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The map label for this gene is pyrG

Identifier: 108760742

GI number: 108760742

Start: 1275284

End: 1276924

Strand: Reverse

Name: pyrG

Synonym: MXAN_1096

Alternate gene names: 108760742

Gene position: 1276924-1275284 (Counterclockwise)

Preceding gene: 108762272

Following gene: 108758560

Centisome position: 13.97

GC content: 66.0

Gene sequence:

>1641_bases
ATGCGCTCCAAGAAAACCAAGTTCATCTTCGTGACGGGCGGAGTGGTCAGCTCCCTCGGCAAGGGTCTCGCCTCCGCTTC
GATTGGCGCCCTGCTGGAGAACCGTGGGCTGGCCGTCACCCTCATCAAGCTGGACCCCTACATCAACGTGGACCCGGGCA
CGATGAGCCCGTTCCAGCACGGCGAGGTGTTCGTCACCGAGGACGGCGGTGAGACGGACATGGACCTCGGCCACTACGAG
CGGTTCACCAACGCGCGGATGAGCCGGCTCAACAACTTCACGTCCGGCCGCATCTACCACGCGGTCATCATGAAGGAGCG
GCGGGGCGAATACCTGGGCAAGACGGTCCAGGTGATTCCGCACGTCACCGACGAAATCAAGTCCAGCATCCGCCAGGCGG
CGCAGGACGCGGACGTGGTCATCGTGGAGGTGGGCGGCACCGTGGGCGACATCGAGTCGCTGCCCTTCCTCGAGGCCATC
CGGCAGATGCGCTACGACGTGGGCAACGAGAACGTCGTCTACGTCCACCTCACGCTGCTGCCGTACATCGGCGCGGCTGG
CGAGGTGAAGACCAAGCCCACGCAGCACTCGGTGATGAAGCTGCGGGAGATAGGCATCCAGCCCGACTTCCTCGTGTGCC
GCACCGACCGCGAGGTGCCCCGCGAGCTGAAGGACAAGATCGCCATGTTCTGCAACGTGGACACGCGCAGCGTCTTCACG
TCGCCGGATGTGCGCAGCACCTACGAGCTGCCGCTGGAGCTGCACCGCCAGGGCCTGGATGAGCGGCTCGCGGAGGTCCT
CAACATCTGGAGCCGGGCGCCCCACCTGGAGCGCTGGGAGAACATCATCCGCAAGGTGTACGAGCCCGCGCGCGGCCAGG
TCCGCATCGCGATTGTCGGCAAGTACGTCAACCTCACGGAGAGCTACAAGAGCCTCAACGAGGCGCTGCTGCACGGCGGC
ATCGCCAACGACGTGAAGGTGAACCTGCACTTCGTCGACAGCCAGGAGGTCGAAGAGCAGGGCGCGGAGAAGCTGCTGGC
CGGCGTGGACGCCATCCTGGTGCCCGGCGGCTTCGGCGTGCGCGGCACCGAGGGCAAGATCGCCGCCGTGCGCTACGCGC
GTGAGAAGAAGGTGCCGTTCTTCGGCATCTGCCTGGGCCTGCAGATGGCCGTGGTGGAGTTCAGCCGCGGCGTGCTGGGC
CTGTCCTCCGCCAACAGCTTGGAGTTCAACGAGCACACGCCGCACCCGGTGGTGACGCTCATGGAGAGCCAGGTGAAGGT
GCAGGACAAGGGCGGCACCATGCGCCTGGGCAGCTACGCCTGTGCGCTGAAGCCCGGCTCGCTCGCCCACCAGCTCTATG
GGCAGGACACCATCCAGGAGCGCCACCGCCACCGCTACGAAGTGAACAACGCGTACCGTAGCAAGCTGCAGGAGGCGGGG
CTGGTCATCTCCGGCTCCAACCCCGAGCTCAACCTGGTGGAGATGATTGAGCTGGCCGACCACCCCTACTTCATCGGCTG
CCAGTTCCACCCTGAATTCAAGAGCAAGCCCTTCGCACCCCACCCCCTCTTCTCCGGCTTCATCCGCGCGGCGCTCGCCC
AGCGGGACGCGAACGCGGCGGCCGGCAAGGTGACCGAATGA

Upstream 100 bases:

>100_bases
TGGGACGGCAACTGACGCCGTCCCCGCCGGCCCGAGCGGGCGGCCGTCCATCGGAAACAGAATAATTGACGCATCCCTGC
CTCAGTAGGCAGAACGGGAC

Downstream 100 bases:

>100_bases
GCGCCCCCAACCCCATCGAGCTGTGTGGCTTCAAGGTCGGCCAAGGTCAGAAGCTGTTCGTCATCGCCGGCCCCGACAGC
ATCGAATCCGAGGACATGGC

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase

Number of amino acids: Translated: 546; Mature: 546

Protein sequence:

>546_residues
MRSKKTKFIFVTGGVVSSLGKGLASASIGALLENRGLAVTLIKLDPYINVDPGTMSPFQHGEVFVTEDGGETDMDLGHYE
RFTNARMSRLNNFTSGRIYHAVIMKERRGEYLGKTVQVIPHVTDEIKSSIRQAAQDADVVIVEVGGTVGDIESLPFLEAI
RQMRYDVGNENVVYVHLTLLPYIGAAGEVKTKPTQHSVMKLREIGIQPDFLVCRTDREVPRELKDKIAMFCNVDTRSVFT
SPDVRSTYELPLELHRQGLDERLAEVLNIWSRAPHLERWENIIRKVYEPARGQVRIAIVGKYVNLTESYKSLNEALLHGG
IANDVKVNLHFVDSQEVEEQGAEKLLAGVDAILVPGGFGVRGTEGKIAAVRYAREKKVPFFGICLGLQMAVVEFSRGVLG
LSSANSLEFNEHTPHPVVTLMESQVKVQDKGGTMRLGSYACALKPGSLAHQLYGQDTIQERHRHRYEVNNAYRSKLQEAG
LVISGSNPELNLVEMIELADHPYFIGCQFHPEFKSKPFAPHPLFSGFIRAALAQRDANAAAGKVTE

Sequences:

>Translated_546_residues
MRSKKTKFIFVTGGVVSSLGKGLASASIGALLENRGLAVTLIKLDPYINVDPGTMSPFQHGEVFVTEDGGETDMDLGHYE
RFTNARMSRLNNFTSGRIYHAVIMKERRGEYLGKTVQVIPHVTDEIKSSIRQAAQDADVVIVEVGGTVGDIESLPFLEAI
RQMRYDVGNENVVYVHLTLLPYIGAAGEVKTKPTQHSVMKLREIGIQPDFLVCRTDREVPRELKDKIAMFCNVDTRSVFT
SPDVRSTYELPLELHRQGLDERLAEVLNIWSRAPHLERWENIIRKVYEPARGQVRIAIVGKYVNLTESYKSLNEALLHGG
IANDVKVNLHFVDSQEVEEQGAEKLLAGVDAILVPGGFGVRGTEGKIAAVRYAREKKVPFFGICLGLQMAVVEFSRGVLG
LSSANSLEFNEHTPHPVVTLMESQVKVQDKGGTMRLGSYACALKPGSLAHQLYGQDTIQERHRHRYEVNNAYRSKLQEAG
LVISGSNPELNLVEMIELADHPYFIGCQFHPEFKSKPFAPHPLFSGFIRAALAQRDANAAAGKVTE
>Mature_546_residues
MRSKKTKFIFVTGGVVSSLGKGLASASIGALLENRGLAVTLIKLDPYINVDPGTMSPFQHGEVFVTEDGGETDMDLGHYE
RFTNARMSRLNNFTSGRIYHAVIMKERRGEYLGKTVQVIPHVTDEIKSSIRQAAQDADVVIVEVGGTVGDIESLPFLEAI
RQMRYDVGNENVVYVHLTLLPYIGAAGEVKTKPTQHSVMKLREIGIQPDFLVCRTDREVPRELKDKIAMFCNVDTRSVFT
SPDVRSTYELPLELHRQGLDERLAEVLNIWSRAPHLERWENIIRKVYEPARGQVRIAIVGKYVNLTESYKSLNEALLHGG
IANDVKVNLHFVDSQEVEEQGAEKLLAGVDAILVPGGFGVRGTEGKIAAVRYAREKKVPFFGICLGLQMAVVEFSRGVLG
LSSANSLEFNEHTPHPVVTLMESQVKVQDKGGTMRLGSYACALKPGSLAHQLYGQDTIQERHRHRYEVNNAYRSKLQEAG
LVISGSNPELNLVEMIELADHPYFIGCQFHPEFKSKPFAPHPLFSGFIRAALAQRDANAAAGKVTE

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Homo sapiens, GI148491070, Length=551, Percent_Identity=46.2794918330309, Blast_Score=498, Evalue=1e-141,
Organism=Homo sapiens, GI28559085, Length=559, Percent_Identity=44.3649373881932, Blast_Score=488, Evalue=1e-138,
Organism=Homo sapiens, GI28559083, Length=559, Percent_Identity=44.3649373881932, Blast_Score=488, Evalue=1e-138,
Organism=Homo sapiens, GI221316689, Length=559, Percent_Identity=44.3649373881932, Blast_Score=488, Evalue=1e-138,
Organism=Escherichia coli, GI1789142, Length=536, Percent_Identity=55.9701492537313, Blast_Score=607, Evalue=1e-175,
Organism=Caenorhabditis elegans, GI25148299, Length=610, Percent_Identity=38.3606557377049, Blast_Score=431, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6322563, Length=563, Percent_Identity=42.4511545293073, Blast_Score=457, Evalue=1e-129,
Organism=Saccharomyces cerevisiae, GI6319432, Length=560, Percent_Identity=41.6071428571429, Blast_Score=444, Evalue=1e-125,
Organism=Drosophila melanogaster, GI24664469, Length=549, Percent_Identity=46.2659380692168, Blast_Score=486, Evalue=1e-137,
Organism=Drosophila melanogaster, GI21357815, Length=494, Percent_Identity=44.7368421052632, Blast_Score=413, Evalue=1e-115,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PYRG_MYXXD (Q1DDB7)

Other databases:

- EMBL:   CP000113
- RefSeq:   YP_629356.1
- ProteinModelPortal:   Q1DDB7
- SMR:   Q1DDB7
- STRING:   Q1DDB7
- GeneID:   4102391
- GenomeReviews:   CP000113_GR
- KEGG:   mxa:MXAN_1096
- TIGR:   MXAN_1096
- eggNOG:   COG0504
- HOGENOM:   HBG597806
- OMA:   RVTMQKL
- PhylomeDB:   Q1DDB7
- ProtClustDB:   PRK05380
- BioCyc:   MXAN246197:MXAN_1096-MONOMER
- HAMAP:   MF_01227
- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991
- TIGRFAMs:   TIGR00337

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase

EC number: =6.3.4.2

Molecular weight: Translated: 60536; Mature: 60536

Theoretical pI: Translated: 7.16; Mature: 7.16

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 384-384 ACT_SITE 510-510 ACT_SITE 512-512

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSKKTKFIFVTGGVVSSLGKGLASASIGALLENRGLAVTLIKLDPYINVDPGTMSPFQH
CCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCEEECCCCCCCCCCC
GEVFVTEDGGETDMDLGHYERFTNARMSRLNNFTSGRIYHAVIMKERRGEYLGKTVQVIP
CCEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHHCCHHHCCHHHHHC
HVTDEIKSSIRQAAQDADVVIVEVGGTVGDIESLPFLEAIRQMRYDVGNENVVYVHLTLL
CHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEEEH
PYIGAAGEVKTKPTQHSVMKLREIGIQPDFLVCRTDREVPRELKDKIAMFCNVDTRSVFT
HCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHEEEECCCCCCEEC
SPDVRSTYELPLELHRQGLDERLAEVLNIWSRAPHLERWENIIRKVYEPARGQVRIAIVG
CCCCCCHHCCCHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEEEEE
KYVNLTESYKSLNEALLHGGIANDVKVNLHFVDSQEVEEQGAEKLLAGVDAILVPGGFGV
EEHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCHHHHHHHHHHHHHCCCEEEECCCCCC
RGTEGKIAAVRYAREKKVPFFGICLGLQMAVVEFSRGVLGLSSANSLEFNEHTPHPVVTL
CCCCCCEEEEEEHHHCCCCEEEHHHHHHHHHHHHHCCEEECCCCCCCCCCCCCCCHHHEE
MESQVKVQDKGGTMRLGSYACALKPGSLAHQLYGQDTIQERHRHRYEVNNAYRSKLQEAG
ECCCEEEECCCCEEEECCEEEEECCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCC
LVISGSNPELNLVEMIELADHPYFIGCQFHPEFKSKPFAPHPLFSGFIRAALAQRDANAA
EEEECCCCCCHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCC
AGKVTE
CCCCCC
>Mature Secondary Structure
MRSKKTKFIFVTGGVVSSLGKGLASASIGALLENRGLAVTLIKLDPYINVDPGTMSPFQH
CCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCEEECCCCCCCCCCC
GEVFVTEDGGETDMDLGHYERFTNARMSRLNNFTSGRIYHAVIMKERRGEYLGKTVQVIP
CCEEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEEEHHHCCHHHCCHHHHHC
HVTDEIKSSIRQAAQDADVVIVEVGGTVGDIESLPFLEAIRQMRYDVGNENVVYVHLTLL
CHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCEEEEEEEEH
PYIGAAGEVKTKPTQHSVMKLREIGIQPDFLVCRTDREVPRELKDKIAMFCNVDTRSVFT
HCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHEEEECCCCCCEEC
SPDVRSTYELPLELHRQGLDERLAEVLNIWSRAPHLERWENIIRKVYEPARGQVRIAIVG
CCCCCCHHCCCHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEEEEE
KYVNLTESYKSLNEALLHGGIANDVKVNLHFVDSQEVEEQGAEKLLAGVDAILVPGGFGV
EEHHHHHHHHHHHHHHHHCCCCCCEEEEEEEECCHHHHHHHHHHHHHCCCEEEECCCCCC
RGTEGKIAAVRYAREKKVPFFGICLGLQMAVVEFSRGVLGLSSANSLEFNEHTPHPVVTL
CCCCCCEEEEEEHHHCCCCEEEHHHHHHHHHHHHHCCEEECCCCCCCCCCCCCCCHHHEE
MESQVKVQDKGGTMRLGSYACALKPGSLAHQLYGQDTIQERHRHRYEVNNAYRSKLQEAG
ECCCEEEECCCCEEEECCEEEEECCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCC
LVISGSNPELNLVEMIELADHPYFIGCQFHPEFKSKPFAPHPLFSGFIRAALAQRDANAA
EEEECCCCCCHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCC
AGKVTE
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA