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The map label for this gene is truD [H]

Identifier: 108761140

GI number: 108761140

Start: 4820976

End: 4822610

Strand: Direct

Name: truD [H]

Synonym: MXAN_3958

Alternate gene names: 108761140

Gene position: 4820976-4822610 (Clockwise)

Preceding gene: 108762476

Following gene: 108763948

Centisome position: 52.75

GC content: 70.21

Gene sequence:

>1635_bases
GTGCGAATCAAACAAAAGCCCGAGGACTTCTCCGTCAAGGAGTCATACCGTTTCGACGAAGTCGACTCGGGACGTCACCG
CGTCTACCTGATGGACAAGCAAAAGCTGTCCACGTTCGACGCCGTGACCCGGCTGCGGGATGCGTTCGGGCTCAAGCCCG
GCGCCATCAGCTACTGCGGCCTCAAGGACAAGCAGGGCCGGACCGAGCAGATCATCGCGGTGGACGGCGCCGACGTGGAC
ATGCAGGAGCCTGACCTGCGGCTGAAGTACCTGGGCCGCACGGACAAGCCGCTGTCCGCCGCCAACATCACCTCCAACCG
CTTCTCCGTCACGGTGCGCGCGCTCCAGCCGGAGTCGCTGGGGCCCCTCAACGTGGCCGCCGCCGAGGTCAACCGCCTGG
GCGTCATCAACTACTTCGACAGCCAGCGCTTCGGCTCGCTGAAGCACGGCCAGGGCTTCATCGCCAAGGACCTCATCCGG
GGCGACTTCGAGGCCGCGCTGCACAACTACATGGCCAAGCCGTCCGAGCTGGACCGGACGGAGGACGCCAAGATCAAGGC
CTTCTGGAAGGAGAACTGGGGCCGCTGGGACGCCCGCGTCCCCTACGAGGGCACGCGCAAGTACCACCGCGTCCTCAAGT
CCCTGCGCGATCAGCCGGGTGACTACCTGCGCGCCTTCATGCAGATCGACGCGGACTACCGCGCGATGCTGATCTTCACG
TACCAGAGCTTCCTCTGGAACGAGGGTGTGCGGCGCTACCTCCAGCTGATGCTGCCGCGCGAGCACCTCTTCCCCATGCG
CTACCAGGCCGGCACGCTGCTGTTCCACCGCGACGCCAGCCCGGAGGTGCTCCGCACGCTGCGCGACGCCTCCTTCCCCC
TGCTCGCGCCGAACTCGACGTTCAGCGACCCGAAGGTGGAGGAGGCCGTGCGCTGGGTGCTGGGCCGCGAGAAGCTCCAA
CTGTCGGACCTGCAAGTCCCCGGCGCCGAGCGCAGGCTCTACTTCAAGCACGAGGAGCGGCCCCTGCTGTCGTTCCCGCA
CAAGCTCGTCGTGGGCCGCACGCAGGCGGACGAGCTCAACCGCGACGACATCAAGGTCAACATCGCCTTCACCCTGCCGC
CTGGCGCCTACGCCACCCTGGTCATCAAGCGGCTGTTCCACTTCGATTACGCCGAGGACAGCGCGGAGACCATCCGCGCC
TCGCAGCGGCCGAAGCTGGCGGAGGCCGAAGCCGCCGCCGCGCACGAGCCCTCCAGCCGCCGGGGCCCGCCCCGCCGTGA
CGCGGACGGCGCGCGCGCCTCGAGCCGTAGCGCTCCGGGCACGGAGACCCGCCGCCGTTCGTCCGGAGACCGCGACACGC
GCGCGCCCGCCGGCAACCGCGATGCCCGGGGCGCAGGCGCTCCGGGCCGCCGCCGCACCGGTCCGCGCGAGGTGGAGCTC
CTGGAGCCCGCCTCGGGCCGCGCCCGCACCCTGGCCGCCAAGGCCCCCGCGCCCGCCAAGGCCGCGGAGCCCGCCGCGCC
GCTGGGCTTCCGTGAGCGGCAGCGCCAGCGCAAGGACGCCCGCTCGGCCGCGCGCGCGGAGACCGAGGCCAAACGTGCAG
CCAAGGCCAAGCCCGCGAAATCACGGAAGAAATAG

Upstream 100 bases:

>100_bases
GCCAGGAGCAACAGGGGAAGAACTCGCATGGGAGGTCACGTTATCCCCTTTCTGGCGCAGGTGCTTCATTCCGGGGCGCC
GCGCTGGTAAGGGGGGCGCC

Downstream 100 bases:

>100_bases
AGATGTATCTCCCGGATGCAATGGGCGGACGGGCGCGCCGTAGACCCAGGCGTGAACGCTCTTGCCCTCGACGACGCTCC
CGGGACGCTTGCCCATGCCA

Product: tRNA pseudouridine synthase D

Products: NA

Alternate protein names: tRNA pseudouridylate synthase D 1; tRNA-uridine isomerase D 1 [H]

Number of amino acids: Translated: 544; Mature: 544

Protein sequence:

>544_residues
MRIKQKPEDFSVKESYRFDEVDSGRHRVYLMDKQKLSTFDAVTRLRDAFGLKPGAISYCGLKDKQGRTEQIIAVDGADVD
MQEPDLRLKYLGRTDKPLSAANITSNRFSVTVRALQPESLGPLNVAAAEVNRLGVINYFDSQRFGSLKHGQGFIAKDLIR
GDFEAALHNYMAKPSELDRTEDAKIKAFWKENWGRWDARVPYEGTRKYHRVLKSLRDQPGDYLRAFMQIDADYRAMLIFT
YQSFLWNEGVRRYLQLMLPREHLFPMRYQAGTLLFHRDASPEVLRTLRDASFPLLAPNSTFSDPKVEEAVRWVLGREKLQ
LSDLQVPGAERRLYFKHEERPLLSFPHKLVVGRTQADELNRDDIKVNIAFTLPPGAYATLVIKRLFHFDYAEDSAETIRA
SQRPKLAEAEAAAAHEPSSRRGPPRRDADGARASSRSAPGTETRRRSSGDRDTRAPAGNRDARGAGAPGRRRTGPREVEL
LEPASGRARTLAAKAPAPAKAAEPAAPLGFRERQRQRKDARSAARAETEAKRAAKAKPAKSRKK

Sequences:

>Translated_544_residues
MRIKQKPEDFSVKESYRFDEVDSGRHRVYLMDKQKLSTFDAVTRLRDAFGLKPGAISYCGLKDKQGRTEQIIAVDGADVD
MQEPDLRLKYLGRTDKPLSAANITSNRFSVTVRALQPESLGPLNVAAAEVNRLGVINYFDSQRFGSLKHGQGFIAKDLIR
GDFEAALHNYMAKPSELDRTEDAKIKAFWKENWGRWDARVPYEGTRKYHRVLKSLRDQPGDYLRAFMQIDADYRAMLIFT
YQSFLWNEGVRRYLQLMLPREHLFPMRYQAGTLLFHRDASPEVLRTLRDASFPLLAPNSTFSDPKVEEAVRWVLGREKLQ
LSDLQVPGAERRLYFKHEERPLLSFPHKLVVGRTQADELNRDDIKVNIAFTLPPGAYATLVIKRLFHFDYAEDSAETIRA
SQRPKLAEAEAAAAHEPSSRRGPPRRDADGARASSRSAPGTETRRRSSGDRDTRAPAGNRDARGAGAPGRRRTGPREVEL
LEPASGRARTLAAKAPAPAKAAEPAAPLGFRERQRQRKDARSAARAETEAKRAAKAKPAKSRKK
>Mature_544_residues
MRIKQKPEDFSVKESYRFDEVDSGRHRVYLMDKQKLSTFDAVTRLRDAFGLKPGAISYCGLKDKQGRTEQIIAVDGADVD
MQEPDLRLKYLGRTDKPLSAANITSNRFSVTVRALQPESLGPLNVAAAEVNRLGVINYFDSQRFGSLKHGQGFIAKDLIR
GDFEAALHNYMAKPSELDRTEDAKIKAFWKENWGRWDARVPYEGTRKYHRVLKSLRDQPGDYLRAFMQIDADYRAMLIFT
YQSFLWNEGVRRYLQLMLPREHLFPMRYQAGTLLFHRDASPEVLRTLRDASFPLLAPNSTFSDPKVEEAVRWVLGREKLQ
LSDLQVPGAERRLYFKHEERPLLSFPHKLVVGRTQADELNRDDIKVNIAFTLPPGAYATLVIKRLFHFDYAEDSAETIRA
SQRPKLAEAEAAAAHEPSSRRGPPRRDADGARASSRSAPGTETRRRSSGDRDTRAPAGNRDARGAGAPGRRRTGPREVEL
LEPASGRARTLAAKAPAPAKAAEPAAPLGFRERQRQRKDARSAARAETEAKRAAKAKPAKSRKK

Specific function: Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs [H]

COG id: COG0585

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 TRUD domain [H]

Homologues:

Organism=Homo sapiens, GI50727002, Length=406, Percent_Identity=22.1674876847291, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI148762985, Length=405, Percent_Identity=21.7283950617284, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI148762961, Length=405, Percent_Identity=21.7283950617284, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI148762948, Length=405, Percent_Identity=21.7283950617284, Blast_Score=69, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020103
- InterPro:   IPR001656
- InterPro:   IPR020119
- InterPro:   IPR011760 [H]

Pfam domain/function: PF01142 TruD [H]

EC number: NA

Molecular weight: Translated: 61438; Mature: 61438

Theoretical pI: Translated: 10.60; Mature: 10.60

Prosite motif: PS50984 TRUD ; PS01268 UPF0024

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIKQKPEDFSVKESYRFDEVDSGRHRVYLMDKQKLSTFDAVTRLRDAFGLKPGAISYCG
CCCCCCCCCCCCHHCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCCEEECC
LKDKQGRTEQIIAVDGADVDMQEPDLRLKYLGRTDKPLSAANITSNRFSVTVRALQPESL
CCCCCCCCEEEEEECCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCEEEEEEEEECCCCC
GPLNVAAAEVNRLGVINYFDSQRFGSLKHGQGFIAKDLIRGDFEAALHNYMAKPSELDRT
CCCHHHHHHHHHCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHCCCC
EDAKIKAFWKENWGRWDARVPYEGTRKYHRVLKSLRDQPGDYLRAFMQIDADYRAMLIFT
CCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEEEH
YQSFLWNEGVRRYLQLMLPREHLFPMRYQAGTLLFHRDASPEVLRTLRDASFPLLAPNST
HHHHHHHHHHHHHHHHHCCHHHCCCCEECCCEEEEECCCCHHHHHHHHHCCCCEECCCCC
FSDPKVEEAVRWVLGREKLQLSDLQVPGAERRLYFKHEERPLLSFPHKLVVGRTQADELN
CCCCHHHHHHHHHHCCCCEECCCCCCCCCCCEEEEECCCCCHHHCCCHHEECCCCHHHCC
RDDIKVNIAFTLPPGAYATLVIKRLFHFDYAEDSAETIRASQRPKLAEAEAAAAHEPSSR
CCCEEEEEEEEECCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCHHHHHHHCCCCCCC
RGPPRRDADGARASSRSAPGTETRRRSSGDRDTRAPAGNRDARGAGAPGRRRTGPREVEL
CCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEE
LEPASGRARTLAAKAPAPAKAAEPAAPLGFRERQRQRKDARSAARAETEAKRAAKAKPAK
ECCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SRKK
CCCC
>Mature Secondary Structure
MRIKQKPEDFSVKESYRFDEVDSGRHRVYLMDKQKLSTFDAVTRLRDAFGLKPGAISYCG
CCCCCCCCCCCCHHCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHCCCCCCEEECC
LKDKQGRTEQIIAVDGADVDMQEPDLRLKYLGRTDKPLSAANITSNRFSVTVRALQPESL
CCCCCCCCEEEEEECCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCEEEEEEEEECCCCC
GPLNVAAAEVNRLGVINYFDSQRFGSLKHGQGFIAKDLIRGDFEAALHNYMAKPSELDRT
CCCHHHHHHHHHCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHCCCC
EDAKIKAFWKENWGRWDARVPYEGTRKYHRVLKSLRDQPGDYLRAFMQIDADYRAMLIFT
CCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEEEH
YQSFLWNEGVRRYLQLMLPREHLFPMRYQAGTLLFHRDASPEVLRTLRDASFPLLAPNST
HHHHHHHHHHHHHHHHHCCHHHCCCCEECCCEEEEECCCCHHHHHHHHHCCCCEECCCCC
FSDPKVEEAVRWVLGREKLQLSDLQVPGAERRLYFKHEERPLLSFPHKLVVGRTQADELN
CCCCHHHHHHHHHHCCCCEECCCCCCCCCCCEEEEECCCCCHHHCCCHHEECCCCHHHCC
RDDIKVNIAFTLPPGAYATLVIKRLFHFDYAEDSAETIRASQRPKLAEAEAAAAHEPSSR
CCCEEEEEEEEECCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCHHHHHHHCCCCCCC
RGPPRRDADGARASSRSAPGTETRRRSSGDRDTRAPAGNRDARGAGAPGRRRTGPREVEL
CCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEE
LEPASGRARTLAAKAPAPAKAAEPAAPLGFRERQRQRKDARSAARAETEAKRAAKAKPAK
ECCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SRKK
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA