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The map label for this gene is yuxL [H]

Identifier: 108760758

GI number: 108760758

Start: 6600741

End: 6602876

Strand: Direct

Name: yuxL [H]

Synonym: MXAN_5299

Alternate gene names: 108760758

Gene position: 6600741-6602876 (Clockwise)

Preceding gene: 108756963

Following gene: 108762141

Centisome position: 72.22

GC content: 67.28

Gene sequence:

>2136_bases
GTGCCACCGCCGCTTCGCAGCGCCTTCCCGCGTCGGAGCAGTTGGGACCGGCGGCTGTGCGCCGGAGCCAACCTCGCACC
CGACGCAGGCAAGGGGTGTGCGCTGAGCCCTCCTCCTGGCGCGGTGCCACGCCTTCCATCTGGAAACTCGTCTCCCGCCC
CCAATCACGCCACAGTCTCTTGCACGCCCCTGCTCCACCGCCCGACTTGTGGAACCCCCATGACCTCCTGGTCCACCCTC
ACGCGAGCCCTTGTCGCCGTCGTGGTCCTTCCCTCACTGGCGCTGTCCGCTCCCCGCGCCGGGGCGACCAGGCCCCCAGG
CCCGGAAAAGCGTTACACCGTCGAGCAGTTCATGGAGACGACCTCCGTTCTCGGTGCGTCCTTCTCCTCGGATGAGAAGC
GGGTGCTGTACTCGTCGAACGAGACCGGCGTCTTCAATGTCTTCTCCGTCCCGGTGACGGGCGGAAAGCCCACGCAACTG
ACCCGCTCCACCCAGGACGCCTCCATCGCCGTCGCCTACTTCCCCACCGATGACCGCGTCCTCTTCACGCGAGACTCGGG
AGGCAACGAACTCGTCCACCTCTACGTCCGCACGCTGGACGGCCAGGAGAAGGACCTCACGCCGGGCGACGAGCACCGCG
CGTCCTTCTTCGGCTGGAGCCAGGACGGCGCCGCCTTCTACGTCCTCACCAATGAGCGCGACGCACGCTTCCAGGACCTC
TACCGCTACGACGCCAAGACGTATGCCCGCACCCTGCTCTACGCGGGCGATAGCGAGCATGTGCCCGGCGCCCTCTCCCC
GGACGAGAAGTGGCTGGCGCTGGAGAAGTCACGGACGCTGTCCGACAGCGACGTCTACCTCTACGAGTTCGCCACCCAGC
AGCGTCGGCACCTCACCGCGCACGAGGGCTCGGTCAGTTGGAAGGCGGCGACCTTCGACCCGGCGTCCTCCGCGCTGTAC
CTGCTCACCAACGAGGGCTCCGAGTTCATTCGCGTGGAGCGCCACGTGCTCGCTACCCGGAAGCGAGAGTTGGTGGAGCA
GGTGGAGTGGGACGTGCTTTCCACGGTGTTCTCGCGACGCGGCGCGTGGCGCATCACCCGCGTCAACGAGGACGGCCGCA
CCACGCTTCGGGTCCACGACGTGAAGGCCGGCAGGCGCGTGTCCCTGCCAGGGATTCCAGAGGGGGCGATCTCCGGTGTG
AGTCTGTCCCGCGGTGAGAAGCGCATGGCCTTCCACGTCGACGGAGACCGCTCGCCCGGCAACCTGTACGTCTACGACTT
CGAGACGAAGAAGCTCACCCGGCTGACCGACACGCTGGGCCGGGCTCTGGACACCCAGCACCTGGTGGAGTCGGAGCGGG
TGCGCTTCAAGTCCTTCGACGGGCTGGAGATTCCGGCGCTGCTCTACAAGCCCCATCAGGCCACCGCGAAGCAGCGCGCC
CCCGCCATCGTCTTCGTCCATGGGGGACCGGGAGGACAGTCCTCCAAGGGCTACAGCAGCTTCTTCCAGTTCCTCGTCCA
CCACGGCTACGTGGTGCTCGCCGTCAACAACCGGGGCAGCGAGGGCTACGGCAAGTCGTTCTTCGCGGCGGATGACCAGC
AGCACGGCAAGGCGCCGCTCCAGGATTGCGTCGAGGCGAAGAAGTACCTGGCCGCCCTCCCCTACGTGGATGGCGCGCGC
GTGGGCATCCTGGGCCCCAGCTACGGCGGATACATGGTGCTCGCGGCGCTGGCGTTCCATCCCGACGTCTTCGCCGTGGG
CGTGGATGCGTTCGGCATCTCAGACTGGCTGAGCGCGCTGCGAGAGCTGCCGCCCCACAAGGAGGCCCTGCGCGAGGCAC
TCTACCAGGAACTGGGCAACCCCCAGACGCAGGAAGCGATGCTTCGAGAAATCTCCCCGCTGTTCCATGCGGAGAAGATT
CGCAGGCCCCTGCTCGTCATCCAGGGCGCCAACGACCCGCGCGTGCCCCAGGCCAAGACGGACGCGCTCGTCGAGGCCGT
CCGGAAGAACGGCGTGCCCGTCGACTACTTCGTCCTCCCCAATGATGGCCATGGCTTCAGCAGCACGAAGAGCGAAGCGG
AGACCTCCGTCAGAATCCTCTCCTTCCTGGACCGGTACCTCCGACGGAGCCCCTGA

Upstream 100 bases:

>100_bases
ATGTCAGTGCAAAACCGGTGCAGAGGCCCGCTTCCTCTGAGGACGCGAGCCCGGGCCGGTCCGTTCCTGACAGCGGCGTC
CTGGCGCGCCGCCTACGCGG

Downstream 100 bases:

>100_bases
AGCCGCGAGCACGGCTTCGCACTTGTGCAATTGCATGCACAGTGGCTGACACGGCCTTCTGTTATTTCATGGGGTTTCGC
ATTGGCATGCCCCTTGATGG

Product: S9C family peptidase

Products: Hydrolyzed protein [C]

Alternate protein names: NA

Number of amino acids: Translated: 711; Mature: 710

Protein sequence:

>711_residues
MPPPLRSAFPRRSSWDRRLCAGANLAPDAGKGCALSPPPGAVPRLPSGNSSPAPNHATVSCTPLLHRPTCGTPMTSWSTL
TRALVAVVVLPSLALSAPRAGATRPPGPEKRYTVEQFMETTSVLGASFSSDEKRVLYSSNETGVFNVFSVPVTGGKPTQL
TRSTQDASIAVAYFPTDDRVLFTRDSGGNELVHLYVRTLDGQEKDLTPGDEHRASFFGWSQDGAAFYVLTNERDARFQDL
YRYDAKTYARTLLYAGDSEHVPGALSPDEKWLALEKSRTLSDSDVYLYEFATQQRRHLTAHEGSVSWKAATFDPASSALY
LLTNEGSEFIRVERHVLATRKRELVEQVEWDVLSTVFSRRGAWRITRVNEDGRTTLRVHDVKAGRRVSLPGIPEGAISGV
SLSRGEKRMAFHVDGDRSPGNLYVYDFETKKLTRLTDTLGRALDTQHLVESERVRFKSFDGLEIPALLYKPHQATAKQRA
PAIVFVHGGPGGQSSKGYSSFFQFLVHHGYVVLAVNNRGSEGYGKSFFAADDQQHGKAPLQDCVEAKKYLAALPYVDGAR
VGILGPSYGGYMVLAALAFHPDVFAVGVDAFGISDWLSALRELPPHKEALREALYQELGNPQTQEAMLREISPLFHAEKI
RRPLLVIQGANDPRVPQAKTDALVEAVRKNGVPVDYFVLPNDGHGFSSTKSEAETSVRILSFLDRYLRRSP

Sequences:

>Translated_711_residues
MPPPLRSAFPRRSSWDRRLCAGANLAPDAGKGCALSPPPGAVPRLPSGNSSPAPNHATVSCTPLLHRPTCGTPMTSWSTL
TRALVAVVVLPSLALSAPRAGATRPPGPEKRYTVEQFMETTSVLGASFSSDEKRVLYSSNETGVFNVFSVPVTGGKPTQL
TRSTQDASIAVAYFPTDDRVLFTRDSGGNELVHLYVRTLDGQEKDLTPGDEHRASFFGWSQDGAAFYVLTNERDARFQDL
YRYDAKTYARTLLYAGDSEHVPGALSPDEKWLALEKSRTLSDSDVYLYEFATQQRRHLTAHEGSVSWKAATFDPASSALY
LLTNEGSEFIRVERHVLATRKRELVEQVEWDVLSTVFSRRGAWRITRVNEDGRTTLRVHDVKAGRRVSLPGIPEGAISGV
SLSRGEKRMAFHVDGDRSPGNLYVYDFETKKLTRLTDTLGRALDTQHLVESERVRFKSFDGLEIPALLYKPHQATAKQRA
PAIVFVHGGPGGQSSKGYSSFFQFLVHHGYVVLAVNNRGSEGYGKSFFAADDQQHGKAPLQDCVEAKKYLAALPYVDGAR
VGILGPSYGGYMVLAALAFHPDVFAVGVDAFGISDWLSALRELPPHKEALREALYQELGNPQTQEAMLREISPLFHAEKI
RRPLLVIQGANDPRVPQAKTDALVEAVRKNGVPVDYFVLPNDGHGFSSTKSEAETSVRILSFLDRYLRRSP
>Mature_710_residues
PPPLRSAFPRRSSWDRRLCAGANLAPDAGKGCALSPPPGAVPRLPSGNSSPAPNHATVSCTPLLHRPTCGTPMTSWSTLT
RALVAVVVLPSLALSAPRAGATRPPGPEKRYTVEQFMETTSVLGASFSSDEKRVLYSSNETGVFNVFSVPVTGGKPTQLT
RSTQDASIAVAYFPTDDRVLFTRDSGGNELVHLYVRTLDGQEKDLTPGDEHRASFFGWSQDGAAFYVLTNERDARFQDLY
RYDAKTYARTLLYAGDSEHVPGALSPDEKWLALEKSRTLSDSDVYLYEFATQQRRHLTAHEGSVSWKAATFDPASSALYL
LTNEGSEFIRVERHVLATRKRELVEQVEWDVLSTVFSRRGAWRITRVNEDGRTTLRVHDVKAGRRVSLPGIPEGAISGVS
LSRGEKRMAFHVDGDRSPGNLYVYDFETKKLTRLTDTLGRALDTQHLVESERVRFKSFDGLEIPALLYKPHQATAKQRAP
AIVFVHGGPGGQSSKGYSSFFQFLVHHGYVVLAVNNRGSEGYGKSFFAADDQQHGKAPLQDCVEAKKYLAALPYVDGARV
GILGPSYGGYMVLAALAFHPDVFAVGVDAFGISDWLSALRELPPHKEALREALYQELGNPQTQEAMLREISPLFHAEKIR
RPLLVIQGANDPRVPQAKTDALVEAVRKNGVPVDYFVLPNDGHGFSSTKSEAETSVRILSFLDRYLRRSP

Specific function: Cleaves Peptide Bonds On The C-Terminal Side Of Lysyl And Argininyl Residues. [C]

COG id: COG1506

COG function: function code E; Dipeptidyl aminopeptidases/acylaminoacyl-peptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9B family [H]

Homologues:

Organism=Homo sapiens, GI37577089, Length=267, Percent_Identity=30.7116104868914, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI18450280, Length=267, Percent_Identity=30.7116104868914, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI194394146, Length=270, Percent_Identity=28.1481481481481, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI23510451, Length=270, Percent_Identity=23.7037037037037, Blast_Score=89, Evalue=2e-17,
Organism=Homo sapiens, GI41349456, Length=582, Percent_Identity=22.680412371134, Blast_Score=83, Evalue=1e-15,
Organism=Homo sapiens, GI295842403, Length=261, Percent_Identity=25.6704980842912, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI85787627, Length=261, Percent_Identity=25.6704980842912, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI52426756, Length=261, Percent_Identity=25.6704980842912, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI295842359, Length=261, Percent_Identity=25.6704980842912, Blast_Score=82, Evalue=3e-15,
Organism=Homo sapiens, GI295849272, Length=261, Percent_Identity=25.6704980842912, Blast_Score=81, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI25144537, Length=634, Percent_Identity=24.7634069400631, Blast_Score=178, Evalue=8e-45,
Organism=Caenorhabditis elegans, GI25144540, Length=338, Percent_Identity=32.2485207100592, Blast_Score=166, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI17552908, Length=271, Percent_Identity=29.520295202952, Blast_Score=112, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI25144543, Length=543, Percent_Identity=22.4677716390424, Blast_Score=111, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17508019, Length=310, Percent_Identity=26.7741935483871, Blast_Score=93, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17508017, Length=310, Percent_Identity=26.7741935483871, Blast_Score=93, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI25149159, Length=267, Percent_Identity=25.0936329588015, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17564632, Length=243, Percent_Identity=27.5720164609054, Blast_Score=69, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17564634, Length=243, Percent_Identity=27.5720164609054, Blast_Score=69, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6324793, Length=236, Percent_Identity=25.8474576271186, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI45550825, Length=249, Percent_Identity=28.5140562248996, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI45553511, Length=249, Percent_Identity=28.5140562248996, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI45551969, Length=249, Percent_Identity=28.1124497991968, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI221510989, Length=469, Percent_Identity=24.0938166311301, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24583414, Length=421, Percent_Identity=24.9406175771971, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24582257, Length=221, Percent_Identity=25.7918552036199, Blast_Score=72, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011042
- InterPro:   IPR011659
- InterPro:   IPR001375 [H]

Pfam domain/function: PF07676 PD40; PF00326 Peptidase_S9 [H]

EC number: 3.4.21.83 [C]

Molecular weight: Translated: 78264; Mature: 78133

Theoretical pI: Translated: 8.75; Mature: 8.75

Prosite motif: PS00708 PRO_ENDOPEP_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPPLRSAFPRRSSWDRRLCAGANLAPDAGKGCALSPPPGAVPRLPSGNSSPAPNHATVS
CCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEE
CTPLLHRPTCGTPMTSWSTLTRALVAVVVLPSLALSAPRAGATRPPGPEKRYTVEQFMET
EEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHH
TSVLGASFSSDEKRVLYSSNETGVFNVFSVPVTGGKPTQLTRSTQDASIAVAYFPTDDRV
HHHHCCCCCCCCCEEEEECCCCCEEEEEEEEECCCCCCCEECCCCCCEEEEEEECCCCEE
LFTRDSGGNELVHLYVRTLDGQEKDLTPGDEHRASFFGWSQDGAAFYVLTNERDARFQDL
EEEECCCCCCEEEEEEEECCCCCCCCCCCCCCCHHHCCCCCCCEEEEEEECCCCHHHHHH
YRYDAKTYARTLLYAGDSEHVPGALSPDEKWLALEKSRTLSDSDVYLYEFATQQRRHLTA
HHHHHHHHHHEEEECCCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEHHHHHHHEEC
HEGSVSWKAATFDPASSALYLLTNEGSEFIRVERHVLATRKRELVEQVEWDVLSTVFSRR
CCCCCEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GAWRITRVNEDGRTTLRVHDVKAGRRVSLPGIPEGAISGVSLSRGEKRMAFHVDGDRSPG
CCEEEEEECCCCCEEEEEEECCCCCEECCCCCCCCCCCCCEECCCCCEEEEEECCCCCCC
NLYVYDFETKKLTRLTDTLGRALDTQHLVESERVRFKSFDGLEIPALLYKPHQATAKQRA
EEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCEEECCCHHHHHHCC
PAIVFVHGGPGGQSSKGYSSFFQFLVHHGYVVLAVNNRGSEGYGKSFFAADDQQHGKAPL
CEEEEEECCCCCCCCCCHHHHHHHHHHCCEEEEEEECCCCCCCCCCEEECCCCCCCCCHH
QDCVEAKKYLAALPYVDGARVGILGPSYGGYMVLAALAFHPDVFAVGVDAFGISDWLSAL
HHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHCCCEEEEECCCCCHHHHHHHH
RELPPHKEALREALYQELGNPQTQEAMLREISPLFHAEKIRRPLLVIQGANDPRVPQAKT
HHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHH
DALVEAVRKNGVPVDYFVLPNDGHGFSSTKSEAETSVRILSFLDRYLRRSP
HHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PPPLRSAFPRRSSWDRRLCAGANLAPDAGKGCALSPPPGAVPRLPSGNSSPAPNHATVS
CCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEE
CTPLLHRPTCGTPMTSWSTLTRALVAVVVLPSLALSAPRAGATRPPGPEKRYTVEQFMET
EEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHH
TSVLGASFSSDEKRVLYSSNETGVFNVFSVPVTGGKPTQLTRSTQDASIAVAYFPTDDRV
HHHHCCCCCCCCCEEEEECCCCCEEEEEEEEECCCCCCCEECCCCCCEEEEEEECCCCEE
LFTRDSGGNELVHLYVRTLDGQEKDLTPGDEHRASFFGWSQDGAAFYVLTNERDARFQDL
EEEECCCCCCEEEEEEEECCCCCCCCCCCCCCCHHHCCCCCCCEEEEEEECCCCHHHHHH
YRYDAKTYARTLLYAGDSEHVPGALSPDEKWLALEKSRTLSDSDVYLYEFATQQRRHLTA
HHHHHHHHHHEEEECCCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEHHHHHHHEEC
HEGSVSWKAATFDPASSALYLLTNEGSEFIRVERHVLATRKRELVEQVEWDVLSTVFSRR
CCCCCEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GAWRITRVNEDGRTTLRVHDVKAGRRVSLPGIPEGAISGVSLSRGEKRMAFHVDGDRSPG
CCEEEEEECCCCCEEEEEEECCCCCEECCCCCCCCCCCCCEECCCCCEEEEEECCCCCCC
NLYVYDFETKKLTRLTDTLGRALDTQHLVESERVRFKSFDGLEIPALLYKPHQATAKQRA
EEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCEEECCCHHHHHHCC
PAIVFVHGGPGGQSSKGYSSFFQFLVHHGYVVLAVNNRGSEGYGKSFFAADDQQHGKAPL
CEEEEEECCCCCCCCCCHHHHHHHHHHCCEEEEEEECCCCCCCCCCEEECCCCCCCCCHH
QDCVEAKKYLAALPYVDGARVGILGPSYGGYMVLAALAFHPDVFAVGVDAFGISDWLSAL
HHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHCCCEEEEECCCCCHHHHHHHH
RELPPHKEALREALYQELGNPQTQEAMLREISPLFHAEKIRRPLLVIQGANDPRVPQAKT
HHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHH
DALVEAVRKNGVPVDYFVLPNDGHGFSSTKSEAETSVRILSFLDRYLRRSP
HHHHHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Ca2+ [C]

Kcat value (1/min): 11820 [C]

Specific activity: NA

Km value (mM): 0.92 {benzoyl-Lys} 0.6 {N-benzoyl-Arg} 0.23 {tosyl-Arg} 0.5 {benzoyl-Arg} 0.48 {benzoyl-Arg} 0.25 {benzoyl-Arg} 0.33 {N-benzyloxycarbonyl-Lys} 0.31 {N-benzyloxycarbonyl-Lys} 80 {acetyl-tyrosine} 0.47 {tosyl-Lys-methyl} [C]

Substrates: Protein; H2O [C]

Specific reaction: Protein + H2O = hydrolyzed protein [C]

General reaction: Peptide bond hydrolysis [C]

Inhibitor: Antipain; Aromaticamidines; Benzamidine; Co2+; DFP; Fe2+; Hg2+; L-Arginine; Leupeptin sulfhydryl agents, trypsin inhibitors, 1, 10-phenanthroline; p-Aminobenzamidine; Tosyl -Leuchloromethyl ketone; Zn2+ [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 3098560 [H]