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The map label for this gene is phrB [H]

Identifier: 108759895

GI number: 108759895

Start: 5081348

End: 5082814

Strand: Direct

Name: phrB [H]

Synonym: MXAN_4136

Alternate gene names: 108759895

Gene position: 5081348-5082814 (Clockwise)

Preceding gene: 108763482

Following gene: 108756821

Centisome position: 55.6

GC content: 68.78

Gene sequence:

>1467_bases
ATGCCTGAAGGCTTCTCGTGGTCCGAACTCGGCGTCGATTCGGCGCGCGTCCAGGTGGTGAAGGACCTCCCGCTTCCTTC
CGGCCGCCGCGACTTCGTCCTCTATTGGTGCATGGTCAACCATCGCGCCGAGCAGAACCACGCGCTGGATGCCGCCATCG
GTCTGGGCAACCACCTGGGCCTGCCCGTCGTCGTCTACCAGGCCATCCGTCCGGACTACCCTCATGCCTCCGACAGGCTC
CACGCCTGGGCCCTGGAGGGGATGATGGACATGGCCACCGGCTGCGCCGCGCGCGGGCTGCCCTACTGGCTGGAGCTGCC
CCGGACCTCGAAGGAGCACCGTCCCCGGCTGGCCCAGCTCGGCCGGCGCGCCGCCGCCATCGTGTCGGACCTGTTCCCCA
CGTACATCATCCCGGGCCACCTGCGCGGCGCCGCCAAGGCCCTGGACGTGCCGCTGTTCGCCGTGGATGCGTCATGCGTG
GTGCCCATGCAGCGCATCGCCACGCGGCAGATTGGCGCCTATACCTTGCGGCCCAAGCTGAAGAAGCTGTGGCCGGAGTA
CCTGGACCGCGCCGTGCCCAACCGCGCGGTGAAGGCCGCCGCGGCCGGACGCAAGCTGGAGCCGGACTTCGCCACGTCAG
ACGCACGCGAGTCCCGCGAGTCCCTGGACGCCTTCGACTTCGACCATTCGGTGGCGCCCATCCAGGAGCGCGGAGGACGC
AAGGCGGGCCTCGATGCGCTCCAGGCCTTCGTGCACCAACGGTTGGAGGGCTATGACGAAGGCCGCAACGACCCGGGCCT
GGCGCGACAGTCCAACCTGTCCCCCTTCTTCCACTGGGGCAACCTCTTCGCGGGAGAGGCCGCGCGCGCCGCCATCCGCG
CACGCGGCGCGCAGGATGCTTCGGTGCAGGGCTTCCTGGAGGAGCTGCTCGTCCGCCGTGAGCTGGGTTTCAACTACTGC
TTCCACACGCCGGGGCCGCAGCAGCTCTCCGTGGCCTCCCTGCCTCCGTGGGCGAAGGAGACACTCACCCGCCACCAGAA
GGACGCGCGCGAGCACCGCTATTCGTTGAAGCAATTGGAGACAGCGCGGACCGCGGACGGCTTGTGGAACGCGGCCCAGC
GCGAGTTGGTGGAGCGTGGCCGCATCCACAACTACCTGCGCATGCTGTGGGGGAAGAAAATCCTGGAGTGGACTCCATCC
CCCCAGGAAGCGCTGCAACGCATCGCGTTCCTCAACGACAAGTACGCGGTGGATGGCAGGGACCCCGCGAGCGTCGCCAA
CTTCATGTGGGTGCTGGGACTGCATGACCGCCCTTTCCAGGAGCGGCAGGTGCTGGGCAAGGTGCGGCCCATGAGCTCCC
TGCGCACGGCGGCCAGGTACAACCTGGCACCCTACCTGGAGCGCTGGGGCCGCCCGGAGGACCCACCGGTGAAGCTCAAG
CGCGTTCGCAAGACGGCAGGCCCGTGA

Upstream 100 bases:

>100_bases
GAAATTGGAGCGCCATCCGACCTTCCCTGTCCCCTCGTTCACAGCCACGCACTTCTTTTCCTCCGCGACGCGAATACGGC
TCGCGTATCAGTGAGGCCCC

Downstream 100 bases:

>100_bases
GCAAGCCTGTTGACATCCGCGCGCCCAAAAGTGACACGGCGGTTCCATTCCCGCTCGGGCACGGATAAACGCACGAAGCG
GGACACCGAGATCAGGAGCC

Product: deoxyribodipyrimidine photolyase

Products: NA

Alternate protein names: DNA photolyase; Photoreactivating enzyme [H]

Number of amino acids: Translated: 488; Mature: 487

Protein sequence:

>488_residues
MPEGFSWSELGVDSARVQVVKDLPLPSGRRDFVLYWCMVNHRAEQNHALDAAIGLGNHLGLPVVVYQAIRPDYPHASDRL
HAWALEGMMDMATGCAARGLPYWLELPRTSKEHRPRLAQLGRRAAAIVSDLFPTYIIPGHLRGAAKALDVPLFAVDASCV
VPMQRIATRQIGAYTLRPKLKKLWPEYLDRAVPNRAVKAAAAGRKLEPDFATSDARESRESLDAFDFDHSVAPIQERGGR
KAGLDALQAFVHQRLEGYDEGRNDPGLARQSNLSPFFHWGNLFAGEAARAAIRARGAQDASVQGFLEELLVRRELGFNYC
FHTPGPQQLSVASLPPWAKETLTRHQKDAREHRYSLKQLETARTADGLWNAAQRELVERGRIHNYLRMLWGKKILEWTPS
PQEALQRIAFLNDKYAVDGRDPASVANFMWVLGLHDRPFQERQVLGKVRPMSSLRTAARYNLAPYLERWGRPEDPPVKLK
RVRKTAGP

Sequences:

>Translated_488_residues
MPEGFSWSELGVDSARVQVVKDLPLPSGRRDFVLYWCMVNHRAEQNHALDAAIGLGNHLGLPVVVYQAIRPDYPHASDRL
HAWALEGMMDMATGCAARGLPYWLELPRTSKEHRPRLAQLGRRAAAIVSDLFPTYIIPGHLRGAAKALDVPLFAVDASCV
VPMQRIATRQIGAYTLRPKLKKLWPEYLDRAVPNRAVKAAAAGRKLEPDFATSDARESRESLDAFDFDHSVAPIQERGGR
KAGLDALQAFVHQRLEGYDEGRNDPGLARQSNLSPFFHWGNLFAGEAARAAIRARGAQDASVQGFLEELLVRRELGFNYC
FHTPGPQQLSVASLPPWAKETLTRHQKDAREHRYSLKQLETARTADGLWNAAQRELVERGRIHNYLRMLWGKKILEWTPS
PQEALQRIAFLNDKYAVDGRDPASVANFMWVLGLHDRPFQERQVLGKVRPMSSLRTAARYNLAPYLERWGRPEDPPVKLK
RVRKTAGP
>Mature_487_residues
PEGFSWSELGVDSARVQVVKDLPLPSGRRDFVLYWCMVNHRAEQNHALDAAIGLGNHLGLPVVVYQAIRPDYPHASDRLH
AWALEGMMDMATGCAARGLPYWLELPRTSKEHRPRLAQLGRRAAAIVSDLFPTYIIPGHLRGAAKALDVPLFAVDASCVV
PMQRIATRQIGAYTLRPKLKKLWPEYLDRAVPNRAVKAAAAGRKLEPDFATSDARESRESLDAFDFDHSVAPIQERGGRK
AGLDALQAFVHQRLEGYDEGRNDPGLARQSNLSPFFHWGNLFAGEAARAAIRARGAQDASVQGFLEELLVRRELGFNYCF
HTPGPQQLSVASLPPWAKETLTRHQKDAREHRYSLKQLETARTADGLWNAAQRELVERGRIHNYLRMLWGKKILEWTPSP
QEALQRIAFLNDKYAVDGRDPASVANFMWVLGLHDRPFQERQVLGKVRPMSSLRTAARYNLAPYLERWGRPEDPPVKLKR
VRKTAGP

Specific function: Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ul

COG id: COG0415

COG function: function code L; Deoxyribodipyrimidine photolyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DNA photolyase domain [H]

Homologues:

Organism=Drosophila melanogaster, GI24586396, Length=443, Percent_Identity=35.4401805869075, Blast_Score=241, Evalue=1e-63,
Organism=Drosophila melanogaster, GI24586398, Length=443, Percent_Identity=35.4401805869075, Blast_Score=240, Evalue=1e-63,
Organism=Drosophila melanogaster, GI24586404, Length=154, Percent_Identity=43.5064935064935, Blast_Score=142, Evalue=5e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008148
- InterPro:   IPR006050
- InterPro:   IPR005101
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00875 DNA_photolyase; PF03441 FAD_binding_7 [H]

EC number: =4.1.99.3 [H]

Molecular weight: Translated: 54954; Mature: 54823

Theoretical pI: Translated: 10.09; Mature: 10.09

Prosite motif: PS00290 IG_MHC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEGFSWSELGVDSARVQVVKDLPLPSGRRDFVLYWCMVNHRAEQNHALDAAIGLGNHLG
CCCCCCHHHHCCCHHHHHHHHHCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCC
LPVVVYQAIRPDYPHASDRLHAWALEGMMDMATGCAARGLPYWLELPRTSKEHRPRLAQL
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHCCCHHHHH
GRRAAAIVSDLFPTYIIPGHLRGAAKALDVPLFAVDASCVVPMQRIATRQIGAYTLRPKL
HHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEEECCHHHHHHHHHHHHHCCCEECCHHH
KKLWPEYLDRAVPNRAVKAAAAGRKLEPDFATSDARESRESLDAFDFDHSVAPIQERGGR
HHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHCCCC
KAGLDALQAFVHQRLEGYDEGRNDPGLARQSNLSPFFHWGNLFAGEAARAAIRARGAQDA
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHCCCCCH
SVQGFLEELLVRRELGFNYCFHTPGPQQLSVASLPPWAKETLTRHQKDAREHRYSLKQLE
HHHHHHHHHHHHHHHCCCEEECCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHH
TARTADGLWNAAQRELVERGRIHNYLRMLWGKKILEWTPSPQEALQRIAFLNDKYAVDGR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCHHHHHHHHHHHCCCCEECCC
DPASVANFMWVLGLHDRPFQERQVLGKVRPMSSLRTAARYNLAPYLERWGRPEDPPVKLK
CHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHCCCCCCCCHHHH
RVRKTAGP
HHHHHCCC
>Mature Secondary Structure 
PEGFSWSELGVDSARVQVVKDLPLPSGRRDFVLYWCMVNHRAEQNHALDAAIGLGNHLG
CCCCCHHHHCCCHHHHHHHHHCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCCC
LPVVVYQAIRPDYPHASDRLHAWALEGMMDMATGCAARGLPYWLELPRTSKEHRPRLAQL
HHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCHHCCCHHHHH
GRRAAAIVSDLFPTYIIPGHLRGAAKALDVPLFAVDASCVVPMQRIATRQIGAYTLRPKL
HHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEEECCHHHHHHHHHHHHHCCCEECCHHH
KKLWPEYLDRAVPNRAVKAAAAGRKLEPDFATSDARESRESLDAFDFDHSVAPIQERGGR
HHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHCCCC
KAGLDALQAFVHQRLEGYDEGRNDPGLARQSNLSPFFHWGNLFAGEAARAAIRARGAQDA
CCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHCCCCCH
SVQGFLEELLVRRELGFNYCFHTPGPQQLSVASLPPWAKETLTRHQKDAREHRYSLKQLE
HHHHHHHHHHHHHHHCCCEEECCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHH
TARTADGLWNAAQRELVERGRIHNYLRMLWGKKILEWTPSPQEALQRIAFLNDKYAVDGR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCHHHHHHHHHHHCCCCEECCC
DPASVANFMWVLGLHDRPFQERQVLGKVRPMSSLRTAARYNLAPYLERWGRPEDPPVKLK
CHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHCCCCCCCCHHHH
RVRKTAGP
HHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7813451; 9371463 [H]