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The map label for this gene is atoC [H]

Identifier: 108760272

GI number: 108760272

Start: 6223426

End: 6224802

Strand: Reverse

Name: atoC [H]

Synonym: MXAN_4977

Alternate gene names: 108760272

Gene position: 6224802-6223426 (Counterclockwise)

Preceding gene: 108760649

Following gene: 108762683

Centisome position: 68.11

GC content: 70.37

Gene sequence:

>1377_bases
ATGTCCGCACCGCACCCGTTGCTGCTCGTGGATGACGACGCCGCGTTCCGCAAAGTCTATGGCGGGCTGCTGCGCGATGC
GGGTTACGAGGTAGTGGAAGCTGCGGACCGGCCTTCCGCTCGCGCGGCCTTCGATGCACGCGACTTCCCCCTGGTGCTGC
TCGACCTGATGCTGCCTCCCGACGGGAGCGTCTCCGCGGGGCTGGAGGGGCTCGCGGCGTTGCTGAGCGCGAAGCCCGGG
ACGAAGGTCATCGTCGTGTCCGGGGCAGGGGACACGCGGCACACGCTGGAAGCGGTGCGCCTGGGCGCGTACGACTTCCT
CACCAAGCCAGTGGACCCGGATGTGCTGCTGGTGGTGGTGCAACGGGCGCTCGCGCGGGTGACACTGGAGCGGCAGGTGG
AGACGCTGCGCAGCTCGCTCACGCGCGCGGCGGGCGGTGTCTCCCTGGTGGGGCAGAGCGCGTCCTTCCTGGCGGCCACG
TCCCTGGCGGAGCGCGTGGCGGCCAGTGAGCTGCCGGTGCTCGTCACTGGCGAGAATGGGACGGGGAAGGAGCTGCTCGC
GCGCACCGTCCACCTCAAGAGCCGCCGCCACGACGGGCCCTTCGTCCCCATCAACTGCGGCGCACTGCCGGAGTCGCTGC
TGGAGAGCGCCCTGTTCGGCCACGTGAAGGGCAGCTTCACCGGGGCGACCAAGGACCACCGTGGCCTCTTCGCGGAGGCG
GACGGAGGCACGCTCTTCCTGGACGAACTGGGCGACATGTCGCCGTCCCTCCAGGTGAAGGTGCTCCGTGCGTTGGAGAC
GGGCGACATCCTTCCGGTGGGCGCGGACCGGCCCGTCCAGGTGGACGTGCGGCTCATCTCCGCCACCCACCAGGACCTGG
GGCGCATGCTTCAGGAAGGCGCCTTCCGCGAGGACCTCTACTGGCGCGTGAAGGGCGTTGAAATTCGCCTGCCGCCCCTG
CGCGAGCGCTCCGCGGACCTTCCGCTGCTGGCCAAGCACTTCCTCAATCAGTGCGCCCACCTGTGCCCGGACGGGCGCGC
CCGGCTGTTGTCGGACGCCGCGGCGGAGGCCCTGCTGGCCCATGCGTGGCCGGGGAATCTGCGCGAGCTGCGCCATGAGA
TGCAGCGCGCCACCGTGCTGGCGGGGGAGCGGCGCGAAATCCAGCCCGAGGATTTGTCCTTCACCGGCAGCGAGCGGCTG
CACGCCACCCGCGCGCCAGGTACAACGACGCTGGCTCAGAAGGTGGAAGCGTTGGAGCGGCGCGAAATCGAGGAGGCCCT
GCGGCGCCTGAATGGCAACCGCACGCACACGGCGGAGGCGCTGGGCCTGTCGCGCCAGGGACTGCTCAAGAAGCTGGAGC
GCTTTGGACTGACGTGA

Upstream 100 bases:

>100_bases
CCGTGCGCCCAGACGCTCATCCAGGTGGCCCTGCGCACCCTGGAGTTGATGGGCACGCCACGCCAGACGCCGCTTCCGGA
CTGAGGCGGAGGCCACACGT

Downstream 100 bases:

>100_bases
GTCAGAAGAGCCGGACGCCCAGGCCCAGTCGTACGCTGTAGCCCAGGCGCGTGTGGCTTTCCCCCGAGCGCTCCTGGAAG
GACTCCACGCCGAGCTGGCC

Product: sigma-54 dependent DNA-binding response regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 458; Mature: 457

Protein sequence:

>458_residues
MSAPHPLLLVDDDAAFRKVYGGLLRDAGYEVVEAADRPSARAAFDARDFPLVLLDLMLPPDGSVSAGLEGLAALLSAKPG
TKVIVVSGAGDTRHTLEAVRLGAYDFLTKPVDPDVLLVVVQRALARVTLERQVETLRSSLTRAAGGVSLVGQSASFLAAT
SLAERVAASELPVLVTGENGTGKELLARTVHLKSRRHDGPFVPINCGALPESLLESALFGHVKGSFTGATKDHRGLFAEA
DGGTLFLDELGDMSPSLQVKVLRALETGDILPVGADRPVQVDVRLISATHQDLGRMLQEGAFREDLYWRVKGVEIRLPPL
RERSADLPLLAKHFLNQCAHLCPDGRARLLSDAAAEALLAHAWPGNLRELRHEMQRATVLAGERREIQPEDLSFTGSERL
HATRAPGTTTLAQKVEALERREIEEALRRLNGNRTHTAEALGLSRQGLLKKLERFGLT

Sequences:

>Translated_458_residues
MSAPHPLLLVDDDAAFRKVYGGLLRDAGYEVVEAADRPSARAAFDARDFPLVLLDLMLPPDGSVSAGLEGLAALLSAKPG
TKVIVVSGAGDTRHTLEAVRLGAYDFLTKPVDPDVLLVVVQRALARVTLERQVETLRSSLTRAAGGVSLVGQSASFLAAT
SLAERVAASELPVLVTGENGTGKELLARTVHLKSRRHDGPFVPINCGALPESLLESALFGHVKGSFTGATKDHRGLFAEA
DGGTLFLDELGDMSPSLQVKVLRALETGDILPVGADRPVQVDVRLISATHQDLGRMLQEGAFREDLYWRVKGVEIRLPPL
RERSADLPLLAKHFLNQCAHLCPDGRARLLSDAAAEALLAHAWPGNLRELRHEMQRATVLAGERREIQPEDLSFTGSERL
HATRAPGTTTLAQKVEALERREIEEALRRLNGNRTHTAEALGLSRQGLLKKLERFGLT
>Mature_457_residues
SAPHPLLLVDDDAAFRKVYGGLLRDAGYEVVEAADRPSARAAFDARDFPLVLLDLMLPPDGSVSAGLEGLAALLSAKPGT
KVIVVSGAGDTRHTLEAVRLGAYDFLTKPVDPDVLLVVVQRALARVTLERQVETLRSSLTRAAGGVSLVGQSASFLAATS
LAERVAASELPVLVTGENGTGKELLARTVHLKSRRHDGPFVPINCGALPESLLESALFGHVKGSFTGATKDHRGLFAEAD
GGTLFLDELGDMSPSLQVKVLRALETGDILPVGADRPVQVDVRLISATHQDLGRMLQEGAFREDLYWRVKGVEIRLPPLR
ERSADLPLLAKHFLNQCAHLCPDGRARLLSDAAAEALLAHAWPGNLRELRHEMQRATVLAGERREIQPEDLSFTGSERLH
ATRAPGTTTLAQKVEALERREIEEALRRLNGNRTHTAEALGLSRQGLLKKLERFGLT

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=462, Percent_Identity=37.012987012987, Blast_Score=303, Evalue=2e-83,
Organism=Escherichia coli, GI1790437, Length=453, Percent_Identity=39.7350993377483, Blast_Score=286, Evalue=1e-78,
Organism=Escherichia coli, GI1788905, Length=462, Percent_Identity=38.7445887445887, Blast_Score=268, Evalue=7e-73,
Organism=Escherichia coli, GI1790299, Length=475, Percent_Identity=34.7368421052632, Blast_Score=259, Evalue=2e-70,
Organism=Escherichia coli, GI1789233, Length=328, Percent_Identity=41.7682926829268, Blast_Score=229, Evalue=3e-61,
Organism=Escherichia coli, GI87082152, Length=324, Percent_Identity=42.2839506172839, Blast_Score=217, Evalue=1e-57,
Organism=Escherichia coli, GI87082117, Length=343, Percent_Identity=39.3586005830904, Blast_Score=216, Evalue=3e-57,
Organism=Escherichia coli, GI87081872, Length=238, Percent_Identity=45.7983193277311, Blast_Score=205, Evalue=4e-54,
Organism=Escherichia coli, GI1789087, Length=355, Percent_Identity=38.3098591549296, Blast_Score=201, Evalue=7e-53,
Organism=Escherichia coli, GI1786524, Length=318, Percent_Identity=40.5660377358491, Blast_Score=197, Evalue=1e-51,
Organism=Escherichia coli, GI1787583, Length=357, Percent_Identity=33.8935574229692, Blast_Score=184, Evalue=1e-47,
Organism=Escherichia coli, GI1789828, Length=327, Percent_Identity=35.1681957186544, Blast_Score=153, Evalue=3e-38,
Organism=Escherichia coli, GI87081858, Length=299, Percent_Identity=29.7658862876254, Blast_Score=120, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 49463; Mature: 49332

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAPHPLLLVDDDAAFRKVYGGLLRDAGYEVVEAADRPSARAAFDARDFPLVLLDLMLPP
CCCCCCEEEECCCHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCCCCCHHHHEEECCC
DGSVSAGLEGLAALLSAKPGTKVIVVSGAGDTRHTLEAVRLGAYDFLTKPVDPDVLLVVV
CCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHCHHHHHCCCCCCHHHHHHH
QRALARVTLERQVETLRSSLTRAAGGVSLVGQSASFLAATSLAERVAASELPVLVTGENG
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHCCCCEEEECCCC
TGKELLARTVHLKSRRHDGPFVPINCGALPESLLESALFGHVKGSFTGATKDHRGLFAEA
CHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEC
DGGTLFLDELGDMSPSLQVKVLRALETGDILPVGADRPVQVDVRLISATHQDLGRMLQEG
CCCEEEHHHHCCCCCCHHHHHHHHHCCCCEEECCCCCCEEEEEEEEHHHHHHHHHHHHCC
AFREDLYWRVKGVEIRLPPLRERSADLPLLAKHFLNQCAHLCPDGRARLLSDAAAEALLA
CCCCCCEEEEECEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
HAWPGNLRELRHEMQRATVLAGERREIQPEDLSFTGSERLHATRAPGTTTLAQKVEALER
HCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHH
REIEEALRRLNGNRTHTAEALGLSRQGLLKKLERFGLT
HHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
SAPHPLLLVDDDAAFRKVYGGLLRDAGYEVVEAADRPSARAAFDARDFPLVLLDLMLPP
CCCCCEEEECCCHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCCCCCHHHHEEECCC
DGSVSAGLEGLAALLSAKPGTKVIVVSGAGDTRHTLEAVRLGAYDFLTKPVDPDVLLVVV
CCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHCHHHHHCCCCCCHHHHHHH
QRALARVTLERQVETLRSSLTRAAGGVSLVGQSASFLAATSLAERVAASELPVLVTGENG
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHCCCCEEEECCCC
TGKELLARTVHLKSRRHDGPFVPINCGALPESLLESALFGHVKGSFTGATKDHRGLFAEA
CHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEC
DGGTLFLDELGDMSPSLQVKVLRALETGDILPVGADRPVQVDVRLISATHQDLGRMLQEG
CCCEEEHHHHCCCCCCHHHHHHHHHCCCCEEECCCCCCEEEEEEEEHHHHHHHHHHHHCC
AFREDLYWRVKGVEIRLPPLRERSADLPLLAKHFLNQCAHLCPDGRARLLSDAAAEALLA
CCCCCCEEEEECEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
HAWPGNLRELRHEMQRATVLAGERREIQPEDLSFTGSERLHATRAPGTTTLAQKVEALER
HCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHH
REIEEALRRLNGNRTHTAEALGLSRQGLLKKLERFGLT
HHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]