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The map label for this gene is uvrC

Identifier: 108761605

GI number: 108761605

Start: 3075439

End: 3077379

Strand: Direct

Name: uvrC

Synonym: MXAN_2633

Alternate gene names: 108761605

Gene position: 3075439-3077379 (Clockwise)

Preceding gene: 108759548

Following gene: 108761855

Centisome position: 33.65

GC content: 66.82

Gene sequence:

>1941_bases
ATGGACGCGAAGCTCCTGGAGAAGCTGGACGCACTGCCCACCGAGCCCGGCGTGTACCTGATGAAGGACCGCCGGGGTCA
GGTCATCTACGTGGGCAAGGCCATCAACCTGCGCAGCAGGGTGCGCTCGTACTTCAACCGCACCGGCGACACGCGCGTCT
TCGTGTCCTTGTTGGACCAGTTGCTGGGTGACCTGGAGACGGTGCTCGTCAGCAACGAGAAGGAAGCGCTGCTGCTCGAA
AACGAGCTCATCAAGAAGCACCGGCCGCGCTTCAACGTCCTGCTCAAGGACGACAAGCAGTTCATCTCCCTGCGCCTGGA
CCGCACCCAGCCCTATCCGCGCCTGGAAGTGGTGCGCAAATACGAGCGCGACGGCGCGCGCTACTTCGGGCCGTACTCCA
GCGCGGGGGCCATCCGCGAGACGCTGCGGGTGGTCAACCGCTTCTTCCGCCTGCGCACGTGCACCGACCACGTGCTGGCC
AACCGCAAGCGGCCCTGCTTGTTGCACCAGATTGGCCGTTGCCCGGCCCCGTGCGTGTACCCGGTGCCCCAGGAGGACTA
CCACCGCAGCGTGGACGAGGTGGTGATGTTCCTGGAGGGCAAGGCGGGGGAGCTGGTGGAGGGCCTGCGCCTGCGCATGA
AGCGCGCCGCGCAGGAGCTGAAGTTCGAGGAGGCCGCGCGGATACGGGACCAGCTCAACGCCATCGAGCGGAGCCTGGAG
CGGCAGAAGGTCGCCACCACCGACTTCAAGGACCAGGATGTCTTCGCCTTCCACCGGGAAGGGGACCGCATCCTGTTCTA
CGTCCTGTGGGTGCGGCAGGGCCGGCTCAACGGCGGGCAGGCCTTCCCCTTCGGCAGCCAGGAGTTTCCCGACGAGGAGC
TGATCGCCTCGTTCGTCAACCTCTACTACGACCAGGGCAGCTTCGTGCCGGAGGAGGTGCTGCTGCCGCTGGAGCTGGAG
GACGGCACCGGGGGGCTCGAGGCACTCCTCACGGAGCGCAAGGGCGAGCGCGTGCGCGTCCTGGTGCCCAAGCGCGGGGA
GAAGCTGGACCTGGTGAAGATGGCGGCGAAGAACGCCGAACAGGCCTTCGTGGAGCGCCGACGCACGAAGGACGAAACGG
ACACCGTGCTGTCCCGGCTCCAACAGCGGCTGGGGCTGCGCAACTTCCCGTGCCGGATGGAGTGCTTCGACATCTCGCAC
TTCCAGGGGTCGGCCATCGTCGCGTCGCAGGTGGCGGTGACGGACGGGGACGCGGACAAGTCGCGCTACCGGAAGTACAA
AATCAAGACGCTGGAGAAGCAGGACGACTTCGCCAGCATGTACGAGGTCATCTCCCGCCGCCTGAAGAAGGGCCTGGAGG
ACAATGACCTGCCGGACCTGCTCGTCATCGACGGAGGCAAGGGGCAACTGGCCAGCGCGCACGCGGCGATGAAGGACGTG
GGCGTGGAGTCGGTGGACGTGGTGGGTCTGGCCAAGAGCCGCGACCTGGAGGTGTTCGACCGCGACGCGGAGAGCGCCCG
GAGCCCCGAGCGCATCTTCGTGGTGGGGCGCAAGGACCCCATCGTCCTGTCCCAGAACTCGGCGGAGATGTTCATGCTCA
CGCGAATGCGGGACGAGGCCCACCGCTTCGCCATCACCTTCCAGAAGCAGGTGCTGCGCAAGAGCCGGGTGCGTTCGGCG
CTGGAGGACATCCCGGGCGTGGGGGAGACGCGGCGCAAGCAACTGCTTCGGCACTTCGGCTCGCTCAAGCGGGTGGGGGA
CGCCTCCATCGAGGAGCTCGCGGAGGTCGTCGGACCGGCCATGGCGGAACGCGTCCATGCGGGCCTTCACGGACATCCAG
AAGAGGATGCGGAAGATCCCGTACGGGAGGCTTCCCTTGACGACGCGCACGAACCCGTTGACGAAAAAACGCAGGGAGGG
TCGCCACCCGGGGCAGCGTGA

Upstream 100 bases:

>100_bases
GGCGAAGGCGGCGGAAGCGGAAGCCCCGAAGAAGGGCAAGGGGCGCGGGGGCGGAGGACGCTCCGCGCGGGCCCGGAGCC
GCAAGTAGGCGGGGGCTGGC

Downstream 100 bases:

>100_bases
TTAATTTCCGCTGCAGACCTGATGGGAAGTGCGCTGGAAGCGCGACGTTCCTGGGGTTTTTCATTGCGACTGGGCTCGGC
GCTGAACTATAGCGGTTGAC

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 646; Mature: 646

Protein sequence:

>646_residues
MDAKLLEKLDALPTEPGVYLMKDRRGQVIYVGKAINLRSRVRSYFNRTGDTRVFVSLLDQLLGDLETVLVSNEKEALLLE
NELIKKHRPRFNVLLKDDKQFISLRLDRTQPYPRLEVVRKYERDGARYFGPYSSAGAIRETLRVVNRFFRLRTCTDHVLA
NRKRPCLLHQIGRCPAPCVYPVPQEDYHRSVDEVVMFLEGKAGELVEGLRLRMKRAAQELKFEEAARIRDQLNAIERSLE
RQKVATTDFKDQDVFAFHREGDRILFYVLWVRQGRLNGGQAFPFGSQEFPDEELIASFVNLYYDQGSFVPEEVLLPLELE
DGTGGLEALLTERKGERVRVLVPKRGEKLDLVKMAAKNAEQAFVERRRTKDETDTVLSRLQQRLGLRNFPCRMECFDISH
FQGSAIVASQVAVTDGDADKSRYRKYKIKTLEKQDDFASMYEVISRRLKKGLEDNDLPDLLVIDGGKGQLASAHAAMKDV
GVESVDVVGLAKSRDLEVFDRDAESARSPERIFVVGRKDPIVLSQNSAEMFMLTRMRDEAHRFAITFQKQVLRKSRVRSA
LEDIPGVGETRRKQLLRHFGSLKRVGDASIEELAEVVGPAMAERVHAGLHGHPEEDAEDPVREASLDDAHEPVDEKTQGG
SPPGAA

Sequences:

>Translated_646_residues
MDAKLLEKLDALPTEPGVYLMKDRRGQVIYVGKAINLRSRVRSYFNRTGDTRVFVSLLDQLLGDLETVLVSNEKEALLLE
NELIKKHRPRFNVLLKDDKQFISLRLDRTQPYPRLEVVRKYERDGARYFGPYSSAGAIRETLRVVNRFFRLRTCTDHVLA
NRKRPCLLHQIGRCPAPCVYPVPQEDYHRSVDEVVMFLEGKAGELVEGLRLRMKRAAQELKFEEAARIRDQLNAIERSLE
RQKVATTDFKDQDVFAFHREGDRILFYVLWVRQGRLNGGQAFPFGSQEFPDEELIASFVNLYYDQGSFVPEEVLLPLELE
DGTGGLEALLTERKGERVRVLVPKRGEKLDLVKMAAKNAEQAFVERRRTKDETDTVLSRLQQRLGLRNFPCRMECFDISH
FQGSAIVASQVAVTDGDADKSRYRKYKIKTLEKQDDFASMYEVISRRLKKGLEDNDLPDLLVIDGGKGQLASAHAAMKDV
GVESVDVVGLAKSRDLEVFDRDAESARSPERIFVVGRKDPIVLSQNSAEMFMLTRMRDEAHRFAITFQKQVLRKSRVRSA
LEDIPGVGETRRKQLLRHFGSLKRVGDASIEELAEVVGPAMAERVHAGLHGHPEEDAEDPVREASLDDAHEPVDEKTQGG
SPPGAA
>Mature_646_residues
MDAKLLEKLDALPTEPGVYLMKDRRGQVIYVGKAINLRSRVRSYFNRTGDTRVFVSLLDQLLGDLETVLVSNEKEALLLE
NELIKKHRPRFNVLLKDDKQFISLRLDRTQPYPRLEVVRKYERDGARYFGPYSSAGAIRETLRVVNRFFRLRTCTDHVLA
NRKRPCLLHQIGRCPAPCVYPVPQEDYHRSVDEVVMFLEGKAGELVEGLRLRMKRAAQELKFEEAARIRDQLNAIERSLE
RQKVATTDFKDQDVFAFHREGDRILFYVLWVRQGRLNGGQAFPFGSQEFPDEELIASFVNLYYDQGSFVPEEVLLPLELE
DGTGGLEALLTERKGERVRVLVPKRGEKLDLVKMAAKNAEQAFVERRRTKDETDTVLSRLQQRLGLRNFPCRMECFDISH
FQGSAIVASQVAVTDGDADKSRYRKYKIKTLEKQDDFASMYEVISRRLKKGLEDNDLPDLLVIDGGKGQLASAHAAMKDV
GVESVDVVGLAKSRDLEVFDRDAESARSPERIFVVGRKDPIVLSQNSAEMFMLTRMRDEAHRFAITFQKQVLRKSRVRSA
LEDIPGVGETRRKQLLRHFGSLKRVGDASIEELAEVVGPAMAERVHAGLHGHPEEDAEDPVREASLDDAHEPVDEKTQGG
SPPGAA

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=626, Percent_Identity=37.220447284345, Blast_Score=353, Evalue=2e-98,
Organism=Escherichia coli, GI1788037, Length=178, Percent_Identity=32.0224719101124, Blast_Score=66, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_MYXXD (Q1D921)

Other databases:

- EMBL:   CP000113
- RefSeq:   YP_630852.1
- ProteinModelPortal:   Q1D921
- STRING:   Q1D921
- GeneID:   4103827
- GenomeReviews:   CP000113_GR
- KEGG:   mxa:MXAN_2633
- TIGR:   MXAN_2633
- eggNOG:   COG0322
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- PhylomeDB:   Q1D921
- ProtClustDB:   PRK00558
- BioCyc:   MXAN246197:MXAN_2633-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 73433; Mature: 73433

Theoretical pI: Translated: 7.64; Mature: 7.64

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDAKLLEKLDALPTEPGVYLMKDRRGQVIYVGKAINLRSRVRSYFNRTGDTRVFVSLLDQ
CCHHHHHHHHCCCCCCCEEEEECCCCCEEEEECCCCHHHHHHHHHHCCCCHHHHHHHHHH
LLGDLETVLVSNEKEALLLENELIKKHRPRFNVLLKDDKQFISLRLDRTQPYPRLEVVRK
HHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEEECCCCEEEEEEECCCCCCHHHHHHHH
YERDGARYFGPYSSAGAIRETLRVVNRFFRLRTCTDHVLANRKRPCLLHQIGRCPAPCVY
HHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCC
PVPQEDYHRSVDEVVMFLEGKAGELVEGLRLRMKRAAQELKFEEAARIRDQLNAIERSLE
CCCCHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RQKVATTDFKDQDVFAFHREGDRILFYVLWVRQGRLNGGQAFPFGSQEFPDEELIASFVN
HHHHHCCCCCCCCEEEEECCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHH
LYYDQGSFVPEEVLLPLELEDGTGGLEALLTERKGERVRVLVPKRGEKLDLVKMAAKNAE
HHHCCCCCCHHHCEEEEEECCCCCHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHCCHH
QAFVERRRTKDETDTVLSRLQQRLGLRNFPCRMECFDISHFQGSAIVASQVAVTDGDADK
HHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCEEEEEEEEECCCCCCH
SRYRKYKIKTLEKQDDFASMYEVISRRLKKGLEDNDLPDLLVIDGGKGQLASAHAAMKDV
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHHC
GVESVDVVGLAKSRDLEVFDRDAESARSPERIFVVGRKDPIVLSQNSAEMFMLTRMRDEA
CCCCEEEEECCCCCCCHHHCCCHHHCCCCCEEEEEECCCCEEEECCCCHHHHHHHHHHHH
HRFAITFQKQVLRKSRVRSALEDIPGVGETRRKQLLRHFGSLKRVGDASIEELAEVVGPA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCHH
MAERVHAGLHGHPEEDAEDPVREASLDDAHEPVDEKTQGGSPPGAA
HHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCCCCHHHCCCCCCCCC
>Mature Secondary Structure
MDAKLLEKLDALPTEPGVYLMKDRRGQVIYVGKAINLRSRVRSYFNRTGDTRVFVSLLDQ
CCHHHHHHHHCCCCCCCEEEEECCCCCEEEEECCCCHHHHHHHHHHCCCCHHHHHHHHHH
LLGDLETVLVSNEKEALLLENELIKKHRPRFNVLLKDDKQFISLRLDRTQPYPRLEVVRK
HHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEEECCCCEEEEEEECCCCCCHHHHHHHH
YERDGARYFGPYSSAGAIRETLRVVNRFFRLRTCTDHVLANRKRPCLLHQIGRCPAPCVY
HHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCCC
PVPQEDYHRSVDEVVMFLEGKAGELVEGLRLRMKRAAQELKFEEAARIRDQLNAIERSLE
CCCCHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RQKVATTDFKDQDVFAFHREGDRILFYVLWVRQGRLNGGQAFPFGSQEFPDEELIASFVN
HHHHHCCCCCCCCEEEEECCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHH
LYYDQGSFVPEEVLLPLELEDGTGGLEALLTERKGERVRVLVPKRGEKLDLVKMAAKNAE
HHHCCCCCCHHHCEEEEEECCCCCHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHCCHH
QAFVERRRTKDETDTVLSRLQQRLGLRNFPCRMECFDISHFQGSAIVASQVAVTDGDADK
HHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCEEEEEEEEECCCCCCH
SRYRKYKIKTLEKQDDFASMYEVISRRLKKGLEDNDLPDLLVIDGGKGQLASAHAAMKDV
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCHHHHHHHHHHC
GVESVDVVGLAKSRDLEVFDRDAESARSPERIFVVGRKDPIVLSQNSAEMFMLTRMRDEA
CCCCEEEEECCCCCCCHHHCCCHHHCCCCCEEEEEECCCCEEEECCCCHHHHHHHHHHHH
HRFAITFQKQVLRKSRVRSALEDIPGVGETRRKQLLRHFGSLKRVGDASIEELAEVVGPA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCHH
MAERVHAGLHGHPEEDAEDPVREASLDDAHEPVDEKTQGGSPPGAA
HHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCCCCHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA