFQIHLPPLRERRDD
VPILVQHFVDKFRGDSGKRVSGVHPEAMEVLKNYDWPGNIRELRNAVERAVILCDGELITREHLPPDMAGKSPERHTFRL
PFGLSLDAVEREYILGSLQRNGNNKARTAEVLGVSEKTLYNKLNRYAAEARAQQAPGGGGGGPLGGQGSDGAMGAMGTNS
FVIR
>Mature_483_residues
GSARILAVDDERDTCEALADMLSAWGHKVEIAFDGHDALRKANEFRPDVVLSDLAMPETDGLWLLRNLKEELPDCPVVFL
TGRGTIDAAVESIREGAYDFIVKPLDTARLKVCIDRALEKKETMREVQTLRRRLKQLGSSDLIAQSVGMRKVIELVEKVA
PSKASVSISGESGTGKEVVSRAVHNLSLRRDKPFIAINCASIPATLIESELFGHERGAFTGADQRRPGVFEMAHGGTLFL
DELGEIPIELQAKLLRVLEEGKLRRLGGKVEIEVDVRVLCATNRDLKQEIKNGRFREDLYFRLNVFQIHLPPLRERRDDV
PILVQHFVDKFRGDSGKRVSGVHPEAMEVLKNYDWPGNIRELRNAVERAVILCDGELITREHLPPDMAGKSPERHTFRLP
FGLSLDAVEREYILGSLQRNGNNKARTAEVLGVSEKTLYNKLNRYAAEARAQQAPGGGGGGPLGGQGSDGAMGAMGTNSF
VIR

Specific function: Member of the two-component regulatory system zraS/zraR. When activated by zraS it acts in conjunction with sigma-54 to regulate the expression of zraP. Positively autoregulates the expression of the zraSR operon [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1790437, Length=445, Percent_Identity=44.7191011235955, Blast_Score=385, Evalue=1e-108,
Organism=Escherichia coli, GI1788550, Length=451, Percent_Identity=42.5720620842572, Blast_Score=375, Evalue=1e-105,
Organism=Escherichia coli, GI1790299, Length=467, Percent_Identity=36.6167023554604, Blast_Score=314, Evalue=8e-87,
Organism=Escherichia coli, GI1788905, Length=452, Percent_Identity=38.716814159292, Blast_Score=303, Evalue=1e-83,
Organism=Escherichia coli, GI87082117, Length=242, Percent_Identity=54.5454545454545, Blast_Score=281, Evalue=7e-77,
Organism=Escherichia coli, GI1789233, Length=317, Percent_Identity=44.4794952681388, Blast_Score=268, Evalue=6e-73,
Organism=Escherichia coli, GI1789087, Length=298, Percent_Identity=46.6442953020134, Blast_Score=267, Evalue=1e-72,
Organism=Escherichia coli, GI87082152, Length=315, Percent_Identity=42.8571428571429, Blast_Score=239, Evalue=2e-64,
Organism=Escherichia coli, GI87081872, Length=309, Percent_Identity=43.6893203883495, Blast_Score=224, Evalue=9e-60,
Organism=Escherichia coli, GI1787583, Length=332, Percent_Identity=38.855421686747, Blast_Score=222, Evalue=5e-59,
Organism=Escherichia coli, GI1786524, Length=318, Percent_Identity=39.622641509434, Blast_Score=222, Evalue=5e-59,
Organism=Escherichia coli, GI87081858, Length=302, Percent_Identity=32.1192052980132, Blast_Score=162, Evalue=4e-41,
Organism=Escherichia coli, GI1789828, Length=285, Percent_Identity=32.9824561403509, Blast_Score=146, Evalue=3e-36,
Organism=Escherichia coli, GI1787375, Length=137, Percent_Identity=30.6569343065693, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 53585; Mature: 53454

Theoretical pI: Translated: 7.06; Mature: 7.06

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSARILAVDDERDTCEALADMLSAWGHKVEIAFDGHDALRKANEFRPDVVLSDLAMPET
CCCCEEEEECCCCHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHCCCCCHHHHHCCCCCC
DGLWLLRNLKEELPDCPVVFLTGRGTIDAAVESIREGAYDFIVKPLDTARLKVCIDRALE
CCHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHCCCHHHEECCCCHHHHHHHHHHHHH
KKETMREVQTLRRRLKQLGSSDLIAQSVGMRKVIELVEKVAPSKASVSISGESGTGKEVV
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHH
SRAVHNLSLRRDKPFIAINCASIPATLIESELFGHERGAFTGADQRRPGVFEMAHGGTLF
HHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCEEE
LDELGEIPIELQAKLLRVLEEGKLRRLGGKVEIEVDVRVLCATNRDLKQEIKNGRFREDL
EHHHCCCCHHHHHHHHHHHHHCCHHHCCCEEEEEEEEEEEEECCHHHHHHHHCCCCCEEE
YFRLNVFQIHLPPLRERRDDVPILVQHFVDKFRGDSGKRVSGVHPEAMEVLKNYDWPGNI
EEEEEEEEEECCCHHHCCCCCHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHCCCCCCCH
RELRNAVERAVILCDGELITREHLPPDMAGKSPERHTFRLPFGLSLDAVEREYILGSLQR
HHHHHHHHHEEEEECCCEEECCCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHC
NGNNKARTAEVLGVSEKTLYNKLNRYAAEARAQQAPGGGGGGPLGGQGSDGAMGAMGTNS
CCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC
FVIR
EEEC
>Mature Secondary Structure 
GSARILAVDDERDTCEALADMLSAWGHKVEIAFDGHDALRKANEFRPDVVLSDLAMPET
CCCEEEEECCCCHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHCCCCCHHHHHCCCCCC
DGLWLLRNLKEELPDCPVVFLTGRGTIDAAVESIREGAYDFIVKPLDTARLKVCIDRALE
CCHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHCCCHHHEECCCCHHHHHHHHHHHHH
KKETMREVQTLRRRLKQLGSSDLIAQSVGMRKVIELVEKVAPSKASVSISGESGTGKEVV
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHHHH
SRAVHNLSLRRDKPFIAINCASIPATLIESELFGHERGAFTGADQRRPGVFEMAHGGTLF
HHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCEEE
LDELGEIPIELQAKLLRVLEEGKLRRLGGKVEIEVDVRVLCATNRDLKQEIKNGRFREDL
EHHHCCCCHHHHHHHHHHHHHCCHHHCCCEEEEEEEEEEEEECCHHHHHHHHCCCCCEEE
YFRLNVFQIHLPPLRERRDDVPILVQHFVDKFRGDSGKRVSGVHPEAMEVLKNYDWPGNI
EEEEEEEEEECCCHHHCCCCCHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHCCCCCCCH
RELRNAVERAVILCDGELITREHLPPDMAGKSPERHTFRLPFGLSLDAVEREYILGSLQR
HHHHHHHHHEEEEECCCEEECCCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHC
NGNNKARTAEVLGVSEKTLYNKLNRYAAEARAQQAPGGGGGGPLGGQGSDGAMGAMGTNS
CCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCC
FVIR
EEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]