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The map label for this gene is purD [H]

Identifier: 108760876

GI number: 108760876

Start: 3415613

End: 3416878

Strand: Direct

Name: purD [H]

Synonym: MXAN_2916

Alternate gene names: 108760876

Gene position: 3415613-3416878 (Clockwise)

Preceding gene: 108762465

Following gene: 108761666

Centisome position: 37.37

GC content: 73.22

Gene sequence:

>1266_bases
GTGGATGTGAAGGTCCTGCTGCTCGGTTCCGGTGGCCGTGAGCACGCGCTCGCGTGGAAGCTGTCGCAGAGCCCCATGTT
GACCCAGCTCTTGTGCGGTCCGGGCAACCCGGGCACGGCGAAGCTGGGCACGAACGTGGCCCTGCGCGCGGACGCACCGG
AGGAAGTCGCCGCGTTCGCGAAGCGCGAGGCCGTGGACCTGGTGGTGGTGGGGCCAGAGGCGCCGCTGGTCGCGGGGGTC
GCTGACGCGCTGGCCGACGCGGGCATCCCCTGCTTCGGGCCCGTGGCGGCGGGCGCGCGCATCGAAGGGTCCAAGGCCTT
CGCGAAGGAGATCATGGCCGAGGCCGGCGTGCCCACCGCCGCCTTCCAGACCTTCACCGACATGGCGGCGGCGGAAGCCT
ACGCGGTGGCGCAGGGCCGCATCGTCGTCAAGGCGGATGGCCTGGCGGCGGGCAAGGGCGTCATCGTCGCCCACGACGTC
GAGGCCGCGCGCGCGGCGGTGCGCGCCGTGGGGGCCATGGGCGTGGCGGGCCAGACGATGGTCCTGGAGGAGCTGCTGGA
GGGCGAAGAGGTGTCCGCGATGGCGCTGTGTGATGGCGAGCGCTACGCCATGCTTCCCTTATCCCAGGACCACAAGCGCG
TGGGCGAAGGCGATACCGGGCCGAACACCGGCGGCATGGGCGCGTACAGCCCCGCGCCTTTCCTGTCCGCCGCGCAGCTC
GCCGAGGTGGGCGAGCGCGTGGTCGCCCCGACGCTGGCCGTGTTGCGCCGGCGCGGAATTCCCTTCCGGGGTGTGCTGTA
TGCGGGGCTGATGCTCACGCGCGGCGGCCCGAAGGTGCTGGAGTTCAACGCGCGCTTCGGTGACCCGGAGACGCAGGTGT
TGATGATGCAACTGGGGGAGGACCTGCTGCCGTTGCTGGACGCGTGTGCCCGGGGCGCGCTCGTGCCGCGGACGCTGGTG
TCCGCGCTTGGTGCCTCGGTGGGCGTGGTGCTGGCGGCGCGGGGCTATCCGGACGCGCCGGAGAAGGGCCAGCGGATTGA
AGGGCTGGACGCGGTGCCACCCGACGCCACGGTGTTCCTGGCGGGCGCGGAGGCGCGCGACGGCGGCGTCGTGACGGCCG
GAGGCCGGGTGCTGACGGTGTGCGCGCGGGGCGAGGACCTGGCTCAGGCACGTGAGCGGGCCTACGCGGCGGTGGCGACC
GTGCGCTTCGAGGGCATGCACTTCCGCCGGGACATCGGCGCGCGAGGGATGAAGGCCGCCCCGTGA

Upstream 100 bases:

>100_bases
CAGGGCAAGGACGTGGCACGAGACACCCTGGTGAAGGTGGTGGGGTTGGATCCGGCATACCTCCCCGCGAAGCGGATGCT
CTACCTGTTGGAACGGTGAG

Downstream 100 bases:

>100_bases
ACCGCCTTTCGCGCTACCTGCTCGGGGAGCTGCTGGTCCCGCTCGGCGTGTGGGTGGCGTTCATGTTCCTGCTGCTCTTC
GTCATGCAGTTCCTGCGGGG

Product: phosphoribosylamine--glycine ligase

Products: NA

Alternate protein names: GARS; Glycinamide ribonucleotide synthetase; Phosphoribosylglycinamide synthetase [H]

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MDVKVLLLGSGGREHALAWKLSQSPMLTQLLCGPGNPGTAKLGTNVALRADAPEEVAAFAKREAVDLVVVGPEAPLVAGV
ADALADAGIPCFGPVAAGARIEGSKAFAKEIMAEAGVPTAAFQTFTDMAAAEAYAVAQGRIVVKADGLAAGKGVIVAHDV
EAARAAVRAVGAMGVAGQTMVLEELLEGEEVSAMALCDGERYAMLPLSQDHKRVGEGDTGPNTGGMGAYSPAPFLSAAQL
AEVGERVVAPTLAVLRRRGIPFRGVLYAGLMLTRGGPKVLEFNARFGDPETQVLMMQLGEDLLPLLDACARGALVPRTLV
SALGASVGVVLAARGYPDAPEKGQRIEGLDAVPPDATVFLAGAEARDGGVVTAGGRVLTVCARGEDLAQARERAYAAVAT
VRFEGMHFRRDIGARGMKAAP

Sequences:

>Translated_421_residues
MDVKVLLLGSGGREHALAWKLSQSPMLTQLLCGPGNPGTAKLGTNVALRADAPEEVAAFAKREAVDLVVVGPEAPLVAGV
ADALADAGIPCFGPVAAGARIEGSKAFAKEIMAEAGVPTAAFQTFTDMAAAEAYAVAQGRIVVKADGLAAGKGVIVAHDV
EAARAAVRAVGAMGVAGQTMVLEELLEGEEVSAMALCDGERYAMLPLSQDHKRVGEGDTGPNTGGMGAYSPAPFLSAAQL
AEVGERVVAPTLAVLRRRGIPFRGVLYAGLMLTRGGPKVLEFNARFGDPETQVLMMQLGEDLLPLLDACARGALVPRTLV
SALGASVGVVLAARGYPDAPEKGQRIEGLDAVPPDATVFLAGAEARDGGVVTAGGRVLTVCARGEDLAQARERAYAAVAT
VRFEGMHFRRDIGARGMKAAP
>Mature_421_residues
MDVKVLLLGSGGREHALAWKLSQSPMLTQLLCGPGNPGTAKLGTNVALRADAPEEVAAFAKREAVDLVVVGPEAPLVAGV
ADALADAGIPCFGPVAAGARIEGSKAFAKEIMAEAGVPTAAFQTFTDMAAAEAYAVAQGRIVVKADGLAAGKGVIVAHDV
EAARAAVRAVGAMGVAGQTMVLEELLEGEEVSAMALCDGERYAMLPLSQDHKRVGEGDTGPNTGGMGAYSPAPFLSAAQL
AEVGERVVAPTLAVLRRRGIPFRGVLYAGLMLTRGGPKVLEFNARFGDPETQVLMMQLGEDLLPLLDACARGALVPRTLV
SALGASVGVVLAARGYPDAPEKGQRIEGLDAVPPDATVFLAGAEARDGGVVTAGGRVLTVCARGEDLAQARERAYAAVAT
VRFEGMHFRRDIGARGMKAAP

Specific function: De novo purine biosynthesis; second step. [C]

COG id: COG0151

COG function: function code F; Phosphoribosylamine-glycine ligase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=426, Percent_Identity=46.7136150234742, Blast_Score=355, Evalue=5e-98,
Organism=Homo sapiens, GI209869995, Length=426, Percent_Identity=46.7136150234742, Blast_Score=355, Evalue=5e-98,
Organism=Homo sapiens, GI209869993, Length=426, Percent_Identity=46.7136150234742, Blast_Score=355, Evalue=5e-98,
Organism=Homo sapiens, GI28416899, Length=426, Percent_Identity=46.7136150234742, Blast_Score=354, Evalue=1e-97,
Organism=Escherichia coli, GI1790438, Length=428, Percent_Identity=47.8971962616822, Blast_Score=351, Evalue=4e-98,
Organism=Caenorhabditis elegans, GI17567511, Length=425, Percent_Identity=42.1176470588235, Blast_Score=302, Evalue=2e-82,
Organism=Saccharomyces cerevisiae, GI6321203, Length=442, Percent_Identity=38.2352941176471, Blast_Score=313, Evalue=3e-86,
Organism=Drosophila melanogaster, GI24582400, Length=436, Percent_Identity=46.7889908256881, Blast_Score=306, Evalue=2e-83,
Organism=Drosophila melanogaster, GI62471619, Length=434, Percent_Identity=46.7741935483871, Blast_Score=305, Evalue=3e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR020561
- InterPro:   IPR000115
- InterPro:   IPR020560
- InterPro:   IPR020559
- InterPro:   IPR020562
- InterPro:   IPR011054 [H]

Pfam domain/function: PF01071 GARS_A; PF02843 GARS_C; PF02844 GARS_N [H]

EC number: =6.3.4.13 [H]

Molecular weight: Translated: 43152; Mature: 43152

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS50975 ATP_GRASP ; PS00184 GARS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVKVLLLGSGGREHALAWKLSQSPMLTQLLCGPGNPGTAKLGTNVALRADAPEEVAAFA
CCEEEEEECCCCCCCEEEEEECCCCCHHHHHCCCCCCCCEECCCCEEEECCCHHHHHHHH
KREAVDLVVVGPEAPLVAGVADALADAGIPCFGPVAAGARIEGSKAFAKEIMAEAGVPTA
HHCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCEECCHHHHHHHHHHHCCCCHH
AFQTFTDMAAAEAYAVAQGRIVVKADGLAAGKGVIVAHDVEAARAAVRAVGAMGVAGQTM
HHHHHHHHHHHHHHEEECCEEEEEECCCCCCCCEEEEECHHHHHHHHHHHHHCCCCCHHH
VLEELLEGEEVSAMALCDGERYAMLPLSQDHKRVGEGDTGPNTGGMGAYSPAPFLSAAQL
HHHHHHCCCCCEEEEEECCCEEEECCCCCHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHH
AEVGERVVAPTLAVLRRRGIPFRGVLYAGLMLTRGGPKVLEFNARFGDPETQVLMMQLGE
HHHHHHHHHHHHHHHHHCCCCCHHHHHHCEEEECCCCCEEEEECCCCCCHHHHHHHHHCH
DLLPLLDACARGALVPRTLVSALGASVGVVLAARGYPDAPEKGQRIEGLDAVPPDATVFL
HHHHHHHHHHCCCCCHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEE
AGAEARDGGVVTAGGRVLTVCARGEDLAQARERAYAAVATVRFEGMHFRRDIGARGMKAA
ECCCCCCCCEEEECCEEEEEEECCCHHHHHHHHHHHHHEEEEECCCHHHHHHCCCCCCCC
P
C
>Mature Secondary Structure
MDVKVLLLGSGGREHALAWKLSQSPMLTQLLCGPGNPGTAKLGTNVALRADAPEEVAAFA
CCEEEEEECCCCCCCEEEEEECCCCCHHHHHCCCCCCCCEECCCCEEEECCCHHHHHHHH
KREAVDLVVVGPEAPLVAGVADALADAGIPCFGPVAAGARIEGSKAFAKEIMAEAGVPTA
HHCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCEECCHHHHHHHHHHHCCCCHH
AFQTFTDMAAAEAYAVAQGRIVVKADGLAAGKGVIVAHDVEAARAAVRAVGAMGVAGQTM
HHHHHHHHHHHHHHEEECCEEEEEECCCCCCCCEEEEECHHHHHHHHHHHHHCCCCCHHH
VLEELLEGEEVSAMALCDGERYAMLPLSQDHKRVGEGDTGPNTGGMGAYSPAPFLSAAQL
HHHHHHCCCCCEEEEEECCCEEEECCCCCHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHH
AEVGERVVAPTLAVLRRRGIPFRGVLYAGLMLTRGGPKVLEFNARFGDPETQVLMMQLGE
HHHHHHHHHHHHHHHHHCCCCCHHHHHHCEEEECCCCCEEEEECCCCCCHHHHHHHHHCH
DLLPLLDACARGALVPRTLVSALGASVGVVLAARGYPDAPEKGQRIEGLDAVPPDATVFL
HHHHHHHHHHCCCCCHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEE
AGAEARDGGVVTAGGRVLTVCARGEDLAQARERAYAAVATVRFEGMHFRRDIGARGMKAA
ECCCCCCCCEEEECCEEEEEEECCCHHHHHHHHHHHHHEEEEECCCHHHHHHCCCCCCCC
P
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]