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The map label for this gene is srrB [H]

Identifier: 108761451

GI number: 108761451

Start: 3627304

End: 3628476

Strand: Reverse

Name: srrB [H]

Synonym: MXAN_3098

Alternate gene names: 108761451

Gene position: 3628476-3627304 (Counterclockwise)

Preceding gene: 108758979

Following gene: 108759402

Centisome position: 39.7

GC content: 68.63

Gene sequence:

>1173_bases
ATGGAAGACACCAACGGCTGCCCCGGACTTGCCAGGCGCATCGCATATTCCGGGCAAGGCGAATCCAAGCAAGACGCCGC
GGACCAGCTCCGGCTGTTGATTGAGAGCGTCACTGACCATGCCATCCTGACGCTCGACCTGGACGGATACGTAGCGAGCT
GGAACCCGGGCGCTGAGCGCATCAAGGGCTACCGCGCGGACGAGATTCTGGGGCAGCACTTCAGCCGCTTCTATCCGCCC
GAAGCCGTGGCGCGGAACCGGCCGCGGCACGGGCTCGAGGTGGCGACGCGTGAGGGCCGCTTCGAGGAGGACGGCTGGCG
CGTCCGCAAGGACGGCAGCCGCTTCTGGGCCAACGTCGTCATCACCGCGCTGTATGACGAGACAGGGCAACTGCGTGGCT
TCGGCAAGGTGACGCGCGACTTCACCGCCCGCTACCAGGCCCAGGAGCAACGGGAGATGGAGCGCCTACGGGAGGCGCTT
CGCATCCGTGACGACTTCCTGTCCGTGGCGTCCCACGAGCTGCGCACGCCGCTCACCCCGCTGCAACTGAAGCTGACGGC
CATGCGCCGCGCCGTCGACAGCGCCCCGGGAGGCATGCTGCCGAGCGAGCGCGTGGAGCGCGACCTCGACGTCGCCGTCC
GCCAGGTGCGCAAGCTGGTGGAGCTGGTGGACGACCTGCTTGACGTGTCACGTATCAGCGTGGGCCAGCTGGCCCTGGAG
CGCGTGCCCGCGGACCTCACGGCGCTGCTTCGAGAGGTCGTCGCCCGCTACCTGCCACAAGCCAGCCAGCTCGGAAGCAC
CGTGGAACTGGACGCGCCTGCGCCCGTGCAGGGCGAATGGGACACACGCCGGGTGGAGCAGGTGATGACCAACCTCCTCT
CCAACGCGCTCAAGTACGGAGGGGGCAAGCCGATTCACGTCAGCCTGCGCGCGGAAGGCGGCATGGCGCTGCTGAGCGTT
CGCGACGAGGGCATCGGCATCGCGCCGGAAGCACTGCCCCACGTCTTCGACCGGTTCATGCGGGCCGTGTCCGGCCGCAA
CTTCAGTGGGCTGGGGCTCGGCCTCTTCATCGCCCACCAGGTCGTTTCGGCGCACGGGGGCGACATCCAGGTGTCCAGCG
TGCCGGACAAAGGGAGCACGTTCAGCGTCCGGCTCCCGCTCGGCCCCACGTAG

Upstream 100 bases:

>100_bases
TGCGCCGGCCGGAGTGTCCGATGGCCGATGGCCACATCGCGCGATTCCCCGTGACGGAGGGGGGCGTGTTCTCATACCAG
CAAGTCAGAGTAGGAGGCTC

Downstream 100 bases:

>100_bases
ACACACGCCATGGGACGCCCCTGTCAGGTGCTCAGCGCACGCACCCGGCCCGCGAGGTTCTGGGTGAAGAGGCGGAAGAT
GCGCAGCGCCGCCGCCTCGT

Product: sensory box histidine kinase

Products: NA

Alternate protein names: Staphylococcal respiratory response protein B [H]

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MEDTNGCPGLARRIAYSGQGESKQDAADQLRLLIESVTDHAILTLDLDGYVASWNPGAERIKGYRADEILGQHFSRFYPP
EAVARNRPRHGLEVATREGRFEEDGWRVRKDGSRFWANVVITALYDETGQLRGFGKVTRDFTARYQAQEQREMERLREAL
RIRDDFLSVASHELRTPLTPLQLKLTAMRRAVDSAPGGMLPSERVERDLDVAVRQVRKLVELVDDLLDVSRISVGQLALE
RVPADLTALLREVVARYLPQASQLGSTVELDAPAPVQGEWDTRRVEQVMTNLLSNALKYGGGKPIHVSLRAEGGMALLSV
RDEGIGIAPEALPHVFDRFMRAVSGRNFSGLGLGLFIAHQVVSAHGGDIQVSSVPDKGSTFSVRLPLGPT

Sequences:

>Translated_390_residues
MEDTNGCPGLARRIAYSGQGESKQDAADQLRLLIESVTDHAILTLDLDGYVASWNPGAERIKGYRADEILGQHFSRFYPP
EAVARNRPRHGLEVATREGRFEEDGWRVRKDGSRFWANVVITALYDETGQLRGFGKVTRDFTARYQAQEQREMERLREAL
RIRDDFLSVASHELRTPLTPLQLKLTAMRRAVDSAPGGMLPSERVERDLDVAVRQVRKLVELVDDLLDVSRISVGQLALE
RVPADLTALLREVVARYLPQASQLGSTVELDAPAPVQGEWDTRRVEQVMTNLLSNALKYGGGKPIHVSLRAEGGMALLSV
RDEGIGIAPEALPHVFDRFMRAVSGRNFSGLGLGLFIAHQVVSAHGGDIQVSSVPDKGSTFSVRLPLGPT
>Mature_390_residues
MEDTNGCPGLARRIAYSGQGESKQDAADQLRLLIESVTDHAILTLDLDGYVASWNPGAERIKGYRADEILGQHFSRFYPP
EAVARNRPRHGLEVATREGRFEEDGWRVRKDGSRFWANVVITALYDETGQLRGFGKVTRDFTARYQAQEQREMERLREAL
RIRDDFLSVASHELRTPLTPLQLKLTAMRRAVDSAPGGMLPSERVERDLDVAVRQVRKLVELVDDLLDVSRISVGQLALE
RVPADLTALLREVVARYLPQASQLGSTVELDAPAPVQGEWDTRRVEQVMTNLLSNALKYGGGKPIHVSLRAEGGMALLSV
RDEGIGIAPEALPHVFDRFMRAVSGRNFSGLGLGLFIAHQVVSAHGGDIQVSSVPDKGSTFSVRLPLGPT

Specific function: Member of the two-component regulatory system srrA/srrB, which is involved in the global regulation of staphylococcal virulence factors in response to environmental oxygen levels. Probably phosphorylates srrA [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI145693157, Length=274, Percent_Identity=32.8467153284672, Blast_Score=128, Evalue=8e-31,
Organism=Escherichia coli, GI1789149, Length=289, Percent_Identity=32.8719723183391, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI48994928, Length=350, Percent_Identity=27.4285714285714, Blast_Score=108, Evalue=8e-25,
Organism=Escherichia coli, GI1788549, Length=372, Percent_Identity=27.1505376344086, Blast_Score=105, Evalue=4e-24,
Organism=Escherichia coli, GI1786912, Length=246, Percent_Identity=35.3658536585366, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI87081816, Length=247, Percent_Identity=32.7935222672065, Blast_Score=101, Evalue=8e-23,
Organism=Escherichia coli, GI1788393, Length=257, Percent_Identity=30.3501945525292, Blast_Score=101, Evalue=1e-22,
Organism=Escherichia coli, GI1788713, Length=257, Percent_Identity=25.6809338521401, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1786600, Length=245, Percent_Identity=33.469387755102, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1787894, Length=222, Percent_Identity=34.6846846846847, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1789808, Length=231, Percent_Identity=30.3030303030303, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1790346, Length=228, Percent_Identity=30.7017543859649, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1790436, Length=249, Percent_Identity=30.1204819277108, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1786783, Length=238, Percent_Identity=28.9915966386555, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI87082128, Length=240, Percent_Identity=29.1666666666667, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 43110; Mature: 43110

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDTNGCPGLARRIAYSGQGESKQDAADQLRLLIESVTDHAILTLDLDGYVASWNPGAER
CCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCEEECCCCCHHH
IKGYRADEILGQHFSRFYPPEAVARNRPRHGLEVATREGRFEEDGWRVRKDGSRFWANVV
HCCCCHHHHHHHHHHHCCCHHHHHCCCCCCCCHHHHCCCCCCCCCCEEECCCHHHHHHHH
ITALYDETGQLRGFGKVTRDFTARYQAQEQREMERLREALRIRDDFLSVASHELRTPLTP
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
LQLKLTAMRRAVDSAPGGMLPSERVERDLDVAVRQVRKLVELVDDLLDVSRISVGQLALE
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RVPADLTALLREVVARYLPQASQLGSTVELDAPAPVQGEWDTRRVEQVMTNLLSNALKYG
HCCHHHHHHHHHHHHHHCCCHHHCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHC
GGKPIHVSLRAEGGMALLSVRDEGIGIAPEALPHVFDRFMRAVSGRNFSGLGLGLFIAHQ
CCCEEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
VVSAHGGDIQVSSVPDKGSTFSVRLPLGPT
HHHCCCCCEEEECCCCCCCEEEEEECCCCC
>Mature Secondary Structure
MEDTNGCPGLARRIAYSGQGESKQDAADQLRLLIESVTDHAILTLDLDGYVASWNPGAER
CCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEECCEEECCCCCHHH
IKGYRADEILGQHFSRFYPPEAVARNRPRHGLEVATREGRFEEDGWRVRKDGSRFWANVV
HCCCCHHHHHHHHHHHCCCHHHHHCCCCCCCCHHHHCCCCCCCCCCEEECCCHHHHHHHH
ITALYDETGQLRGFGKVTRDFTARYQAQEQREMERLREALRIRDDFLSVASHELRTPLTP
HHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
LQLKLTAMRRAVDSAPGGMLPSERVERDLDVAVRQVRKLVELVDDLLDVSRISVGQLALE
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RVPADLTALLREVVARYLPQASQLGSTVELDAPAPVQGEWDTRRVEQVMTNLLSNALKYG
HCCHHHHHHHHHHHHHHCCCHHHCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHC
GGKPIHVSLRAEGGMALLSVRDEGIGIAPEALPHVFDRFMRAVSGRNFSGLGLGLFIAHQ
CCCEEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
VVSAHGGDIQVSSVPDKGSTFSVRLPLGPT
HHHCCCCCEEEECCCCCCCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA