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The map label for this gene is mrdA [H]

Identifier: 108761171

GI number: 108761171

Start: 3089922

End: 3091961

Strand: Direct

Name: mrdA [H]

Synonym: MXAN_2647

Alternate gene names: 108761171

Gene position: 3089922-3091961 (Clockwise)

Preceding gene: 108759179

Following gene: 108759095

Centisome position: 33.81

GC content: 69.07

Gene sequence:

>2040_bases
GTGACCCCACCCACCTTGGGCAACACGACGCCGGGGCGCGAGCTCAAGCGGCGCTTCCTGTGGCTGGGCCTGGCCATGAT
GGCGGGCCTGGGGCTGATTTCCATCCAGCTCTACCGCCTGCAAATCACCCGGGGCGAGGAGTACGCCGCCAAGAGCGTGG
CCAACTTCGTCAAGGAAGTGCGGCTGCGCGCCGACCGCGGCGTCATCAAGGACGCGCGCGGCACCATCCTGGTGGACAGC
CGCCCGTCCTTCGACGCCTTCATCACCCCGGCCTTCTGCACGGACTGCTACGAGCAGGTCATCCCCCGCCTGGCGGAGCT
GCTCCAGTGGGACCCGGACCAGCGCAAGAAGGTGGAGGACATGGTGCGCATGGGGCGGCGCAACGCCCCCTTCCAGCCGG
TGCCGGTGCGCGTGGACCTGTCGCGCGACGAGTACGACCGGCTGGCTGCGCGCCGCGACATCCTGGACGGCGTGGAGGTG
GCGCCCGTGCCGCACCGGCACTACCGCACCAACTCCGTGCTGTCGCACGTGCTGGGCTACATGAATGAAATCACCCAGGA
GGAGCTGGAGCGCCTCAATGGCGACGGCGCCCGCTACGCCCTGGGGGACTACATTGGCCGGCGCGGGCTGGAGCGCTACT
TCGAGCAGCGGCTGCGCGGCACCGACGGCGTGCGCAAGGAAGTGGTGAACGCGCGCGGGCAGACCATTGAAGAGCTGAAC
GACAAGCTGGGCGACAACGCTGTGGTGTCGCCGCGTCCGGGCAACAACCTGGTGCTGTCCATCGACATGCGGTTGCAGGA
GGAGGCGGAGCGGGCCTTCCCCGGCGTGACGGGCGCGGTGGTCGCCATCGACGCCAACACGGGCTTCATCCGCGCGCTGG
TGTCGCGACCGGGCTTCGACCCCAACCTGCTCACTGGCCGCGTGACGCCCGCGCAGATGGCGCTCCTGTCGAGAGATCCG
CTGGACCCGATGATCAACCGCGTGGCCGCCGAGCACTACAGCCCAGGCTCCACCTTCAAGGTCGTCACCGCGCTGGCCGC
GTTCAAGTCCGGCGCCTTCCGCCCGGAGACGGTGGTGAACTGCCCCGGAGGCTACCGCCTGGGCGCGCGCACCTGGCGTT
GCCACAGGGACGCCGGACACGGGCTCGTGGATGGCTTCACGGCGATGAAGTCGTCCTGCGACACCTGGTACTACAAGGTG
GCGGACACCATCGGCCTGGACCCCATTGGAGAGATGGGCAAGGCCCTGGGCCTGGGCAGCCCCACGGGCGTCAACGTGGT
GGCCGAGGTCCCAGGCATCATGCCGACCAGCGCCTATCACGACAAGGCGTCGCCCGGCGGCTACACCAAGGGCATGGCGC
TCAACAGTTCCATTGGCCAGGGCGACAACAACGTCACGCCCCTCCAGTTGGCGCTGGTGTACGCGGCCATCGCCAACGGC
GGCACGCTCTACAAGCCGCAGATGGTGAACCGTCTGGAGAACCTGGACGGGCAGACCATCGAGTCGTTCCAGCCGGAGGT
GGTGCGGAAGGTGGACCTGCCGCCCGCGCACCTCAAGGCGGTGGTGGATAGCCTGGTGATGGTGGCGCACGAGCCGGGCG
GTACCGCCTATCGCGCGCGCATGAATCACATGCGGGACAAGGACATCCTGGTGGCGTCCAAGACGGGGACCGCGCAGGTG
GCCCGCCTGGGGGCAATCCGGCTGCGGACGCACCAGATGAGCTACTTCGAGCGCGACCACGCCTGGTACGCGGGGTTCGC
GCCGGCGGACAAGCCGGAGCTGGTCATCGTCGTGCTCAACGAGCACGGCGGCCACGGCGGTTCGGACGCGGCGCCCACCG
CGATGGCGGTGTTCCAGAAGTACTTCGATTTGAAGAAGCTGGACGCCACGGCTCCGCCGCCGCGTCCCAACCAGCCCTAC
ACGCCGTCCTCCGTGACGCGCGCGCCCTCGGCCGACGAGGCGGCGCTGACGCGAAGGGTACGGCCACCGGCCCGGCTTCC
GGGCGATGAAGAGGACCGCACGCGTGCAACTGCGGATTGA

Upstream 100 bases:

>100_bases
TGCCGCTGCAGGTGGCGCTCACGGGCATCGCGGCGCTGGCGCTCTACCCGTTGCTGCGGCGCTTCGAGGCGTCTCAGGAG
CGGCCCACGGGGTTGCTGCG

Downstream 100 bases:

>100_bases
GCGCCGGATGGTGCCCCACATCCCCTGGGGCCTCATCTTCTCCGTGCTGGCGGTGTGCGGGCTGGGCATCTGGAACCTCG
CCTCGGCGTCACGGCCGCCG

Product: putative penicillin-binding protein 2

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 679; Mature: 678

Protein sequence:

>679_residues
MTPPTLGNTTPGRELKRRFLWLGLAMMAGLGLISIQLYRLQITRGEEYAAKSVANFVKEVRLRADRGVIKDARGTILVDS
RPSFDAFITPAFCTDCYEQVIPRLAELLQWDPDQRKKVEDMVRMGRRNAPFQPVPVRVDLSRDEYDRLAARRDILDGVEV
APVPHRHYRTNSVLSHVLGYMNEITQEELERLNGDGARYALGDYIGRRGLERYFEQRLRGTDGVRKEVVNARGQTIEELN
DKLGDNAVVSPRPGNNLVLSIDMRLQEEAERAFPGVTGAVVAIDANTGFIRALVSRPGFDPNLLTGRVTPAQMALLSRDP
LDPMINRVAAEHYSPGSTFKVVTALAAFKSGAFRPETVVNCPGGYRLGARTWRCHRDAGHGLVDGFTAMKSSCDTWYYKV
ADTIGLDPIGEMGKALGLGSPTGVNVVAEVPGIMPTSAYHDKASPGGYTKGMALNSSIGQGDNNVTPLQLALVYAAIANG
GTLYKPQMVNRLENLDGQTIESFQPEVVRKVDLPPAHLKAVVDSLVMVAHEPGGTAYRARMNHMRDKDILVASKTGTAQV
ARLGAIRLRTHQMSYFERDHAWYAGFAPADKPELVIVVLNEHGGHGGSDAAPTAMAVFQKYFDLKKLDATAPPPRPNQPY
TPSSVTRAPSADEAALTRRVRPPARLPGDEEDRTRATAD

Sequences:

>Translated_679_residues
MTPPTLGNTTPGRELKRRFLWLGLAMMAGLGLISIQLYRLQITRGEEYAAKSVANFVKEVRLRADRGVIKDARGTILVDS
RPSFDAFITPAFCTDCYEQVIPRLAELLQWDPDQRKKVEDMVRMGRRNAPFQPVPVRVDLSRDEYDRLAARRDILDGVEV
APVPHRHYRTNSVLSHVLGYMNEITQEELERLNGDGARYALGDYIGRRGLERYFEQRLRGTDGVRKEVVNARGQTIEELN
DKLGDNAVVSPRPGNNLVLSIDMRLQEEAERAFPGVTGAVVAIDANTGFIRALVSRPGFDPNLLTGRVTPAQMALLSRDP
LDPMINRVAAEHYSPGSTFKVVTALAAFKSGAFRPETVVNCPGGYRLGARTWRCHRDAGHGLVDGFTAMKSSCDTWYYKV
ADTIGLDPIGEMGKALGLGSPTGVNVVAEVPGIMPTSAYHDKASPGGYTKGMALNSSIGQGDNNVTPLQLALVYAAIANG
GTLYKPQMVNRLENLDGQTIESFQPEVVRKVDLPPAHLKAVVDSLVMVAHEPGGTAYRARMNHMRDKDILVASKTGTAQV
ARLGAIRLRTHQMSYFERDHAWYAGFAPADKPELVIVVLNEHGGHGGSDAAPTAMAVFQKYFDLKKLDATAPPPRPNQPY
TPSSVTRAPSADEAALTRRVRPPARLPGDEEDRTRATAD
>Mature_678_residues
TPPTLGNTTPGRELKRRFLWLGLAMMAGLGLISIQLYRLQITRGEEYAAKSVANFVKEVRLRADRGVIKDARGTILVDSR
PSFDAFITPAFCTDCYEQVIPRLAELLQWDPDQRKKVEDMVRMGRRNAPFQPVPVRVDLSRDEYDRLAARRDILDGVEVA
PVPHRHYRTNSVLSHVLGYMNEITQEELERLNGDGARYALGDYIGRRGLERYFEQRLRGTDGVRKEVVNARGQTIEELND
KLGDNAVVSPRPGNNLVLSIDMRLQEEAERAFPGVTGAVVAIDANTGFIRALVSRPGFDPNLLTGRVTPAQMALLSRDPL
DPMINRVAAEHYSPGSTFKVVTALAAFKSGAFRPETVVNCPGGYRLGARTWRCHRDAGHGLVDGFTAMKSSCDTWYYKVA
DTIGLDPIGEMGKALGLGSPTGVNVVAEVPGIMPTSAYHDKASPGGYTKGMALNSSIGQGDNNVTPLQLALVYAAIANGG
TLYKPQMVNRLENLDGQTIESFQPEVVRKVDLPPAHLKAVVDSLVMVAHEPGGTAYRARMNHMRDKDILVASKTGTAQVA
RLGAIRLRTHQMSYFERDHAWYAGFAPADKPELVIVVLNEHGGHGGSDAAPTAMAVFQKYFDLKKLDATAPPPRPNQPYT
PSSVTRAPSADEAALTRRVRPPARLPGDEEDRTRATAD

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=595, Percent_Identity=30.5882352941176, Blast_Score=275, Evalue=5e-75,
Organism=Escherichia coli, GI1786272, Length=476, Percent_Identity=25.8403361344538, Blast_Score=113, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 74470; Mature: 74339

Theoretical pI: Translated: 8.93; Mature: 8.93

Prosite motif: PS00337 BETA_LACTAMASE_D

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPPTLGNTTPGRELKRRFLWLGLAMMAGLGLISIQLYRLQITRGEEYAAKSVANFVKEV
CCCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHEEEEEEEEEEECCHHHHHHHHHHHHHHH
RLRADRGVIKDARGTILVDSRPSFDAFITPAFCTDCYEQVIPRLAELLQWDPDQRKKVED
HHHHHCCCCCCCCCEEEECCCCCCCCEECHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
MVRMGRRNAPFQPVPVRVDLSRDEYDRLAARRDILDGVEVAPVPHRHYRTNSVLSHVLGY
HHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
MNEITQEELERLNGDGARYALGDYIGRRGLERYFEQRLRGTDGVRKEVVNARGQTIEELN
HHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHH
DKLGDNAVVSPRPGNNLVLSIDMRLQEEAERAFPGVTGAVVAIDANTGFIRALVSRPGFD
HHCCCCCEECCCCCCCEEEEEECHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHCCCCC
PNLLTGRVTPAQMALLSRDPLDPMINRVAAEHYSPGSTFKVVTALAAFKSGAFRPETVVN
CCCEECCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCEEEE
CPGGYRLGARTWRCHRDAGHGLVDGFTAMKSSCDTWYYKVADTIGLDPIGEMGKALGLGS
CCCCCEECCCEEEECCCCCCCHHHHHHHHHHCCCCEEEEHHHHCCCCCHHHHHHHHCCCC
PTGVNVVAEVPGIMPTSAYHDKASPGGYTKGMALNSSIGQGDNNVTPLQLALVYAAIANG
CCCCEEHHHCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHCC
GTLYKPQMVNRLENLDGQTIESFQPEVVRKVDLPPAHLKAVVDSLVMVAHEPGGTAYRAR
CCEECCHHHHHHHCCCCCCHHHCCHHHHHHCCCCHHHHHHHHHHHHHHEECCCCCHHHHH
MNHMRDKDILVASKTGTAQVARLGAIRLRTHQMSYFERDHAWYAGFAPADKPELVIVVLN
HHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCEEEEEEE
EHGGHGGSDAAPTAMAVFQKYFDLKKLDATAPPPRPNQPYTPSSVTRAPSADEAALTRRV
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCC
RPPARLPGDEEDRTRATAD
CCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TPPTLGNTTPGRELKRRFLWLGLAMMAGLGLISIQLYRLQITRGEEYAAKSVANFVKEV
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHEEEEEEEEEEECCHHHHHHHHHHHHHHH
RLRADRGVIKDARGTILVDSRPSFDAFITPAFCTDCYEQVIPRLAELLQWDPDQRKKVED
HHHHHCCCCCCCCCEEEECCCCCCCCEECHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
MVRMGRRNAPFQPVPVRVDLSRDEYDRLAARRDILDGVEVAPVPHRHYRTNSVLSHVLGY
HHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
MNEITQEELERLNGDGARYALGDYIGRRGLERYFEQRLRGTDGVRKEVVNARGQTIEELN
HHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHHH
DKLGDNAVVSPRPGNNLVLSIDMRLQEEAERAFPGVTGAVVAIDANTGFIRALVSRPGFD
HHCCCCCEECCCCCCCEEEEEECHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHCCCCC
PNLLTGRVTPAQMALLSRDPLDPMINRVAAEHYSPGSTFKVVTALAAFKSGAFRPETVVN
CCCEECCCCHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCEEEE
CPGGYRLGARTWRCHRDAGHGLVDGFTAMKSSCDTWYYKVADTIGLDPIGEMGKALGLGS
CCCCCEECCCEEEECCCCCCCHHHHHHHHHHCCCCEEEEHHHHCCCCCHHHHHHHHCCCC
PTGVNVVAEVPGIMPTSAYHDKASPGGYTKGMALNSSIGQGDNNVTPLQLALVYAAIANG
CCCCEEHHHCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHCC
GTLYKPQMVNRLENLDGQTIESFQPEVVRKVDLPPAHLKAVVDSLVMVAHEPGGTAYRAR
CCEECCHHHHHHHCCCCCCHHHCCHHHHHHCCCCHHHHHHHHHHHHHHEECCCCCHHHHH
MNHMRDKDILVASKTGTAQVARLGAIRLRTHQMSYFERDHAWYAGFAPADKPELVIVVLN
HHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCEEEEEEE
EHGGHGGSDAAPTAMAVFQKYFDLKKLDATAPPPRPNQPYTPSSVTRAPSADEAALTRRV
CCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCC
RPPARLPGDEEDRTRATAD
CCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]