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The map label for this gene is 108760215

Identifier: 108760215

GI number: 108760215

Start: 709919

End: 711979

Strand: Direct

Name: 108760215

Synonym: MXAN_0613

Alternate gene names: NA

Gene position: 709919-711979 (Clockwise)

Preceding gene: 108758532

Following gene: 108758413

Centisome position: 7.77

GC content: 70.21

Gene sequence:

>2061_bases
ATGCGCACCCACTTCGTCCGGCATCTGCTGGCGCTTTCGCTCGTGCTTGCGACGGGCGCCCAGGCGGCCAGCCAGCCCTG
GCGGACCTCCCCTCATCCGGAGTCCTCCGCGTCCGGCCTGACGGGCGCGTGCGAAGACGCGCGGGACTTCCTGCTGGGCG
CGGGCAGCGCCGACATCACCGGCCCCGCCGCCGAGGTGGGGATGATGGGCTACGGCATGCTGGAACAGCAGACCACCGGC
ATCCACCAGCGGCTGCACTCGCGCGCGTTCGTCATCGCCTCGCCCTGCAATGGTAAGCGGGTGGCCTTCGTCAGCGCGGA
CCTGGGCATGGTGTTCCAGGCGGTGAAGCAGCAGGTCGTGGAGCGGCTGCGCGCGCGTTATGGCGACCTGTACACCGACG
ACAACGTGCTGCTGAGCGCCACCCACACCCACTCCGGGCCCGGGGGCTATTCGCACTACACCCTCTACAACCTCACCACG
CTGGGCTTCTCGCCGCAGAACTTCGAGGCCATCGTCTCCGGCATCGTCGCCTCCATCGTTCGGGCGCATGAGCGGCTCGC
CGAGGGCACGCTGCGCCTGTCGTCGGGGGAGTTGTTCGGGGCCAGCCGCAACCGCTCCCCCAACGCCTACCTGCTCAACC
CGGCCGAGGAGCGCGCCCGCTACGCGCACGACGTGGACACGCGGATGACGCTGCTGCGCCTCACTCGTGCGGATGGCACC
GACATGGGGCTCATCAACTGGTTCGCGGTGCACGCCACGTCCATGGGCAACGGCAACACGCTCATCAGTGGCGACAACAA
GGGCCTGGCCTCGTACCTCGCCGAGCAGGCGCAGGGGGCCGGGGACACGTTCGTCGCCGCATTCGCCAACGCGAACGAGG
GCGACGTGACGCCCAACATCCTGGGAGGCACCCACGGCGGCGGTGCCAATGACTTCGAGGACACGGACCTCTCCGGTCGC
AAGCAGTACGACTTCGCCGCGAAGCTGTGGGCGGAGGCGAAGACGCCGCTCACGGGCGGCGTGGACTACCGGCACGTCTA
CGTGAAGATGGACGCGGTGGACGTGGCGCCAGCCTTCGCGGACGGGGCGCCGCGAACCACCTGCCCGGCCGCCATCGGCG
TGTCCATGCTGGCAGGGGCGGAGGACGGGCCGGGCGTCGGCGTGGAGGGCGTCACTTGCGCCGCCGGCCAGAATGCCTGG
GGGCAGTTCAGTTGCTCGCTCGCCACCACGCCGTGTCAGGCGGAGAAGCCCATCGTCCTGGAGATGGGCAGCATGCGGCC
CTTCCCGTGGACGCCGGAGGTGCTGCCCCTGCAACTGGTCACCATCGGCAACCTGGCGCTGGTGGCGGTGCCCTTCGAGC
TGACGACCATGGCCGGACGCCGCCTGCGCGACACCGTGGAGACGGCGCTGGCGCCCGCGGGCGTGACGGACGTCGTCATC
GCGGGCCTGTCCAATGCCTATTCGGGCTACGTGGCCACCCGCGAGGAGTACGCGCGTCAGGACTACGAAGGTGCTTCCAC
GCACTTCGGCCCGTGGACGCTCGCGGCCCTCCAACAGAACTTCCACCTGCTGGCCACGTCGCTGCGGGACGGCGCCGGTG
TGCCTCCCGGGCCCACGCCCAGGGACCTGCGCAAGGAGCAGCTCAGCCTGCAACCCGGCGTGGTGTTCGACGACAAGCTC
TTGTGGGTGGACTTCGGCGAGGTCGTCACCGACGCGCGGCCCACGTACTCGCGCGGCGACACGGCGAGCGCCACCTTCTG
GGGCGGGCATCCCAAGAATGACCTGCGCCTGGAGGGCACCTTCCTGCGCGTGCAGCGGCGCGAGCCGGACGGCACCTGGA
CGGACGTGGCCACCGACGCGGACCCGGCCACGCGCTACCAGTGGCGGCGCGAGAACTGCGTGCCCACGTTGGCGTGCTCC
CACGTCACCGTGACGTGGGGCATCCCCGACGACACGGTGCCGGGCACGTACCGGCTCGTCCACGAAGGCAACTGGAAGTC
GGGCTGGGACGGCAATGTGCGGCCCTACTCCGGTGCCTCACGGACCTTCACGGTGAAGTGA

Upstream 100 bases:

>100_bases
AGCCCTCTCGACGGCTCGTTCTTCCGGTACTGCGCGCCCGCCCTGAAGCGTTATCCACTTCCACCCCAGGGGATGTCCCC
TGGCGCCTTGGAGGCAGGCC

Downstream 100 bases:

>100_bases
CGCGCGGCCCGCGTCACAGCACCACCTCCGCGCGCATCAACGTGGACGCGGGTGTGGTCAGCCGGTGGGGCTGCACGCGG
CGGATGAGCTCGCACAGCCG

Product: alkaline ceramidase

Products: NA

Alternate protein names: N-CDase; NCDase; Acylsphingosine deacylase; N-acylsphingosine amidohydrolase [H]

Number of amino acids: Translated: 686; Mature: 686

Protein sequence:

>686_residues
MRTHFVRHLLALSLVLATGAQAASQPWRTSPHPESSASGLTGACEDARDFLLGAGSADITGPAAEVGMMGYGMLEQQTTG
IHQRLHSRAFVIASPCNGKRVAFVSADLGMVFQAVKQQVVERLRARYGDLYTDDNVLLSATHTHSGPGGYSHYTLYNLTT
LGFSPQNFEAIVSGIVASIVRAHERLAEGTLRLSSGELFGASRNRSPNAYLLNPAEERARYAHDVDTRMTLLRLTRADGT
DMGLINWFAVHATSMGNGNTLISGDNKGLASYLAEQAQGAGDTFVAAFANANEGDVTPNILGGTHGGGANDFEDTDLSGR
KQYDFAAKLWAEAKTPLTGGVDYRHVYVKMDAVDVAPAFADGAPRTTCPAAIGVSMLAGAEDGPGVGVEGVTCAAGQNAW
GQFSCSLATTPCQAEKPIVLEMGSMRPFPWTPEVLPLQLVTIGNLALVAVPFELTTMAGRRLRDTVETALAPAGVTDVVI
AGLSNAYSGYVATREEYARQDYEGASTHFGPWTLAALQQNFHLLATSLRDGAGVPPGPTPRDLRKEQLSLQPGVVFDDKL
LWVDFGEVVTDARPTYSRGDTASATFWGGHPKNDLRLEGTFLRVQRREPDGTWTDVATDADPATRYQWRRENCVPTLACS
HVTVTWGIPDDTVPGTYRLVHEGNWKSGWDGNVRPYSGASRTFTVK

Sequences:

>Translated_686_residues
MRTHFVRHLLALSLVLATGAQAASQPWRTSPHPESSASGLTGACEDARDFLLGAGSADITGPAAEVGMMGYGMLEQQTTG
IHQRLHSRAFVIASPCNGKRVAFVSADLGMVFQAVKQQVVERLRARYGDLYTDDNVLLSATHTHSGPGGYSHYTLYNLTT
LGFSPQNFEAIVSGIVASIVRAHERLAEGTLRLSSGELFGASRNRSPNAYLLNPAEERARYAHDVDTRMTLLRLTRADGT
DMGLINWFAVHATSMGNGNTLISGDNKGLASYLAEQAQGAGDTFVAAFANANEGDVTPNILGGTHGGGANDFEDTDLSGR
KQYDFAAKLWAEAKTPLTGGVDYRHVYVKMDAVDVAPAFADGAPRTTCPAAIGVSMLAGAEDGPGVGVEGVTCAAGQNAW
GQFSCSLATTPCQAEKPIVLEMGSMRPFPWTPEVLPLQLVTIGNLALVAVPFELTTMAGRRLRDTVETALAPAGVTDVVI
AGLSNAYSGYVATREEYARQDYEGASTHFGPWTLAALQQNFHLLATSLRDGAGVPPGPTPRDLRKEQLSLQPGVVFDDKL
LWVDFGEVVTDARPTYSRGDTASATFWGGHPKNDLRLEGTFLRVQRREPDGTWTDVATDADPATRYQWRRENCVPTLACS
HVTVTWGIPDDTVPGTYRLVHEGNWKSGWDGNVRPYSGASRTFTVK
>Mature_686_residues
MRTHFVRHLLALSLVLATGAQAASQPWRTSPHPESSASGLTGACEDARDFLLGAGSADITGPAAEVGMMGYGMLEQQTTG
IHQRLHSRAFVIASPCNGKRVAFVSADLGMVFQAVKQQVVERLRARYGDLYTDDNVLLSATHTHSGPGGYSHYTLYNLTT
LGFSPQNFEAIVSGIVASIVRAHERLAEGTLRLSSGELFGASRNRSPNAYLLNPAEERARYAHDVDTRMTLLRLTRADGT
DMGLINWFAVHATSMGNGNTLISGDNKGLASYLAEQAQGAGDTFVAAFANANEGDVTPNILGGTHGGGANDFEDTDLSGR
KQYDFAAKLWAEAKTPLTGGVDYRHVYVKMDAVDVAPAFADGAPRTTCPAAIGVSMLAGAEDGPGVGVEGVTCAAGQNAW
GQFSCSLATTPCQAEKPIVLEMGSMRPFPWTPEVLPLQLVTIGNLALVAVPFELTTMAGRRLRDTVETALAPAGVTDVVI
AGLSNAYSGYVATREEYARQDYEGASTHFGPWTLAALQQNFHLLATSLRDGAGVPPGPTPRDLRKEQLSLQPGVVFDDKL
LWVDFGEVVTDARPTYSRGDTASATFWGGHPKNDLRLEGTFLRVQRREPDGTWTDVATDADPATRYQWRRENCVPTLACS
HVTVTWGIPDDTVPGTYRLVHEGNWKSGWDGNVRPYSGASRTFTVK

Specific function: Hydrolyzes the ceramides into sphingosine and free fatty acid at an optimal pH of 8-9 [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the neutral ceramidase family [H]

Homologues:

Organism=Homo sapiens, GI221218981, Length=696, Percent_Identity=38.6494252873563, Blast_Score=445, Evalue=1e-125,
Organism=Homo sapiens, GI221307475, Length=668, Percent_Identity=38.622754491018, Blast_Score=425, Evalue=1e-119,
Organism=Homo sapiens, GI118442845, Length=103, Percent_Identity=37.8640776699029, Blast_Score=67, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24651405, Length=685, Percent_Identity=37.6642335766423, Blast_Score=436, Evalue=1e-122,
Organism=Drosophila melanogaster, GI24651403, Length=685, Percent_Identity=37.6642335766423, Blast_Score=436, Evalue=1e-122,
Organism=Drosophila melanogaster, GI24651401, Length=685, Percent_Identity=37.6642335766423, Blast_Score=436, Evalue=1e-122,
Organism=Drosophila melanogaster, GI24651397, Length=685, Percent_Identity=37.6642335766423, Blast_Score=436, Evalue=1e-122,
Organism=Drosophila melanogaster, GI24651399, Length=685, Percent_Identity=37.6642335766423, Blast_Score=436, Evalue=1e-122,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006823 [H]

Pfam domain/function: NA

EC number: =3.5.1.23 [H]

Molecular weight: Translated: 73583; Mature: 73583

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTHFVRHLLALSLVLATGAQAASQPWRTSPHPESSASGLTGACEDARDFLLGAGSADIT
CCHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHEEECCCCCCC
GPAAEVGMMGYGMLEQQTTGIHQRLHSRAFVIASPCNGKRVAFVSADLGMVFQAVKQQVV
CCHHHHHHHCCCHHHHHHHHHHHHHHCCEEEEECCCCCCEEEEEECCHHHHHHHHHHHHH
ERLRARYGDLYTDDNVLLSATHTHSGPGGYSHYTLYNLTTLGFSPQNFEAIVSGIVASIV
HHHHHHHCCCCCCCCEEEEEECCCCCCCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHH
RAHERLAEGTLRLSSGELFGASRNRSPNAYLLNPAEERARYAHDVDTRMTLLRLTRADGT
HHHHHHHHCEEEEECCCEECCCCCCCCCEEEECCHHHHHHHHHHHHHHEEEEEEECCCCC
DMGLINWFAVHATSMGNGNTLISGDNKGLASYLAEQAQGAGDTFVAAFANANEGDVTPNI
CCCHHEEEEEEEEECCCCCEEEECCCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCC
LGGTHGGGANDFEDTDLSGRKQYDFAAKLWAEAKTPLTGGVDYRHVYVKMDAVDVAPAFA
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEECCCHHC
DGAPRTTCPAAIGVSMLAGAEDGPGVGVEGVTCAAGQNAWGQFSCSLATTPCQAEKPIVL
CCCCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCEEEEEEECCCCCCCCCEEE
EMGSMRPFPWTPEVLPLQLVTIGNLALVAVPFELTTMAGRRLRDTVETALAPAGVTDVVI
EECCCCCCCCCCCCCEEEEEEECCEEEEEECHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
AGLSNAYSGYVATREEYARQDYEGASTHFGPWTLAALQQNFHLLATSLRDGAGVPPGPTP
HHHHHHHCCCEECHHHHHHCCCCCCCCCCCCCHHHHHHHCHHEEEHHHCCCCCCCCCCCH
RDLRKEQLSLQPGVVFDDKLLWVDFGEVVTDARPTYSRGDTASATFWGGHPKNDLRLEGT
HHHHHHHHCCCCCEEECCEEEEEEHHHHHCCCCCCCCCCCCCCEEEECCCCCCCEEEEEE
FLRVQRREPDGTWTDVATDADPATRYQWRRENCVPTLACSHVTVTWGIPDDTVPGTYRLV
EEEEEECCCCCCEEECCCCCCCHHHHHHHHCCCCCEEEECEEEEEECCCCCCCCCCEEEE
HEGNWKSGWDGNVRPYSGASRTFTVK
ECCCCCCCCCCCCCCCCCCCCEEEEC
>Mature Secondary Structure
MRTHFVRHLLALSLVLATGAQAASQPWRTSPHPESSASGLTGACEDARDFLLGAGSADIT
CCHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHEEECCCCCCC
GPAAEVGMMGYGMLEQQTTGIHQRLHSRAFVIASPCNGKRVAFVSADLGMVFQAVKQQVV
CCHHHHHHHCCCHHHHHHHHHHHHHHCCEEEEECCCCCCEEEEEECCHHHHHHHHHHHHH
ERLRARYGDLYTDDNVLLSATHTHSGPGGYSHYTLYNLTTLGFSPQNFEAIVSGIVASIV
HHHHHHHCCCCCCCCEEEEEECCCCCCCCCCEEEEEEEEEECCCCCHHHHHHHHHHHHHH
RAHERLAEGTLRLSSGELFGASRNRSPNAYLLNPAEERARYAHDVDTRMTLLRLTRADGT
HHHHHHHHCEEEEECCCEECCCCCCCCCEEEECCHHHHHHHHHHHHHHEEEEEEECCCCC
DMGLINWFAVHATSMGNGNTLISGDNKGLASYLAEQAQGAGDTFVAAFANANEGDVTPNI
CCCHHEEEEEEEEECCCCCEEEECCCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCC
LGGTHGGGANDFEDTDLSGRKQYDFAAKLWAEAKTPLTGGVDYRHVYVKMDAVDVAPAFA
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEEEEEEEEECCCHHC
DGAPRTTCPAAIGVSMLAGAEDGPGVGVEGVTCAAGQNAWGQFSCSLATTPCQAEKPIVL
CCCCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCEEEEEEECCCCCCCCCEEE
EMGSMRPFPWTPEVLPLQLVTIGNLALVAVPFELTTMAGRRLRDTVETALAPAGVTDVVI
EECCCCCCCCCCCCCEEEEEEECCEEEEEECHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
AGLSNAYSGYVATREEYARQDYEGASTHFGPWTLAALQQNFHLLATSLRDGAGVPPGPTP
HHHHHHHCCCEECHHHHHHCCCCCCCCCCCCCHHHHHHHCHHEEEHHHCCCCCCCCCCCH
RDLRKEQLSLQPGVVFDDKLLWVDFGEVVTDARPTYSRGDTASATFWGGHPKNDLRLEGT
HHHHHHHHCCCCCEEECCEEEEEEHHHHHCCCCCCCCCCCCCCEEEECCCCCCCEEEEEE
FLRVQRREPDGTWTDVATDADPATRYQWRRENCVPTLACSHVTVTWGIPDDTVPGTYRLV
EEEEEECCCCCCEEECCCCCCCHHHHHHHHCCCCCEEEECEEEEEECCCCCCCCCCEEEE
HEGNWKSGWDGNVRPYSGASRTFTVK
ECCCCCCCCCCCCCCCCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10593963; 10984043 [H]