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The map label for this gene is pbpB [H]

Identifier: 108761518

GI number: 108761518

Start: 3759707

End: 3761224

Strand: Direct

Name: pbpB [H]

Synonym: MXAN_3210

Alternate gene names: 108761518

Gene position: 3759707-3761224 (Clockwise)

Preceding gene: 108762960

Following gene: 108761345

Centisome position: 41.14

GC content: 71.94

Gene sequence:

>1518_bases
GTGGACAGCGCGCCCCCAGCCGGTAGGATCCAGCCGTCGCTCACCCCCCCGGAGCCCCCCGTAGCAATGCGCTTCCACCG
CCGTCTCCTGTCCGCCGCCGCGCTGCTCCCCCTGGTCCTCGTCATTGGAGCGACCGAGCCGGAGCAGCCCGCGTCCGCCG
GTGCCTCCGAAGACGGAGGGGTGGGGGTCGCCGCCCCTGACACGACGTCGCAGGCCGCCCAGGCGGACGCGGGGACGTCG
GGGGCCGCCACGGCGTCCCAGGGCGCCCAGCCCGATGCGGGGACTTCAGGATCCGCCGCCGTCTCCGCCGCCGCGGTGCT
CGGGGGCGAGTCGCCGGATGGTGGACTGGCGGCGCTTGCCGCGGAGCCGGGGATGGTGCCCCCCGTGCCCGTGCCCTCGC
GCGAGAAGGCGCCGCCCATCGCCACGGTGAAGTCGCTTCCCAGGTCCGCGGACCTCATGGCCCGCGCGGCGCTGGAGGAC
GGGAAGCTGGTGGTGAAGGAGAAGGGCGGAAAGAAGAAGCAGCTCACCATCGACCCGGTGCTGCAAGCGTCGCTGACGCA
GATCCTCCGCAACTACGAGACGCCCTACGGCGCGGCCGTGGTGCTGGAGCCGTCCACCGGACGGGTGCTGGCGTTGGCGG
AGCACTCGGCGGCGAGGCCGGAGCTGCGAGGGCTGCCGGTTCGCGCGGTGTTCCCCGCGGCCAGCATCTTCAAAGTCATC
ACCGGCGGCGCGCTGCTGGAGGCCGGCGTCACACCGGATACTGAAGAGTGCTTCCACGGCGGCAAGCGGCGCATCTCCGA
GAAGCACCTGCAGGACAGCGAGCGGGACAGCTCCTGCTATTCGCTGGCGCTGGCCATGGGCAAGAGCGCCAACGTCATCT
TCGCCAAGCTGACGAACAAGCACCTCACGGTGGACTCGCTGCGCCGCATGGCGGCCCGCTTCCGTTTCAACCGTGAGATT
GAGTTCCCCGTGCCGACGGATGTGTCGCTCGCCGCCATCCCCGAGGAGACCTTCAGCCTGGCCAACACGGGCGCGGGTTT
CGGGGACGTGTACCTGTCCCCGCTGCACGGCGCGCTCGTCGCCGCGGTGGCCGCCAACGAGGGCCGCTGGGTGGACCCCA
TCCTCTTCGAGCCCGAAGGACCGGCGCCGCTGCTCCCGGTGGAAGGCGAGCCCGTCCTCACGCCGGAGGTTGCGAAGGAC
CTCACGGCGCTGCTGGAGGAGACCGTCACCAGCGGCACCGCGCGCGCCGTGTTCCGCGAGCGTGGCTTCCGCGTGGATGA
CGCCGTGGGCAAGACGGGCTCACTGGCGGACCGCGAGCCCTTCCGCGACTACTCGTGGTTCGTGGGCTTCGCGCCCAAGG
ACAACCCGCGTGTCGCCGTGGCCGCCATCATCGTCAATGACCCGAAGTGGCGCATCCGAGGCACCTGGCTGGGCCGCGAG
GCGCTCCGCCTGGGGCTGGAGCGAATGCCCGCGCCGGTGGAGATGACGGCCCCGGCCTCCGCCGCTGGCAAGCACTGA

Upstream 100 bases:

>100_bases
TTTCAATCCGTCCAAAGTGTGGGCGAACCTAGCGGAGTTGCACACCCCTCCGCCAAGTTTCTGATTTCACCGAGGGACGG
AAGCGACCAGGGAGGCATCC

Downstream 100 bases:

>100_bases
CGCTTCCGTCAGCGCGGCGTCAGCTTCACCAGCGTCGCGTCCACGAAGCCGGCGAAGAACTTCAGCGCATCCAGCTCCTG
CAGCGGCGACACGTGGACGA

Product: penicillin-binding protein transpeptidase domain-containing protein

Products: NA

Alternate protein names: PBP-2B; Penicillin-binding protein B [H]

Number of amino acids: Translated: 505; Mature: 505

Protein sequence:

>505_residues
MDSAPPAGRIQPSLTPPEPPVAMRFHRRLLSAAALLPLVLVIGATEPEQPASAGASEDGGVGVAAPDTTSQAAQADAGTS
GAATASQGAQPDAGTSGSAAVSAAAVLGGESPDGGLAALAAEPGMVPPVPVPSREKAPPIATVKSLPRSADLMARAALED
GKLVVKEKGGKKKQLTIDPVLQASLTQILRNYETPYGAAVVLEPSTGRVLALAEHSAARPELRGLPVRAVFPAASIFKVI
TGGALLEAGVTPDTEECFHGGKRRISEKHLQDSERDSSCYSLALAMGKSANVIFAKLTNKHLTVDSLRRMAARFRFNREI
EFPVPTDVSLAAIPEETFSLANTGAGFGDVYLSPLHGALVAAVAANEGRWVDPILFEPEGPAPLLPVEGEPVLTPEVAKD
LTALLEETVTSGTARAVFRERGFRVDDAVGKTGSLADREPFRDYSWFVGFAPKDNPRVAVAAIIVNDPKWRIRGTWLGRE
ALRLGLERMPAPVEMTAPASAAGKH

Sequences:

>Translated_505_residues
MDSAPPAGRIQPSLTPPEPPVAMRFHRRLLSAAALLPLVLVIGATEPEQPASAGASEDGGVGVAAPDTTSQAAQADAGTS
GAATASQGAQPDAGTSGSAAVSAAAVLGGESPDGGLAALAAEPGMVPPVPVPSREKAPPIATVKSLPRSADLMARAALED
GKLVVKEKGGKKKQLTIDPVLQASLTQILRNYETPYGAAVVLEPSTGRVLALAEHSAARPELRGLPVRAVFPAASIFKVI
TGGALLEAGVTPDTEECFHGGKRRISEKHLQDSERDSSCYSLALAMGKSANVIFAKLTNKHLTVDSLRRMAARFRFNREI
EFPVPTDVSLAAIPEETFSLANTGAGFGDVYLSPLHGALVAAVAANEGRWVDPILFEPEGPAPLLPVEGEPVLTPEVAKD
LTALLEETVTSGTARAVFRERGFRVDDAVGKTGSLADREPFRDYSWFVGFAPKDNPRVAVAAIIVNDPKWRIRGTWLGRE
ALRLGLERMPAPVEMTAPASAAGKH
>Mature_505_residues
MDSAPPAGRIQPSLTPPEPPVAMRFHRRLLSAAALLPLVLVIGATEPEQPASAGASEDGGVGVAAPDTTSQAAQADAGTS
GAATASQGAQPDAGTSGSAAVSAAAVLGGESPDGGLAALAAEPGMVPPVPVPSREKAPPIATVKSLPRSADLMARAALED
GKLVVKEKGGKKKQLTIDPVLQASLTQILRNYETPYGAAVVLEPSTGRVLALAEHSAARPELRGLPVRAVFPAASIFKVI
TGGALLEAGVTPDTEECFHGGKRRISEKHLQDSERDSSCYSLALAMGKSANVIFAKLTNKHLTVDSLRRMAARFRFNREI
EFPVPTDVSLAAIPEETFSLANTGAGFGDVYLSPLHGALVAAVAANEGRWVDPILFEPEGPAPLLPVEGEPVLTPEVAKD
LTALLEETVTSGTARAVFRERGFRVDDAVGKTGSLADREPFRDYSWFVGFAPKDNPRVAVAAIIVNDPKWRIRGTWLGRE
ALRLGLERMPAPVEMTAPASAAGKH

Specific function: Penicillin-binding proteins (PBPs) function in the late steps of murein biosynthesis. PBP-2B is required for vegetative cell division and sporulation septation. Beta-lactamase inactivates the PBPs by acylating an essential serine residue in the active sit

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PASTA domains [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005543
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03793 PASTA; PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 52661; Mature: 52661

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSAPPAGRIQPSLTPPEPPVAMRFHRRLLSAAALLPLVLVIGATEPEQPASAGASEDGG
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
VGVAAPDTTSQAAQADAGTSGAATASQGAQPDAGTSGSAAVSAAAVLGGESPDGGLAALA
EEEECCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEE
AEPGMVPPVPVPSREKAPPIATVKSLPRSADLMARAALEDGKLVVKEKGGKKKQLTIDPV
CCCCCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHCCCCEEEEECCCCCCEEEHHHH
LQASLTQILRNYETPYGAAVVLEPSTGRVLALAEHSAARPELRGLPVRAVFPAASIFKVI
HHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEECCCCCCCHHHCCCCHHHCCHHHHHHHH
TGGALLEAGVTPDTEECFHGGKRRISEKHLQDSERDSSCYSLALAMGKSANVIFAKLTNK
HCCCEEECCCCCCHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCEEEEEECCC
HLTVDSLRRMAARFRFNREIEFPVPTDVSLAAIPEETFSLANTGAGFGDVYLSPLHGALV
CCCHHHHHHHHHHHHCCCEECCCCCCCCEEEECCHHHHHHHHCCCCCCHHHHHHHHHHHE
AAVAANEGRWVDPILFEPEGPAPLLPVEGEPVLTPEVAKDLTALLEETVTSGTARAVFRE
EEEECCCCCCCCCEEECCCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHH
RGFRVDDAVGKTGSLADREPFRDYSWFVGFAPKDNPRVAVAAIIVNDPKWRIRGTWLGRE
CCCCCHHHCCCCCCCCCCCCCCCCCEEEEECCCCCCCEEEEEEEEECCCEEEEEEECCHH
ALRLGLERMPAPVEMTAPASAAGKH
HHHHHHHHCCCCEEECCCCCCCCCC
>Mature Secondary Structure
MDSAPPAGRIQPSLTPPEPPVAMRFHRRLLSAAALLPLVLVIGATEPEQPASAGASEDGG
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
VGVAAPDTTSQAAQADAGTSGAATASQGAQPDAGTSGSAAVSAAAVLGGESPDGGLAALA
EEEECCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEE
AEPGMVPPVPVPSREKAPPIATVKSLPRSADLMARAALEDGKLVVKEKGGKKKQLTIDPV
CCCCCCCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHCCCCEEEEECCCCCCEEEHHHH
LQASLTQILRNYETPYGAAVVLEPSTGRVLALAEHSAARPELRGLPVRAVFPAASIFKVI
HHHHHHHHHHHCCCCCCEEEEEECCCCCEEEEECCCCCCCHHHCCCCHHHCCHHHHHHHH
TGGALLEAGVTPDTEECFHGGKRRISEKHLQDSERDSSCYSLALAMGKSANVIFAKLTNK
HCCCEEECCCCCCHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCEEEEEECCC
HLTVDSLRRMAARFRFNREIEFPVPTDVSLAAIPEETFSLANTGAGFGDVYLSPLHGALV
CCCHHHHHHHHHHHHCCCEECCCCCCCCEEEECCHHHHHHHHCCCCCCHHHHHHHHHHHE
AAVAANEGRWVDPILFEPEGPAPLLPVEGEPVLTPEVAKDLTALLEETVTSGTARAVFRE
EEEECCCCCCCCCEEECCCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHH
RGFRVDDAVGKTGSLADREPFRDYSWFVGFAPKDNPRVAVAAIIVNDPKWRIRGTWLGRE
CCCCCHHHCCCCCCCCCCCCCCCCCEEEEECCCCCCCEEEEEEEEECCCEEEEEEECCHH
ALRLGLERMPAPVEMTAPASAAGKH
HHHHHHHHCCCCEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8244929; 9384377; 8289242 [H]