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The map label for this gene is hemB [H]

Identifier: 108761062

GI number: 108761062

Start: 5045002

End: 5046009

Strand: Reverse

Name: hemB [H]

Synonym: MXAN_4100

Alternate gene names: 108761062

Gene position: 5046009-5045002 (Counterclockwise)

Preceding gene: 108760746

Following gene: 108761968

Centisome position: 55.21

GC content: 68.85

Gene sequence:

>1008_bases
ATGAAGGTGCGGCGCCGCCGGTTTATACCGGCGACCGCCATGGCCTATCCCATCCACCGACCCCGCCGCCTGCGCCGCAA
CGCCGTCCTGCGTGACATGGTGCGCGAGACGCGCCTCGACCCGGGCGACTTCATCTACCCCCTCTTCGTCGTGGAAGGCC
GGGACGTGCGCCGTCCCATCGTCTCCATGCCGGGGATCTTCAACCTGTCGCTGGAGCACGTCGTCGCCGAGGCCAGGCAC
GCCCGGAAGCTGGGCGTGCCCGCCGTCCTCCTGTTCGGCATCCCCAACCACAAGGACGCCCGCGGCACCCAGGCCTACGC
CGACGACGGCATCGTCCAGCGCGCCATTCAGGAGATCAAGGCGGCCGAGCCGGACCTCCAGGTCATCGTCGACGTCTGCC
TGTGCGAGTTCACCGACCACGGCCACTGCGGCGTGTTGGAAGGCGGCCACGTCGTCAATGACGCCACGCTGGCGCTGCTG
GCGAAGATGTCCGTGAGCTGCGCCAAGGCGGGCGCGGACATCATCGCTCCGTCGGACATGATGGATGGCCGCGTGGCCGC
CATCCGCGCCGCCCTGGACGAGACGGGCTTCGGCGAGCTGCCCATCATGGCGTACTCGGCCAAGTTCGCGTCCGGCTACT
ACGGGCCGTTCCGCGAGGCCGCCCAGAACACGCCCACCTCCGGTGACCGCCGGGGCTACCAGATGGACCCCGGCAACGTC
CGCGAGGCCCTCAAGGAAGTGGCCCTGGACGTGGAGGAGGGCGCGGACATGATCATGGTCAAGCCCGCGCTGGCCTACCT
GGACGTCATCCGCGCCGTGCGCGAGCGCTGGGAGCTGCCCGTCGTCTCCTACAACGTGTCCGGCGAGTACTCGATGCTCA
AGGCCGCCGGGCAGAACGGGTGGATTGACTACGAGCGGGTGATGCTGGAGACGCTCACGTCCATGAAGCGCGCCGGCTCC
GACCTCATCATCACCTACCACGCCCTGGAGGCGGCGAAGCTCCTGTAG

Upstream 100 bases:

>100_bases
GCCGAGCGCCGCGCCCTGCGGCACGCACGGGAGGCTCGGAACCATCAGAAGAGCTGGAGGCTCGTCGCAGGCTGAGCAGG
CGGGCCGGGGGCGCAAAACG

Downstream 100 bases:

>100_bases
GCAACAGCCGGGCGGACCCGCGGCGGGTTGAGTCTTGATCCGCCGCGCGCGTTGCGTCCAAATGTGCGTCGCACGATGCC
AACCAAAAAGCGGCCTGGAC

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MKVRRRRFIPATAMAYPIHRPRRLRRNAVLRDMVRETRLDPGDFIYPLFVVEGRDVRRPIVSMPGIFNLSLEHVVAEARH
ARKLGVPAVLLFGIPNHKDARGTQAYADDGIVQRAIQEIKAAEPDLQVIVDVCLCEFTDHGHCGVLEGGHVVNDATLALL
AKMSVSCAKAGADIIAPSDMMDGRVAAIRAALDETGFGELPIMAYSAKFASGYYGPFREAAQNTPTSGDRRGYQMDPGNV
REALKEVALDVEEGADMIMVKPALAYLDVIRAVRERWELPVVSYNVSGEYSMLKAAGQNGWIDYERVMLETLTSMKRAGS
DLIITYHALEAAKLL

Sequences:

>Translated_335_residues
MKVRRRRFIPATAMAYPIHRPRRLRRNAVLRDMVRETRLDPGDFIYPLFVVEGRDVRRPIVSMPGIFNLSLEHVVAEARH
ARKLGVPAVLLFGIPNHKDARGTQAYADDGIVQRAIQEIKAAEPDLQVIVDVCLCEFTDHGHCGVLEGGHVVNDATLALL
AKMSVSCAKAGADIIAPSDMMDGRVAAIRAALDETGFGELPIMAYSAKFASGYYGPFREAAQNTPTSGDRRGYQMDPGNV
REALKEVALDVEEGADMIMVKPALAYLDVIRAVRERWELPVVSYNVSGEYSMLKAAGQNGWIDYERVMLETLTSMKRAGS
DLIITYHALEAAKLL
>Mature_335_residues
MKVRRRRFIPATAMAYPIHRPRRLRRNAVLRDMVRETRLDPGDFIYPLFVVEGRDVRRPIVSMPGIFNLSLEHVVAEARH
ARKLGVPAVLLFGIPNHKDARGTQAYADDGIVQRAIQEIKAAEPDLQVIVDVCLCEFTDHGHCGVLEGGHVVNDATLALL
AKMSVSCAKAGADIIAPSDMMDGRVAAIRAALDETGFGELPIMAYSAKFASGYYGPFREAAQNTPTSGDRRGYQMDPGNV
REALKEVALDVEEGADMIMVKPALAYLDVIRAVRERWELPVVSYNVSGEYSMLKAAGQNGWIDYERVMLETLTSMKRAGS
DLIITYHALEAAKLL

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=304, Percent_Identity=43.75, Blast_Score=253, Evalue=2e-67,
Organism=Escherichia coli, GI87081728, Length=316, Percent_Identity=50.6329113924051, Blast_Score=305, Evalue=2e-84,
Organism=Saccharomyces cerevisiae, GI6321398, Length=308, Percent_Identity=39.9350649350649, Blast_Score=214, Evalue=1e-56,
Organism=Drosophila melanogaster, GI21358291, Length=306, Percent_Identity=40.5228758169935, Blast_Score=241, Evalue=5e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 37009; Mature: 37009

Theoretical pI: Translated: 7.23; Mature: 7.23

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVRRRRFIPATAMAYPIHRPRRLRRNAVLRDMVRETRLDPGDFIYPLFVVEGRDVRRPI
CCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCHHHCHH
VSMPGIFNLSLEHVVAEARHARKLGVPAVLLFGIPNHKDARGTQAYADDGIVQRAIQEIK
HCCCCEECHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHCHHHHHHHHHHHH
AAEPDLQVIVDVCLCEFTDHGHCGVLEGGHVVNDATLALLAKMSVSCAKAGADIIAPSDM
CCCCHHHHHHHHHHHHCCCCCCEEEECCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCC
MDGRVAAIRAALDETGFGELPIMAYSAKFASGYYGPFREAAQNTPTSGDRRGYQMDPGNV
CCCHHHHHHHHHHCCCCCCCCEEEEEHHHHCCCCCHHHHHHCCCCCCCCCCCCCCCCHHH
REALKEVALDVEEGADMIMVKPALAYLDVIRAVRERWELPVVSYNVSGEYSMLKAAGQNG
HHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHCCCCC
WIDYERVMLETLTSMKRAGSDLIITYHALEAAKLL
CCHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHCC
>Mature Secondary Structure
MKVRRRRFIPATAMAYPIHRPRRLRRNAVLRDMVRETRLDPGDFIYPLFVVEGRDVRRPI
CCCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCCHHHCHH
VSMPGIFNLSLEHVVAEARHARKLGVPAVLLFGIPNHKDARGTQAYADDGIVQRAIQEIK
HCCCCEECHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHCHHHHHHHHHHHH
AAEPDLQVIVDVCLCEFTDHGHCGVLEGGHVVNDATLALLAKMSVSCAKAGADIIAPSDM
CCCCHHHHHHHHHHHHCCCCCCEEEECCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCC
MDGRVAAIRAALDETGFGELPIMAYSAKFASGYYGPFREAAQNTPTSGDRRGYQMDPGNV
CCCHHHHHHHHHHCCCCCCCCEEEEEHHHHCCCCCHHHHHHCCCCCCCCCCCCCCCCHHH
REALKEVALDVEEGADMIMVKPALAYLDVIRAVRERWELPVVSYNVSGEYSMLKAAGQNG
HHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHCCCCC
WIDYERVMLETLTSMKRAGSDLIITYHALEAAKLL
CCHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8123787 [H]