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The map label for this gene is uppS [H]

Identifier: 108760968

GI number: 108760968

Start: 2974930

End: 2975721

Strand: Direct

Name: uppS [H]

Synonym: MXAN_2555

Alternate gene names: 108760968

Gene position: 2974930-2975721 (Clockwise)

Preceding gene: 108763970

Following gene: 108761978

Centisome position: 32.55

GC content: 67.8

Gene sequence:

>792_bases
ATGGAACGCCCTTCAGTGATTTCCACCCTGGAACAAGCCGTCAAGGCCCGGCCGATGCCGCGCCACGTGGGCATCATCAT
GGACGGCAACGGGCGATGGGCGGAGTCCCGAGGGCTGCCCCGGCTGGAGGGGCACCGGGAGGCGACGTCGAGTGTGCGTG
AAGTGACGCGCACCGCGCGCCGCCTGGGCATCCAGGCGCTGACGCTCTACGCGTTCTCGTCGCAGAACTGGGCGCGTCCG
GCGGAAGAGGTCGCCGGATTGATGGACCTGCTCCGGGAGTATCTGGAGCGCGAGCGCTCCGAAATCCTGGACAACGGCAT
TCGCCTCAACGCCATTGGAGACGTGGACCGGCTGCCGCGCTACGTGCGTGATCCGCTGGACCGGCTCCGGGCCGACTCCG
CGCACAACACCGGCATGGTGCTGTCGCTGGCGTTGTCCTACGGCGGGCGGGAGGAAATCCTCCACGCGGCGCGGCGGCTG
GCCGAGGCCGTGGAGCGAGGCGAACTGGCGGCGGGACGGTTGGAGGAGAGCGACTTCGAGCAGTTCCTCTGGACGCAGGG
ACTGCCCCCGTTGGACCTGATGGTGAGGACCAGTGGGGAGCTGCGCGTGTCCAACTTCCTGCTCTGGCAAATGGCGTACG
CGGAGATGTGCTTCACCGACGCCTTGTGGCCGGACTTCCGTACTGACGAGTTCCTTCGCTGCGTGTCGCAGTACCAGCAG
CGTGAGCGCCGCTTCGGCCTCACGTCCGCACAGGTGCAGCGGGAGGACGCTCCTCAGCAGGCCAAGGCGTGA

Upstream 100 bases:

>100_bases
CCACCCACCGCCACCGGGCGACCATTCAGGGGCCGACCGTGACGGTTGGGGCACGCGCCCGTGGACGGCGCGCGGCGGCA
TCGCTAGGGTGCGCGGCTTC

Downstream 100 bases:

>100_bases
ACGACAAGAACCGAAACCTCGTCATCCGCGTCGTCTCCGCGGTGACACTGCTGCCGCTGGTCCTCCTGCTGCTGTTCCTC
GGTGGTTACTGGAGCGCGGC

Product: undecaprenyl diphosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 263; Mature: 263

Protein sequence:

>263_residues
MERPSVISTLEQAVKARPMPRHVGIIMDGNGRWAESRGLPRLEGHREATSSVREVTRTARRLGIQALTLYAFSSQNWARP
AEEVAGLMDLLREYLERERSEILDNGIRLNAIGDVDRLPRYVRDPLDRLRADSAHNTGMVLSLALSYGGREEILHAARRL
AEAVERGELAAGRLEESDFEQFLWTQGLPPLDLMVRTSGELRVSNFLLWQMAYAEMCFTDALWPDFRTDEFLRCVSQYQQ
RERRFGLTSAQVQREDAPQQAKA

Sequences:

>Translated_263_residues
MERPSVISTLEQAVKARPMPRHVGIIMDGNGRWAESRGLPRLEGHREATSSVREVTRTARRLGIQALTLYAFSSQNWARP
AEEVAGLMDLLREYLERERSEILDNGIRLNAIGDVDRLPRYVRDPLDRLRADSAHNTGMVLSLALSYGGREEILHAARRL
AEAVERGELAAGRLEESDFEQFLWTQGLPPLDLMVRTSGELRVSNFLLWQMAYAEMCFTDALWPDFRTDEFLRCVSQYQQ
RERRFGLTSAQVQREDAPQQAKA
>Mature_263_residues
MERPSVISTLEQAVKARPMPRHVGIIMDGNGRWAESRGLPRLEGHREATSSVREVTRTARRLGIQALTLYAFSSQNWARP
AEEVAGLMDLLREYLERERSEILDNGIRLNAIGDVDRLPRYVRDPLDRLRADSAHNTGMVLSLALSYGGREEILHAARRL
AEAVERGELAAGRLEESDFEQFLWTQGLPPLDLMVRTSGELRVSNFLLWQMAYAEMCFTDALWPDFRTDEFLRCVSQYQQ
RERRFGLTSAQVQREDAPQQAKA

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580742, Length=229, Percent_Identity=34.9344978165939, Blast_Score=158, Evalue=4e-39,
Organism=Homo sapiens, GI45580738, Length=229, Percent_Identity=34.9344978165939, Blast_Score=158, Evalue=5e-39,
Organism=Escherichia coli, GI1786371, Length=228, Percent_Identity=46.9298245614035, Blast_Score=216, Evalue=9e-58,
Organism=Caenorhabditis elegans, GI71993029, Length=267, Percent_Identity=32.2097378277154, Blast_Score=125, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6319474, Length=213, Percent_Identity=36.150234741784, Blast_Score=130, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6323748, Length=227, Percent_Identity=30.8370044052863, Blast_Score=115, Evalue=6e-27,
Organism=Drosophila melanogaster, GI18857969, Length=225, Percent_Identity=32.8888888888889, Blast_Score=139, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 30043; Mature: 30043

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERPSVISTLEQAVKARPMPRHVGIIMDGNGRWAESRGLPRLEGHREATSSVREVTRTAR
CCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHH
RLGIQALTLYAFSSQNWARPAEEVAGLMDLLREYLERERSEILDNGIRLNAIGDVDRLPR
HHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHH
YVRDPLDRLRADSAHNTGMVLSLALSYGGREEILHAARRLAEAVERGELAAGRLEESDFE
HHHHHHHHHHCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHCCCCHHHHH
QFLWTQGLPPLDLMVRTSGELRVSNFLLWQMAYAEMCFTDALWPDFRTDEFLRCVSQYQQ
HHHHHCCCCCHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
RERRFGLTSAQVQREDAPQQAKA
HHHHCCCCHHHHHHHCCCCCCCC
>Mature Secondary Structure
MERPSVISTLEQAVKARPMPRHVGIIMDGNGRWAESRGLPRLEGHREATSSVREVTRTAR
CCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHH
RLGIQALTLYAFSSQNWARPAEEVAGLMDLLREYLERERSEILDNGIRLNAIGDVDRLPR
HHHHHHHHHEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCHHHHHH
YVRDPLDRLRADSAHNTGMVLSLALSYGGREEILHAARRLAEAVERGELAAGRLEESDFE
HHHHHHHHHHCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHCCCCHHHHH
QFLWTQGLPPLDLMVRTSGELRVSNFLLWQMAYAEMCFTDALWPDFRTDEFLRCVSQYQQ
HHHHHCCCCCHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
RERRFGLTSAQVQREDAPQQAKA
HHHHCCCCHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]