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The map label for this gene is hemH [H]

Identifier: 108761702

GI number: 108761702

Start: 1805525

End: 1806619

Strand: Direct

Name: hemH [H]

Synonym: MXAN_1537

Alternate gene names: 108761702

Gene position: 1805525-1806619 (Clockwise)

Preceding gene: 108757984

Following gene: 108763710

Centisome position: 19.75

GC content: 71.05

Gene sequence:

>1095_bases
ATGCCAACGCCCACTTCGAAGCGAGGGCTGCTGCTCGTCAACCTGGGGACGCCGGATGCTCCGCAGACGGGGCCCGTGCG
CCGCTACCTGCGCGAGTTCCTCAATGACCCGCGCGTCATCGACATCCACCCGCTGGGGCGCTGGGCGCTGCTCAACTTCA
TCATCCTTCCGATGCGTCCGGCGAAGAGCGCGGAGGCGTACCGCAAAATCTGGATGAAGGAGGGCTCGCCGCTGCTCGTG
TACAGCCAGGCCCTGGCGGCCCAGGTGGCCGAGCGGCTGGCGGGGGAGTACGAGGTGGTGCTGGCCATGCGGTATGGCTC
GCCCTCCATCCCCGACGGCATCGCGGCGCTCAAGGCGCGCGGCGTGTCGGAGTTCACCGTGCTGCCGCTGTACCCGCAGG
AGGCCGCGTCCTCCACCGCGTCCTCGCTGGCGCGCACCTATGAGGTGCTGGCCCAGTCGTGGGACGTGCCCTTCGTGCGC
GCGGTGCCGGCCTTCTTCGAGCACCCAGGCTTCCTGGATGCCTTCACGGCCGTGGCGCGGCCGGTGATTGACGACGCGCG
CGCCGACTACGTCCTCTTCAGCTTCCATGGCCTGCCGGAGCGGCACATGCGCAAGAGCGACCCCACGGGGACGCACTGCC
TGTCCACCGCCTCGTGCTGCGACGCCATGACGGACGCCAACCGCCACTGCTACCGCGCGCAGAGCTACGCGACGGCGCGG
GGGCTGGCCCAGCGGCTGGGCCTGCCGGCGGAGGGGTGGAGCGTGTCCTTCCAGTCGCGGCTGGGCCGCACGCCGTGGGT
GAAGCCGTACACGGACGTGGTGTTGCCGGAGCTGGCGAAGAAGGGCGTGAAGCGCCTGGCGGTGATGTGCCCGGCCTTCG
TGGCGGACTGCCTGGAGACGCTGGAGGAGATTGGCCTCCGCGCGCGGGAGCAGTTCCTGGAGGCGGGAGGGGAGTCGCTG
ACGTTGGTCCCCTCCCTCAACGCCCACCCGGCCTGGGTGGACGCCGTGGTGCGCATGGTGCGCGAGTCGGACGGGCCGCC
TACTGCTGTGGCTGGGCCGTTGGCGTCGGCGCGGGAGCCGATTCCACCGCGGTGA

Upstream 100 bases:

>100_bases
GCACCATGCGCGGCACCTATGACATGGTGCGGCCGGACGGCACGCACTTCGAAGCGCGCATCGCCGAGTTCGCGCTCACC
CTTCCCAACTCCCTGCACTG

Downstream 100 bases:

>100_bases
GGCGCAGCTTCAGGGCGCCGGTGGGCACCTGGAGCGCGGCGGTGGGGAAGCCGCCCTTCGTCACCGACGTGACGGTGCCT
TCCCACGAGCGCCACCGCCC

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 364; Mature: 363

Protein sequence:

>364_residues
MPTPTSKRGLLLVNLGTPDAPQTGPVRRYLREFLNDPRVIDIHPLGRWALLNFIILPMRPAKSAEAYRKIWMKEGSPLLV
YSQALAAQVAERLAGEYEVVLAMRYGSPSIPDGIAALKARGVSEFTVLPLYPQEAASSTASSLARTYEVLAQSWDVPFVR
AVPAFFEHPGFLDAFTAVARPVIDDARADYVLFSFHGLPERHMRKSDPTGTHCLSTASCCDAMTDANRHCYRAQSYATAR
GLAQRLGLPAEGWSVSFQSRLGRTPWVKPYTDVVLPELAKKGVKRLAVMCPAFVADCLETLEEIGLRAREQFLEAGGESL
TLVPSLNAHPAWVDAVVRMVRESDGPPTAVAGPLASAREPIPPR

Sequences:

>Translated_364_residues
MPTPTSKRGLLLVNLGTPDAPQTGPVRRYLREFLNDPRVIDIHPLGRWALLNFIILPMRPAKSAEAYRKIWMKEGSPLLV
YSQALAAQVAERLAGEYEVVLAMRYGSPSIPDGIAALKARGVSEFTVLPLYPQEAASSTASSLARTYEVLAQSWDVPFVR
AVPAFFEHPGFLDAFTAVARPVIDDARADYVLFSFHGLPERHMRKSDPTGTHCLSTASCCDAMTDANRHCYRAQSYATAR
GLAQRLGLPAEGWSVSFQSRLGRTPWVKPYTDVVLPELAKKGVKRLAVMCPAFVADCLETLEEIGLRAREQFLEAGGESL
TLVPSLNAHPAWVDAVVRMVRESDGPPTAVAGPLASAREPIPPR
>Mature_363_residues
PTPTSKRGLLLVNLGTPDAPQTGPVRRYLREFLNDPRVIDIHPLGRWALLNFIILPMRPAKSAEAYRKIWMKEGSPLLVY
SQALAAQVAERLAGEYEVVLAMRYGSPSIPDGIAALKARGVSEFTVLPLYPQEAASSTASSLARTYEVLAQSWDVPFVRA
VPAFFEHPGFLDAFTAVARPVIDDARADYVLFSFHGLPERHMRKSDPTGTHCLSTASCCDAMTDANRHCYRAQSYATARG
LAQRLGLPAEGWSVSFQSRLGRTPWVKPYTDVVLPELAKKGVKRLAVMCPAFVADCLETLEEIGLRAREQFLEAGGESLT
LVPSLNAHPAWVDAVVRMVRESDGPPTAVAGPLASAREPIPPR

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499021, Length=349, Percent_Identity=23.7822349570201, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI60499025, Length=348, Percent_Identity=23.8505747126437, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI1786681, Length=336, Percent_Identity=38.6904761904762, Blast_Score=228, Evalue=6e-61,
Organism=Drosophila melanogaster, GI17864156, Length=356, Percent_Identity=22.4719101123595, Blast_Score=83, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 39846; Mature: 39715

Theoretical pI: Translated: 8.35; Mature: 8.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTPTSKRGLLLVNLGTPDAPQTGPVRRYLREFLNDPRVIDIHPLGRWALLNFIILPMRP
CCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHCCCCC
AKSAEAYRKIWMKEGSPLLVYSQALAAQVAERLAGEYEVVLAMRYGSPSIPDGIAALKAR
CCHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHHHHC
GVSEFTVLPLYPQEAASSTASSLARTYEVLAQSWDVPFVRAVPAFFEHPGFLDAFTAVAR
CCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHH
PVIDDARADYVLFSFHGLPERHMRKSDPTGTHCLSTASCCDAMTDANRHCYRAQSYATAR
HHHHHCCCCEEEEEECCCCHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
GLAQRLGLPAEGWSVSFQSRLGRTPWVKPYTDVVLPELAKKGVKRLAVMCPAFVADCLET
HHHHHCCCCCCCCCEEHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEEIGLRAREQFLEAGGESLTLVPSLNAHPAWVDAVVRMVRESDGPPTAVAGPLASAREP
HHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCHHHCCHHHCCCC
IPPR
CCCC
>Mature Secondary Structure 
PTPTSKRGLLLVNLGTPDAPQTGPVRRYLREFLNDPRVIDIHPLGRWALLNFIILPMRP
CCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHCCCCC
AKSAEAYRKIWMKEGSPLLVYSQALAAQVAERLAGEYEVVLAMRYGSPSIPDGIAALKAR
CCHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHHHHC
GVSEFTVLPLYPQEAASSTASSLARTYEVLAQSWDVPFVRAVPAFFEHPGFLDAFTAVAR
CCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHH
PVIDDARADYVLFSFHGLPERHMRKSDPTGTHCLSTASCCDAMTDANRHCYRAQSYATAR
HHHHHCCCCEEEEEECCCCHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
GLAQRLGLPAEGWSVSFQSRLGRTPWVKPYTDVVLPELAKKGVKRLAVMCPAFVADCLET
HHHHHCCCCCCCCCEEHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEEIGLRAREQFLEAGGESLTLVPSLNAHPAWVDAVVRMVRESDGPPTAVAGPLASAREP
HHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCHHHCCHHHCCCC
IPPR
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA