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The map label for this gene is loxA [H]

Identifier: 108759761

GI number: 108759761

Start: 2066844

End: 2068871

Strand: Reverse

Name: loxA [H]

Synonym: MXAN_1744

Alternate gene names: 108759761

Gene position: 2068871-2066844 (Counterclockwise)

Preceding gene: 108759366

Following gene: 108759270

Centisome position: 22.64

GC content: 68.15

Gene sequence:

>2028_bases
ATGACTGTCGAGTACAAACTCACGATTCGGACGGGCACGAAGCTCGGCGCGGGGACGGATGCCGACATTTCCATCGTCCT
CGTGGGCACGCGAGGAGAGAGCGCCCCCCGCGTGCTGGACAAGCACTTCCACAACGACTTCGAGGCGGGCGCGGAGGACG
TCTACGCCCTCTCCTCCGAGGACCTCGGTGACCTGGTCCTGTTGCGCTTCAGCAACGCGGGCGGCGTGGCGGCCGACTGG
CTGCTCGACTGGGCAATCGTCACGGCCGGAGAGAAGCAGTGGCACTTCCCTTTCTACCGGTGGGTGCTGAGTGGCGCCAC
GGTCGACGTGCTCGAGGGGACCGCGAAGCTCGCTCGCCAGGCAAGCAGCGAGCGCGAGTCCACGGCGCGGCGCGAGCTGC
TCGAGGCCCGCCAGCGGATGTACCCGTGGCGCGCGCCTGAGATGACCGAGGGGCTTCCCGGCGCGCTCGACCTCCGTGAG
GGGAGGCCGCTGCCGAAGGACGAGCTCTACCGGGGCCTGACGGAGGGCAGCTACGAAGTGGTCATCGCGAAGACGCTGGC
GGCCATCAAGCTGAACCTGCCCATGCTGACCCGCGCCTGGAACGGGCTGGTGGACATCTTCGACTTCTTCAAACACCTGG
AGGTGCCCCAGCTCGCCCAGCGCTGGAAGGACGACCTCGAGTTCGCGCGGCAGGCCGTCCAGGGCATCGCCCCCCTCCAC
ATCACGCTCGTCCCCAGTCTGCCGCAGGGCATGCCGCTCACCGACGACGACGTCCGGGGCCTCTTGTCGCCCGGCACCAC
GCTGGCCAGGGCGCTCGACGCCAAGCGCATCTTCCTGATCGACTTCGAAATCCTCGACGACATCAGGATGTACCGGAAGG
TCGGCGAGGACGGAGTCGAGGAGCGGCGCTGGGCTCCCGCGGCGCGCTGCCTGCTGTACCTGGATGACCAGCGTCAACTG
CGACCCCTGGCCATCCAGCTCGGGCGGGACGCCCAGAAGGACCCTGTCTTCACGCCGAACGACGACGCGTACGACTGGCT
CGCCGCGAAAATCTACCTCCGGTGCAGCGAGGGCAACTCGCACCAGATGGTGTCGCACGCGCTGCGCACACACTTCGTGG
CGGAGCCGTTCGTCATGGCGACGATGCGCAACCTGCCGGACCCGCACCCCGTCTACAAACTGCTGCGGCGGCACTTCCGC
TACACGCTCGCCATCAACGAGGGCGCACGCAAGGGCCTGCTCGACGCAGGCGGGGTGTTCGACGACTTCATCGCGACAGG
CGGCCCCGACAAGGGCCACCTCCAGTTGGGCAAGAAGGGCTTCCAGCGCTGGACGCTGGCGGACAACAAGCCCCGTGCTG
ACCTGGAGCGGCGGGGCGTGCTGGACCCTGCCGTGCTCCCCAACTACCCGTACCGGGACGACGCCCTGCCCTTGTGGGAC
GCGTTCGAGGAGTACGTCGGCGGCGTCCTCAGGCACTTCTACCGGACCGATGCCGACCTCGAGGCCGACACCGAGATGCA
GCAATGGTGGAAGGACCTCACCGAGCACGGGCTGCCCGTGGACAAGCTGCCCTGCCGGGAGCTGCGCCGCGTCGACGACC
TGGTCGACATCCTCACCACCGTCCTCTTCACGGTCAGCGTGCAGCACGCGGCGGTGAACTACCTGCAATACGAGCACTAC
GCCTTCGTACCGAATGCGCCCCTGAGCATGCGCCGGGAGCCACCCCGCCAGAAGGGGACGCTGCGTGCAGAGGACATCCC
CGAGATGATTCCCACCAAGTCCCAGATGCTCTGGCAGGTCGCCATCGGCCGGGCGCTCTCCAGCTTCGGAGACGACGAGG
AGTACCTGCTGCACGAGGGCGGCTGGCGCGAGGAGTACTTCCACGAACCGGAGCTGGTGGCCATCCGCCAGCGGTTCCAG
GAGCGCCTGCGCGCCCAGCGCGAGGCGGTGGAGGCGCGCAACGCGGGCGCCGAGGTGCCCTACACCATCCTGCGTCCCGA
CCGGATTCCCTGCGGCATCACCGTCTGA

Upstream 100 bases:

>100_bases
CGCTGAGCGACGCCGGCTTCATTCCCTGAGGGGAGGATACCATGGCTTGAGGTCCTACTATTCTCGTTCTACGGTCTGCG
CCCGCTACACAGAGGGTTCC

Downstream 100 bases:

>100_bases
GCCCTTGGAGACACACGCTCATGCCCAACCTGCTCTCTCGAGGTCTCTTCAGTCTGTTCTTCGGTGGCCGGCGCAAGCCC
CTGGCCAGCCTTCCTGGCCC

Product: lipoxygenase family protein

Products: NA

Alternate protein names: 15-LOX [H]

Number of amino acids: Translated: 675; Mature: 674

Protein sequence:

>675_residues
MTVEYKLTIRTGTKLGAGTDADISIVLVGTRGESAPRVLDKHFHNDFEAGAEDVYALSSEDLGDLVLLRFSNAGGVAADW
LLDWAIVTAGEKQWHFPFYRWVLSGATVDVLEGTAKLARQASSERESTARRELLEARQRMYPWRAPEMTEGLPGALDLRE
GRPLPKDELYRGLTEGSYEVVIAKTLAAIKLNLPMLTRAWNGLVDIFDFFKHLEVPQLAQRWKDDLEFARQAVQGIAPLH
ITLVPSLPQGMPLTDDDVRGLLSPGTTLARALDAKRIFLIDFEILDDIRMYRKVGEDGVEERRWAPAARCLLYLDDQRQL
RPLAIQLGRDAQKDPVFTPNDDAYDWLAAKIYLRCSEGNSHQMVSHALRTHFVAEPFVMATMRNLPDPHPVYKLLRRHFR
YTLAINEGARKGLLDAGGVFDDFIATGGPDKGHLQLGKKGFQRWTLADNKPRADLERRGVLDPAVLPNYPYRDDALPLWD
AFEEYVGGVLRHFYRTDADLEADTEMQQWWKDLTEHGLPVDKLPCRELRRVDDLVDILTTVLFTVSVQHAAVNYLQYEHY
AFVPNAPLSMRREPPRQKGTLRAEDIPEMIPTKSQMLWQVAIGRALSSFGDDEEYLLHEGGWREEYFHEPELVAIRQRFQ
ERLRAQREAVEARNAGAEVPYTILRPDRIPCGITV

Sequences:

>Translated_675_residues
MTVEYKLTIRTGTKLGAGTDADISIVLVGTRGESAPRVLDKHFHNDFEAGAEDVYALSSEDLGDLVLLRFSNAGGVAADW
LLDWAIVTAGEKQWHFPFYRWVLSGATVDVLEGTAKLARQASSERESTARRELLEARQRMYPWRAPEMTEGLPGALDLRE
GRPLPKDELYRGLTEGSYEVVIAKTLAAIKLNLPMLTRAWNGLVDIFDFFKHLEVPQLAQRWKDDLEFARQAVQGIAPLH
ITLVPSLPQGMPLTDDDVRGLLSPGTTLARALDAKRIFLIDFEILDDIRMYRKVGEDGVEERRWAPAARCLLYLDDQRQL
RPLAIQLGRDAQKDPVFTPNDDAYDWLAAKIYLRCSEGNSHQMVSHALRTHFVAEPFVMATMRNLPDPHPVYKLLRRHFR
YTLAINEGARKGLLDAGGVFDDFIATGGPDKGHLQLGKKGFQRWTLADNKPRADLERRGVLDPAVLPNYPYRDDALPLWD
AFEEYVGGVLRHFYRTDADLEADTEMQQWWKDLTEHGLPVDKLPCRELRRVDDLVDILTTVLFTVSVQHAAVNYLQYEHY
AFVPNAPLSMRREPPRQKGTLRAEDIPEMIPTKSQMLWQVAIGRALSSFGDDEEYLLHEGGWREEYFHEPELVAIRQRFQ
ERLRAQREAVEARNAGAEVPYTILRPDRIPCGITV
>Mature_674_residues
TVEYKLTIRTGTKLGAGTDADISIVLVGTRGESAPRVLDKHFHNDFEAGAEDVYALSSEDLGDLVLLRFSNAGGVAADWL
LDWAIVTAGEKQWHFPFYRWVLSGATVDVLEGTAKLARQASSERESTARRELLEARQRMYPWRAPEMTEGLPGALDLREG
RPLPKDELYRGLTEGSYEVVIAKTLAAIKLNLPMLTRAWNGLVDIFDFFKHLEVPQLAQRWKDDLEFARQAVQGIAPLHI
TLVPSLPQGMPLTDDDVRGLLSPGTTLARALDAKRIFLIDFEILDDIRMYRKVGEDGVEERRWAPAARCLLYLDDQRQLR
PLAIQLGRDAQKDPVFTPNDDAYDWLAAKIYLRCSEGNSHQMVSHALRTHFVAEPFVMATMRNLPDPHPVYKLLRRHFRY
TLAINEGARKGLLDAGGVFDDFIATGGPDKGHLQLGKKGFQRWTLADNKPRADLERRGVLDPAVLPNYPYRDDALPLWDA
FEEYVGGVLRHFYRTDADLEADTEMQQWWKDLTEHGLPVDKLPCRELRRVDDLVDILTTVLFTVSVQHAAVNYLQYEHYA
FVPNAPLSMRREPPRQKGTLRAEDIPEMIPTKSQMLWQVAIGRALSSFGDDEEYLLHEGGWREEYFHEPELVAIRQRFQE
RLRAQREAVEARNAGAEVPYTILRPDRIPCGITV

Specific function: Converts arachidonic acid to 15S- hydroperoxyeicosatetraenoic acid (HpETE) which is rapidly reduced to hydroxyeicosatetraenoic acid (HETE). Could act on exogenous human-derived substrates to potentially modulate the local inflammatory responses during P.a

COG id: NA

COG function: NA

Gene ontology:

Cell location: Periplasm. Secreted, extracellular space. Note=Periplasmic with some activity further secreted to the extracellular milieu [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 lipoxygenase domain [H]

Homologues:

Organism=Homo sapiens, GI4502057, Length=683, Percent_Identity=33.8213762811127, Blast_Score=377, Evalue=1e-104,
Organism=Homo sapiens, GI182765464, Length=725, Percent_Identity=31.8620689655172, Blast_Score=312, Evalue=8e-85,
Organism=Homo sapiens, GI260166612, Length=725, Percent_Identity=31.8620689655172, Blast_Score=311, Evalue=1e-84,
Organism=Homo sapiens, GI4502053, Length=715, Percent_Identity=31.6083916083916, Blast_Score=308, Evalue=9e-84,
Organism=Homo sapiens, GI85067501, Length=691, Percent_Identity=31.9826338639653, Blast_Score=286, Evalue=4e-77,
Organism=Homo sapiens, GI154426292, Length=683, Percent_Identity=31.1859443631039, Blast_Score=278, Evalue=1e-74,
Organism=Homo sapiens, GI40316937, Length=691, Percent_Identity=32.1273516642547, Blast_Score=268, Evalue=1e-71,
Organism=Homo sapiens, GI85067499, Length=691, Percent_Identity=29.8118668596237, Blast_Score=254, Evalue=3e-67,
Organism=Homo sapiens, GI85067503, Length=688, Percent_Identity=28.6337209302326, Blast_Score=220, Evalue=3e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000907
- InterPro:   IPR013819
- InterPro:   IPR020834
- InterPro:   IPR020833 [H]

Pfam domain/function: PF00305 Lipoxygenase [H]

EC number: =1.13.11.33 [H]

Molecular weight: Translated: 76756; Mature: 76625

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: PS50095 PLAT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVEYKLTIRTGTKLGAGTDADISIVLVGTRGESAPRVLDKHFHNDFEAGAEDVYALSSE
CEEEEEEEEEECCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHCCHHHCCCHHEEECCCC
DLGDLVLLRFSNAGGVAADWLLDWAIVTAGEKQWHFPFYRWVLSGATVDVLEGTAKLARQ
CCCCEEEEEECCCCCHHHHHHHHHHHEECCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHH
ASSERESTARRELLEARQRMYPWRAPEMTEGLPGALDLREGRPLPKDELYRGLTEGSYEV
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCEEE
VIAKTLAAIKLNLPMLTRAWNGLVDIFDFFKHLEVPQLAQRWKDDLEFARQAVQGIAPLH
EHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEE
ITLVPSLPQGMPLTDDDVRGLLSPGTTLARALDAKRIFLIDFEILDDIRMYRKVGEDGVE
EEEECCCCCCCCCCCHHHHHHCCCCHHHHHHHCCCEEEEEEHHHHHHHHHHHHHCCCCHH
ERRWAPAARCLLYLDDQRQLRPLAIQLGRDAQKDPVFTPNDDAYDWLAAKIYLRCSEGNS
HHHCCCHHHEEEEECCCCCCCHHHHHHCCCCCCCCCCCCCCCHHHHEEEEEEEEECCCCC
HQMVSHALRTHFVAEPFVMATMRNLPDPHPVYKLLRRHFRYTLAINEGARKGLLDAGGVF
HHHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHCEEEEEECCCCCCCCCCCCCHH
DDFIATGGPDKGHLQLGKKGFQRWTLADNKPRADLERRGVLDPAVLPNYPYRDDALPLWD
HHHHHCCCCCCCHHHHCHHHHCEECCCCCCCCCCHHHCCCCCCHHCCCCCCCCCCCCHHH
AFEEYVGGVLRHFYRTDADLEADTEMQQWWKDLTEHGLPVDKLPCRELRRVDDLVDILTT
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
VLFTVSVQHAAVNYLQYEHYAFVPNAPLSMRREPPRQKGTLRAEDIPEMIPTKSQMLWQV
HHHHHHHHHHHHHHHHHCCEEECCCCCHHCCCCCCCCCCCCCHHCCHHHCCCHHHHHHHH
AIGRALSSFGDDEEYLLHEGGWREEYFHEPELVAIRQRFQERLRAQREAVEARNAGAEVP
HHHHHHHHCCCCCHHHCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
YTILRPDRIPCGITV
EEEECCCCCCCCCCC
>Mature Secondary Structure 
TVEYKLTIRTGTKLGAGTDADISIVLVGTRGESAPRVLDKHFHNDFEAGAEDVYALSSE
EEEEEEEEEECCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHCCHHHCCCHHEEECCCC
DLGDLVLLRFSNAGGVAADWLLDWAIVTAGEKQWHFPFYRWVLSGATVDVLEGTAKLARQ
CCCCEEEEEECCCCCHHHHHHHHHHHEECCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHH
ASSERESTARRELLEARQRMYPWRAPEMTEGLPGALDLREGRPLPKDELYRGLTEGSYEV
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCCEEE
VIAKTLAAIKLNLPMLTRAWNGLVDIFDFFKHLEVPQLAQRWKDDLEFARQAVQGIAPLH
EHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEE
ITLVPSLPQGMPLTDDDVRGLLSPGTTLARALDAKRIFLIDFEILDDIRMYRKVGEDGVE
EEEECCCCCCCCCCCHHHHHHCCCCHHHHHHHCCCEEEEEEHHHHHHHHHHHHHCCCCHH
ERRWAPAARCLLYLDDQRQLRPLAIQLGRDAQKDPVFTPNDDAYDWLAAKIYLRCSEGNS
HHHCCCHHHEEEEECCCCCCCHHHHHHCCCCCCCCCCCCCCCHHHHEEEEEEEEECCCCC
HQMVSHALRTHFVAEPFVMATMRNLPDPHPVYKLLRRHFRYTLAINEGARKGLLDAGGVF
HHHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHCEEEEEECCCCCCCCCCCCCHH
DDFIATGGPDKGHLQLGKKGFQRWTLADNKPRADLERRGVLDPAVLPNYPYRDDALPLWD
HHHHHCCCCCCCHHHHCHHHHCEECCCCCCCCCCHHHCCCCCCHHCCCCCCCCCCCCHHH
AFEEYVGGVLRHFYRTDADLEADTEMQQWWKDLTEHGLPVDKLPCRELRRVDDLVDILTT
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHH
VLFTVSVQHAAVNYLQYEHYAFVPNAPLSMRREPPRQKGTLRAEDIPEMIPTKSQMLWQV
HHHHHHHHHHHHHHHHHCCEEECCCCCHHCCCCCCCCCCCCCHHCCHHHCCCHHHHHHHH
AIGRALSSFGDDEEYLLHEGGWREEYFHEPELVAIRQRFQERLRAQREAVEARNAGAEVP
HHHHHHHHCCCCCHHHCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
YTILRPDRIPCGITV
EEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]