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The map label for this gene is lysA [H]

Identifier: 108760390

GI number: 108760390

Start: 2740999

End: 2742441

Strand: Reverse

Name: lysA [H]

Synonym: MXAN_2358

Alternate gene names: 108760390

Gene position: 2742441-2740999 (Counterclockwise)

Preceding gene: 108756965

Following gene: 108762934

Centisome position: 30.01

GC content: 71.03

Gene sequence:

>1443_bases
ATGAGCCTCAAGAGCCGGCTTCTCGGGACGGCCAGACGCCAGGTGAAGCAGACGCTGCGCCCGGTGCTCCAGCGGGCCAT
GGCCCCGGCGCGCAACCACATCCCCGCCTCGCACTGGGGCCTGCGGGACGTGCCCGGCCAGGGCCTGAGCCTGGAGGGTG
TCCCGCTGGCGCAGTTGGTGGAGCGCTGGGGCTCGCCGCTGCACGTGGTGCACATGGCGGCACTGCGGCGCAACGCGGAG
CGCTTCCTCGCGGTGCCTCCGGGGCGCACGGGCGGCTGTGAAGTCTATTACTCGTACAAAACGAACCCGGTGCCCGGCGT
GCTGTCCTTCCTGCACGGCCTGGGCGTGGGCGCGGAGGTCATCTCCGCCTACGAGATGTGGCTGGCGCTGAAGCTGGGCG
TGCCCCCGGAGCGCATCGTCTACAACGGCCCGGTGAAGTCGGAGGCCTCCGTGCGCGAGGCCATCTCCCGGGGCATCCAG
TTGCTGGCCGCCAACCACGCGGAGGAGATAGCCGTCTTCGCCCGGCTGGCCGCGGAGCTGGACCGCCGCCCGCGCGTCGC
CGTGCGGGTGACGACGAACAGCGGCTGGTCCGCGCAGTTCGGCACGCCCATCGCGGGAGGCGCCGCGCTGCGGGCCTACC
AGCAGGCGCGCGGCTCGAAGCACCTGGACGTGGTGGGCCTGCACGCGCACCGTGGAGAAACCATCCGCACGGAGGGCGAC
TTCACGGCCTTCGTGGAGTCGGTGCTCGACTTCACGGACACGCTGCACCAGGAGCTGGGACTGGACTTGGAGGTGCTCGA
TTTGGGCGGCAGCCTCAACACGCCCACCGTCGAGCACATCGCCGAGCGCGACTGGCGCCTCAACCTCACCTTCTTCCGCG
ACGTGCCCGCGCCCGACCCGGCGGCGTCGCTGTCCATCGACCGCTACGTGGCGCTGGCGGTGGAGATGGTGGAGACGCAC
TACGCGCGGCGCGGCCGGCAGCGTCCCCGCATCTTCCTGGAGCCGGGCCGCGCCATGACGGGCGACACGCAGCTCTTGCT
GGGCCGCGTGCACGCGCTCAAGGCGGGGGAAGACAGGACGTGGGCGGTGCTGGACGCCGGCATCAACCATGCCGAGTGCG
TGCGCAACGAATACCACCAGCTCTTCCACGTGAACCGGCCGGACGCGCCGGCCGACAAGGTTTACACGGTGGTGGGCCCC
ATCTGCACGCCGGGCGACACGCTCTACCACGCGAAGCGGCTACCCGACCTGCGCGTGGGGGACACGCTGGCCATCATGGA
TGCGGGCGCCTACTTCGTGCCCTTCGCCACGTCCTTCTCCTATCCCCAGCCGGCCATCGTCGCGCTGGAGGACGGGAAGG
AGCGGCTGCTGCGGCGCGCGGAGACGTTCGATGACCTGGTGACGTTCGACGCGCTGGACAGCCGCGCCGCGCTCACCGGT
TGA

Upstream 100 bases:

>100_bases
GCATGCTGGAGTACCGCCTCATGCAGGCCGCCCTGCGGGTGCTGCCCTTCGAGGTCGCCCGCCGTCTGCCGCTGCGCCTG
CGCAACCAGGGCCGCGCGTC

Downstream 100 bases:

>100_bases
GCACCATCATCCGGATGAAGGCCCGGGGGTGGCGCGCGGAGCCGTAGAGAATCTGCGCCACCTCCACCGCGGTGGGCATC
AGGTCATCCGAGTCGATGAG

Product: pyridoxal-dependent decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 480; Mature: 479

Protein sequence:

>480_residues
MSLKSRLLGTARRQVKQTLRPVLQRAMAPARNHIPASHWGLRDVPGQGLSLEGVPLAQLVERWGSPLHVVHMAALRRNAE
RFLAVPPGRTGGCEVYYSYKTNPVPGVLSFLHGLGVGAEVISAYEMWLALKLGVPPERIVYNGPVKSEASVREAISRGIQ
LLAANHAEEIAVFARLAAELDRRPRVAVRVTTNSGWSAQFGTPIAGGAALRAYQQARGSKHLDVVGLHAHRGETIRTEGD
FTAFVESVLDFTDTLHQELGLDLEVLDLGGSLNTPTVEHIAERDWRLNLTFFRDVPAPDPAASLSIDRYVALAVEMVETH
YARRGRQRPRIFLEPGRAMTGDTQLLLGRVHALKAGEDRTWAVLDAGINHAECVRNEYHQLFHVNRPDAPADKVYTVVGP
ICTPGDTLYHAKRLPDLRVGDTLAIMDAGAYFVPFATSFSYPQPAIVALEDGKERLLRRAETFDDLVTFDALDSRAALTG

Sequences:

>Translated_480_residues
MSLKSRLLGTARRQVKQTLRPVLQRAMAPARNHIPASHWGLRDVPGQGLSLEGVPLAQLVERWGSPLHVVHMAALRRNAE
RFLAVPPGRTGGCEVYYSYKTNPVPGVLSFLHGLGVGAEVISAYEMWLALKLGVPPERIVYNGPVKSEASVREAISRGIQ
LLAANHAEEIAVFARLAAELDRRPRVAVRVTTNSGWSAQFGTPIAGGAALRAYQQARGSKHLDVVGLHAHRGETIRTEGD
FTAFVESVLDFTDTLHQELGLDLEVLDLGGSLNTPTVEHIAERDWRLNLTFFRDVPAPDPAASLSIDRYVALAVEMVETH
YARRGRQRPRIFLEPGRAMTGDTQLLLGRVHALKAGEDRTWAVLDAGINHAECVRNEYHQLFHVNRPDAPADKVYTVVGP
ICTPGDTLYHAKRLPDLRVGDTLAIMDAGAYFVPFATSFSYPQPAIVALEDGKERLLRRAETFDDLVTFDALDSRAALTG
>Mature_479_residues
SLKSRLLGTARRQVKQTLRPVLQRAMAPARNHIPASHWGLRDVPGQGLSLEGVPLAQLVERWGSPLHVVHMAALRRNAER
FLAVPPGRTGGCEVYYSYKTNPVPGVLSFLHGLGVGAEVISAYEMWLALKLGVPPERIVYNGPVKSEASVREAISRGIQL
LAANHAEEIAVFARLAAELDRRPRVAVRVTTNSGWSAQFGTPIAGGAALRAYQQARGSKHLDVVGLHAHRGETIRTEGDF
TAFVESVLDFTDTLHQELGLDLEVLDLGGSLNTPTVEHIAERDWRLNLTFFRDVPAPDPAASLSIDRYVALAVEMVETHY
ARRGRQRPRIFLEPGRAMTGDTQLLLGRVHALKAGEDRTWAVLDAGINHAECVRNEYHQLFHVNRPDAPADKVYTVVGPI
CTPGDTLYHAKRLPDLRVGDTLAIMDAGAYFVPFATSFSYPQPAIVALEDGKERLLRRAETFDDLVTFDALDSRAALTG

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=382, Percent_Identity=24.6073298429319, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI16506287, Length=356, Percent_Identity=25.561797752809, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1789203, Length=402, Percent_Identity=24.3781094527363, Blast_Score=71, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 52718; Mature: 52587

Theoretical pI: Translated: 7.83; Mature: 7.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLKSRLLGTARRQVKQTLRPVLQRAMAPARNHIPASHWGLRDVPGQGLSLEGVPLAQLV
CCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHH
ERWGSPLHVVHMAALRRNAERFLAVPPGRTGGCEVYYSYKTNPVPGVLSFLHGLGVGAEV
HHHCCCHHHHHHHHHHCCCCCEEECCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCHHHH
ISAYEMWLALKLGVPPERIVYNGPVKSEASVREAISRGIQLLAANHAEEIAVFARLAAEL
HHHHHHHHHEECCCCHHHEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
DRRPRVAVRVTTNSGWSAQFGTPIAGGAALRAYQQARGSKHLDVVGLHAHRGETIRTEGD
CCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCEEEECCH
FTAFVESVLDFTDTLHQELGLDLEVLDLGGSLNTPTVEHIAERDWRLNLTFFRDVPAPDP
HHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHCCCEEEEEEEEECCCCCCC
AASLSIDRYVALAVEMVETHYARRGRQRPRIFLEPGRAMTGDTQLLLGRVHALKAGEDRT
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCHHHHHHHHHHHCCCCCCE
WAVLDAGINHAECVRNEYHQLFHVNRPDAPADKVYTVVGPICTPGDTLYHAKRLPDLRVG
EEEEECCCCHHHHHHHHHHHHEECCCCCCCHHCEEEEECCCCCCCCHHHHHHCCCCCCCC
DTLAIMDAGAYFVPFATSFSYPQPAIVALEDGKERLLRRAETFDDLVTFDALDSRAALTG
CEEEEEECCCEEEEEECCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SLKSRLLGTARRQVKQTLRPVLQRAMAPARNHIPASHWGLRDVPGQGLSLEGVPLAQLV
CHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHH
ERWGSPLHVVHMAALRRNAERFLAVPPGRTGGCEVYYSYKTNPVPGVLSFLHGLGVGAEV
HHHCCCHHHHHHHHHHCCCCCEEECCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCHHHH
ISAYEMWLALKLGVPPERIVYNGPVKSEASVREAISRGIQLLAANHAEEIAVFARLAAEL
HHHHHHHHHEECCCCHHHEEECCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
DRRPRVAVRVTTNSGWSAQFGTPIAGGAALRAYQQARGSKHLDVVGLHAHRGETIRTEGD
CCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCEEEECCH
FTAFVESVLDFTDTLHQELGLDLEVLDLGGSLNTPTVEHIAERDWRLNLTFFRDVPAPDP
HHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHCCCEEEEEEEEECCCCCCC
AASLSIDRYVALAVEMVETHYARRGRQRPRIFLEPGRAMTGDTQLLLGRVHALKAGEDRT
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCHHHHHHHHHHHCCCCCCE
WAVLDAGINHAECVRNEYHQLFHVNRPDAPADKVYTVVGPICTPGDTLYHAKRLPDLRVG
EEEEECCCCHHHHHHHHHHHHEECCCCCCCHHCEEEEECCCCCCCCHHHHHHCCCCCCCC
DTLAIMDAGAYFVPFATSFSYPQPAIVALEDGKERLLRRAETFDDLVTFDALDSRAALTG
CEEEEEECCCEEEEEECCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]