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The map label for this gene is phoR [H]

Identifier: 108760671

GI number: 108760671

Start: 239406

End: 241313

Strand: Direct

Name: phoR [H]

Synonym: MXAN_0196

Alternate gene names: 108760671

Gene position: 239406-241313 (Clockwise)

Preceding gene: 108761729

Following gene: 108763154

Centisome position: 2.62

GC content: 71.59

Gene sequence:

>1908_bases
ATGCGCTACAAAGGGACAGAGAATCTGGATTTCCGGGCAGGCAAGCAAGGGGGCTTCGATGACCCTGGCAGGCGCGGGAT
GGGGACGGCGCCCCTTCTGCTGTTCTGTGGAAACACGGAGGCTGCCCTTCGTCCGGGGAAGGAGACATGCCTCCATGTTG
CCTCTGCTCGCGGGAAGTCCCTCATGGCCTCTGGAAGCGCCCCGCTTTCGATGACGCATCTGGACTCCGAAGAGGCGGAC
GCCCTGCTGAAGGAGGGCGTCCTCCGGTTGCTGCTCGAGCAGGCGGGCGAGGCGCTCGTGTTGGTGGATGTCACCGGGCG
TGTGCTCGCCTTCAACACGGAGGCCGGGCGTCAGTTCCGTATGAGCCGGCCCGAACGCGCCGAGCAGGGTTGGTTGCCCG
GTTGTGTATGGACGCGTGCGGAGGATGCGTCCATGTCGGTGGAGGTGCCGCCCCTGGCGCGCGCGCTCACGGGCGAGTGG
GTGGCGGAGGCCCGCTGGCGGGTGCGCCGGCCGGATGGGACGCACGTCCTGCTGCGCGCCTCCGCGGTGCCGCTGGAGCA
CGACGCGGGCCCGACGGCTGGAGCGCTGCTTCGCGCATGTGAGGTGGCCTCGGCCGTGGGGTTGGACGCGGTGGGCTCGG
CGCGGCTGCTGGCGGAGGCCGGTGCGCTGCTGGGCGCCGCGTTCGACGATGAGGCCGCGCCGCGGTTGCTCCGCTTGCTG
GTGCCCGCGCTCGCGGACGCGGCGGTGCTGTACCTGGGCCAGCCCGGCGGGCCGCCGCGCCCGGTGACGGCGCTGCACGC
CGAGCCGGAGCGCCATGGCCTGCTGGAGGAGATGCTGCGCTGCTACCCATTGCCGCCTGAGCGCGTGCTGCCGTTGTTCG
GCACTGGCCAGTCGGAGCGGTTGCGGGTGACGGAGGCCCACGTGGAGGCCACCGCGCGGGACGCGGAGCACGCGCGGCTG
CTGCGGGGGCTGGGCCTGCGCTGCTACCTGGGCGTGCCGCTGGTGGCGCGCGAGCGCGTCATCGGCACGCTGGCCCTCTT
CCGCGCGGATGAAGCCCGTGACTTCAGCGCGGAGGAGCTGCGGCTGGCGGAGGAGGTGGCCCGCCGCACCGCGCTCTCCG
TGGACAACGCGCAGCTCCTCCAGGAGGCGCGCGAGGCGGTGCGCCTGCGCGACGAGTTCCTGGGAATCGCCAGTCACGAG
CTGAAGACGCCGCTGACGCCGCTGCACCTCAAGGTGCAATTGCTGCAGAAGCAGGTGGATGGGATGGCGGCCCACAACCA
GCCGGTGTCCGCCGAGCGCGTGTCGGAGACGCTGGAGGTGGTGCAGCGGCAGGTGCGCAAGCTGACGAGCCTGGTGGACA
ACCTGCTCGATGTGTCGCGAATCACCGCGGGCCGCCTGCGGCTGGAAGTGGAGGAGATGGACCTGGCCAGCGTGGCGGCG
GAAATCCTCTACCGCTTCGCGCCCTCCGCCTCGCAGTTGAAGTGTGAGCTGGAGCTGCACGCGCCGGTGCCCGTCATGGG
CCGGTGGGACCGGCTGCGGCTGGAGCAGGTGGTGACCAACCTGCTGTCCAACGCGCTGAAGTACGGCGCGGGACACCCCG
TGCGCGTGGTGGTGGAGGCGGAGGGGCTCACCGCCCGCCTGACGGTGCGCGACGGCGGCATCGGCATCTCCGCGGAGGAT
TTGCCGCGCATCTTCGAGCGCTTCGAGCGCGCGGTGAGTGACAGGCACTACGGCGGCCTGGGCCTGGGGCTCTACATCAC
CCGGCAGATTGTGGAGGCCTTCGGCGGCACGGTGCGCGCCACCAGCGAGCCGGGGCAGGGCTCCCTCTTCGTGCTGGAGC
TGCCGCGCGGCGACATCCCCGAGGAATGGCTGACGGCGCACGGCGCGCCGGAGCCGTCGTCGTCCTGA

Upstream 100 bases:

>100_bases
GTAACGGTGCTCGTTGGAGGTCCAGTCAGGCGTGGAGTGCGGCTTCTGCATGATGGAACTCGAGAAAGTGGGCCGCGCGG
GTGGACGCAAGGTCACCCGG

Downstream 100 bases:

>100_bases
CGCGCTAGGCCGCGCTCGCGGATGCCGCGGGCTCGGCGCGGCGGGGCAGCCGCACGTGGAAGCTGCTGCCGCGCTGGGGC
CCCGGGCTCTCCGCCCAGAT

Product: sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 635; Mature: 635

Protein sequence:

>635_residues
MRYKGTENLDFRAGKQGGFDDPGRRGMGTAPLLLFCGNTEAALRPGKETCLHVASARGKSLMASGSAPLSMTHLDSEEAD
ALLKEGVLRLLLEQAGEALVLVDVTGRVLAFNTEAGRQFRMSRPERAEQGWLPGCVWTRAEDASMSVEVPPLARALTGEW
VAEARWRVRRPDGTHVLLRASAVPLEHDAGPTAGALLRACEVASAVGLDAVGSARLLAEAGALLGAAFDDEAAPRLLRLL
VPALADAAVLYLGQPGGPPRPVTALHAEPERHGLLEEMLRCYPLPPERVLPLFGTGQSERLRVTEAHVEATARDAEHARL
LRGLGLRCYLGVPLVARERVIGTLALFRADEARDFSAEELRLAEEVARRTALSVDNAQLLQEAREAVRLRDEFLGIASHE
LKTPLTPLHLKVQLLQKQVDGMAAHNQPVSAERVSETLEVVQRQVRKLTSLVDNLLDVSRITAGRLRLEVEEMDLASVAA
EILYRFAPSASQLKCELELHAPVPVMGRWDRLRLEQVVTNLLSNALKYGAGHPVRVVVEAEGLTARLTVRDGGIGISAED
LPRIFERFERAVSDRHYGGLGLGLYITRQIVEAFGGTVRATSEPGQGSLFVLELPRGDIPEEWLTAHGAPEPSSS

Sequences:

>Translated_635_residues
MRYKGTENLDFRAGKQGGFDDPGRRGMGTAPLLLFCGNTEAALRPGKETCLHVASARGKSLMASGSAPLSMTHLDSEEAD
ALLKEGVLRLLLEQAGEALVLVDVTGRVLAFNTEAGRQFRMSRPERAEQGWLPGCVWTRAEDASMSVEVPPLARALTGEW
VAEARWRVRRPDGTHVLLRASAVPLEHDAGPTAGALLRACEVASAVGLDAVGSARLLAEAGALLGAAFDDEAAPRLLRLL
VPALADAAVLYLGQPGGPPRPVTALHAEPERHGLLEEMLRCYPLPPERVLPLFGTGQSERLRVTEAHVEATARDAEHARL
LRGLGLRCYLGVPLVARERVIGTLALFRADEARDFSAEELRLAEEVARRTALSVDNAQLLQEAREAVRLRDEFLGIASHE
LKTPLTPLHLKVQLLQKQVDGMAAHNQPVSAERVSETLEVVQRQVRKLTSLVDNLLDVSRITAGRLRLEVEEMDLASVAA
EILYRFAPSASQLKCELELHAPVPVMGRWDRLRLEQVVTNLLSNALKYGAGHPVRVVVEAEGLTARLTVRDGGIGISAED
LPRIFERFERAVSDRHYGGLGLGLYITRQIVEAFGGTVRATSEPGQGSLFVLELPRGDIPEEWLTAHGAPEPSSS
>Mature_635_residues
MRYKGTENLDFRAGKQGGFDDPGRRGMGTAPLLLFCGNTEAALRPGKETCLHVASARGKSLMASGSAPLSMTHLDSEEAD
ALLKEGVLRLLLEQAGEALVLVDVTGRVLAFNTEAGRQFRMSRPERAEQGWLPGCVWTRAEDASMSVEVPPLARALTGEW
VAEARWRVRRPDGTHVLLRASAVPLEHDAGPTAGALLRACEVASAVGLDAVGSARLLAEAGALLGAAFDDEAAPRLLRLL
VPALADAAVLYLGQPGGPPRPVTALHAEPERHGLLEEMLRCYPLPPERVLPLFGTGQSERLRVTEAHVEATARDAEHARL
LRGLGLRCYLGVPLVARERVIGTLALFRADEARDFSAEELRLAEEVARRTALSVDNAQLLQEAREAVRLRDEFLGIASHE
LKTPLTPLHLKVQLLQKQVDGMAAHNQPVSAERVSETLEVVQRQVRKLTSLVDNLLDVSRITAGRLRLEVEEMDLASVAA
EILYRFAPSASQLKCELELHAPVPVMGRWDRLRLEQVVTNLLSNALKYGAGHPVRVVVEAEGLTARLTVRDGGIGISAED
LPRIFERFERAVSDRHYGGLGLGLYITRQIVEAFGGTVRATSEPGQGSLFVLELPRGDIPEEWLTAHGAPEPSSS

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=246, Percent_Identity=34.5528455284553, Blast_Score=126, Evalue=4e-30,
Organism=Escherichia coli, GI145693157, Length=262, Percent_Identity=31.2977099236641, Blast_Score=115, Evalue=7e-27,
Organism=Escherichia coli, GI1786912, Length=301, Percent_Identity=31.2292358803987, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI1788393, Length=249, Percent_Identity=33.3333333333333, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1788713, Length=242, Percent_Identity=25.2066115702479, Blast_Score=99, Evalue=1e-21,
Organism=Escherichia coli, GI87081816, Length=265, Percent_Identity=32.0754716981132, Blast_Score=96, Evalue=1e-20,
Organism=Escherichia coli, GI48994928, Length=250, Percent_Identity=31.2, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1786600, Length=279, Percent_Identity=29.3906810035842, Blast_Score=89, Evalue=9e-19,
Organism=Escherichia coli, GI1790346, Length=229, Percent_Identity=32.7510917030568, Blast_Score=86, Evalue=1e-17,
Organism=Escherichia coli, GI87082128, Length=231, Percent_Identity=29.8701298701299, Blast_Score=76, Evalue=6e-15,
Organism=Escherichia coli, GI1786783, Length=242, Percent_Identity=27.2727272727273, Blast_Score=75, Evalue=2e-14,
Organism=Escherichia coli, GI1790436, Length=221, Percent_Identity=28.9592760180996, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1789808, Length=209, Percent_Identity=28.7081339712919, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1787894, Length=234, Percent_Identity=32.0512820512821, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1788549, Length=229, Percent_Identity=26.6375545851528, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 68881; Mature: 68881

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYKGTENLDFRAGKQGGFDDPGRRGMGTAPLLLFCGNTEAALRPGKETCLHVASARGKS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHCCCCHHHHHHHHHHCCCE
LMASGSAPLSMTHLDSEEADALLKEGVLRLLLEQAGEALVLVDVTGRVLAFNTEAGRQFR
EEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCEEEEECCCCCCCC
MSRPERAEQGWLPGCVWTRAEDASMSVEVPPLARALTGEWVAEARWRVRRPDGTHVLLRA
CCCCCHHHCCCCCCEEEECCCCCCCEEECCHHHHHHHHHHHHHCCCEEECCCCCEEEEEE
SAVPLEHDAGPTAGALLRACEVASAVGLDAVGSARLLAEAGALLGAAFDDEAAPRLLRLL
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHH
VPALADAAVLYLGQPGGPPRPVTALHAEPERHGLLEEMLRCYPLPPERVLPLFGTGQSER
HHHHHCCEEEEEECCCCCCCCEEEECCCCHHCCHHHHHHHHCCCCHHHCCEEECCCCCCE
LRVTEAHVEATARDAEHARLLRGLGLRCYLGVPLVARERVIGTLALFRADEARDFSAEEL
EEEEHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCCHHHH
RLAEEVARRTALSVDNAQLLQEAREAVRLRDEFLGIASHELKTPLTPLHLKVQLLQKQVD
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
GMAAHNQPVSAERVSETLEVVQRQVRKLTSLVDNLLDVSRITAGRLRLEVEEMDLASVAA
CHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHH
EILYRFAPSASQLKCELELHAPVPVMGRWDRLRLEQVVTNLLSNALKYGAGHPVRVVVEA
HHHHHHCCCHHHEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEE
EGLTARLTVRDGGIGISAEDLPRIFERFERAVSDRHYGGLGLGLYITRQIVEAFGGTVRA
CCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEEE
TSEPGQGSLFVLELPRGDIPEEWLTAHGAPEPSSS
CCCCCCCCEEEEECCCCCCCHHHHHCCCCCCCCCC
>Mature Secondary Structure
MRYKGTENLDFRAGKQGGFDDPGRRGMGTAPLLLFCGNTEAALRPGKETCLHVASARGKS
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHCCCCHHHHHHHHHHCCCE
LMASGSAPLSMTHLDSEEADALLKEGVLRLLLEQAGEALVLVDVTGRVLAFNTEAGRQFR
EEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCEEEEECCCCCCCC
MSRPERAEQGWLPGCVWTRAEDASMSVEVPPLARALTGEWVAEARWRVRRPDGTHVLLRA
CCCCCHHHCCCCCCEEEECCCCCCCEEECCHHHHHHHHHHHHHCCCEEECCCCCEEEEEE
SAVPLEHDAGPTAGALLRACEVASAVGLDAVGSARLLAEAGALLGAAFDDEAAPRLLRLL
CCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHH
VPALADAAVLYLGQPGGPPRPVTALHAEPERHGLLEEMLRCYPLPPERVLPLFGTGQSER
HHHHHCCEEEEEECCCCCCCCEEEECCCCHHCCHHHHHHHHCCCCHHHCCEEECCCCCCE
LRVTEAHVEATARDAEHARLLRGLGLRCYLGVPLVARERVIGTLALFRADEARDFSAEEL
EEEEHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCCHHHH
RLAEEVARRTALSVDNAQLLQEAREAVRLRDEFLGIASHELKTPLTPLHLKVQLLQKQVD
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
GMAAHNQPVSAERVSETLEVVQRQVRKLTSLVDNLLDVSRITAGRLRLEVEEMDLASVAA
CHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHH
EILYRFAPSASQLKCELELHAPVPVMGRWDRLRLEQVVTNLLSNALKYGAGHPVRVVVEA
HHHHHHCCCHHHEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEE
EGLTARLTVRDGGIGISAEDLPRIFERFERAVSDRHYGGLGLGLYITRQIVEAFGGTVRA
CCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEEE
TSEPGQGSLFVLELPRGDIPEEWLTAHGAPEPSSS
CCCCCCCCEEEEECCCCCCCHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]