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The map label for this gene is dpp4 [H]

Identifier: 108759702

GI number: 108759702

Start: 573724

End: 576012

Strand: Direct

Name: dpp4 [H]

Synonym: MXAN_0515

Alternate gene names: 108759702

Gene position: 573724-576012 (Clockwise)

Preceding gene: 108759316

Following gene: 108762858

Centisome position: 6.28

GC content: 68.41

Gene sequence:

>2289_bases
ATGGGCTCTTCACTCTCCCGGAACATGGCCATGCCATCCTCTCGCCGCGTTATGAGCCATCATTCCGGTGACTCCTCCCA
CACCCCCATGCGAATCCTCCTCACCGCTCTGGTCCTGCTGAGCGCTCCAGTCCTCGCCCAGCCCAAGTCCGTGCCCACTC
CGAAGGCGGCGCCGAAGTCGGACGGCTTCATCCGCCAGCTCGTGGAGACGCGCTACTTCAACATCGGCCGTCCCATGGGC
ACGAGCTTCACCCCGGACGAGCAGACGCTCTTCTTCCTGCGCAATCCGGAGGGCTCACGCGCCCTCGCGCTCCACGCGTT
CGACGTGGCCACGGGACAGACGCGCGAGCACCTCACCGCGGAGCGCCTTCTGCAGCGTGCCCGGGAGAACCTCGCCGTCG
AGCCGAAGGCGCGCCAGGAGCCCGCGCGTGTGTCCTCGCGGGGCCTGAGCTCCTATGCCCTGTCCGAGGACGGCGAGAAG
TTGCTCGTGGGCTTGTCCGGCAAGCAGTACATCGTCACGCGCGCGTCCGGGAAGGTGACGGAGCTGAAGACGGGCCCCGG
CGCCATGGACGTGCGCTTCTCTCCCGATGCCACCCAGGTGGCCTATGTGCGGGGGCATGACGTGTATCGCCTGGACCTGG
CCACGAACATCGAGCACCAGGTGACGAAGGGCGGCACGGAGGAGAAGAGCCACGGGCTGGCGGAGTTCATCGCCACGAGC
GAGATGATGCGCTTCTCCGGCTACTGGTGGAGCCCGGACGGAAAGGCCCTGGCCTACACGGAGTCCGACACGAGCGGCGT
GGAGAAGCTCGCCATCGCGGACGCGCTCCACCCGGAGAACGATGCGCGGCGGCTCGCCTTCCCGCGCGCCGGCAAGGCCA
ACGCCCGGGTGCGCCTGGGTATCATCCCCATCACAGGCGGCAAGACGACGTGGGTGCGCTGGGACGTGGAGAAGTATCCC
TACCTCGCCACGGTGCGCTGGCCGGCGAAGGGCCCTCTGACGGTGCTGGTGCAGAACCGGCTCCAGACGGAGGAGCTCCT
GCTCGCGGTGGACCCGAGGACGGGGAGCACGCGCACGCTGCTCGTGGAGAGGGACGACGCTTGGCTCACGCTGCACCAGA
CGTTCCCCCACTGGCTGGAGGATGGAAGCGGCTTCCTCTGGTACACAGAGCGCAACGGCGCTGGCGAAGTGGAGCTGCGC
GACGCCTCGGGCAAGTTCGTGCGCTCGCTCGTGCCGCCCGGCGCGGGCTTCTATGACATGGCGGGCTACGTTGAGAAGGA
CGGCACCGTCTACTTCACCGGCGGCCCAACCTCCGACGAGCGCTACGTGTGGCGCCTGAGCCCGGGCGGGAGGCCCACCC
GCGTCACCTCGGAGAGCCCGGCGCTGGAGCTGGCCCGGATGTCCAAGCGGGGCGGCTTGCTGGCCATCACGTCCGAGGGC
CCCCGGCGCATGCGTCACACCACTGTGATGAAGGCGGACGGCACTCGCGTGGGCGAGCTGCCCTCGGTGGCAATGGAGCC
GCCGTTCCAGCCGCGAGTGGAGGTGCGGTACGTGGGCAAGGAGCGCTACCCCACGTCGCTGGTGCGTCCTCGCGACGCGA
AGCCCGGCGTGAAGCTGCCCGTCATCGTGGACATCTACGCGGGGCCCGGCATCCCCATGGTGTACCAGAGCATGCAGCAG
CACCTCACCAACCAGTGGCTCGCGGACGAGGGCTTCATCGTGGTGAAACTGGACGGGCGAGGAGTTTCGCCCACCGCCGA
CGCGAAGCTGCGCAAGCCGAAGTACGACTGGCCCCGGCTGCTGCTGGACGAGCAGGTGGCCGCGCTGCGCGCGCTCGCGG
CCGAGGTGCCGGAAATGGACCTGAGCCGCGTGGGCATCACTGGCGCGAGCAACGGCGGCTACATGTCCGCGCTGGCCGTG
CTCACCCGCCCGGACGTCTTCAAGGCCGCGGTGGCCGTGTCCTCAGTGACGGACTGGCGCGACTACGACTCACACCTGAC
GGAGCGCTTCTTCGGCCTACCCGACGAGCACCCCCAGGCCTACGAGCAGGCCTCGCTCCTTACTCACGTGAAGGCCGACC
AGCCCATGGGAAAGCTCCTGTTCATCCATGGCACTGCGGACGACAACGTCCTCTTCTTCCACGCCCTCAAGCTTTCGGAC
GCGCTGTTTCGGGCGGGCCAGCCCCACGAGTTCCTGCCCCTCAGCGGCATGCCGCACATGGTGTTCGACCCGGTGCTGGC
CGAGCGCATGTGGGAGGAGACCGCGCGCTACTTCAAGCGGCATCTCTAA

Upstream 100 bases:

>100_bases
TGGCCACTTACGGACGATTGCTCTCCCCGTTCGCGGCTGTGCCATGGAACTGTCATGGTCAACGCCAATCATCTGACGCG
CCACGTTGCCCTCCAAGCCG

Downstream 100 bases:

>100_bases
ACCGCCTCGGCAAGTCCGCTAAACATGGAGCCCGGCATGCTCGAGCGTGTCGCCGCAGCCAAGCGCTGACCGCCTTGGAA
CGGTGCGCCTGAAGGCGGTC

Product: dipeptidyl peptidase IV

Products: NA

Alternate protein names: PTP; Prolyl tripeptidyl peptidase A [H]

Number of amino acids: Translated: 762; Mature: 761

Protein sequence:

>762_residues
MGSSLSRNMAMPSSRRVMSHHSGDSSHTPMRILLTALVLLSAPVLAQPKSVPTPKAAPKSDGFIRQLVETRYFNIGRPMG
TSFTPDEQTLFFLRNPEGSRALALHAFDVATGQTREHLTAERLLQRARENLAVEPKARQEPARVSSRGLSSYALSEDGEK
LLVGLSGKQYIVTRASGKVTELKTGPGAMDVRFSPDATQVAYVRGHDVYRLDLATNIEHQVTKGGTEEKSHGLAEFIATS
EMMRFSGYWWSPDGKALAYTESDTSGVEKLAIADALHPENDARRLAFPRAGKANARVRLGIIPITGGKTTWVRWDVEKYP
YLATVRWPAKGPLTVLVQNRLQTEELLLAVDPRTGSTRTLLVERDDAWLTLHQTFPHWLEDGSGFLWYTERNGAGEVELR
DASGKFVRSLVPPGAGFYDMAGYVEKDGTVYFTGGPTSDERYVWRLSPGGRPTRVTSESPALELARMSKRGGLLAITSEG
PRRMRHTTVMKADGTRVGELPSVAMEPPFQPRVEVRYVGKERYPTSLVRPRDAKPGVKLPVIVDIYAGPGIPMVYQSMQQ
HLTNQWLADEGFIVVKLDGRGVSPTADAKLRKPKYDWPRLLLDEQVAALRALAAEVPEMDLSRVGITGASNGGYMSALAV
LTRPDVFKAAVAVSSVTDWRDYDSHLTERFFGLPDEHPQAYEQASLLTHVKADQPMGKLLFIHGTADDNVLFFHALKLSD
ALFRAGQPHEFLPLSGMPHMVFDPVLAERMWEETARYFKRHL

Sequences:

>Translated_762_residues
MGSSLSRNMAMPSSRRVMSHHSGDSSHTPMRILLTALVLLSAPVLAQPKSVPTPKAAPKSDGFIRQLVETRYFNIGRPMG
TSFTPDEQTLFFLRNPEGSRALALHAFDVATGQTREHLTAERLLQRARENLAVEPKARQEPARVSSRGLSSYALSEDGEK
LLVGLSGKQYIVTRASGKVTELKTGPGAMDVRFSPDATQVAYVRGHDVYRLDLATNIEHQVTKGGTEEKSHGLAEFIATS
EMMRFSGYWWSPDGKALAYTESDTSGVEKLAIADALHPENDARRLAFPRAGKANARVRLGIIPITGGKTTWVRWDVEKYP
YLATVRWPAKGPLTVLVQNRLQTEELLLAVDPRTGSTRTLLVERDDAWLTLHQTFPHWLEDGSGFLWYTERNGAGEVELR
DASGKFVRSLVPPGAGFYDMAGYVEKDGTVYFTGGPTSDERYVWRLSPGGRPTRVTSESPALELARMSKRGGLLAITSEG
PRRMRHTTVMKADGTRVGELPSVAMEPPFQPRVEVRYVGKERYPTSLVRPRDAKPGVKLPVIVDIYAGPGIPMVYQSMQQ
HLTNQWLADEGFIVVKLDGRGVSPTADAKLRKPKYDWPRLLLDEQVAALRALAAEVPEMDLSRVGITGASNGGYMSALAV
LTRPDVFKAAVAVSSVTDWRDYDSHLTERFFGLPDEHPQAYEQASLLTHVKADQPMGKLLFIHGTADDNVLFFHALKLSD
ALFRAGQPHEFLPLSGMPHMVFDPVLAERMWEETARYFKRHL
>Mature_761_residues
GSSLSRNMAMPSSRRVMSHHSGDSSHTPMRILLTALVLLSAPVLAQPKSVPTPKAAPKSDGFIRQLVETRYFNIGRPMGT
SFTPDEQTLFFLRNPEGSRALALHAFDVATGQTREHLTAERLLQRARENLAVEPKARQEPARVSSRGLSSYALSEDGEKL
LVGLSGKQYIVTRASGKVTELKTGPGAMDVRFSPDATQVAYVRGHDVYRLDLATNIEHQVTKGGTEEKSHGLAEFIATSE
MMRFSGYWWSPDGKALAYTESDTSGVEKLAIADALHPENDARRLAFPRAGKANARVRLGIIPITGGKTTWVRWDVEKYPY
LATVRWPAKGPLTVLVQNRLQTEELLLAVDPRTGSTRTLLVERDDAWLTLHQTFPHWLEDGSGFLWYTERNGAGEVELRD
ASGKFVRSLVPPGAGFYDMAGYVEKDGTVYFTGGPTSDERYVWRLSPGGRPTRVTSESPALELARMSKRGGLLAITSEGP
RRMRHTTVMKADGTRVGELPSVAMEPPFQPRVEVRYVGKERYPTSLVRPRDAKPGVKLPVIVDIYAGPGIPMVYQSMQQH
LTNQWLADEGFIVVKLDGRGVSPTADAKLRKPKYDWPRLLLDEQVAALRALAAEVPEMDLSRVGITGASNGGYMSALAVL
TRPDVFKAAVAVSSVTDWRDYDSHLTERFFGLPDEHPQAYEQASLLTHVKADQPMGKLLFIHGTADDNVLFFHALKLSDA
LFRAGQPHEFLPLSGMPHMVFDPVLAERMWEETARYFKRHL

Specific function: Serine proteinase. Releases tripeptides from the free amino terminus of proteins. Has a requirement for Pro in the P1 position, but is inactivated by Pro in the P1' position [H]

COG id: COG1506

COG function: function code E; Dipeptidyl aminopeptidases/acylaminoacyl-peptidases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9B family [H]

Homologues:

Organism=Homo sapiens, GI85787627, Length=561, Percent_Identity=23.7076648841355, Blast_Score=139, Evalue=9e-33,
Organism=Homo sapiens, GI295842359, Length=561, Percent_Identity=23.7076648841355, Blast_Score=139, Evalue=9e-33,
Organism=Homo sapiens, GI52426756, Length=561, Percent_Identity=23.7076648841355, Blast_Score=139, Evalue=1e-32,
Organism=Homo sapiens, GI295849272, Length=561, Percent_Identity=23.7076648841355, Blast_Score=139, Evalue=1e-32,
Organism=Homo sapiens, GI295842403, Length=561, Percent_Identity=23.7076648841355, Blast_Score=139, Evalue=1e-32,
Organism=Homo sapiens, GI37577089, Length=208, Percent_Identity=36.5384615384615, Blast_Score=133, Evalue=5e-31,
Organism=Homo sapiens, GI18450280, Length=208, Percent_Identity=36.5384615384615, Blast_Score=133, Evalue=5e-31,
Organism=Homo sapiens, GI194394146, Length=254, Percent_Identity=33.0708661417323, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI18765694, Length=688, Percent_Identity=22.093023255814, Blast_Score=132, Evalue=2e-30,
Organism=Homo sapiens, GI16933540, Length=708, Percent_Identity=21.8926553672316, Blast_Score=130, Evalue=5e-30,
Organism=Homo sapiens, GI86792774, Length=606, Percent_Identity=22.2772277227723, Blast_Score=129, Evalue=1e-29,
Organism=Homo sapiens, GI86792778, Length=606, Percent_Identity=22.2772277227723, Blast_Score=129, Evalue=2e-29,
Organism=Homo sapiens, GI86792863, Length=606, Percent_Identity=22.2772277227723, Blast_Score=129, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17508019, Length=261, Percent_Identity=30.6513409961686, Blast_Score=115, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI17508017, Length=261, Percent_Identity=30.6513409961686, Blast_Score=115, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI17550672, Length=610, Percent_Identity=21.9672131147541, Blast_Score=99, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17564632, Length=571, Percent_Identity=25.569176882662, Blast_Score=87, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17564634, Length=571, Percent_Identity=25.569176882662, Blast_Score=87, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6324793, Length=596, Percent_Identity=21.4765100671141, Blast_Score=102, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6321817, Length=627, Percent_Identity=23.6044657097289, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI45550825, Length=729, Percent_Identity=25.3772290809328, Blast_Score=166, Evalue=4e-41,
Organism=Drosophila melanogaster, GI45553511, Length=729, Percent_Identity=25.3772290809328, Blast_Score=166, Evalue=4e-41,
Organism=Drosophila melanogaster, GI45551969, Length=729, Percent_Identity=25.3772290809328, Blast_Score=166, Evalue=6e-41,
Organism=Drosophila melanogaster, GI161083744, Length=755, Percent_Identity=23.5761589403974, Blast_Score=116, Evalue=7e-26,
Organism=Drosophila melanogaster, GI17933704, Length=755, Percent_Identity=23.4437086092715, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI221331178, Length=755, Percent_Identity=23.4437086092715, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24582032, Length=639, Percent_Identity=22.0657276995305, Blast_Score=100, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24582257, Length=191, Percent_Identity=29.3193717277487, Blast_Score=93, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001375
- InterPro:   IPR002469 [H]

Pfam domain/function: PF00930 DPPIV_N; PF00326 Peptidase_S9 [H]

EC number: =3.4.14.12 [H]

Molecular weight: Translated: 84480; Mature: 84349

Theoretical pI: Translated: 9.41; Mature: 9.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSSLSRNMAMPSSRRVMSHHSGDSSHTPMRILLTALVLLSAPVLAQPKSVPTPKAAPKS
CCCCCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
DGFIRQLVETRYFNIGRPMGTSFTPDEQTLFFLRNPEGSRALALHAFDVATGQTREHLTA
CHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCEEEEEEEECCCCCCHHHHHH
ERLLQRARENLAVEPKARQEPARVSSRGLSSYALSEDGEKLLVGLSGKQYIVTRASGKVT
HHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCEEECCCCCEEEEEECCCEEEEEECCCCEE
ELKTGPGAMDVRFSPDATQVAYVRGHDVYRLDLATNIEHQVTKGGTEEKSHGLAEFIATS
EEECCCCEEEEEECCCCCEEEEEECCCEEEEEEECCCCHHHHCCCCCHHHHHHHHHHHHH
EMMRFSGYWWSPDGKALAYTESDTSGVEKLAIADALHPENDARRLAFPRAGKANARVRLG
HHHHHCCEEECCCCCEEEEECCCCCCHHHHHHHHCCCCCCCCCEEECCCCCCCCCEEEEE
IIPITGGKTTWVRWDVEKYPYLATVRWPAKGPLTVLVQNRLQTEELLLAVDPRTGSTRTL
EEEECCCCEEEEEEEHHHCCEEEEEEECCCCCEEEEEECCCCCEEEEEEECCCCCCCEEE
LVERDDAWLTLHQTFPHWLEDGSGFLWYTERNGAGEVELRDASGKFVRSLVPPGAGFYDM
EEECCCCEEEEEHHCCHHHHCCCEEEEEEECCCCCEEEEECCCCHHHHHHCCCCCCHHHH
AGYVEKDGTVYFTGGPTSDERYVWRLSPGGRPTRVTSESPALELARMSKRGGLLAITSEG
CCEEECCCEEEECCCCCCCCCEEEEECCCCCCCEECCCCCHHHHHHHHCCCCEEEEECCC
PRRMRHTTVMKADGTRVGELPSVAMEPPFQPRVEVRYVGKERYPTSLVRPRDAKPGVKLP
CHHHHHEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCHHCCCCCCCCCCCCC
VIVDIYAGPGIPMVYQSMQQHLTNQWLADEGFIVVKLDGRGVSPTADAKLRKPKYDWPRL
EEEEEECCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHH
LLDEQVAALRALAAEVPEMDLSRVGITGASNGGYMSALAVLTRPDVFKAAVAVSSVTDWR
HHHHHHHHHHHHHHHCCCCCHHHEEEECCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHH
DYDSHLTERFFGLPDEHPQAYEQASLLTHVKADQPMGKLLFIHGTADDNVLFFHALKLSD
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEEEEEEHHHH
ALFRAGQPHEFLPLSGMPHMVFDPVLAERMWEETARYFKRHL
HHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GSSLSRNMAMPSSRRVMSHHSGDSSHTPMRILLTALVLLSAPVLAQPKSVPTPKAAPKS
CCCCCCCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
DGFIRQLVETRYFNIGRPMGTSFTPDEQTLFFLRNPEGSRALALHAFDVATGQTREHLTA
CHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCEEEEEEEECCCCCCHHHHHH
ERLLQRARENLAVEPKARQEPARVSSRGLSSYALSEDGEKLLVGLSGKQYIVTRASGKVT
HHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCEEECCCCCEEEEEECCCEEEEEECCCCEE
ELKTGPGAMDVRFSPDATQVAYVRGHDVYRLDLATNIEHQVTKGGTEEKSHGLAEFIATS
EEECCCCEEEEEECCCCCEEEEEECCCEEEEEEECCCCHHHHCCCCCHHHHHHHHHHHHH
EMMRFSGYWWSPDGKALAYTESDTSGVEKLAIADALHPENDARRLAFPRAGKANARVRLG
HHHHHCCEEECCCCCEEEEECCCCCCHHHHHHHHCCCCCCCCCEEECCCCCCCCCEEEEE
IIPITGGKTTWVRWDVEKYPYLATVRWPAKGPLTVLVQNRLQTEELLLAVDPRTGSTRTL
EEEECCCCEEEEEEEHHHCCEEEEEEECCCCCEEEEEECCCCCEEEEEEECCCCCCCEEE
LVERDDAWLTLHQTFPHWLEDGSGFLWYTERNGAGEVELRDASGKFVRSLVPPGAGFYDM
EEECCCCEEEEEHHCCHHHHCCCEEEEEEECCCCCEEEEECCCCHHHHHHCCCCCCHHHH
AGYVEKDGTVYFTGGPTSDERYVWRLSPGGRPTRVTSESPALELARMSKRGGLLAITSEG
CCEEECCCEEEECCCCCCCCCEEEEECCCCCCCEECCCCCHHHHHHHHCCCCEEEEECCC
PRRMRHTTVMKADGTRVGELPSVAMEPPFQPRVEVRYVGKERYPTSLVRPRDAKPGVKLP
CHHHHHEEEEEECCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCHHCCCCCCCCCCCCC
VIVDIYAGPGIPMVYQSMQQHLTNQWLADEGFIVVKLDGRGVSPTADAKLRKPKYDWPRL
EEEEEECCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHH
LLDEQVAALRALAAEVPEMDLSRVGITGASNGGYMSALAVLTRPDVFKAAVAVSSVTDWR
HHHHHHHHHHHHHHHCCCCCHHHEEEECCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHH
DYDSHLTERFFGLPDEHPQAYEQASLLTHVKADQPMGKLLFIHGTADDNVLFFHALKLSD
HHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEEEEEEEHHHH
ALFRAGQPHEFLPLSGMPHMVFDPVLAERMWEETARYFKRHL
HHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA