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The map label for this gene is gor [H]

Identifier: 108760081

GI number: 108760081

Start: 2695928

End: 2697346

Strand: Direct

Name: gor [H]

Synonym: MXAN_2318

Alternate gene names: 108760081

Gene position: 2695928-2697346 (Clockwise)

Preceding gene: 108757295

Following gene: 108760904

Centisome position: 29.5

GC content: 68.57

Gene sequence:

>1419_bases
ATGGCCCGATACGACTTCGACCTGTTCACCATTGGCGGCGGCTCTGGCGGTGTGGCGGCCAGCCGCAGGGCCGGGGCACA
CGGGGCCGGGGTGGCGCTGTGTGAGGACCGCGACGTGGGCGGCACGTGTGTCCACCGTGGTTGCGTGCCCAAGAAGCTCC
TGGTGTACGGAGCACACTTCCGGGAGGAGTTCCAGGACGCGGAGGGCTATGGCTGGACGGTCCAGGAGCCGCTGTTCACC
TGGAGCAAGCTGCTGGCCGCCAAGGACAAGGAGTTGGACCGGCTGCGTGGCGTGTATGCGCGCTTGTTGCGCGACTCGGG
CGTGACGCTGCTGGAAGGGCGCGGGCGCGTGGTGGACCCGCACACGGTGGAGGTGGCCGGAAAGCTGTACACGGCCGAGC
GCATCCTGATTGCCACGGGCTCGCGGCCCTACCTGCCGCCCGACATCACCGGCATCGAGCACGCCATCACCTCCGATGAG
GCGCTGTCCTTCCCCGAGCTGCCTCGGCGGCTGGCCGTCGTCGGGGCCGGGTACATCGGCGTGGAGCTGGCGGGCGTCTT
CCACGGGCTGGGCTCCAAGGTGACGATGTTGATTCGCGGCGCCAGCGTGCTGGGTGGGTTCGATGACGACGTCCGCTCCT
TCCTCACGGACGAGATGCGCAAGAAGGGCATCGAGCTGATGACGGACACCTTCATCCGGGACATCGAAAAGCGAGCCGAG
GGTGGGGTGAGCCTGCTGACGGGCGGGGGCGAGACGGTGGAGGCGGACGCGGTGCTGTTCGCCACCGGGCGCGTTCCCAA
CTCGGGGGGGCTGGGACTGGAGGAAGTGGGAGTGACGCTGGACGCGCGCGGCGCGGTGGTGGTGGACGCGTGGTCCCGCA
CCTCGGTGGAGAGCATCTATGCGGTGGGCGACATCACCGACCGCATCAACCTCACGCCGGTGGCCATCTCGGAAGGGCGT
GCCCTGGCGGAGACGCTCTTCAACGACAACCCGACGCAGATGGACCACACCAACGTACCGTCGGCTGTCTTCAGCCAGCC
GCCCGTGGCCTCCGTGGGGCTGACGGAGCAGGAGGCACGGGAGCGTCATGGGAAGCTGGACATCTATGTCACCAGCTTCC
GCCCCATGAAGCACACCCTGAGCGGGCGTAACGAGCGCACCATGATGAAGGTGGTCGTGGAGCGCGAGTCCAACCGCGTG
CTCGGCTGTCACATGGTGGGGACGGACGCACCGGAAATCATCCAGGGACTGGCGGTGGCGGTGAAGTGTGGCGTCACCAA
GAAGCAGCTCGATGCCACCGTGGGCATCCACCCCACCGCGGCCGAGGAGTTCGTCACCCTGCGCGACAAGCGGCCGGACC
CCGACGAGCGGCTGGCGGCGGAGCTGGGCCGTGATGCGGCGGCGTCTACCCGGCGCTGA

Upstream 100 bases:

>100_bases
GATTACGCGGCGGAGGCGCACGTCGACGGTGCGCGACGCCCCATCCGAGCGCTATCTCTTCAAGCTCATTCGCGAATGCC
ACCGAGGAGAGTCAAAACGC

Downstream 100 bases:

>100_bases
GGCCCGCCTCGGGTCGGGTCAGGGGGGCGCTCGTCCCGCCGTCCCTGGGCGGCTTTCGCATCGATTCGAGAGGTGATGAC
CCCATGAGTGATTCATCGAC

Product: glutathione-disulfide reductase

Products: NA

Alternate protein names: GR; GRase [H]

Number of amino acids: Translated: 472; Mature: 471

Protein sequence:

>472_residues
MARYDFDLFTIGGGSGGVAASRRAGAHGAGVALCEDRDVGGTCVHRGCVPKKLLVYGAHFREEFQDAEGYGWTVQEPLFT
WSKLLAAKDKELDRLRGVYARLLRDSGVTLLEGRGRVVDPHTVEVAGKLYTAERILIATGSRPYLPPDITGIEHAITSDE
ALSFPELPRRLAVVGAGYIGVELAGVFHGLGSKVTMLIRGASVLGGFDDDVRSFLTDEMRKKGIELMTDTFIRDIEKRAE
GGVSLLTGGGETVEADAVLFATGRVPNSGGLGLEEVGVTLDARGAVVVDAWSRTSVESIYAVGDITDRINLTPVAISEGR
ALAETLFNDNPTQMDHTNVPSAVFSQPPVASVGLTEQEARERHGKLDIYVTSFRPMKHTLSGRNERTMMKVVVERESNRV
LGCHMVGTDAPEIIQGLAVAVKCGVTKKQLDATVGIHPTAAEEFVTLRDKRPDPDERLAAELGRDAAASTRR

Sequences:

>Translated_472_residues
MARYDFDLFTIGGGSGGVAASRRAGAHGAGVALCEDRDVGGTCVHRGCVPKKLLVYGAHFREEFQDAEGYGWTVQEPLFT
WSKLLAAKDKELDRLRGVYARLLRDSGVTLLEGRGRVVDPHTVEVAGKLYTAERILIATGSRPYLPPDITGIEHAITSDE
ALSFPELPRRLAVVGAGYIGVELAGVFHGLGSKVTMLIRGASVLGGFDDDVRSFLTDEMRKKGIELMTDTFIRDIEKRAE
GGVSLLTGGGETVEADAVLFATGRVPNSGGLGLEEVGVTLDARGAVVVDAWSRTSVESIYAVGDITDRINLTPVAISEGR
ALAETLFNDNPTQMDHTNVPSAVFSQPPVASVGLTEQEARERHGKLDIYVTSFRPMKHTLSGRNERTMMKVVVERESNRV
LGCHMVGTDAPEIIQGLAVAVKCGVTKKQLDATVGIHPTAAEEFVTLRDKRPDPDERLAAELGRDAAASTRR
>Mature_471_residues
ARYDFDLFTIGGGSGGVAASRRAGAHGAGVALCEDRDVGGTCVHRGCVPKKLLVYGAHFREEFQDAEGYGWTVQEPLFTW
SKLLAAKDKELDRLRGVYARLLRDSGVTLLEGRGRVVDPHTVEVAGKLYTAERILIATGSRPYLPPDITGIEHAITSDEA
LSFPELPRRLAVVGAGYIGVELAGVFHGLGSKVTMLIRGASVLGGFDDDVRSFLTDEMRKKGIELMTDTFIRDIEKRAEG
GVSLLTGGGETVEADAVLFATGRVPNSGGLGLEEVGVTLDARGAVVVDAWSRTSVESIYAVGDITDRINLTPVAISEGRA
LAETLFNDNPTQMDHTNVPSAVFSQPPVASVGLTEQEARERHGKLDIYVTSFRPMKHTLSGRNERTMMKVVVERESNRVL
GCHMVGTDAPEIIQGLAVAVKCGVTKKQLDATVGIHPTAAEEFVTLRDKRPDPDERLAAELGRDAAASTRR

Specific function: Maintains High Levels Of Reduced Glutathione In The Cytosol. [C]

COG id: COG1249

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family [H]

Homologues:

Organism=Homo sapiens, GI50301238, Length=459, Percent_Identity=41.8300653594771, Blast_Score=332, Evalue=4e-91,
Organism=Homo sapiens, GI33519430, Length=432, Percent_Identity=37.2685185185185, Blast_Score=270, Evalue=1e-72,
Organism=Homo sapiens, GI33519428, Length=432, Percent_Identity=37.2685185185185, Blast_Score=270, Evalue=1e-72,
Organism=Homo sapiens, GI33519426, Length=432, Percent_Identity=37.2685185185185, Blast_Score=270, Evalue=1e-72,
Organism=Homo sapiens, GI148277071, Length=432, Percent_Identity=37.2685185185185, Blast_Score=270, Evalue=2e-72,
Organism=Homo sapiens, GI148277065, Length=432, Percent_Identity=37.2685185185185, Blast_Score=270, Evalue=2e-72,
Organism=Homo sapiens, GI22035672, Length=428, Percent_Identity=37.6168224299065, Blast_Score=259, Evalue=3e-69,
Organism=Homo sapiens, GI291045266, Length=431, Percent_Identity=36.8909512761021, Blast_Score=256, Evalue=2e-68,
Organism=Homo sapiens, GI291045268, Length=429, Percent_Identity=34.032634032634, Blast_Score=219, Evalue=6e-57,
Organism=Homo sapiens, GI91199540, Length=455, Percent_Identity=29.2307692307692, Blast_Score=190, Evalue=3e-48,
Organism=Escherichia coli, GI1789915, Length=431, Percent_Identity=41.7633410672854, Blast_Score=345, Evalue=4e-96,
Organism=Escherichia coli, GI1786307, Length=466, Percent_Identity=30.4721030042918, Blast_Score=198, Evalue=7e-52,
Organism=Escherichia coli, GI87082354, Length=456, Percent_Identity=30.0438596491228, Blast_Score=186, Evalue=4e-48,
Organism=Escherichia coli, GI87081717, Length=452, Percent_Identity=27.6548672566372, Blast_Score=161, Evalue=9e-41,
Organism=Escherichia coli, GI1789065, Length=242, Percent_Identity=28.9256198347107, Blast_Score=76, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71983419, Length=450, Percent_Identity=41.1111111111111, Blast_Score=288, Evalue=5e-78,
Organism=Caenorhabditis elegans, GI71983429, Length=450, Percent_Identity=41.1111111111111, Blast_Score=287, Evalue=7e-78,
Organism=Caenorhabditis elegans, GI17557007, Length=479, Percent_Identity=33.8204592901879, Blast_Score=264, Evalue=1e-70,
Organism=Caenorhabditis elegans, GI71982272, Length=495, Percent_Identity=32.3232323232323, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI32565766, Length=458, Percent_Identity=31.6593886462882, Blast_Score=196, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6325166, Length=464, Percent_Identity=37.9310344827586, Blast_Score=310, Evalue=3e-85,
Organism=Saccharomyces cerevisiae, GI6321091, Length=461, Percent_Identity=29.5010845986985, Blast_Score=176, Evalue=5e-45,
Organism=Saccharomyces cerevisiae, GI6325240, Length=469, Percent_Identity=28.1449893390192, Blast_Score=150, Evalue=5e-37,
Organism=Drosophila melanogaster, GI24640549, Length=471, Percent_Identity=37.791932059448, Blast_Score=263, Evalue=2e-70,
Organism=Drosophila melanogaster, GI24640553, Length=471, Percent_Identity=37.791932059448, Blast_Score=263, Evalue=2e-70,
Organism=Drosophila melanogaster, GI24640551, Length=471, Percent_Identity=37.791932059448, Blast_Score=262, Evalue=4e-70,
Organism=Drosophila melanogaster, GI17737741, Length=476, Percent_Identity=36.9747899159664, Blast_Score=246, Evalue=2e-65,
Organism=Drosophila melanogaster, GI21358499, Length=455, Percent_Identity=30.3296703296703, Blast_Score=189, Evalue=3e-48,

Paralogues:

None

Copy number: 650 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016156
- InterPro:   IPR013027
- InterPro:   IPR006324
- InterPro:   IPR004099
- InterPro:   IPR012999
- InterPro:   IPR001327 [H]

Pfam domain/function: PF00070 Pyr_redox; PF07992 Pyr_redox_2; PF02852 Pyr_redox_dim [H]

EC number: =1.8.1.7 [H]

Molecular weight: Translated: 50765; Mature: 50634

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS00076 PYRIDINE_REDOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARYDFDLFTIGGGSGGVAASRRAGAHGAGVALCEDRDVGGTCVHRGCVPKKLLVYGAHF
CCEEEEEEEEEECCCCCCCCCCCCCCCCCCEEEECCCCCCCHHHCCCCCCHHHHHHCHHH
REEFQDAEGYGWTVQEPLFTWSKLLAAKDKELDRLRGVYARLLRDSGVTLLEGRGRVVDP
HHHHHCCCCCCCEECCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEECCCCEECC
HTVEVAGKLYTAERILIATGSRPYLPPDITGIEHAITSDEALSFPELPRRLAVVGAGYIG
CEEEECCEEEEEEEEEEEECCCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHEECCHHH
VELAGVFHGLGSKVTMLIRGASVLGGFDDDVRSFLTDEMRKKGIELMTDTFIRDIEKRAE
HHHHHHHHCCCCEEEEEEECHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHC
GGVSLLTGGGETVEADAVLFATGRVPNSGGLGLEEVGVTLDARGAVVVDAWSRTSVESIY
CCEEEEECCCCEEECCEEEEEECCCCCCCCCCHHHHCEEEECCCEEEEECCCCCCHHHEE
AVGDITDRINLTPVAISEGRALAETLFNDNPTQMDHTNVPSAVFSQPPVASVGLTEQEAR
EEECCCCCCEEEEEEECCCHHHHHHHHCCCCCCCCCCCCCHHHHCCCCCCCCCCCHHHHH
ERHGKLDIYVTSFRPMKHTLSGRNERTMMKVVVERESNRVLGCHMVGTDAPEIIQGLAVA
HHCCCEEEEEECCCCHHHHHCCCCCCEEEEEEEECCCCCEEEEEEECCCHHHHHHHHHHH
VKCGVTKKQLDATVGIHPTAAEEFVTLRDKRPDPDERLAAELGRDAAASTRR
HHCCCCHHHHHHCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
ARYDFDLFTIGGGSGGVAASRRAGAHGAGVALCEDRDVGGTCVHRGCVPKKLLVYGAHF
CEEEEEEEEEECCCCCCCCCCCCCCCCCCEEEECCCCCCCHHHCCCCCCHHHHHHCHHH
REEFQDAEGYGWTVQEPLFTWSKLLAAKDKELDRLRGVYARLLRDSGVTLLEGRGRVVDP
HHHHHCCCCCCCEECCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEECCCCEECC
HTVEVAGKLYTAERILIATGSRPYLPPDITGIEHAITSDEALSFPELPRRLAVVGAGYIG
CEEEECCEEEEEEEEEEEECCCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHEECCHHH
VELAGVFHGLGSKVTMLIRGASVLGGFDDDVRSFLTDEMRKKGIELMTDTFIRDIEKRAE
HHHHHHHHCCCCEEEEEEECHHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHC
GGVSLLTGGGETVEADAVLFATGRVPNSGGLGLEEVGVTLDARGAVVVDAWSRTSVESIY
CCEEEEECCCCEEECCEEEEEECCCCCCCCCCHHHHCEEEECCCEEEEECCCCCCHHHEE
AVGDITDRINLTPVAISEGRALAETLFNDNPTQMDHTNVPSAVFSQPPVASVGLTEQEAR
EEECCCCCCEEEEEEECCCHHHHHHHHCCCCCCCCCCCCCHHHHCCCCCCCCCCCHHHHH
ERHGKLDIYVTSFRPMKHTLSGRNERTMMKVVVERESNRVLGCHMVGTDAPEIIQGLAVA
HHCCCEEEEEECCCCHHHHHCCCCCCEEEEEEEECCCCCEEEEEEECCCHHHHHHHHHHH
VKCGVTKKQLDATVGIHPTAAEEFVTLRDKRPDPDERLAAELGRDAAASTRR
HHCCCCHHHHHHCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7538273 [H]