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The map label for this gene is metR [H]

Identifier: 108760942

GI number: 108760942

Start: 2462214

End: 2463125

Strand: Direct

Name: metR [H]

Synonym: MXAN_2128

Alternate gene names: 108760942

Gene position: 2462214-2463125 (Clockwise)

Preceding gene: 108762861

Following gene: 108758363

Centisome position: 26.94

GC content: 72.15

Gene sequence:

>912_bases
ATGTCCCAGGAGAGCACCCTCGAGGCGCGAGACCTCCGCCTCATCCAGGCCATCGTCGAGGAGGGCAGCGTGACGCGCGC
GGCGCGGCGGCTGTACCTGAGCCAGTCGGCGATCAGCCACCAGCTTTCAGGGCTCGAAACGCGGCTCGGAGTCACCCTCT
TCGAGCGCGTGCGCAAGCGCATGGTCATCACGCCCGCGGGCCAACGGCTGGCGGCGCTCGCCGCCGAGGTGCTGCCGAGG
CTCGCACGGGAACAGGCCCTGCTGCGCGCCGCGCTGACGCCCACGCCGCCACGTCCCTTGCGCCTCGCCGCCCAGTGCTA
CACCTGCTACCAGTGGCTGCCGCGGTTGCTGACGGGGCTGTCCACAGCGCACCCAGAGGTGGACCTGCGGCTGGACGTGG
AAGCCACGCGCTCGGCGGAAGCGGCCCTGCTCGAAGACCGGCTGGACGTGGCCCTCTGTTGCTACCCCGTGAGCACTCCC
GGGCTCGTCTCCACGCCCCTCTTCCGCGATGAGCTCGTGGCCGTGCTGCCCGCGGGCCACCCGCTGGCCGCGCGCCCCTA
CGTCAGCGGACCGGACCTGACAGAGCAGGCCGTCTACTTCTACCCGCTCCCCGCGGAGGACGAGGAGCGCTTCCGCCGAG
AGCTCCTGCCACGGAGGCCCGATGCACTGCGCGTCCGCACGCTTCCACTCACCGAGGCCATGGTGGAGCTGGTGCGGAGC
GGGCACGGGGTGTCCCTCATCGCGCGCTGGTCACTCGGGCCGCACCTGGCACAAGGGGGGCTCGTCACCCGCGGCCTCGG
TCGCAAGGGCTACTGGCGACAGTGGAGCGCGGTGCACAAGCGTCACAGCCCACTCGCCCCGGCGCTCGCCACACTCGTGG
ACCTGCTGCGCAGCGCGGTGCTCTCCGCCTGA

Upstream 100 bases:

>100_bases
CCTCGGGCGGGCCTCCGGATTGAGTCAGACATGTGCCTTCCGAGGGGTTGTTGCGTCCAACGCATTGATGGCATCCAAGT
TCATGCAGTAGCCTCATGAC

Downstream 100 bases:

>100_bases
GCAGCCTGGGTCGCGAGGGAGACCCCGGAGCATCAGGAAATGCTCCAATCATGATCCAACCATGATGCTCCGGCCGGCCA
GATGGGCCTTTATCGGCGTC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 303; Mature: 302

Protein sequence:

>303_residues
MSQESTLEARDLRLIQAIVEEGSVTRAARRLYLSQSAISHQLSGLETRLGVTLFERVRKRMVITPAGQRLAALAAEVLPR
LAREQALLRAALTPTPPRPLRLAAQCYTCYQWLPRLLTGLSTAHPEVDLRLDVEATRSAEAALLEDRLDVALCCYPVSTP
GLVSTPLFRDELVAVLPAGHPLAARPYVSGPDLTEQAVYFYPLPAEDEERFRRELLPRRPDALRVRTLPLTEAMVELVRS
GHGVSLIARWSLGPHLAQGGLVTRGLGRKGYWRQWSAVHKRHSPLAPALATLVDLLRSAVLSA

Sequences:

>Translated_303_residues
MSQESTLEARDLRLIQAIVEEGSVTRAARRLYLSQSAISHQLSGLETRLGVTLFERVRKRMVITPAGQRLAALAAEVLPR
LAREQALLRAALTPTPPRPLRLAAQCYTCYQWLPRLLTGLSTAHPEVDLRLDVEATRSAEAALLEDRLDVALCCYPVSTP
GLVSTPLFRDELVAVLPAGHPLAARPYVSGPDLTEQAVYFYPLPAEDEERFRRELLPRRPDALRVRTLPLTEAMVELVRS
GHGVSLIARWSLGPHLAQGGLVTRGLGRKGYWRQWSAVHKRHSPLAPALATLVDLLRSAVLSA
>Mature_302_residues
SQESTLEARDLRLIQAIVEEGSVTRAARRLYLSQSAISHQLSGLETRLGVTLFERVRKRMVITPAGQRLAALAAEVLPRL
AREQALLRAALTPTPPRPLRLAAQCYTCYQWLPRLLTGLSTAHPEVDLRLDVEATRSAEAALLEDRLDVALCCYPVSTPG
LVSTPLFRDELVAVLPAGHPLAARPYVSGPDLTEQAVYFYPLPAEDEERFRRELLPRRPDALRVRTLPLTEAMVELVRSG
HGVSLIARWSLGPHLAQGGLVTRGLGRKGYWRQWSAVHKRHSPLAPALATLVDLLRSAVLSA

Specific function: Control of the last step in methionine biosynthesis; metR is a positive activator of the metA, metE and metH genes [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790262, Length=272, Percent_Identity=31.25, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1788481, Length=290, Percent_Identity=28.2758620689655, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI157672245, Length=192, Percent_Identity=32.2916666666667, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788887, Length=247, Percent_Identity=29.9595141700405, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1787806, Length=244, Percent_Identity=22.5409836065574, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1787879, Length=256, Percent_Identity=28.515625, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1789204, Length=262, Percent_Identity=28.2442748091603, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI87082132, Length=305, Percent_Identity=24.5901639344262, Blast_Score=68, Evalue=9e-13,
Organism=Escherichia coli, GI1790399, Length=310, Percent_Identity=24.1935483870968, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789173, Length=238, Percent_Identity=26.0504201680672, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1790208, Length=248, Percent_Identity=26.6129032258064, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1787530, Length=257, Percent_Identity=26.4591439688716, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI145693105, Length=188, Percent_Identity=23.4042553191489, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1786401, Length=272, Percent_Identity=22.7941176470588, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33469; Mature: 33338

Theoretical pI: Translated: 9.84; Mature: 9.84

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQESTLEARDLRLIQAIVEEGSVTRAARRLYLSQSAISHQLSGLETRLGVTLFERVRKR
CCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
MVITPAGQRLAALAAEVLPRLAREQALLRAALTPTPPRPLRLAAQCYTCYQWLPRLLTGL
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
STAHPEVDLRLDVEATRSAEAALLEDRLDVALCCYPVSTPGLVSTPLFRDELVAVLPAGH
CCCCCCEEEEEECHHHCCHHHHHHHHCCCEEEEEEECCCCCCCCCCCHHHHHHHEECCCC
PLAARPYVSGPDLTEQAVYFYPLPAEDEERFRRELLPRRPDALRVRTLPLTEAMVELVRS
CCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHC
GHGVSLIARWSLGPHLAQGGLVTRGLGRKGYWRQWSAVHKRHSPLAPALATLVDLLRSAV
CCCEEEEEECCCCHHHHCCCCEECCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
LSA
HCC
>Mature Secondary Structure 
SQESTLEARDLRLIQAIVEEGSVTRAARRLYLSQSAISHQLSGLETRLGVTLFERVRKR
CCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
MVITPAGQRLAALAAEVLPRLAREQALLRAALTPTPPRPLRLAAQCYTCYQWLPRLLTGL
EECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
STAHPEVDLRLDVEATRSAEAALLEDRLDVALCCYPVSTPGLVSTPLFRDELVAVLPAGH
CCCCCCEEEEEECHHHCCHHHHHHHHCCCEEEEEEECCCCCCCCCCCHHHHHHHEECCCC
PLAARPYVSGPDLTEQAVYFYPLPAEDEERFRRELLPRRPDALRVRTLPLTEAMVELVRS
CCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHC
GHGVSLIARWSLGPHLAQGGLVTRGLGRKGYWRQWSAVHKRHSPLAPALATLVDLLRSAV
CCCEEEEEECCCCHHHHCCCCEECCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
LSA
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]