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The map label for this gene is mrpD [H]

Identifier: 108760979

GI number: 108760979

Start: 4640648

End: 4642153

Strand: Direct

Name: mrpD [H]

Synonym: MXAN_3861

Alternate gene names: 108760979

Gene position: 4640648-4642153 (Clockwise)

Preceding gene: 108758259

Following gene: 108761987

Centisome position: 50.77

GC content: 69.52

Gene sequence:

>1506_bases
ATGACGCCCTCCACGCTGCTCAGCCTGCCCATGATCCTGTGCCTGGGCGCCGCGGCCGCGGGGCTGCTCGCCCCGTCACG
CGCGTGGCCGCGCCGGTGGCTGGCGCTGATGACCATGGTGTCCCTCGCCGTGGTGGGCGCGATGCTGCTGGTGACGGTGC
GCCGCGAAGGCATCCAGTCCATGCAGGTGGGCGGGTGGGCGGCGCCCTTTGGCATCACCCTGGTCGCGGACCTGCTGAGC
GCCTTGCTGGTGCTCGTCACCGGGGTGATGGGCCTGACGGTGGTCTCCTACTCCGCGGCCACGCTCCCAGCGTCGAAGGA
GGCGGGCGCCTACTACCCACTGGTGCTGGTGCTGGTGGGCGGCGTGTGCGGCGCGTTCCTGACCGGAGACCTCTTCAACC
TCTTCGTGTGGATCGAGGTCATGCTGGGCGCCTCGTTCGTGCTGCTCGCGCTGGAGGCCCGCCAGGAGCAGCTCGAAGCG
TCCATCAAATACATGTCGCTGAGCCTCATGGGCTCGGTGGTGCTGCTGTGCGCGGTGGGCCTGCTGTACGGGGCGGCGGG
CACGCTGAACCTGGCGGACCTGGCCGTCACGGTGCCGGGCCTGGGCACGCCGAACCTGATGACGGCCGTGTCCATGTTCT
TCCTGGTGGCCTTCGCGCTGAAGGCGGGCGCCTTTCCCCTCTTCTTCTGGCTGCCGGCCTCGTACCACACGCCCCCGGCG
GCGGTGACGACGCTCTTCTCCGCGCTCCTCACCAAGGTCGGCGTCTACGCCCTGGCGCGCGTGTTCACCCTGGTCTTCAC
GCAGGACTCTCAGCTCACCAGCACCCTCCTGCTGGTGATGGGCGGCCTCACCATGGTGACGGGCGTGCTGGGCGCGGTGG
CGCAGTACGACATGCGCCGGCTGCTGTCCTTCCACATCATCAGCCAGATTGGCTACCTCATCGCCGCCCTGGGGCTGCTC
ACCCGGAGCGCGCTGACGGCGCTCATCGCCTTCCTCATCCACTACATCTTCGCGAAGTCGGCGCTCTTCCTGGTGAGCGG
GGCCACCGCGCGCGTCACCCGCACCTATGACCTGCACCAGATGGGCAACCTGTACCGGACCCAGCCCCTGCTGGCCGCGC
TGTTCTTCATCCCCGCGCTGTCGCTCGCGGGCGTGCCGCCCTTCTCCGGGTTCTTCGCCAAGCTGGCCGTCATCCAGGCC
GCGCTGCGGGCCGAAAACTGGATCATCGCGGGAACGGCTGTCGTCGTGGGCCTGCTCACCCTCTTCTCCATGATGAAGAT
CTGGCGCGAGGCCTTCTGGAAGGCGCCGCCGGAGGACCAGCCGCAGGAACCCACCCGGCCGCTGAGCCTGGGAGACGGCG
TGCTCGGGCCCTGCATGGCGATGACACTGTTCATGGTCGTCCTGGGCCTGGGCGCCGAGCCACTGCTGGAGCTGGCGGAC
GCCGCCGCGGGCCAGTTGCTGGACCCGGAGGAGTACGTGCGGGCGGTGCTGGGGGGACGCCCATGA

Upstream 100 bases:

>100_bases
GCCTGCTCGCGCTGCTGCTGGTGCTGGTGCACCGCGCCGCGCAGGAGACGGGGACCGATGACACGCGGGCCCTGCGCACC
GAGCTGAAGGACTCCCAGCG

Downstream 100 bases:

>100_bases
CCGCGTTCCTCTGGAACCTGATGCTGGCGCTCCTCTGGGCCGCGATGCTGGGGAACGTCACTTCGGAGAACCTCCTCACG
GGGTTCATCATCGGCTTCGT

Product: NADH-ubiquinone/plastoquinone oxidoreductase family protein

Products: NA

Alternate protein names: Mrp complex subunit D; Multiple resistance and pH homeostasis protein D [H]

Number of amino acids: Translated: 501; Mature: 500

Protein sequence:

>501_residues
MTPSTLLSLPMILCLGAAAAGLLAPSRAWPRRWLALMTMVSLAVVGAMLLVTVRREGIQSMQVGGWAAPFGITLVADLLS
ALLVLVTGVMGLTVVSYSAATLPASKEAGAYYPLVLVLVGGVCGAFLTGDLFNLFVWIEVMLGASFVLLALEARQEQLEA
SIKYMSLSLMGSVVLLCAVGLLYGAAGTLNLADLAVTVPGLGTPNLMTAVSMFFLVAFALKAGAFPLFFWLPASYHTPPA
AVTTLFSALLTKVGVYALARVFTLVFTQDSQLTSTLLLVMGGLTMVTGVLGAVAQYDMRRLLSFHIISQIGYLIAALGLL
TRSALTALIAFLIHYIFAKSALFLVSGATARVTRTYDLHQMGNLYRTQPLLAALFFIPALSLAGVPPFSGFFAKLAVIQA
ALRAENWIIAGTAVVVGLLTLFSMMKIWREAFWKAPPEDQPQEPTRPLSLGDGVLGPCMAMTLFMVVLGLGAEPLLELAD
AAAGQLLDPEEYVRAVLGGRP

Sequences:

>Translated_501_residues
MTPSTLLSLPMILCLGAAAAGLLAPSRAWPRRWLALMTMVSLAVVGAMLLVTVRREGIQSMQVGGWAAPFGITLVADLLS
ALLVLVTGVMGLTVVSYSAATLPASKEAGAYYPLVLVLVGGVCGAFLTGDLFNLFVWIEVMLGASFVLLALEARQEQLEA
SIKYMSLSLMGSVVLLCAVGLLYGAAGTLNLADLAVTVPGLGTPNLMTAVSMFFLVAFALKAGAFPLFFWLPASYHTPPA
AVTTLFSALLTKVGVYALARVFTLVFTQDSQLTSTLLLVMGGLTMVTGVLGAVAQYDMRRLLSFHIISQIGYLIAALGLL
TRSALTALIAFLIHYIFAKSALFLVSGATARVTRTYDLHQMGNLYRTQPLLAALFFIPALSLAGVPPFSGFFAKLAVIQA
ALRAENWIIAGTAVVVGLLTLFSMMKIWREAFWKAPPEDQPQEPTRPLSLGDGVLGPCMAMTLFMVVLGLGAEPLLELAD
AAAGQLLDPEEYVRAVLGGRP
>Mature_500_residues
TPSTLLSLPMILCLGAAAAGLLAPSRAWPRRWLALMTMVSLAVVGAMLLVTVRREGIQSMQVGGWAAPFGITLVADLLSA
LLVLVTGVMGLTVVSYSAATLPASKEAGAYYPLVLVLVGGVCGAFLTGDLFNLFVWIEVMLGASFVLLALEARQEQLEAS
IKYMSLSLMGSVVLLCAVGLLYGAAGTLNLADLAVTVPGLGTPNLMTAVSMFFLVAFALKAGAFPLFFWLPASYHTPPAA
VTTLFSALLTKVGVYALARVFTLVFTQDSQLTSTLLLVMGGLTMVTGVLGAVAQYDMRRLLSFHIISQIGYLIAALGLLT
RSALTALIAFLIHYIFAKSALFLVSGATARVTRTYDLHQMGNLYRTQPLLAALFFIPALSLAGVPPFSGFFAKLAVIQAA
LRAENWIIAGTAVVVGLLTLFSMMKIWREAFWKAPPEDQPQEPTRPLSLGDGVLGPCMAMTLFMVVLGLGAEPLLELADA
AAGQLLDPEEYVRAVLGGRP

Specific function: Mrp complex is a Na(+)/H(+) antiporter involved in Na(+) excretion and Na(+) resistance [H]

COG id: COG0651

COG function: function code CP; Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CPA3 antiporters (TC 2.A.63) subunit D family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=353, Percent_Identity=23.5127478753541, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI1788829, Length=401, Percent_Identity=29.1770573566085, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI1788613, Length=529, Percent_Identity=24.952741020794, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1788831, Length=401, Percent_Identity=26.9326683291771, Blast_Score=113, Evalue=3e-26,
Organism=Escherichia coli, GI145693160, Length=387, Percent_Identity=28.4237726098191, Blast_Score=112, Evalue=5e-26,
Organism=Escherichia coli, GI1788827, Length=409, Percent_Identity=25.6723716381418, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI2367154, Length=435, Percent_Identity=23.9080459770115, Blast_Score=86, Evalue=8e-18,
Organism=Escherichia coli, GI1788614, Length=338, Percent_Identity=25.7396449704142, Blast_Score=84, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 53054; Mature: 52923

Theoretical pI: Translated: 8.29; Mature: 8.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHCCCCCCHHHHHHHHHCCCC
>Mature Secondary Structure 
TPSTLLSLPMILCLGAAAAGLLAPSRAWPRRWLALMTMVSLAVVGAMLLVTVRREGIQS
CCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH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HHCCCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11356194 [H]